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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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Fusion gene ID: 8861

FusionGeneSummary for CTNND1_ZNFX1

check button Fusion gene summary
Fusion gene informationFusion gene name: CTNND1_ZNFX1
Fusion gene ID: 8861
HgeneTgene
Gene symbol

CTNND1

ZNFX1

Gene ID

1500

57169

Gene namecatenin delta 1zinc finger NFX1-type containing 1
SynonymsBCDS2|CAS|CTNND|P120CAS|P120CTN|p120|p120(CAS)|p120(CTN)-
Cytomap

11q12.1

20q13.13

Type of geneprotein-codingprotein-coding
Descriptioncatenin delta-1cadherin-associated Src substratecatenin (cadherin-associated protein), delta 1p120 cateninNFX1-type zinc finger-containing protein 1
Modification date2018052320180523
UniProtAcc

O60716

Q9P2E3

Ensembl transtripts involved in fusion geneENST00000524630, ENST00000529919, 
ENST00000399039, ENST00000360682, 
ENST00000361796, ENST00000361391, 
ENST00000530094, ENST00000428599, 
ENST00000361332, ENST00000527467, 
ENST00000415361, ENST00000532245, 
ENST00000532463, ENST00000528232, 
ENST00000529986, ENST00000531014, 
ENST00000358694, ENST00000526772, 
ENST00000532787, ENST00000533667, 
ENST00000529873, ENST00000525902, 
ENST00000529526, ENST00000532649, 
ENST00000426142, ENST00000532844, 
ENST00000528621, ENST00000399050, 
ENST00000526357, ENST00000530748, 
ENST00000534579, ENST00000526938, 
ENST00000371754, ENST00000469991, 
ENST00000371752, ENST00000396105, 
Fusion gene scores* DoF score17 X 11 X 12=224427 X 5 X 14=1890
# samples 1931
** MAII scorelog2(19/2244*10)=-3.56200135227784
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(31/1890*10)=-2.6080461138342
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CTNND1 [Title/Abstract] AND ZNFX1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVBLCATCGA-FD-A3SO-01ACTNND1chr11

57586650

+ZNFX1chr20

47863418

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-intronENST00000524630ENST00000371754CTNND1chr11

