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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 8881

FusionGeneSummary for CTPS2_SEC31A

check button Fusion gene summary
Fusion gene informationFusion gene name: CTPS2_SEC31A
Fusion gene ID: 8881
HgeneTgene
Gene symbol

CTPS2

SEC31A

Gene ID

56474

22872

Gene nameCTP synthase 2SEC31 homolog A, COPII coat complex component
Synonyms-ABP125|ABP130|HSPC275|HSPC334|SEC31L1
Cytomap

Xp22.2

4q21.22

Type of geneprotein-codingprotein-coding
DescriptionCTP synthase 2CTP synthase IICTP synthetase type 2UTP-ammonia ligase 2cytidine 5'-triphosphate synthetase 2protein transport protein Sec31ASEC31 homolog A, COPII coating complex componentSEC31-like protein 1SEC31-related protein Aweb1-like proteinyeast Sec31p homolog
Modification date2018052220180523
UniProtAcc

Q9NRF8

O94979

Ensembl transtripts involved in fusion geneENST00000443824, ENST00000359276, 
ENST00000380241, ENST00000483053, 
ENST00000348405, ENST00000513858, 
ENST00000395310, ENST00000443462, 
ENST00000509142, ENST00000326950, 
ENST00000432794, ENST00000311785, 
ENST00000448323, ENST00000505472, 
ENST00000500777, ENST00000508502, 
ENST00000355196, ENST00000264405, 
ENST00000505984, ENST00000508479, 
ENST00000436790, 
Fusion gene scores* DoF score5 X 5 X 4=1008 X 8 X 4=256
# samples 69
** MAII scorelog2(6/100*10)=-0.736965594166206
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(9/256*10)=-1.50814690367033
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CTPS2 [Title/Abstract] AND SEC31A [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneSEC31A

GO:0051592

response to calcium ion

17196169

TgeneSEC31A

GO:0090110

cargo loading into COPII-coated vesicle

17499046|18843296


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BF839137CTPS2chrX

16672693

+SEC31Achr4

83803824

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000443824ENST00000348405CTPS2chrX

16672693

+SEC31Achr4

83803824

-
intron-intronENST00000443824ENST00000513858CTPS2chrX

16672693

+SEC31Achr4

83803824

-
intron-intronENST00000443824ENST00000395310CTPS2chrX

16672693

+SEC31Achr4

83803824

-
intron-intronENST00000443824ENST00000443462CTPS2chrX

16672693

+SEC31Achr4

83803824

-
intron-intronENST00000443824ENST00000509142CTPS2chrX

16672693

+SEC31Achr4

83803824

-
intron-intronENST00000443824ENST00000326950CTPS2chrX

16672693

+SEC31Achr4

83803824

-
intron-intronENST00000443824ENST00000432794CTPS2chrX

16672693

+SEC31Achr4

83803824

-
intron-intronENST00000443824ENST00000311785CTPS2chrX

16672693

+SEC31Achr4

83803824

-
intron-intronENST00000443824ENST00000448323CTPS2chrX

16672693

+SEC31Achr4

83803824

-
intron-intronENST00000443824ENST00000505472CTPS2chrX

16672693

+SEC31Achr4

83803824

-
intron-intronENST00000443824ENST00000500777CTPS2chrX

16672693

+SEC31Achr4

83803824

-
intron-intronENST00000443824ENST00000508502CTPS2chrX

16672693

+SEC31Achr4

83803824

-
intron-intronENST00000443824ENST00000355196CTPS2chrX

16672693

+SEC31Achr4

83803824

-
intron-intronENST00000443824ENST00000264405CTPS2chrX

16672693

+SEC31Achr4

83803824

-
intron-intronENST00000443824ENST00000505984CTPS2chrX

16672693

+SEC31Achr4

83803824

-
intron-intronENST00000443824ENST00000508479CTPS2chrX

16672693

+SEC31Achr4

83803824

-
intron-intronENST00000443824ENST00000436790CTPS2chrX

16672693

+SEC31Achr4

83803824

-
intron-intronENST00000359276ENST00000348405CTPS2chrX

16672693

+SEC31Achr4

83803824

-
intron-intronENST00000359276ENST00000513858CTPS2chrX

16672693

+SEC31Achr4

83803824

-
intron-intronENST00000359276ENST00000395310CTPS2chrX

16672693

+SEC31Achr4

83803824

-
intron-intronENST00000359276ENST00000443462CTPS2chrX

16672693

+SEC31Achr4

83803824

-
intron-intronENST00000359276ENST00000509142CTPS2chrX

16672693

+SEC31Achr4

83803824

-
intron-intronENST00000359276ENST00000326950CTPS2chrX

16672693

+SEC31Achr4

83803824

-
intron-intronENST00000359276ENST00000432794CTPS2chrX

16672693

+SEC31Achr4

83803824

-
intron-intronENST00000359276ENST00000311785CTPS2chrX

16672693

+SEC31Achr4

83803824

-
intron-intronENST00000359276ENST00000448323CTPS2chrX

16672693

+SEC31Achr4

83803824

-
intron-intronENST00000359276ENST00000505472CTPS2chrX

16672693

+SEC31Achr4

83803824

-
intron-intronENST00000359276ENST00000500777CTPS2chrX

16672693

+SEC31Achr4

83803824

-
intron-intronENST00000359276ENST00000508502CTPS2chrX

16672693

+SEC31Achr4

83803824

-
intron-intronENST00000359276ENST00000355196CTPS2chrX

16672693

+SEC31Achr4

83803824

-
intron-intronENST00000359276ENST00000264405CTPS2chrX

16672693

+SEC31Achr4

83803824

-
intron-intronENST00000359276ENST00000505984CTPS2chrX

16672693

+SEC31Achr4

83803824

-
intron-intronENST00000359276ENST00000508479CTPS2chrX

16672693

+SEC31Achr4

83803824

-
intron-intronENST00000359276ENST00000436790CTPS2chrX

16672693

+SEC31Achr4

83803824

-
intron-intronENST00000380241ENST00000348405CTPS2chrX

16672693

+SEC31Achr4

83803824

-
intron-intronENST00000380241ENST00000513858CTPS2chrX

16672693

+SEC31Achr4

83803824

-
intron-intronENST00000380241ENST00000395310CTPS2chrX

16672693

+SEC31Achr4

83803824

-
intron-intronENST00000380241ENST00000443462CTPS2chrX

16672693

+SEC31Achr4

83803824

-
intron-intronENST00000380241ENST00000509142CTPS2chrX

16672693

+SEC31Achr4

83803824

-
intron-intronENST00000380241ENST00000326950CTPS2chrX

16672693

+SEC31Achr4

83803824

-
intron-intronENST00000380241ENST00000432794CTPS2chrX

16672693

+SEC31Achr4

83803824

-
intron-intronENST00000380241ENST00000311785CTPS2chrX

16672693

+SEC31Achr4

83803824

-
intron-intronENST00000380241ENST00000448323CTPS2chrX

16672693

+SEC31Achr4

83803824

-
intron-intronENST00000380241ENST00000505472CTPS2chrX

16672693

+SEC31Achr4

83803824

-
intron-intronENST00000380241ENST00000500777CTPS2chrX

16672693

+SEC31Achr4

83803824

-
intron-intronENST00000380241ENST00000508502CTPS2chrX

16672693

+SEC31Achr4

83803824

-
intron-intronENST00000380241ENST00000355196CTPS2chrX

16672693

+SEC31Achr4

83803824

-
intron-intronENST00000380241ENST00000264405CTPS2chrX

16672693

+SEC31Achr4

83803824

-
intron-intronENST00000380241ENST00000505984CTPS2chrX

16672693

+SEC31Achr4

83803824

-
intron-intronENST00000380241ENST00000508479CTPS2chrX

16672693

+SEC31Achr4

83803824

-
intron-intronENST00000380241ENST00000436790CTPS2chrX

16672693

+SEC31Achr4

83803824

-
intron-intronENST00000483053ENST00000348405CTPS2chrX

16672693

+SEC31Achr4

83803824

-
intron-intronENST00000483053ENST00000513858CTPS2chrX

16672693

+SEC31Achr4

83803824

-
intron-intronENST00000483053ENST00000395310CTPS2chrX

16672693

+SEC31Achr4

83803824

-
intron-intronENST00000483053ENST00000443462CTPS2chrX

16672693

+SEC31Achr4

83803824

-
intron-intronENST00000483053ENST00000509142CTPS2chrX

16672693

+SEC31Achr4

83803824

-
intron-intronENST00000483053ENST00000326950CTPS2chrX

16672693

+SEC31Achr4

83803824

-
intron-intronENST00000483053ENST00000432794CTPS2chrX

16672693

+SEC31Achr4

83803824

-
intron-intronENST00000483053ENST00000311785CTPS2chrX

16672693

+SEC31Achr4

83803824

-
intron-intronENST00000483053ENST00000448323CTPS2chrX

16672693

+SEC31Achr4

83803824

-
intron-intronENST00000483053ENST00000505472CTPS2chrX

16672693

+SEC31Achr4

83803824

-
intron-intronENST00000483053ENST00000500777CTPS2chrX

16672693

+SEC31Achr4

83803824

-
intron-intronENST00000483053ENST00000508502CTPS2chrX

16672693

+SEC31Achr4

83803824

-
intron-intronENST00000483053ENST00000355196CTPS2chrX

16672693

+SEC31Achr4

83803824

-
intron-intronENST00000483053ENST00000264405CTPS2chrX

16672693

+SEC31Achr4

83803824

-
intron-intronENST00000483053ENST00000505984CTPS2chrX

16672693

+SEC31Achr4

83803824

-
intron-intronENST00000483053ENST00000508479CTPS2chrX

16672693

+SEC31Achr4

83803824

-
intron-intronENST00000483053ENST00000436790CTPS2chrX

16672693

+SEC31Achr4

83803824

-

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FusionProtFeatures for CTPS2_SEC31A


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CTPS2

Q9NRF8

SEC31A

O94979

Catalyzes the ATP-dependent amination of UTP to CTP witheither L-glutamine or ammonia as the source of nitrogen.Constitutes the rate-limiting enzyme in the synthesis of cytosinenucleotides. {ECO:0000269|PubMed:10899599,ECO:0000269|PubMed:16179339}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for CTPS2_SEC31A


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for CTPS2_SEC31A


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for CTPS2_SEC31A


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for CTPS2_SEC31A


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneSEC31AC0079744Diffuse Large B-Cell Lymphoma1CTD_human