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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 8854

FusionGeneSummary for CTNND1_PLD5

check button Fusion gene summary
Fusion gene informationFusion gene name: CTNND1_PLD5
Fusion gene ID: 8854
HgeneTgene
Gene symbol

CTNND1

PLD5

Gene ID

1500

200150

Gene namecatenin delta 1phospholipase D family member 5
SynonymsBCDS2|CAS|CTNND|P120CAS|P120CTN|p120|p120(CAS)|p120(CTN)PLDC
Cytomap

11q12.1

1q43

Type of geneprotein-codingprotein-coding
Descriptioncatenin delta-1cadherin-associated Src substratecatenin (cadherin-associated protein), delta 1p120 catenininactive phospholipase D5inactive PLD 5inactive choline phosphatase 5inactive phosphatidylcholine-hydrolyzing phospholipase D5
Modification date2018052320180402
UniProtAcc

O60716

Q8N7P1

Ensembl transtripts involved in fusion geneENST00000524630, ENST00000529919, 
ENST00000399039, ENST00000360682, 
ENST00000361796, ENST00000361391, 
ENST00000530094, ENST00000428599, 
ENST00000361332, ENST00000527467, 
ENST00000415361, ENST00000532245, 
ENST00000532463, ENST00000528232, 
ENST00000529986, ENST00000531014, 
ENST00000358694, ENST00000526772, 
ENST00000532787, ENST00000533667, 
ENST00000529873, ENST00000525902, 
ENST00000529526, ENST00000532649, 
ENST00000426142, ENST00000532844, 
ENST00000528621, ENST00000399050, 
ENST00000526357, ENST00000530748, 
ENST00000534579, ENST00000526938, 
ENST00000536534, ENST00000427495, 
ENST00000442594, ENST00000474177, 
Fusion gene scores* DoF score17 X 11 X 12=22442 X 2 X 2=8
# samples 192
** MAII scorelog2(19/2244*10)=-3.56200135227784
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(2/8*10)=1.32192809488736
Context

PubMed: CTNND1 [Title/Abstract] AND PLD5 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BQ925294CTNND1chr11

57510507

+PLD5chr1

242625898

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000524630ENST00000536534CTNND1chr11

57510507

+PLD5chr1

242625898

+
intron-intronENST00000524630ENST00000427495CTNND1chr11

57510507

+PLD5chr1

242625898

+
intron-intronENST00000524630ENST00000442594CTNND1chr11

57510507

+PLD5chr1

242625898

+
intron-intronENST00000524630ENST00000474177CTNND1chr11

57510507

+PLD5chr1

242625898

+
intron-intronENST00000529919ENST00000536534CTNND1chr11

57510507

+PLD5chr1

242625898

+
intron-intronENST00000529919ENST00000427495CTNND1chr11

57510507

+PLD5chr1

242625898

+
intron-intronENST00000529919ENST00000442594CTNND1chr11

57510507

+PLD5chr1

242625898

+
intron-intronENST00000529919ENST00000474177CTNND1chr11

57510507

+PLD5chr1

242625898

+
intron-intronENST00000399039ENST00000536534CTNND1chr11

57510507

+PLD5chr1

242625898

+
intron-intronENST00000399039ENST00000427495CTNND1chr11

57510507

+PLD5chr1

242625898

+
intron-intronENST00000399039ENST00000442594CTNND1chr11

57510507

+PLD5chr1

242625898

+
intron-intronENST00000399039ENST00000474177CTNND1chr11

57510507

+PLD5chr1

242625898

+
intron-intronENST00000360682ENST00000536534CTNND1chr11

57510507

+PLD5chr1

242625898

+
intron-intronENST00000360682ENST00000427495CTNND1chr11

57510507

+PLD5chr1

242625898

+
intron-intronENST00000360682ENST00000442594CTNND1chr11

57510507

+PLD5chr1

242625898

+
intron-intronENST00000360682ENST00000474177CTNND1chr11

57510507

+PLD5chr1

242625898

+
intron-intronENST00000361796ENST00000536534CTNND1chr11

57510507

+PLD5chr1

242625898

+
intron-intronENST00000361796ENST00000427495CTNND1chr11

57510507

+PLD5chr1

242625898

+
intron-intronENST00000361796ENST00000442594CTNND1chr11

57510507

+PLD5chr1

242625898

+
intron-intronENST00000361796ENST00000474177CTNND1chr11

57510507

+PLD5chr1

242625898

+
intron-intronENST00000361391ENST00000536534CTNND1chr11

57510507

+PLD5chr1

242625898

+
intron-intronENST00000361391ENST00000427495CTNND1chr11

57510507

+PLD5chr1

242625898

+
intron-intronENST00000361391ENST00000442594CTNND1chr11

57510507

+PLD5chr1

242625898

+
intron-intronENST00000361391ENST00000474177CTNND1chr11

57510507

+PLD5chr1

242625898

+
intron-intronENST00000530094ENST00000536534CTNND1chr11

57510507

+PLD5chr1

242625898

+
intron-intronENST00000530094ENST00000427495CTNND1chr11

57510507

+PLD5chr1

242625898

+
intron-intronENST00000530094ENST00000442594CTNND1chr11

57510507

+PLD5chr1

242625898

+
intron-intronENST00000530094ENST00000474177CTNND1chr11

57510507

+PLD5chr1

242625898

+
intron-intronENST00000428599ENST00000536534CTNND1chr11

57510507

+PLD5chr1

242625898

+
intron-intronENST00000428599ENST00000427495CTNND1chr11

57510507

+PLD5chr1

242625898

+
intron-intronENST00000428599ENST00000442594CTNND1chr11

57510507

+PLD5chr1

242625898

+
intron-intronENST00000428599ENST00000474177CTNND1chr11

57510507

+PLD5chr1

242625898

+
intron-intronENST00000361332ENST00000536534CTNND1chr11

57510507

+PLD5chr1

242625898

+
intron-intronENST00000361332ENST00000427495CTNND1chr11

57510507

+PLD5chr1

242625898

+
intron-intronENST00000361332ENST00000442594CTNND1chr11

57510507

+PLD5chr1

242625898

+
intron-intronENST00000361332ENST00000474177CTNND1chr11

57510507

+PLD5chr1

242625898

+
intron-intronENST00000527467ENST00000536534CTNND1chr11

57510507

+PLD5chr1

242625898

+
intron-intronENST00000527467ENST00000427495CTNND1chr11

57510507

+PLD5chr1

242625898

+
intron-intronENST00000527467ENST00000442594CTNND1chr11

57510507

+PLD5chr1

242625898

+
intron-intronENST00000527467ENST00000474177CTNND1chr11

57510507

+PLD5chr1

242625898

+
intron-intronENST00000415361ENST00000536534CTNND1chr11

57510507

+PLD5chr1

242625898

+
intron-intronENST00000415361ENST00000427495CTNND1chr11

57510507

+PLD5chr1

242625898

+
intron-intronENST00000415361ENST00000442594CTNND1chr11

57510507

+PLD5chr1

242625898

+
intron-intronENST00000415361ENST00000474177CTNND1chr11

57510507

+PLD5chr1

242625898

+
intron-intronENST00000532245ENST00000536534CTNND1chr11

57510507

+PLD5chr1

242625898

+
intron-intronENST00000532245ENST00000427495CTNND1chr11

57510507

+PLD5chr1

242625898

+
intron-intronENST00000532245ENST00000442594CTNND1chr11

57510507

+PLD5chr1

242625898

+
intron-intronENST00000532245ENST00000474177CTNND1chr11

57510507

+PLD5chr1

242625898

+
intron-intronENST00000532463ENST00000536534CTNND1chr11

57510507

+PLD5chr1

242625898

+
intron-intronENST00000532463ENST00000427495CTNND1chr11

57510507

+PLD5chr1

242625898

+
intron-intronENST00000532463ENST00000442594CTNND1chr11

57510507

+PLD5chr1

242625898

+
intron-intronENST00000532463ENST00000474177CTNND1chr11

57510507

+PLD5chr1

242625898

+
intron-intronENST00000528232ENST00000536534CTNND1chr11

57510507

+PLD5chr1

242625898

+
intron-intronENST00000528232ENST00000427495CTNND1chr11

57510507

+PLD5chr1

242625898

+
intron-intronENST00000528232ENST00000442594CTNND1chr11

57510507

+PLD5chr1

242625898

+
intron-intronENST00000528232ENST00000474177CTNND1chr11

57510507

+PLD5chr1

242625898

+
intron-intronENST00000529986ENST00000536534CTNND1chr11

57510507

+PLD5chr1

242625898

+
intron-intronENST00000529986ENST00000427495CTNND1chr11

57510507

+PLD5chr1

242625898

+
intron-intronENST00000529986ENST00000442594CTNND1chr11

57510507

+PLD5chr1

242625898

+
intron-intronENST00000529986ENST00000474177CTNND1chr11

57510507

+PLD5chr1

242625898

+
intron-intronENST00000531014ENST00000536534CTNND1chr11

57510507

+PLD5chr1

242625898

+
intron-intronENST00000531014ENST00000427495CTNND1chr11

57510507

+PLD5chr1

242625898

+
intron-intronENST00000531014ENST00000442594CTNND1chr11

57510507

+PLD5chr1

242625898

+
intron-intronENST00000531014ENST00000474177CTNND1chr11

57510507

+PLD5chr1

242625898

+
intron-intronENST00000358694ENST00000536534CTNND1chr11

57510507

+PLD5chr1

242625898

+
intron-intronENST00000358694ENST00000427495CTNND1chr11

57510507

+PLD5chr1

242625898

+
intron-intronENST00000358694ENST00000442594CTNND1chr11

57510507

+PLD5chr1

242625898

+
intron-intronENST00000358694ENST00000474177CTNND1chr11

57510507

+PLD5chr1

242625898

+
intron-intronENST00000526772ENST00000536534CTNND1chr11

57510507

+PLD5chr1

242625898

+
intron-intronENST00000526772ENST00000427495CTNND1chr11

57510507

+PLD5chr1

242625898

+
intron-intronENST00000526772ENST00000442594CTNND1chr11

57510507

+PLD5chr1

242625898

+
intron-intronENST00000526772ENST00000474177CTNND1chr11

57510507

+PLD5chr1

242625898

+
intron-intronENST00000532787ENST00000536534CTNND1chr11

57510507

+PLD5chr1

242625898

+
intron-intronENST00000532787ENST00000427495CTNND1chr11

57510507

+PLD5chr1

242625898

+
intron-intronENST00000532787ENST00000442594CTNND1chr11

57510507

+PLD5chr1

242625898

+
intron-intronENST00000532787ENST00000474177CTNND1chr11

57510507

+PLD5chr1

242625898

+
intron-intronENST00000533667ENST00000536534CTNND1chr11

57510507

+PLD5chr1

242625898

+
intron-intronENST00000533667ENST00000427495CTNND1chr11

57510507

+PLD5chr1

242625898

+
intron-intronENST00000533667ENST00000442594CTNND1chr11

57510507

+PLD5chr1

242625898

+
intron-intronENST00000533667ENST00000474177CTNND1chr11

57510507

+PLD5chr1

242625898

+
intron-intronENST00000529873ENST00000536534CTNND1chr11

57510507

+PLD5chr1

242625898

+
intron-intronENST00000529873ENST00000427495CTNND1chr11

57510507

+PLD5chr1

242625898

+
intron-intronENST00000529873ENST00000442594CTNND1chr11

57510507

+PLD5chr1

242625898

+
intron-intronENST00000529873ENST00000474177CTNND1chr11

57510507

+PLD5chr1

242625898

+
intron-intronENST00000525902ENST00000536534CTNND1chr11

57510507

+PLD5chr1

242625898

+
intron-intronENST00000525902ENST00000427495CTNND1chr11

57510507

+PLD5chr1

242625898

+
intron-intronENST00000525902ENST00000442594CTNND1chr11

57510507

+PLD5chr1

242625898

+
intron-intronENST00000525902ENST00000474177CTNND1chr11

57510507

+PLD5chr1

242625898

+
intron-intronENST00000529526ENST00000536534CTNND1chr11

57510507

+PLD5chr1

242625898

+
intron-intronENST00000529526ENST00000427495CTNND1chr11

57510507

+PLD5chr1

242625898

+
intron-intronENST00000529526ENST00000442594CTNND1chr11

57510507

+PLD5chr1

242625898

+
intron-intronENST00000529526ENST00000474177CTNND1chr11

57510507

+PLD5chr1

242625898

+
intron-intronENST00000532649ENST00000536534CTNND1chr11

57510507

+PLD5chr1

242625898

+
intron-intronENST00000532649ENST00000427495CTNND1chr11

57510507

+PLD5chr1

242625898

+
intron-intronENST00000532649ENST00000442594CTNND1chr11

57510507

+PLD5chr1

242625898

+
intron-intronENST00000532649ENST00000474177CTNND1chr11

57510507

+PLD5chr1

242625898

+
intron-intronENST00000426142ENST00000536534CTNND1chr11

57510507

+PLD5chr1

242625898

+
intron-intronENST00000426142ENST00000427495CTNND1chr11

57510507

+PLD5chr1

242625898

+
intron-intronENST00000426142ENST00000442594CTNND1chr11

57510507

+PLD5chr1

242625898

+
intron-intronENST00000426142ENST00000474177CTNND1chr11

57510507

+PLD5chr1

242625898

+
intron-intronENST00000532844ENST00000536534CTNND1chr11

57510507

+PLD5chr1

242625898

+
intron-intronENST00000532844ENST00000427495CTNND1chr11

57510507

+PLD5chr1

242625898

+
intron-intronENST00000532844ENST00000442594CTNND1chr11

57510507

+PLD5chr1

242625898

+
intron-intronENST00000532844ENST00000474177CTNND1chr11

57510507

+PLD5chr1

242625898

+
intron-intronENST00000528621ENST00000536534CTNND1chr11

57510507

+PLD5chr1

242625898

+
intron-intronENST00000528621ENST00000427495CTNND1chr11

57510507

+PLD5chr1

242625898

+
intron-intronENST00000528621ENST00000442594CTNND1chr11

57510507

+PLD5chr1

242625898

+
intron-intronENST00000528621ENST00000474177CTNND1chr11

57510507

+PLD5chr1

242625898

+
intron-intronENST00000399050ENST00000536534CTNND1chr11

57510507

+PLD5chr1

242625898

+
intron-intronENST00000399050ENST00000427495CTNND1chr11

57510507

+PLD5chr1

242625898

+
intron-intronENST00000399050ENST00000442594CTNND1chr11

57510507

+PLD5chr1

242625898

+
intron-intronENST00000399050ENST00000474177CTNND1chr11

57510507

+PLD5chr1

242625898

+
intron-intronENST00000526357ENST00000536534CTNND1chr11

57510507

+PLD5chr1

242625898

+
intron-intronENST00000526357ENST00000427495CTNND1chr11

57510507

+PLD5chr1

242625898

+
intron-intronENST00000526357ENST00000442594CTNND1chr11

57510507

+PLD5chr1

242625898

+
intron-intronENST00000526357ENST00000474177CTNND1chr11

57510507

+PLD5chr1

242625898

+
intron-intronENST00000530748ENST00000536534CTNND1chr11

57510507

+PLD5chr1

242625898

+
intron-intronENST00000530748ENST00000427495CTNND1chr11

57510507

+PLD5chr1

242625898

+
intron-intronENST00000530748ENST00000442594CTNND1chr11

57510507

+PLD5chr1

242625898

+
intron-intronENST00000530748ENST00000474177CTNND1chr11

57510507

+PLD5chr1

242625898

+
intron-intronENST00000534579ENST00000536534CTNND1chr11

57510507

+PLD5chr1

242625898

+
intron-intronENST00000534579ENST00000427495CTNND1chr11

57510507

+PLD5chr1

242625898

+
intron-intronENST00000534579ENST00000442594CTNND1chr11

57510507

+PLD5chr1

242625898

+
intron-intronENST00000534579ENST00000474177CTNND1chr11

57510507

+PLD5chr1

242625898

+
intron-intronENST00000526938ENST00000536534CTNND1chr11

57510507

+PLD5chr1

242625898

+
intron-intronENST00000526938ENST00000427495CTNND1chr11

57510507

+PLD5chr1

242625898

+
intron-intronENST00000526938ENST00000442594CTNND1chr11

57510507

+PLD5chr1

242625898

+
intron-intronENST00000526938ENST00000474177CTNND1chr11

57510507

+PLD5chr1

242625898

+

Top

FusionProtFeatures for CTNND1_PLD5


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CTNND1

O60716

PLD5

Q8N7P1


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for CTNND1_PLD5


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for CTNND1_PLD5


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for CTNND1_PLD5


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for CTNND1_PLD5


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgenePLD5C0004352Autistic Disorder1CTD_human