FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 8851

FusionGeneSummary for CTNND1_DTX4

check button Fusion gene summary
Fusion gene informationFusion gene name: CTNND1_DTX4
Fusion gene ID: 8851
HgeneTgene
Gene symbol

CTNND1

DTX4

Gene ID

1500

23220

Gene namecatenin delta 1deltex E3 ubiquitin ligase 4
SynonymsBCDS2|CAS|CTNND|P120CAS|P120CTN|p120|p120(CAS)|p120(CTN)RNF155
Cytomap

11q12.1

11q12.1

Type of geneprotein-codingprotein-coding
Descriptioncatenin delta-1cadherin-associated Src substratecatenin (cadherin-associated protein), delta 1p120 cateninE3 ubiquitin-protein ligase DTX4RING finger protein 155RING-type E3 ubiquitin transferase DTX4deltex 4 homologdeltex 4, E3 ubiquitin ligasedeltex homolog 4deltex4protein deltex-4
Modification date2018052320180519
UniProtAcc

O60716

Q9Y2E6

Ensembl transtripts involved in fusion geneENST00000524630, ENST00000529919, 
ENST00000399039, ENST00000360682, 
ENST00000361796, ENST00000361391, 
ENST00000530094, ENST00000428599, 
ENST00000361332, ENST00000527467, 
ENST00000415361, ENST00000532245, 
ENST00000532463, ENST00000528232, 
ENST00000529986, ENST00000531014, 
ENST00000358694, ENST00000526772, 
ENST00000532787, ENST00000533667, 
ENST00000529873, ENST00000525902, 
ENST00000529526, ENST00000532649, 
ENST00000426142, ENST00000532844, 
ENST00000528621, ENST00000399050, 
ENST00000526357, ENST00000530748, 
ENST00000534579, ENST00000526938, 
ENST00000532982, ENST00000227451, 
ENST00000531902, 
Fusion gene scores* DoF score17 X 11 X 12=22444 X 3 X 3=36
# samples 199
** MAII scorelog2(19/2244*10)=-3.56200135227784
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(9/36*10)=1.32192809488736
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: CTNND1 [Title/Abstract] AND DTX4 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVPRADTCGA-YL-A8SH-01BCTNND1chr11

57529518

+DTX4chr11

58949212

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-5UTRENST00000524630ENST00000532982CTNND1chr11

57529518

+DTX4chr11

58949212

+
intron-5UTRENST00000524630ENST00000227451CTNND1chr11

57529518

+DTX4chr11

58949212

+
intron-intronENST00000524630ENST00000531902CTNND1chr11

57529518

+DTX4chr11

58949212

+
intron-5UTRENST00000529919ENST00000532982CTNND1chr11

57529518

+DTX4chr11

58949212

+
intron-5UTRENST00000529919ENST00000227451CTNND1chr11

57529518

+DTX4chr11

58949212

+
intron-intronENST00000529919ENST00000531902CTNND1chr11

57529518

+DTX4chr11

58949212

+
intron-5UTRENST00000399039ENST00000532982CTNND1chr11

57529518

+DTX4chr11

58949212

+
intron-5UTRENST00000399039ENST00000227451CTNND1chr11

57529518

+DTX4chr11

58949212

+
intron-intronENST00000399039ENST00000531902CTNND1chr11

57529518

+DTX4chr11

58949212

+
5UTR-5UTRENST00000360682ENST00000532982CTNND1chr11

57529518

+DTX4chr11

58949212

+
5UTR-5UTRENST00000360682ENST00000227451CTNND1chr11

57529518

+DTX4chr11

58949212

+
5UTR-intronENST00000360682ENST00000531902CTNND1chr11

57529518

+DTX4chr11

58949212

+
5UTR-5UTRENST00000361796ENST00000532982CTNND1chr11

57529518

+DTX4chr11

58949212

+
5UTR-5UTRENST00000361796ENST00000227451CTNND1chr11

57529518

+DTX4chr11

58949212

+
5UTR-intronENST00000361796ENST00000531902CTNND1chr11

57529518

+DTX4chr11

58949212

+
5UTR-5UTRENST00000361391ENST00000532982CTNND1chr11

57529518

+DTX4chr11

58949212

+
5UTR-5UTRENST00000361391ENST00000227451CTNND1chr11

57529518

+DTX4chr11

58949212

+
5UTR-intronENST00000361391ENST00000531902CTNND1chr11

57529518

+DTX4chr11

58949212

+
5UTR-5UTRENST00000530094ENST00000532982CTNND1chr11

57529518

+DTX4chr11

58949212

+
5UTR-5UTRENST00000530094ENST00000227451CTNND1chr11

57529518

+DTX4chr11

58949212

+
5UTR-intronENST00000530094ENST00000531902CTNND1chr11

57529518

+DTX4chr11

58949212

+
5UTR-5UTRENST00000428599ENST00000532982CTNND1chr11

57529518

+DTX4chr11

58949212

+
5UTR-5UTRENST00000428599ENST00000227451CTNND1chr11

57529518

+DTX4chr11

58949212

+
5UTR-intronENST00000428599ENST00000531902CTNND1chr11

57529518

+DTX4chr11

58949212

+
5UTR-5UTRENST00000361332ENST00000532982CTNND1chr11

57529518

+DTX4chr11

58949212

+
5UTR-5UTRENST00000361332ENST00000227451CTNND1chr11

57529518

+DTX4chr11

58949212

+
5UTR-intronENST00000361332ENST00000531902CTNND1chr11

57529518

+DTX4chr11

58949212

+
5UTR-5UTRENST00000527467ENST00000532982CTNND1chr11

57529518

+DTX4chr11

58949212

+
5UTR-5UTRENST00000527467ENST00000227451CTNND1chr11

57529518

+DTX4chr11

58949212

+
5UTR-intronENST00000527467ENST00000531902CTNND1chr11

57529518

+DTX4chr11

58949212

+
5UTR-5UTRENST00000415361ENST00000532982CTNND1chr11

57529518

+DTX4chr11

58949212

+
5UTR-5UTRENST00000415361ENST00000227451CTNND1chr11

57529518

+DTX4chr11

58949212

+
5UTR-intronENST00000415361ENST00000531902CTNND1chr11

57529518

+DTX4chr11

58949212

+
5UTR-5UTRENST00000532245ENST00000532982CTNND1chr11

57529518

+DTX4chr11

58949212

+
5UTR-5UTRENST00000532245ENST00000227451CTNND1chr11

57529518

+DTX4chr11

58949212

+
5UTR-intronENST00000532245ENST00000531902CTNND1chr11

57529518

+DTX4chr11

58949212

+
5UTR-5UTRENST00000532463ENST00000532982CTNND1chr11

57529518

+DTX4chr11

58949212

+
5UTR-5UTRENST00000532463ENST00000227451CTNND1chr11

57529518

+DTX4chr11

58949212

+
5UTR-intronENST00000532463ENST00000531902CTNND1chr11

57529518

+DTX4chr11

58949212

+
5UTR-5UTRENST00000528232ENST00000532982CTNND1chr11

57529518

+DTX4chr11

58949212

+
5UTR-5UTRENST00000528232ENST00000227451CTNND1chr11

57529518

+DTX4chr11

58949212

+
5UTR-intronENST00000528232ENST00000531902CTNND1chr11

57529518

+DTX4chr11

58949212

+
5UTR-5UTRENST00000529986ENST00000532982CTNND1chr11

57529518

+DTX4chr11

58949212

+
5UTR-5UTRENST00000529986ENST00000227451CTNND1chr11

57529518

+DTX4chr11

58949212

+
5UTR-intronENST00000529986ENST00000531902CTNND1chr11

57529518

+DTX4chr11

58949212

+
5UTR-5UTRENST00000531014ENST00000532982CTNND1chr11

57529518

+DTX4chr11

58949212

+
5UTR-5UTRENST00000531014ENST00000227451CTNND1chr11

57529518

+DTX4chr11

58949212

+
5UTR-intronENST00000531014ENST00000531902CTNND1chr11

57529518

+DTX4chr11

58949212

+
5UTR-5UTRENST00000358694ENST00000532982CTNND1chr11

57529518

+DTX4chr11

58949212

+
5UTR-5UTRENST00000358694ENST00000227451CTNND1chr11

57529518

+DTX4chr11

58949212

+
5UTR-intronENST00000358694ENST00000531902CTNND1chr11

57529518

+DTX4chr11

58949212

+
5UTR-5UTRENST00000526772ENST00000532982CTNND1chr11

57529518

+DTX4chr11

58949212

+
5UTR-5UTRENST00000526772ENST00000227451CTNND1chr11

57529518

+DTX4chr11

58949212

+
5UTR-intronENST00000526772ENST00000531902CTNND1chr11

57529518

+DTX4chr11

58949212

+
5UTR-5UTRENST00000532787ENST00000532982CTNND1chr11

57529518

+DTX4chr11

58949212

+
5UTR-5UTRENST00000532787ENST00000227451CTNND1chr11

57529518

+DTX4chr11

58949212

+
5UTR-intronENST00000532787ENST00000531902CTNND1chr11

57529518

+DTX4chr11

58949212

+
5UTR-5UTRENST00000533667ENST00000532982CTNND1chr11

57529518

+DTX4chr11

58949212

+
5UTR-5UTRENST00000533667ENST00000227451CTNND1chr11

57529518

+DTX4chr11

58949212

+
5UTR-intronENST00000533667ENST00000531902CTNND1chr11

57529518

+DTX4chr11

58949212

+
5UTR-5UTRENST00000529873ENST00000532982CTNND1chr11

57529518

+DTX4chr11

58949212

+
5UTR-5UTRENST00000529873ENST00000227451CTNND1chr11

57529518

+DTX4chr11

58949212

+
5UTR-intronENST00000529873ENST00000531902CTNND1chr11

57529518

+DTX4chr11

58949212

+
5UTR-5UTRENST00000525902ENST00000532982CTNND1chr11

57529518

+DTX4chr11

58949212

+
5UTR-5UTRENST00000525902ENST00000227451CTNND1chr11

57529518

+DTX4chr11

58949212

+
5UTR-intronENST00000525902ENST00000531902CTNND1chr11

57529518

+DTX4chr11

58949212

+
5UTR-5UTRENST00000529526ENST00000532982CTNND1chr11

57529518

+DTX4chr11

58949212

+
5UTR-5UTRENST00000529526ENST00000227451CTNND1chr11

57529518

+DTX4chr11

58949212

+
5UTR-intronENST00000529526ENST00000531902CTNND1chr11

57529518

+DTX4chr11

58949212

+
5UTR-5UTRENST00000532649ENST00000532982CTNND1chr11

57529518

+DTX4chr11

58949212

+
5UTR-5UTRENST00000532649ENST00000227451CTNND1chr11

57529518

+DTX4chr11

58949212

+
5UTR-intronENST00000532649ENST00000531902CTNND1chr11

57529518

+DTX4chr11

58949212

+
5UTR-5UTRENST00000426142ENST00000532982CTNND1chr11

57529518

+DTX4chr11

58949212

+
5UTR-5UTRENST00000426142ENST00000227451CTNND1chr11

57529518

+DTX4chr11

58949212

+
5UTR-intronENST00000426142ENST00000531902CTNND1chr11

57529518

+DTX4chr11

58949212

+
5UTR-5UTRENST00000532844ENST00000532982CTNND1chr11

57529518

+DTX4chr11

58949212

+
5UTR-5UTRENST00000532844ENST00000227451CTNND1chr11

57529518

+DTX4chr11

58949212

+
5UTR-intronENST00000532844ENST00000531902CTNND1chr11

57529518

+DTX4chr11

58949212

+
5UTR-5UTRENST00000528621ENST00000532982CTNND1chr11

57529518

+DTX4chr11

58949212

+
5UTR-5UTRENST00000528621ENST00000227451CTNND1chr11

57529518

+DTX4chr11

58949212

+
5UTR-intronENST00000528621ENST00000531902CTNND1chr11

57529518

+DTX4chr11

58949212

+
5UTR-5UTRENST00000399050ENST00000532982CTNND1chr11

57529518

+DTX4chr11

58949212

+
5UTR-5UTRENST00000399050ENST00000227451CTNND1chr11

57529518

+DTX4chr11

58949212

+
5UTR-intronENST00000399050ENST00000531902CTNND1chr11

57529518

+DTX4chr11

58949212

+
5UTR-5UTRENST00000526357ENST00000532982CTNND1chr11

57529518

+DTX4chr11

58949212

+
5UTR-5UTRENST00000526357ENST00000227451CTNND1chr11

57529518

+DTX4chr11

58949212

+
5UTR-intronENST00000526357ENST00000531902CTNND1chr11

57529518

+DTX4chr11

58949212

+
5UTR-5UTRENST00000530748ENST00000532982CTNND1chr11

57529518

+DTX4chr11

58949212

+
5UTR-5UTRENST00000530748ENST00000227451CTNND1chr11

57529518

+DTX4chr11

58949212

+
5UTR-intronENST00000530748ENST00000531902CTNND1chr11

57529518

+DTX4chr11

58949212

+
5UTR-5UTRENST00000534579ENST00000532982CTNND1chr11

57529518

+DTX4chr11

58949212

+
5UTR-5UTRENST00000534579ENST00000227451CTNND1chr11

57529518

+DTX4chr11

58949212

+
5UTR-intronENST00000534579ENST00000531902CTNND1chr11

57529518

+DTX4chr11

58949212

+
5UTR-5UTRENST00000526938ENST00000532982CTNND1chr11

57529518

+DTX4chr11

58949212

+
5UTR-5UTRENST00000526938ENST00000227451CTNND1chr11

57529518

+DTX4chr11

58949212

+
5UTR-intronENST00000526938ENST00000531902CTNND1chr11

57529518

+DTX4chr11

58949212

+

Top

FusionProtFeatures for CTNND1_DTX4


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CTNND1

O60716

DTX4

Q9Y2E6

Regulator of Notch signaling, a signaling pathwayinvolved in cell-cell communications that regulates a broadspectrum of cell-fate determinations (By similarity). Functions asa ubiquitin ligase protein in vivo, mediating 'Lys48'-linkedpolyubiquitination and promoting degradation of TBK1, targeting toTBK1 requires interaction with NLRP4. {ECO:0000250,ECO:0000269|PubMed:22388039}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for CTNND1_DTX4


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for CTNND1_DTX4


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
CTNND1CDH1, CTNNB1, EGFR, CTNNA1, CDH2, ACTG1, CTTN, FYN, LCK, SRC, YES1, PTPRJ, ZBTB33, CDH3, CDH5, MUC1, PSEN1, PTPN6, PTPRM, COL17A1, ERBB2IP, WDR48, SQSTM1, SNCA, RIPK3, ARRB2, CUL3, CSNK1E, APP, VCP, MYC, ATF2, SOX2, ATP4A, AP2M1, AURKA, KCTD6, NXF1, CCDC8, BMI1, SUMO2, NTRK1, IFI16, CEP135, TMEM17, TMEM216, XPO1, PPP4R1, FOXB1, MCM2, CDC5L, OTUB1, PPAP2B, BTRC, GSK3B, CTDSPL, MTMR7, CDH8, CTNNA3, G3BP1DTX4NLRP4, TBK1, HSP90AA1, NOTCH1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for CTNND1_DTX4


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for CTNND1_DTX4


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneDTX4C0010606Adenoid Cystic Carcinoma1CTD_human
TgeneDTX4C0887833Carcinoma, Pancreatic Ductal1CTD_human