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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 8859

FusionGeneSummary for CTNND1_TMX2

check button Fusion gene summary
Fusion gene informationFusion gene name: CTNND1_TMX2
Fusion gene ID: 8859
HgeneTgene
Gene symbol

CTNND1

TMX2

Gene ID

1500

51075

Gene namecatenin delta 1thioredoxin related transmembrane protein 2
SynonymsBCDS2|CAS|CTNND|P120CAS|P120CTN|p120|p120(CAS)|p120(CTN)CGI-31|PDIA12|PIG26|TXNDC14
Cytomap

11q12.1

11q12.1

Type of geneprotein-codingprotein-coding
Descriptioncatenin delta-1cadherin-associated Src substratecatenin (cadherin-associated protein), delta 1p120 cateninthioredoxin-related transmembrane protein 2cell proliferation-inducing gene 26 proteingrowth-inhibiting gene 11protein disulfide isomerase family A, member 12thioredoxin domain-containing protein 14
Modification date2018052320180519
UniProtAcc

O60716

Q9Y320

Ensembl transtripts involved in fusion geneENST00000524630, ENST00000529919, 
ENST00000399039, ENST00000360682, 
ENST00000361796, ENST00000361391, 
ENST00000530094, ENST00000428599, 
ENST00000361332, ENST00000527467, 
ENST00000415361, ENST00000532245, 
ENST00000532463, ENST00000528232, 
ENST00000529986, ENST00000531014, 
ENST00000358694, ENST00000526772, 
ENST00000532787, ENST00000533667, 
ENST00000529873, ENST00000525902, 
ENST00000529526, ENST00000532649, 
ENST00000426142, ENST00000532844, 
ENST00000528621, ENST00000399050, 
ENST00000526357, ENST00000530748, 
ENST00000534579, ENST00000526938, 
ENST00000378312, ENST00000278422, 
Fusion gene scores* DoF score17 X 11 X 12=22441 X 1 X 2=2
# samples 192
** MAII scorelog2(19/2244*10)=-3.56200135227784
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(2/2*10)=3.32192809488736
Context

PubMed: CTNND1 [Title/Abstract] AND TMX2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVBRCATCGA-AR-A1AH-01ACTNND1chr11

57529518

+TMX2chr11

57505080

+
TCGARVKIRCTCGA-BP-4962-01ACTNND1chr11

57529518

+TMX2chr11

57505080

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000524630ENST00000378312CTNND1chr11

57529518

+TMX2chr11

57505080

+
intron-3CDSENST00000524630ENST00000278422CTNND1chr11

57529518

+TMX2chr11

57505080

+
intron-3CDSENST00000529919ENST00000378312CTNND1chr11

57529518

+TMX2chr11

57505080

+
intron-3CDSENST00000529919ENST00000278422CTNND1chr11

57529518

+TMX2chr11

57505080

+
intron-3CDSENST00000399039ENST00000378312CTNND1chr11

57529518

+TMX2chr11

57505080

+
intron-3CDSENST00000399039ENST00000278422CTNND1chr11

57529518

+TMX2chr11

57505080

+
5UTR-3CDSENST00000360682ENST00000378312CTNND1chr11

57529518

+TMX2chr11

57505080

+
5UTR-3CDSENST00000360682ENST00000278422CTNND1chr11

57529518

+TMX2chr11

57505080

+
5UTR-3CDSENST00000361796ENST00000378312CTNND1chr11

57529518

+TMX2chr11

57505080

+
5UTR-3CDSENST00000361796ENST00000278422CTNND1chr11

57529518

+TMX2chr11

57505080

+
5UTR-3CDSENST00000361391ENST00000378312CTNND1chr11

57529518

+TMX2chr11

57505080

+
5UTR-3CDSENST00000361391ENST00000278422CTNND1chr11

57529518

+TMX2chr11

57505080

+
5UTR-3CDSENST00000530094ENST00000378312CTNND1chr11

57529518

+TMX2chr11

57505080

+
5UTR-3CDSENST00000530094ENST00000278422CTNND1chr11

57529518

+TMX2chr11

57505080

+
5UTR-3CDSENST00000428599ENST00000378312CTNND1chr11

57529518

+TMX2chr11

57505080

+
5UTR-3CDSENST00000428599ENST00000278422CTNND1chr11

57529518

+TMX2chr11

57505080

+
5UTR-3CDSENST00000361332ENST00000378312CTNND1chr11

57529518

+TMX2chr11

57505080

+
5UTR-3CDSENST00000361332ENST00000278422CTNND1chr11

57529518

+TMX2chr11

57505080

+
5UTR-3CDSENST00000527467ENST00000378312CTNND1chr11

57529518

+TMX2chr11

57505080

+
5UTR-3CDSENST00000527467ENST00000278422CTNND1chr11

57529518

+TMX2chr11

57505080

+
5UTR-3CDSENST00000415361ENST00000378312CTNND1chr11

57529518

+TMX2chr11

57505080

+
5UTR-3CDSENST00000415361ENST00000278422CTNND1chr11

57529518

+TMX2chr11

57505080

+
5UTR-3CDSENST00000532245ENST00000378312CTNND1chr11

57529518

+TMX2chr11

57505080

+
5UTR-3CDSENST00000532245ENST00000278422CTNND1chr11

57529518

+TMX2chr11

57505080

+
5UTR-3CDSENST00000532463ENST00000378312CTNND1chr11

57529518

+TMX2chr11

57505080

+
5UTR-3CDSENST00000532463ENST00000278422CTNND1chr11

57529518

+TMX2chr11

57505080

+
5UTR-3CDSENST00000528232ENST00000378312CTNND1chr11

57529518

+TMX2chr11

57505080

+
5UTR-3CDSENST00000528232ENST00000278422CTNND1chr11

57529518

+TMX2chr11

57505080

+
5UTR-3CDSENST00000529986ENST00000378312CTNND1chr11

57529518

+TMX2chr11

57505080

+
5UTR-3CDSENST00000529986ENST00000278422CTNND1chr11

57529518

+TMX2chr11

57505080

+
5UTR-3CDSENST00000531014ENST00000378312CTNND1chr11

57529518

+TMX2chr11

57505080

+
5UTR-3CDSENST00000531014ENST00000278422CTNND1chr11

57529518

+TMX2chr11

57505080

+
5UTR-3CDSENST00000358694ENST00000378312CTNND1chr11

57529518

+TMX2chr11

57505080

+
5UTR-3CDSENST00000358694ENST00000278422CTNND1chr11

57529518

+TMX2chr11

57505080

+
5UTR-3CDSENST00000526772ENST00000378312CTNND1chr11

57529518

+TMX2chr11

57505080

+
5UTR-3CDSENST00000526772ENST00000278422CTNND1chr11

57529518

+TMX2chr11

57505080

+
5UTR-3CDSENST00000532787ENST00000378312CTNND1chr11

57529518

+TMX2chr11

57505080

+
5UTR-3CDSENST00000532787ENST00000278422CTNND1chr11

57529518

+TMX2chr11

57505080

+
5UTR-3CDSENST00000533667ENST00000378312CTNND1chr11

57529518

+TMX2chr11

57505080

+
5UTR-3CDSENST00000533667ENST00000278422CTNND1chr11

57529518

+TMX2chr11

57505080

+
5UTR-3CDSENST00000529873ENST00000378312CTNND1chr11

57529518

+TMX2chr11

57505080

+
5UTR-3CDSENST00000529873ENST00000278422CTNND1chr11

57529518

+TMX2chr11

57505080

+
5UTR-3CDSENST00000525902ENST00000378312CTNND1chr11

57529518

+TMX2chr11

57505080

+
5UTR-3CDSENST00000525902ENST00000278422CTNND1chr11

57529518

+TMX2chr11

57505080

+
5UTR-3CDSENST00000529526ENST00000378312CTNND1chr11

57529518

+TMX2chr11

57505080

+
5UTR-3CDSENST00000529526ENST00000278422CTNND1chr11

57529518

+TMX2chr11

57505080

+
5UTR-3CDSENST00000532649ENST00000378312CTNND1chr11

57529518

+TMX2chr11

57505080

+
5UTR-3CDSENST00000532649ENST00000278422CTNND1chr11

57529518

+TMX2chr11

57505080

+
5UTR-3CDSENST00000426142ENST00000378312CTNND1chr11

57529518

+TMX2chr11

57505080

+
5UTR-3CDSENST00000426142ENST00000278422CTNND1chr11

57529518

+TMX2chr11

57505080

+
5UTR-3CDSENST00000532844ENST00000378312CTNND1chr11

57529518

+TMX2chr11

57505080

+
5UTR-3CDSENST00000532844ENST00000278422CTNND1chr11

57529518

+TMX2chr11

57505080

+
5UTR-3CDSENST00000528621ENST00000378312CTNND1chr11

57529518

+TMX2chr11

57505080

+
5UTR-3CDSENST00000528621ENST00000278422CTNND1chr11

57529518

+TMX2chr11

57505080

+
5UTR-3CDSENST00000399050ENST00000378312CTNND1chr11

57529518

+TMX2chr11

57505080

+
5UTR-3CDSENST00000399050ENST00000278422CTNND1chr11

57529518

+TMX2chr11

57505080

+
5UTR-3CDSENST00000526357ENST00000378312CTNND1chr11

57529518

+TMX2chr11

57505080

+
5UTR-3CDSENST00000526357ENST00000278422CTNND1chr11

57529518

+TMX2chr11

57505080

+
5UTR-3CDSENST00000530748ENST00000378312CTNND1chr11

57529518

+TMX2chr11

57505080

+
5UTR-3CDSENST00000530748ENST00000278422CTNND1chr11

57529518

+TMX2chr11

57505080

+
5UTR-3CDSENST00000534579ENST00000378312CTNND1chr11

57529518

+TMX2chr11

57505080

+
5UTR-3CDSENST00000534579ENST00000278422CTNND1chr11

57529518

+TMX2chr11

57505080

+
5UTR-3CDSENST00000526938ENST00000378312CTNND1chr11

57529518

+TMX2chr11

57505080

+
5UTR-3CDSENST00000526938ENST00000278422CTNND1chr11

57529518

+TMX2chr11

57505080

+

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FusionProtFeatures for CTNND1_TMX2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CTNND1

O60716

TMX2

Q9Y320


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for CTNND1_TMX2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for CTNND1_TMX2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
CTNND1CDH1, CTNNB1, EGFR, CTNNA1, CDH2, ACTG1, CTTN, FYN, LCK, SRC, YES1, PTPRJ, ZBTB33, CDH3, CDH5, MUC1, PSEN1, PTPN6, PTPRM, COL17A1, ERBB2IP, WDR48, SQSTM1, SNCA, RIPK3, ARRB2, CUL3, CSNK1E, APP, VCP, MYC, ATF2, SOX2, ATP4A, AP2M1, AURKA, KCTD6, NXF1, CCDC8, BMI1, SUMO2, NTRK1, IFI16, CEP135, TMEM17, TMEM216, XPO1, PPP4R1, FOXB1, MCM2, CDC5L, OTUB1, PPAP2B, BTRC, GSK3B, CTDSPL, MTMR7, CDH8, CTNNA3, G3BP1TMX2COMMD8, ABCC1, HNRNPU, TM9SF4, SRSF5, ATXN1, SRPRB, HSD11B1, PEX19, NDUFV3, NDUFA7, KCNK16, GINM1, PTH1R, HTR3C, CHRNA9, CNGA3, SLC4A8, ZNRF4, ASIC4, TLR5, KCNA5, SLC39A8, MTNR1A, TRIM25


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for CTNND1_TMX2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for CTNND1_TMX2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource