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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 8858

FusionGeneSummary for CTNND1_TIMM10

check button Fusion gene summary
Fusion gene informationFusion gene name: CTNND1_TIMM10
Fusion gene ID: 8858
HgeneTgene
Gene symbol

CTNND1

TIMM10

Gene ID

1500

26519

Gene namecatenin delta 1translocase of inner mitochondrial membrane 10
SynonymsBCDS2|CAS|CTNND|P120CAS|P120CTN|p120|p120(CAS)|p120(CTN)TIM10|TIM10A|TIMM10A
Cytomap

11q12.1

11q12.1

Type of geneprotein-codingprotein-coding
Descriptioncatenin delta-1cadherin-associated Src substratecatenin (cadherin-associated protein), delta 1p120 cateninmitochondrial import inner membrane translocase subunit Tim10translocase of inner mitochondrial membrane 10 homolog
Modification date2018052320180523
UniProtAcc

O60716

P62072

Ensembl transtripts involved in fusion geneENST00000524630, ENST00000529919, 
ENST00000399039, ENST00000360682, 
ENST00000361796, ENST00000361391, 
ENST00000530094, ENST00000428599, 
ENST00000361332, ENST00000527467, 
ENST00000415361, ENST00000532245, 
ENST00000532463, ENST00000528232, 
ENST00000529986, ENST00000531014, 
ENST00000358694, ENST00000526772, 
ENST00000532787, ENST00000533667, 
ENST00000529873, ENST00000525902, 
ENST00000529526, ENST00000532649, 
ENST00000426142, ENST00000532844, 
ENST00000528621, ENST00000399050, 
ENST00000526357, ENST00000530748, 
ENST00000534579, ENST00000526938, 
ENST00000257245, ENST00000525587, 
ENST00000525158, 
Fusion gene scores* DoF score17 X 11 X 12=22441 X 1 X 1=1
# samples 191
** MAII scorelog2(19/2244*10)=-3.56200135227784
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(1/1*10)=3.32192809488736
Context

PubMed: CTNND1 [Title/Abstract] AND TIMM10 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneTIMM10

GO:0045039

protein import into mitochondrial inner membrane

16387659

TgeneTIMM10

GO:0072321

chaperone-mediated protein transport

16387659


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDBRCATCGA-E2-A1LS-01ACTNND1chr11

57529518

+TIMM10chr11

57297707

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-5UTRENST00000524630ENST00000257245CTNND1chr11

57529518

+TIMM10chr11

57297707

-
intron-5UTRENST00000524630ENST00000525587CTNND1chr11

57529518

+TIMM10chr11

57297707

-
intron-5UTRENST00000524630ENST00000525158CTNND1chr11

57529518

+TIMM10chr11

57297707

-
intron-5UTRENST00000529919ENST00000257245CTNND1chr11

57529518

+TIMM10chr11

57297707

-
intron-5UTRENST00000529919ENST00000525587CTNND1chr11

57529518

+TIMM10chr11

57297707

-
intron-5UTRENST00000529919ENST00000525158CTNND1chr11

57529518

+TIMM10chr11

57297707

-
intron-5UTRENST00000399039ENST00000257245CTNND1chr11

57529518

+TIMM10chr11

57297707

-
intron-5UTRENST00000399039ENST00000525587CTNND1chr11

57529518

+TIMM10chr11

57297707

-
intron-5UTRENST00000399039ENST00000525158CTNND1chr11

57529518

+TIMM10chr11

57297707

-
5UTR-5UTRENST00000360682ENST00000257245CTNND1chr11

57529518

+TIMM10chr11

57297707

-
5UTR-5UTRENST00000360682ENST00000525587CTNND1chr11

57529518

+TIMM10chr11

57297707

-
5UTR-5UTRENST00000360682ENST00000525158CTNND1chr11

57529518

+TIMM10chr11

57297707

-
5UTR-5UTRENST00000361796ENST00000257245CTNND1chr11

57529518

+TIMM10chr11

57297707

-
5UTR-5UTRENST00000361796ENST00000525587CTNND1chr11

57529518

+TIMM10chr11

57297707

-
5UTR-5UTRENST00000361796ENST00000525158CTNND1chr11

57529518

+TIMM10chr11

57297707

-
5UTR-5UTRENST00000361391ENST00000257245CTNND1chr11

57529518

+TIMM10chr11

57297707

-
5UTR-5UTRENST00000361391ENST00000525587CTNND1chr11

57529518

+TIMM10chr11

57297707

-
5UTR-5UTRENST00000361391ENST00000525158CTNND1chr11

57529518

+TIMM10chr11

57297707

-
5UTR-5UTRENST00000530094ENST00000257245CTNND1chr11

57529518

+TIMM10chr11

57297707

-
5UTR-5UTRENST00000530094ENST00000525587CTNND1chr11

57529518

+TIMM10chr11

57297707

-
5UTR-5UTRENST00000530094ENST00000525158CTNND1chr11

57529518

+TIMM10chr11

57297707

-
5UTR-5UTRENST00000428599ENST00000257245CTNND1chr11

57529518

+TIMM10chr11

57297707

-
5UTR-5UTRENST00000428599ENST00000525587CTNND1chr11

57529518

+TIMM10chr11

57297707

-
5UTR-5UTRENST00000428599ENST00000525158CTNND1chr11

57529518

+TIMM10chr11

57297707

-
5UTR-5UTRENST00000361332ENST00000257245CTNND1chr11

57529518

+TIMM10chr11

57297707

-
5UTR-5UTRENST00000361332ENST00000525587CTNND1chr11

57529518

+TIMM10chr11

57297707

-
5UTR-5UTRENST00000361332ENST00000525158CTNND1chr11

57529518

+TIMM10chr11

57297707

-
5UTR-5UTRENST00000527467ENST00000257245CTNND1chr11

57529518

+TIMM10chr11

57297707

-
5UTR-5UTRENST00000527467ENST00000525587CTNND1chr11

57529518

+TIMM10chr11

57297707

-
5UTR-5UTRENST00000527467ENST00000525158CTNND1chr11

57529518

+TIMM10chr11

57297707

-
5UTR-5UTRENST00000415361ENST00000257245CTNND1chr11

57529518

+TIMM10chr11

57297707

-
5UTR-5UTRENST00000415361ENST00000525587CTNND1chr11

57529518

+TIMM10chr11

57297707

-
5UTR-5UTRENST00000415361ENST00000525158CTNND1chr11

57529518

+TIMM10chr11

57297707

-
5UTR-5UTRENST00000532245ENST00000257245CTNND1chr11

57529518

+TIMM10chr11

57297707

-
5UTR-5UTRENST00000532245ENST00000525587CTNND1chr11

57529518

+TIMM10chr11

57297707

-
5UTR-5UTRENST00000532245ENST00000525158CTNND1chr11

57529518

+TIMM10chr11

57297707

-
5UTR-5UTRENST00000532463ENST00000257245CTNND1chr11

57529518

+TIMM10chr11

57297707

-
5UTR-5UTRENST00000532463ENST00000525587CTNND1chr11

57529518

+TIMM10chr11

57297707

-
5UTR-5UTRENST00000532463ENST00000525158CTNND1chr11

57529518

+TIMM10chr11

57297707

-
5UTR-5UTRENST00000528232ENST00000257245CTNND1chr11

57529518

+TIMM10chr11

57297707

-
5UTR-5UTRENST00000528232ENST00000525587CTNND1chr11

57529518

+TIMM10chr11

57297707

-
5UTR-5UTRENST00000528232ENST00000525158CTNND1chr11

57529518

+TIMM10chr11

57297707

-
5UTR-5UTRENST00000529986ENST00000257245CTNND1chr11

57529518

+TIMM10chr11

57297707

-
5UTR-5UTRENST00000529986ENST00000525587CTNND1chr11

57529518

+TIMM10chr11

57297707

-
5UTR-5UTRENST00000529986ENST00000525158CTNND1chr11

57529518

+TIMM10chr11

57297707

-
5UTR-5UTRENST00000531014ENST00000257245CTNND1chr11

57529518

+TIMM10chr11

57297707

-
5UTR-5UTRENST00000531014ENST00000525587CTNND1chr11

57529518

+TIMM10chr11

57297707

-
5UTR-5UTRENST00000531014ENST00000525158CTNND1chr11

57529518

+TIMM10chr11

57297707

-
5UTR-5UTRENST00000358694ENST00000257245CTNND1chr11

57529518

+TIMM10chr11

57297707

-
5UTR-5UTRENST00000358694ENST00000525587CTNND1chr11

57529518

+TIMM10chr11

57297707

-
5UTR-5UTRENST00000358694ENST00000525158CTNND1chr11

57529518

+TIMM10chr11

57297707

-
5UTR-5UTRENST00000526772ENST00000257245CTNND1chr11

57529518

+TIMM10chr11

57297707

-
5UTR-5UTRENST00000526772ENST00000525587CTNND1chr11

57529518

+TIMM10chr11

57297707

-
5UTR-5UTRENST00000526772ENST00000525158CTNND1chr11

57529518

+TIMM10chr11

57297707

-
5UTR-5UTRENST00000532787ENST00000257245CTNND1chr11

57529518

+TIMM10chr11

57297707

-
5UTR-5UTRENST00000532787ENST00000525587CTNND1chr11

57529518

+TIMM10chr11

57297707

-
5UTR-5UTRENST00000532787ENST00000525158CTNND1chr11

57529518

+TIMM10chr11

57297707

-
5UTR-5UTRENST00000533667ENST00000257245CTNND1chr11

57529518

+TIMM10chr11

57297707

-
5UTR-5UTRENST00000533667ENST00000525587CTNND1chr11

57529518

+TIMM10chr11

57297707

-
5UTR-5UTRENST00000533667ENST00000525158CTNND1chr11

57529518

+TIMM10chr11

57297707

-
5UTR-5UTRENST00000529873ENST00000257245CTNND1chr11

57529518

+TIMM10chr11

57297707

-
5UTR-5UTRENST00000529873ENST00000525587CTNND1chr11

57529518

+TIMM10chr11

57297707

-
5UTR-5UTRENST00000529873ENST00000525158CTNND1chr11

57529518

+TIMM10chr11

57297707

-
5UTR-5UTRENST00000525902ENST00000257245CTNND1chr11

57529518

+TIMM10chr11

57297707

-
5UTR-5UTRENST00000525902ENST00000525587CTNND1chr11

57529518

+TIMM10chr11

57297707

-
5UTR-5UTRENST00000525902ENST00000525158CTNND1chr11

57529518

+TIMM10chr11

57297707

-
5UTR-5UTRENST00000529526ENST00000257245CTNND1chr11

57529518

+TIMM10chr11

57297707

-
5UTR-5UTRENST00000529526ENST00000525587CTNND1chr11

57529518

+TIMM10chr11

57297707

-
5UTR-5UTRENST00000529526ENST00000525158CTNND1chr11

57529518

+TIMM10chr11

57297707

-
5UTR-5UTRENST00000532649ENST00000257245CTNND1chr11

57529518

+TIMM10chr11

57297707

-
5UTR-5UTRENST00000532649ENST00000525587CTNND1chr11

57529518

+TIMM10chr11

57297707

-
5UTR-5UTRENST00000532649ENST00000525158CTNND1chr11

57529518

+TIMM10chr11

57297707

-
5UTR-5UTRENST00000426142ENST00000257245CTNND1chr11

57529518

+TIMM10chr11

57297707

-
5UTR-5UTRENST00000426142ENST00000525587CTNND1chr11

57529518

+TIMM10chr11

57297707

-
5UTR-5UTRENST00000426142ENST00000525158CTNND1chr11

57529518

+TIMM10chr11

57297707

-
5UTR-5UTRENST00000532844ENST00000257245CTNND1chr11

57529518

+TIMM10chr11

57297707

-
5UTR-5UTRENST00000532844ENST00000525587CTNND1chr11

57529518

+TIMM10chr11

57297707

-
5UTR-5UTRENST00000532844ENST00000525158CTNND1chr11

57529518

+TIMM10chr11

57297707

-
5UTR-5UTRENST00000528621ENST00000257245CTNND1chr11

57529518

+TIMM10chr11

57297707

-
5UTR-5UTRENST00000528621ENST00000525587CTNND1chr11

57529518

+TIMM10chr11

57297707

-
5UTR-5UTRENST00000528621ENST00000525158CTNND1chr11

57529518

+TIMM10chr11

57297707

-
5UTR-5UTRENST00000399050ENST00000257245CTNND1chr11

57529518

+TIMM10chr11

57297707

-
5UTR-5UTRENST00000399050ENST00000525587CTNND1chr11

57529518

+TIMM10chr11

57297707

-
5UTR-5UTRENST00000399050ENST00000525158CTNND1chr11

57529518

+TIMM10chr11

57297707

-
5UTR-5UTRENST00000526357ENST00000257245CTNND1chr11

57529518

+TIMM10chr11

57297707

-
5UTR-5UTRENST00000526357ENST00000525587CTNND1chr11

57529518

+TIMM10chr11

57297707

-
5UTR-5UTRENST00000526357ENST00000525158CTNND1chr11

57529518

+TIMM10chr11

57297707

-
5UTR-5UTRENST00000530748ENST00000257245CTNND1chr11

57529518

+TIMM10chr11

57297707

-
5UTR-5UTRENST00000530748ENST00000525587CTNND1chr11

57529518

+TIMM10chr11

57297707

-
5UTR-5UTRENST00000530748ENST00000525158CTNND1chr11

57529518

+TIMM10chr11

57297707

-
5UTR-5UTRENST00000534579ENST00000257245CTNND1chr11

57529518

+TIMM10chr11

57297707

-
5UTR-5UTRENST00000534579ENST00000525587CTNND1chr11

57529518

+TIMM10chr11

57297707

-
5UTR-5UTRENST00000534579ENST00000525158CTNND1chr11

57529518

+TIMM10chr11

57297707

-
5UTR-5UTRENST00000526938ENST00000257245CTNND1chr11

57529518

+TIMM10chr11

57297707

-
5UTR-5UTRENST00000526938ENST00000525587CTNND1chr11

57529518

+TIMM10chr11

57297707

-
5UTR-5UTRENST00000526938ENST00000525158CTNND1chr11

57529518

+TIMM10chr11

57297707

-

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FusionProtFeatures for CTNND1_TIMM10


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CTNND1

O60716

TIMM10

P62072

Mitochondrial intermembrane chaperone that participatesin the import and insertion of multi-pass transmembrane proteinsinto the mitochondrial inner membrane. May also be required forthe transfer of beta-barrel precursors from the TOM complex to thesorting and assembly machinery (SAM complex) of the outermembrane. Acts as a chaperone-like protein that protects thehydrophobic precursors from aggregation and guide them through themitochondrial intermembrane space. {ECO:0000269|PubMed:14726512}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for CTNND1_TIMM10


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for CTNND1_TIMM10


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
CTNND1CDH1, CTNNB1, EGFR, CTNNA1, CDH2, ACTG1, CTTN, FYN, LCK, SRC, YES1, PTPRJ, ZBTB33, CDH3, CDH5, MUC1, PSEN1, PTPN6, PTPRM, COL17A1, ERBB2IP, WDR48, SQSTM1, SNCA, RIPK3, ARRB2, CUL3, CSNK1E, APP, VCP, MYC, ATF2, SOX2, ATP4A, AP2M1, AURKA, KCTD6, NXF1, CCDC8, BMI1, SUMO2, NTRK1, IFI16, CEP135, TMEM17, TMEM216, XPO1, PPP4R1, FOXB1, MCM2, CDC5L, OTUB1, PPAP2B, BTRC, GSK3B, CTDSPL, MTMR7, CDH8, CTNNA3, G3BP1TIMM10TIMM9, SUGP2, SFPQ, SLC25A6, NNT, UQCRB, CHCHD4, HNRNPR, SART1, RPS2, NOMO1, MRPL49, SSR4, BAG3, TIMM13, TIMM8A, AGK, CTDSP1, ADCYAP1, ANKS6, C19orf52


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for CTNND1_TIMM10


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for CTNND1_TIMM10


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneTIMM10C0035412Rhabdomyosarcoma1CTD_human