57586650

+ZNFX1chr20

47863418

-
3UTR-intronENST00000524630ENST00000469991CTNND1chr11

57586650

+ZNFX1chr20

47863418

-
3UTR-3UTRENST00000524630ENST00000371752CTNND1chr11

57586650

+ZNFX1chr20

47863418

-
3UTR-3UTRENST00000524630ENST00000396105CTNND1chr11

57586650

+ZNFX1chr20

47863418

-
intron-intronENST00000529919ENST00000371754CTNND1chr11

57586650

+ZNFX1chr20

47863418

-
intron-intronENST00000529919ENST00000469991CTNND1chr11

57586650

+ZNFX1chr20

47863418

-
intron-3UTRENST00000529919ENST00000371752CTNND1chr11

57586650

+ZNFX1chr20

47863418

-
intron-3UTRENST00000529919ENST00000396105CTNND1chr11

57586650

+ZNFX1chr20

47863418

-
intron-intronENST00000399039ENST00000371754CTNND1chr11

57586650

+ZNFX1chr20

47863418

-
intron-intronENST00000399039ENST00000469991CTNND1chr11

57586650

+ZNFX1chr20

47863418

-
intron-3UTRENST00000399039ENST00000371752CTNND1chr11

57586650

+ZNFX1chr20

47863418

-
intron-3UTRENST00000399039ENST00000396105CTNND1chr11

57586650

+ZNFX1chr20

47863418

-
5CDS-intronENST00000360682ENST00000371754CTNND1chr11

57586650

+ZNFX1chr20

47863418

-
5CDS-intronENST00000360682ENST00000469991CTNND1chr11

57586650

+ZNFX1chr20

47863418

-
5CDS-3UTRENST00000360682ENST00000371752CTNND1chr11

57586650

+ZNFX1chr20

47863418

-
5CDS-3UTRENST00000360682ENST00000396105CTNND1chr11

57586650

+ZNFX1chr20

47863418

-
5CDS-intronENST00000361796ENST00000371754CTNND1chr11

57586650

+ZNFX1chr20

47863418

-
5CDS-intronENST00000361796ENST00000469991CTNND1chr11

57586650

+ZNFX1chr20

47863418

-
5CDS-3UTRENST00000361796ENST00000371752CTNND1chr11

57586650

+ZNFX1chr20

47863418

-
5CDS-3UTRENST00000361796ENST00000396105CTNND1chr11

57586650

+ZNFX1chr20

47863418

-
5CDS-intronENST00000361391ENST00000371754CTNND1chr11

57586650

+ZNFX1chr20

47863418

-
5CDS-intronENST00000361391ENST00000469991CTNND1chr11

57586650

+ZNFX1chr20

47863418

-
5CDS-3UTRENST00000361391ENST00000371752CTNND1chr11

57586650

+ZNFX1chr20

47863418

-
5CDS-3UTRENST00000361391ENST00000396105CTNND1chr11

57586650

+ZNFX1chr20

47863418

-
5CDS-intronENST00000530094ENST00000371754CTNND1chr11

57586650

+ZNFX1chr20

47863418

-
5CDS-intronENST00000530094ENST00000469991CTNND1chr11

57586650

+ZNFX1chr20

47863418

-
5CDS-3UTRENST00000530094ENST00000371752CTNND1chr11

57586650

+ZNFX1chr20

47863418

-
5CDS-3UTRENST00000530094ENST00000396105CTNND1chr11

57586650

+ZNFX1chr20

47863418

-
5CDS-intronENST00000428599ENST00000371754CTNND1chr11

57586650

+ZNFX1chr20

47863418

-
5CDS-intronENST00000428599ENST00000469991CTNND1chr11

57586650

+ZNFX1chr20

47863418

-
5CDS-3UTRENST00000428599ENST00000371752CTNND1chr11

57586650

+ZNFX1chr20

47863418

-
5CDS-3UTRENST00000428599ENST00000396105CTNND1chr11

57586650

+ZNFX1chr20

47863418

-
5CDS-intronENST00000361332ENST00000371754CTNND1chr11

57586650

+ZNFX1chr20

47863418

-
5CDS-intronENST00000361332ENST00000469991CTNND1chr11

57586650

+ZNFX1chr20

47863418

-
5CDS-3UTRENST00000361332ENST00000371752CTNND1chr11

57586650

+ZNFX1chr20

47863418

-
5CDS-3UTRENST00000361332ENST00000396105CTNND1chr11

57586650

+ZNFX1chr20

47863418

-
5CDS-intronENST00000527467ENST00000371754CTNND1chr11

57586650

+ZNFX1chr20

47863418

-
5CDS-intronENST00000527467ENST00000469991CTNND1chr11

57586650

+ZNFX1chr20

47863418

-
5CDS-3UTRENST00000527467ENST00000371752CTNND1chr11

57586650

+ZNFX1chr20

47863418

-
5CDS-3UTRENST00000527467ENST00000396105CTNND1chr11

57586650

+ZNFX1chr20

47863418

-
5CDS-intronENST00000415361ENST00000371754CTNND1chr11

57586650

+ZNFX1chr20

47863418

-
5CDS-intronENST00000415361ENST00000469991CTNND1chr11

57586650

+ZNFX1chr20

47863418

-
5CDS-3UTRENST00000415361ENST00000371752CTNND1chr11

57586650

+ZNFX1chr20

47863418

-
5CDS-3UTRENST00000415361ENST00000396105CTNND1chr11

57586650

+ZNFX1chr20

47863418

-
5CDS-intronENST00000532245ENST00000371754CTNND1chr11

57586650

+ZNFX1chr20

47863418

-
5CDS-intronENST00000532245ENST00000469991CTNND1chr11

57586650

+ZNFX1chr20

47863418

-
5CDS-3UTRENST00000532245ENST00000371752CTNND1chr11

57586650

+ZNFX1chr20

47863418

-
5CDS-3UTRENST00000532245ENST00000396105CTNND1chr11

57586650

+ZNFX1chr20

47863418

-
5CDS-intronENST00000532463ENST00000371754CTNND1chr11

57586650

+ZNFX1chr20

47863418

-
5CDS-intronENST00000532463ENST00000469991CTNND1chr11

57586650

+ZNFX1chr20

47863418

-
5CDS-3UTRENST00000532463ENST00000371752CTNND1chr11

57586650

+ZNFX1chr20

47863418

-
5CDS-3UTRENST00000532463ENST00000396105CTNND1chr11

57586650

+ZNFX1chr20

47863418

-
5CDS-intronENST00000528232ENST00000371754CTNND1chr11

57586650

+ZNFX1chr20

47863418

-
5CDS-intronENST00000528232ENST00000469991CTNND1chr11

57586650

+ZNFX1chr20

47863418

-
5CDS-3UTRENST00000528232ENST00000371752CTNND1chr11

57586650

+ZNFX1chr20

47863418

-
5CDS-3UTRENST00000528232ENST00000396105CTNND1chr11

57586650

+ZNFX1chr20

47863418

-
5CDS-intronENST00000529986ENST00000371754CTNND1chr11

57586650

+ZNFX1chr20

47863418

-
5CDS-intronENST00000529986ENST00000469991CTNND1chr11

57586650

+ZNFX1chr20

47863418

-
5CDS-3UTRENST00000529986ENST00000371752CTNND1chr11

57586650

+ZNFX1chr20

47863418

-
5CDS-3UTRENST00000529986ENST00000396105CTNND1chr11

57586650

+ZNFX1chr20

47863418

-
5CDS-intronENST00000531014ENST00000371754CTNND1chr11

57586650

+ZNFX1chr20

47863418

-
5CDS-intronENST00000531014ENST00000469991CTNND1chr11

57586650

+ZNFX1chr20

47863418

-
5CDS-3UTRENST00000531014ENST00000371752CTNND1chr11

57586650

+ZNFX1chr20

47863418

-
5CDS-3UTRENST00000531014ENST00000396105CTNND1chr11

57586650

+ZNFX1chr20

47863418

-
5CDS-intronENST00000358694ENST00000371754CTNND1chr11

57586650

+ZNFX1chr20

47863418

-
5CDS-intronENST00000358694ENST00000469991CTNND1chr11

57586650

+ZNFX1chr20

47863418

-
5CDS-3UTRENST00000358694ENST00000371752CTNND1chr11

57586650

+ZNFX1chr20

47863418

-
5CDS-3UTRENST00000358694ENST00000396105CTNND1chr11

57586650

+ZNFX1chr20

47863418

-
5CDS-intronENST00000526772ENST00000371754CTNND1chr11

57586650

+ZNFX1chr20

47863418

-
5CDS-intronENST00000526772ENST00000469991CTNND1chr11

57586650

+ZNFX1chr20

47863418

-
5CDS-3UTRENST00000526772ENST00000371752CTNND1chr11

57586650

+ZNFX1chr20

47863418

-
5CDS-3UTRENST00000526772ENST00000396105CTNND1chr11

57586650

+ZNFX1chr20

47863418

-
5CDS-intronENST00000532787ENST00000371754CTNND1chr11

57586650

+ZNFX1chr20

47863418

-
5CDS-intronENST00000532787ENST00000469991CTNND1chr11

57586650

+ZNFX1chr20

47863418

-
5CDS-3UTRENST00000532787ENST00000371752CTNND1chr11

57586650

+ZNFX1chr20

47863418

-
5CDS-3UTRENST00000532787ENST00000396105CTNND1chr11

57586650

+ZNFX1chr20

47863418

-
5CDS-intronENST00000533667ENST00000371754CTNND1chr11

57586650

+ZNFX1chr20

47863418

-
5CDS-intronENST00000533667ENST00000469991CTNND1chr11

57586650

+ZNFX1chr20

47863418

-
5CDS-3UTRENST00000533667ENST00000371752CTNND1chr11

57586650

+ZNFX1chr20

47863418

-
5CDS-3UTRENST00000533667ENST00000396105CTNND1chr11

57586650

+ZNFX1chr20

47863418

-
5CDS-intronENST00000529873ENST00000371754CTNND1chr11

57586650

+ZNFX1chr20

47863418

-
5CDS-intronENST00000529873ENST00000469991CTNND1chr11

57586650

+ZNFX1chr20

47863418

-
5CDS-3UTRENST00000529873ENST00000371752CTNND1chr11

57586650

+ZNFX1chr20

47863418

-
5CDS-3UTRENST00000529873ENST00000396105CTNND1chr11

57586650

+ZNFX1chr20

47863418

-
5CDS-intronENST00000525902ENST00000371754CTNND1chr11

57586650

+ZNFX1chr20

47863418

-
5CDS-intronENST00000525902ENST00000469991CTNND1chr11

57586650

+ZNFX1chr20

47863418

-
5CDS-3UTRENST00000525902ENST00000371752CTNND1chr11

57586650

+ZNFX1chr20

47863418

-
5CDS-3UTRENST00000525902ENST00000396105CTNND1chr11

57586650

+ZNFX1chr20

47863418

-
5CDS-intronENST00000529526ENST00000371754CTNND1chr11

57586650

+ZNFX1chr20

47863418

-
5CDS-intronENST00000529526ENST00000469991CTNND1chr11

57586650

+ZNFX1chr20

47863418

-
5CDS-3UTRENST00000529526ENST00000371752CTNND1chr11

57586650

+ZNFX1chr20

47863418

-
5CDS-3UTRENST00000529526ENST00000396105CTNND1chr11

57586650

+ZNFX1chr20

47863418

-
5CDS-intronENST00000532649ENST00000371754CTNND1chr11

57586650

+ZNFX1chr20

47863418

-
5CDS-intronENST00000532649ENST00000469991CTNND1chr11

57586650

+ZNFX1chr20

47863418

-
5CDS-3UTRENST00000532649ENST00000371752CTNND1chr11

57586650

+ZNFX1chr20

47863418

-
5CDS-3UTRENST00000532649ENST00000396105CTNND1chr11

57586650

+ZNFX1chr20

47863418

-
5CDS-intronENST00000426142ENST00000371754CTNND1chr11

57586650

+ZNFX1chr20

47863418

-
5CDS-intronENST00000426142ENST00000469991CTNND1chr11

57586650

+ZNFX1chr20

47863418

-
5CDS-3UTRENST00000426142ENST00000371752CTNND1chr11

57586650

+ZNFX1chr20

47863418

-
5CDS-3UTRENST00000426142ENST00000396105CTNND1chr11

57586650

+ZNFX1chr20

47863418

-
5CDS-intronENST00000532844ENST00000371754CTNND1chr11

57586650

+ZNFX1chr20

47863418

-
5CDS-intronENST00000532844ENST00000469991CTNND1chr11

57586650

+ZNFX1chr20

47863418

-
5CDS-3UTRENST00000532844ENST00000371752CTNND1chr11

57586650

+ZNFX1chr20

47863418

-
5CDS-3UTRENST00000532844ENST00000396105CTNND1chr11

57586650

+ZNFX1chr20

47863418

-
5CDS-intronENST00000528621ENST00000371754CTNND1chr11

57586650

+ZNFX1chr20

47863418

-
5CDS-intronENST00000528621ENST00000469991CTNND1chr11

57586650

+ZNFX1chr20

47863418

-
5CDS-3UTRENST00000528621ENST00000371752CTNND1chr11

57586650

+ZNFX1chr20

47863418

-
5CDS-3UTRENST00000528621ENST00000396105CTNND1chr11

57586650

+ZNFX1chr20

47863418

-
5CDS-intronENST00000399050ENST00000371754CTNND1chr11

57586650

+ZNFX1chr20

47863418

-
5CDS-intronENST00000399050ENST00000469991CTNND1chr11

57586650

+ZNFX1chr20

47863418

-
5CDS-3UTRENST00000399050ENST00000371752CTNND1chr11

57586650

+ZNFX1chr20

47863418

-
5CDS-3UTRENST00000399050ENST00000396105CTNND1chr11

57586650

+ZNFX1chr20

47863418

-
5CDS-intronENST00000526357ENST00000371754CTNND1chr11

57586650

+ZNFX1chr20

47863418

-
5CDS-intronENST00000526357ENST00000469991CTNND1chr11

57586650

+ZNFX1chr20

47863418

-
5CDS-3UTRENST00000526357ENST00000371752CTNND1chr11

57586650

+ZNFX1chr20

47863418

-
5CDS-3UTRENST00000526357ENST00000396105CTNND1chr11

57586650

+ZNFX1chr20

47863418

-
5CDS-intronENST00000530748ENST00000371754CTNND1chr11

57586650

+ZNFX1chr20

47863418

-
5CDS-intronENST00000530748ENST00000469991CTNND1chr11

57586650

+ZNFX1chr20

47863418

-
5CDS-3UTRENST00000530748ENST00000371752CTNND1chr11

57586650

+ZNFX1chr20

47863418

-
5CDS-3UTRENST00000530748ENST00000396105CTNND1chr11

57586650

+ZNFX1chr20

47863418

-
5CDS-intronENST00000534579ENST00000371754CTNND1chr11

57586650

+ZNFX1chr20

47863418

-
5CDS-intronENST00000534579ENST00000469991CTNND1chr11

57586650

+ZNFX1chr20

47863418

-
5CDS-3UTRENST00000534579ENST00000371752CTNND1chr11

57586650

+ZNFX1chr20

47863418

-
5CDS-3UTRENST00000534579ENST00000396105CTNND1chr11

57586650

+ZNFX1chr20

47863418

-
intron-intronENST00000526938ENST00000371754CTNND1chr11

57586650

+ZNFX1chr20

47863418

-
intron-intronENST00000526938ENST00000469991CTNND1chr11

57586650

+ZNFX1chr20

47863418

-
intron-3UTRENST00000526938ENST00000371752CTNND1chr11

57586650

+ZNFX1chr20

47863418

-
intron-3UTRENST00000526938ENST00000396105CTNND1chr11

57586650

+ZNFX1chr20

47863418

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Top

FusionProtFeatures for CTNND1_ZNFX1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CTNND1

O60716

ZNFX1

Q9P2E3


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for CTNND1_ZNFX1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for CTNND1_ZNFX1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
CTNND1CDH1, CTNNB1, EGFR, CTNNA1, CDH2, ACTG1, CTTN, FYN, LCK, SRC, YES1, PTPRJ, ZBTB33, CDH3, CDH5, MUC1, PSEN1, PTPN6, PTPRM, COL17A1, ERBB2IP, WDR48, SQSTM1, SNCA, RIPK3, ARRB2, CUL3, CSNK1E, APP, VCP, MYC, ATF2, SOX2, ATP4A, AP2M1, AURKA, KCTD6, NXF1, CCDC8, BMI1, SUMO2, NTRK1, IFI16, CEP135, TMEM17, TMEM216, XPO1, PPP4R1, FOXB1, MCM2, CDC5L, OTUB1, PPAP2B, BTRC, GSK3B, CTDSPL, MTMR7, CDH8, CTNNA3, G3BP1ZNFX1ENO1, SHMT2, MOV10, NXF1, XPO1, FYN, CSDE1, DROSHA, SS18L2, AMZ2, MIEF1, IMP3, DDX27, CDK4, HSF2, PCDH1, PDK1, SCAF11, UGGT1, CXXC4, TUBA1C, DRC1, LACTB, STRAP, OS9


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for CTNND1_ZNFX1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for CTNND1_ZNFX1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource