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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 8850

FusionGeneSummary for CTNND1_DOCK8

check button Fusion gene summary
Fusion gene informationFusion gene name: CTNND1_DOCK8
Fusion gene ID: 8850
HgeneTgene
Gene symbol

CTNND1

DOCK8

Gene ID

1500

81704

Gene namecatenin delta 1dedicator of cytokinesis 8
SynonymsBCDS2|CAS|CTNND|P120CAS|P120CTN|p120|p120(CAS)|p120(CTN)HEL-205|MRD2|ZIR8
Cytomap

11q12.1

9p24.3

Type of geneprotein-codingprotein-coding
Descriptioncatenin delta-1cadherin-associated Src substratecatenin (cadherin-associated protein), delta 1p120 catenindedicator of cytokinesis protein 81200017A24Rikepididymis luminal protein 205
Modification date2018052320180519
UniProtAcc

O60716

Q8NF50

Ensembl transtripts involved in fusion geneENST00000524630, ENST00000529919, 
ENST00000399039, ENST00000360682, 
ENST00000361796, ENST00000361391, 
ENST00000530094, ENST00000428599, 
ENST00000361332, ENST00000527467, 
ENST00000415361, ENST00000532245, 
ENST00000532463, ENST00000528232, 
ENST00000529986, ENST00000531014, 
ENST00000358694, ENST00000526772, 
ENST00000532787, ENST00000533667, 
ENST00000529873, ENST00000525902, 
ENST00000529526, ENST00000532649, 
ENST00000426142, ENST00000532844, 
ENST00000528621, ENST00000399050, 
ENST00000526357, ENST00000530748, 
ENST00000534579, ENST00000526938, 
ENST00000453981, ENST00000432829, 
ENST00000469391, ENST00000382331, 
ENST00000382329, ENST00000493666, 
Fusion gene scores* DoF score17 X 11 X 12=22445 X 8 X 7=280
# samples 198
** MAII scorelog2(19/2244*10)=-3.56200135227784
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(8/280*10)=-1.8073549220576
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CTNND1 [Title/Abstract] AND DOCK8 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotationTumor suppressor gene involved fusion gene, retained protein feature but frameshift.
DDR (DNA damage repair) gene involved fusion gene, in-frame but not retained their domain.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneDOCK8

GO:0043547

positive regulation of GTPase activity

28028151


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVLUADTCGA-83-5908-01ACTNND1chr11

57574455

+DOCK8chr9

304581

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shitENST00000524630ENST00000453981CTNND1chr11

57574455

+DOCK8chr9

304581

+
Frame-shitENST00000524630ENST00000432829CTNND1chr11

57574455

+DOCK8chr9

304581

+
Frame-shitENST00000524630ENST00000469391CTNND1chr11

57574455

+DOCK8chr9

304581

+
5CDS-intronENST00000524630ENST00000382331CTNND1chr11

57574455

+DOCK8chr9

304581

+
5CDS-intronENST00000524630ENST00000382329CTNND1chr11

57574455

+DOCK8chr9

304581

+
5CDS-intronENST00000524630ENST00000493666CTNND1chr11

57574455

+DOCK8chr9

304581

+
Frame-shitENST00000529919ENST00000453981CTNND1chr11

57574455

+DOCK8chr9

304581

+
Frame-shitENST00000529919ENST00000432829CTNND1chr11

57574455

+DOCK8chr9

304581

+
Frame-shitENST00000529919ENST00000469391CTNND1chr11

57574455

+DOCK8chr9

304581

+
5CDS-intronENST00000529919ENST00000382331CTNND1chr11

57574455

+DOCK8chr9

304581

+
5CDS-intronENST00000529919ENST00000382329CTNND1chr11

57574455

+DOCK8chr9

304581

+
5CDS-intronENST00000529919ENST00000493666CTNND1chr11

57574455

+DOCK8chr9

304581

+
Frame-shitENST00000399039ENST00000453981CTNND1chr11

57574455

+DOCK8chr9

304581

+
Frame-shitENST00000399039ENST00000432829CTNND1chr11

57574455

+DOCK8chr9

304581

+
Frame-shitENST00000399039ENST00000469391CTNND1chr11

57574455

+DOCK8chr9

304581

+
5CDS-intronENST00000399039ENST00000382331CTNND1chr11

57574455

+DOCK8chr9

304581

+
5CDS-intronENST00000399039ENST00000382329CTNND1chr11

57574455

+DOCK8chr9

304581

+
5CDS-intronENST00000399039ENST00000493666CTNND1chr11

57574455

+DOCK8chr9

304581

+
Frame-shitENST00000360682ENST00000453981CTNND1chr11

57574455

+DOCK8chr9

304581

+
Frame-shitENST00000360682ENST00000432829CTNND1chr11

57574455

+DOCK8chr9

304581

+
Frame-shitENST00000360682ENST00000469391CTNND1chr11

57574455

+DOCK8chr9

304581

+
5CDS-intronENST00000360682ENST00000382331CTNND1chr11

57574455

+DOCK8chr9

304581

+
5CDS-intronENST00000360682ENST00000382329CTNND1chr11

57574455

+DOCK8chr9

304581

+
5CDS-intronENST00000360682ENST00000493666CTNND1chr11

57574455

+DOCK8chr9

304581

+
Frame-shitENST00000361796ENST00000453981CTNND1chr11

57574455

+DOCK8chr9

304581

+
Frame-shitENST00000361796ENST00000432829CTNND1chr11

57574455

+DOCK8chr9

304581

+
Frame-shitENST00000361796ENST00000469391CTNND1chr11

57574455

+DOCK8chr9

304581

+
5CDS-intronENST00000361796ENST00000382331CTNND1chr11

57574455

+DOCK8chr9

304581

+
5CDS-intronENST00000361796ENST00000382329CTNND1chr11

57574455

+DOCK8chr9

304581

+
5CDS-intronENST00000361796ENST00000493666CTNND1chr11

57574455

+DOCK8chr9

304581

+
Frame-shitENST00000361391ENST00000453981CTNND1chr11

57574455

+DOCK8chr9

304581

+
Frame-shitENST00000361391ENST00000432829CTNND1chr11

57574455

+DOCK8chr9

304581

+
Frame-shitENST00000361391ENST00000469391CTNND1chr11

57574455

+DOCK8chr9

304581

+
5CDS-intronENST00000361391ENST00000382331CTNND1chr11

57574455

+DOCK8chr9

304581

+
5CDS-intronENST00000361391ENST00000382329CTNND1chr11

57574455

+DOCK8chr9

304581

+
5CDS-intronENST00000361391ENST00000493666CTNND1chr11

57574455

+DOCK8chr9

304581

+
Frame-shitENST00000530094ENST00000453981CTNND1chr11

57574455

+DOCK8chr9

304581

+
Frame-shitENST00000530094ENST00000432829CTNND1chr11

57574455

+DOCK8chr9

304581

+
Frame-shitENST00000530094ENST00000469391CTNND1chr11

57574455

+DOCK8chr9

304581

+
5CDS-intronENST00000530094ENST00000382331CTNND1chr11

57574455

+DOCK8chr9

304581

+
5CDS-intronENST00000530094ENST00000382329CTNND1chr11

57574455

+DOCK8chr9

304581

+
5CDS-intronENST00000530094ENST00000493666CTNND1chr11

57574455

+DOCK8chr9

304581

+
Frame-shitENST00000428599ENST00000453981CTNND1chr11

57574455

+DOCK8chr9

304581

+
Frame-shitENST00000428599ENST00000432829CTNND1chr11

57574455

+DOCK8chr9

304581

+
Frame-shitENST00000428599ENST00000469391CTNND1chr11

57574455

+DOCK8chr9

304581

+
5CDS-intronENST00000428599ENST00000382331CTNND1chr11

57574455

+DOCK8chr9

304581

+
5CDS-intronENST00000428599ENST00000382329CTNND1chr11

57574455

+DOCK8chr9

304581

+
5CDS-intronENST00000428599ENST00000493666CTNND1chr11

57574455

+DOCK8chr9

304581

+
Frame-shitENST00000361332ENST00000453981CTNND1chr11

57574455

+DOCK8chr9

304581

+
Frame-shitENST00000361332ENST00000432829CTNND1chr11

57574455

+DOCK8chr9

304581

+
Frame-shitENST00000361332ENST00000469391CTNND1chr11

57574455

+DOCK8chr9

304581

+
5CDS-intronENST00000361332ENST00000382331CTNND1chr11

57574455

+DOCK8chr9

304581

+
5CDS-intronENST00000361332ENST00000382329CTNND1chr11

57574455

+DOCK8chr9

304581

+
5CDS-intronENST00000361332ENST00000493666CTNND1chr11

57574455

+DOCK8chr9

304581

+
Frame-shitENST00000527467ENST00000453981CTNND1chr11

57574455

+DOCK8chr9

304581

+
Frame-shitENST00000527467ENST00000432829CTNND1chr11

57574455

+DOCK8chr9

304581

+
Frame-shitENST00000527467ENST00000469391CTNND1chr11

57574455

+DOCK8chr9

304581

+
5CDS-intronENST00000527467ENST00000382331CTNND1chr11

57574455

+DOCK8chr9

304581

+
5CDS-intronENST00000527467ENST00000382329CTNND1chr11

57574455

+DOCK8chr9

304581

+
5CDS-intronENST00000527467ENST00000493666CTNND1chr11

57574455

+DOCK8chr9

304581

+
Frame-shitENST00000415361ENST00000453981CTNND1chr11

57574455

+DOCK8chr9

304581

+
Frame-shitENST00000415361ENST00000432829CTNND1chr11

57574455

+DOCK8chr9

304581

+
Frame-shitENST00000415361ENST00000469391CTNND1chr11

57574455

+DOCK8chr9

304581

+
5CDS-intronENST00000415361ENST00000382331CTNND1chr11

57574455

+DOCK8chr9

304581

+
5CDS-intronENST00000415361ENST00000382329CTNND1chr11

57574455

+DOCK8chr9

304581

+
5CDS-intronENST00000415361ENST00000493666CTNND1chr11

57574455

+DOCK8chr9

304581

+
Frame-shitENST00000532245ENST00000453981CTNND1chr11

57574455

+DOCK8chr9

304581

+
Frame-shitENST00000532245ENST00000432829CTNND1chr11

57574455

+DOCK8chr9

304581

+
Frame-shitENST00000532245ENST00000469391CTNND1chr11

57574455

+DOCK8chr9

304581

+
5CDS-intronENST00000532245ENST00000382331CTNND1chr11

57574455

+DOCK8chr9

304581

+
5CDS-intronENST00000532245ENST00000382329CTNND1chr11

57574455

+DOCK8chr9

304581

+
5CDS-intronENST00000532245ENST00000493666CTNND1chr11

57574455

+DOCK8chr9

304581

+
Frame-shitENST00000532463ENST00000453981CTNND1chr11

57574455

+DOCK8chr9

304581

+
Frame-shitENST00000532463ENST00000432829CTNND1chr11

57574455

+DOCK8chr9

304581

+
Frame-shitENST00000532463ENST00000469391CTNND1chr11

57574455

+DOCK8chr9

304581

+
5CDS-intronENST00000532463ENST00000382331CTNND1chr11

57574455

+DOCK8chr9

304581

+
5CDS-intronENST00000532463ENST00000382329CTNND1chr11

57574455

+DOCK8chr9

304581

+
5CDS-intronENST00000532463ENST00000493666CTNND1chr11

57574455

+DOCK8chr9

304581

+
Frame-shitENST00000528232ENST00000453981CTNND1chr11

57574455

+DOCK8chr9

304581

+
Frame-shitENST00000528232ENST00000432829CTNND1chr11

57574455

+DOCK8chr9

304581

+
Frame-shitENST00000528232ENST00000469391CTNND1chr11

57574455

+DOCK8chr9

304581

+
5CDS-intronENST00000528232ENST00000382331CTNND1chr11

57574455

+DOCK8chr9

304581

+
5CDS-intronENST00000528232ENST00000382329CTNND1chr11

57574455

+DOCK8chr9

304581

+
5CDS-intronENST00000528232ENST00000493666CTNND1chr11

57574455

+DOCK8chr9

304581

+
Frame-shitENST00000529986ENST00000453981CTNND1chr11

57574455

+DOCK8chr9

304581

+
Frame-shitENST00000529986ENST00000432829CTNND1chr11

57574455

+DOCK8chr9

304581

+
Frame-shitENST00000529986ENST00000469391CTNND1chr11

57574455

+DOCK8chr9

304581

+
5CDS-intronENST00000529986ENST00000382331CTNND1chr11

57574455

+DOCK8chr9

304581

+
5CDS-intronENST00000529986ENST00000382329CTNND1chr11

57574455

+DOCK8chr9

304581

+
5CDS-intronENST00000529986ENST00000493666CTNND1chr11

57574455

+DOCK8chr9

304581

+
Frame-shitENST00000531014ENST00000453981CTNND1chr11

57574455

+DOCK8chr9

304581

+
Frame-shitENST00000531014ENST00000432829CTNND1chr11

57574455

+DOCK8chr9

304581

+
Frame-shitENST00000531014ENST00000469391CTNND1chr11

57574455

+DOCK8chr9

304581

+
5CDS-intronENST00000531014ENST00000382331CTNND1chr11

57574455

+DOCK8chr9

304581

+
5CDS-intronENST00000531014ENST00000382329CTNND1chr11

57574455

+DOCK8chr9

304581

+
5CDS-intronENST00000531014ENST00000493666CTNND1chr11

57574455

+DOCK8chr9

304581

+
Frame-shitENST00000358694ENST00000453981CTNND1chr11

57574455

+DOCK8chr9

304581

+
Frame-shitENST00000358694ENST00000432829CTNND1chr11

57574455

+DOCK8chr9

304581

+
Frame-shitENST00000358694ENST00000469391CTNND1chr11

57574455

+DOCK8chr9

304581

+
5CDS-intronENST00000358694ENST00000382331CTNND1chr11

57574455

+DOCK8chr9

304581

+
5CDS-intronENST00000358694ENST00000382329CTNND1chr11

57574455

+DOCK8chr9

304581

+
5CDS-intronENST00000358694ENST00000493666CTNND1chr11

57574455

+DOCK8chr9

304581

+
Frame-shitENST00000526772ENST00000453981CTNND1chr11

57574455

+DOCK8chr9

304581

+
Frame-shitENST00000526772ENST00000432829CTNND1chr11

57574455

+DOCK8chr9

304581

+
Frame-shitENST00000526772ENST00000469391CTNND1chr11

57574455

+DOCK8chr9

304581

+
5CDS-intronENST00000526772ENST00000382331CTNND1chr11

57574455

+DOCK8chr9

304581

+
5CDS-intronENST00000526772ENST00000382329CTNND1chr11

57574455

+DOCK8chr9

304581

+
5CDS-intronENST00000526772ENST00000493666CTNND1chr11

57574455

+DOCK8chr9

304581

+
Frame-shitENST00000532787ENST00000453981CTNND1chr11

57574455

+DOCK8chr9

304581

+
Frame-shitENST00000532787ENST00000432829CTNND1chr11

57574455

+DOCK8chr9

304581

+
Frame-shitENST00000532787ENST00000469391CTNND1chr11

57574455

+DOCK8chr9

304581

+
5CDS-intronENST00000532787ENST00000382331CTNND1chr11

57574455

+DOCK8chr9

304581

+
5CDS-intronENST00000532787ENST00000382329CTNND1chr11

57574455

+DOCK8chr9

304581

+
5CDS-intronENST00000532787ENST00000493666CTNND1chr11

57574455

+DOCK8chr9

304581

+
Frame-shitENST00000533667ENST00000453981CTNND1chr11

57574455

+DOCK8chr9

304581

+
Frame-shitENST00000533667ENST00000432829CTNND1chr11

57574455

+DOCK8chr9

304581

+
Frame-shitENST00000533667ENST00000469391CTNND1chr11

57574455

+DOCK8chr9

304581

+
5CDS-intronENST00000533667ENST00000382331CTNND1chr11

57574455

+DOCK8chr9

304581

+
5CDS-intronENST00000533667ENST00000382329CTNND1chr11

57574455

+DOCK8chr9

304581

+
5CDS-intronENST00000533667ENST00000493666CTNND1chr11

57574455

+DOCK8chr9

304581

+
Frame-shitENST00000529873ENST00000453981CTNND1chr11

57574455

+DOCK8chr9

304581

+
Frame-shitENST00000529873ENST00000432829CTNND1chr11

57574455

+DOCK8chr9

304581

+
Frame-shitENST00000529873ENST00000469391CTNND1chr11

57574455

+DOCK8chr9

304581

+
5CDS-intronENST00000529873ENST00000382331CTNND1chr11

57574455

+DOCK8chr9

304581

+
5CDS-intronENST00000529873ENST00000382329CTNND1chr11

57574455

+DOCK8chr9

304581

+
5CDS-intronENST00000529873ENST00000493666CTNND1chr11

57574455

+DOCK8chr9

304581

+
Frame-shitENST00000525902ENST00000453981CTNND1chr11

57574455

+DOCK8chr9

304581

+
Frame-shitENST00000525902ENST00000432829CTNND1chr11

57574455

+DOCK8chr9

304581

+
Frame-shitENST00000525902ENST00000469391CTNND1chr11

57574455

+DOCK8chr9

304581

+
5CDS-intronENST00000525902ENST00000382331CTNND1chr11

57574455

+DOCK8chr9

304581

+
5CDS-intronENST00000525902ENST00000382329CTNND1chr11

57574455

+DOCK8chr9

304581

+
5CDS-intronENST00000525902ENST00000493666CTNND1chr11

57574455

+DOCK8chr9

304581

+
Frame-shitENST00000529526ENST00000453981CTNND1chr11

57574455

+DOCK8chr9

304581

+
Frame-shitENST00000529526ENST00000432829CTNND1chr11

57574455

+DOCK8chr9

304581

+
Frame-shitENST00000529526ENST00000469391CTNND1chr11

57574455

+DOCK8chr9

304581

+
5CDS-intronENST00000529526ENST00000382331CTNND1chr11

57574455

+DOCK8chr9

304581

+
5CDS-intronENST00000529526ENST00000382329CTNND1chr11

57574455

+DOCK8chr9

304581

+
5CDS-intronENST00000529526ENST00000493666CTNND1chr11

57574455

+DOCK8chr9

304581

+
Frame-shitENST00000532649ENST00000453981CTNND1chr11

57574455

+DOCK8chr9

304581

+
Frame-shitENST00000532649ENST00000432829CTNND1chr11

57574455

+DOCK8chr9

304581

+
Frame-shitENST00000532649ENST00000469391CTNND1chr11

57574455

+DOCK8chr9

304581

+
5CDS-intronENST00000532649ENST00000382331CTNND1chr11

57574455

+DOCK8chr9

304581

+
5CDS-intronENST00000532649ENST00000382329CTNND1chr11

57574455

+DOCK8chr9

304581

+
5CDS-intronENST00000532649ENST00000493666CTNND1chr11

57574455

+DOCK8chr9

304581

+
Frame-shitENST00000426142ENST00000453981CTNND1chr11

57574455

+DOCK8chr9

304581

+
Frame-shitENST00000426142ENST00000432829CTNND1chr11

57574455

+DOCK8chr9

304581

+
Frame-shitENST00000426142ENST00000469391CTNND1chr11

57574455

+DOCK8chr9

304581

+
5CDS-intronENST00000426142ENST00000382331CTNND1chr11

57574455

+DOCK8chr9

304581

+
5CDS-intronENST00000426142ENST00000382329CTNND1chr11

57574455

+DOCK8chr9

304581

+
5CDS-intronENST00000426142ENST00000493666CTNND1chr11

57574455

+DOCK8chr9

304581

+
Frame-shitENST00000532844ENST00000453981CTNND1chr11

57574455

+DOCK8chr9

304581

+
Frame-shitENST00000532844ENST00000432829CTNND1chr11

57574455

+DOCK8chr9

304581

+
Frame-shitENST00000532844ENST00000469391CTNND1chr11

57574455

+DOCK8chr9

304581

+
5CDS-intronENST00000532844ENST00000382331CTNND1chr11

57574455

+DOCK8chr9

304581

+
5CDS-intronENST00000532844ENST00000382329CTNND1chr11

57574455

+DOCK8chr9

304581

+
5CDS-intronENST00000532844ENST00000493666CTNND1chr11

57574455

+DOCK8chr9

304581

+
Frame-shitENST00000528621ENST00000453981CTNND1chr11

57574455

+DOCK8chr9

304581

+
Frame-shitENST00000528621ENST00000432829CTNND1chr11

57574455

+DOCK8chr9

304581

+
Frame-shitENST00000528621ENST00000469391CTNND1chr11

57574455

+DOCK8chr9

304581

+
5CDS-intronENST00000528621ENST00000382331CTNND1chr11

57574455

+DOCK8chr9

304581

+
5CDS-intronENST00000528621ENST00000382329CTNND1chr11

57574455

+DOCK8chr9

304581

+
5CDS-intronENST00000528621ENST00000493666CTNND1chr11

57574455

+DOCK8chr9

304581

+
Frame-shitENST00000399050ENST00000453981CTNND1chr11

57574455

+DOCK8chr9

304581

+
Frame-shitENST00000399050ENST00000432829CTNND1chr11

57574455

+DOCK8chr9

304581

+
Frame-shitENST00000399050ENST00000469391CTNND1chr11

57574455

+DOCK8chr9

304581

+
5CDS-intronENST00000399050ENST00000382331CTNND1chr11

57574455

+DOCK8chr9

304581

+
5CDS-intronENST00000399050ENST00000382329CTNND1chr11

57574455

+DOCK8chr9

304581

+
5CDS-intronENST00000399050ENST00000493666CTNND1chr11

57574455

+DOCK8chr9

304581

+
Frame-shitENST00000526357ENST00000453981CTNND1chr11

57574455

+DOCK8chr9

304581

+
Frame-shitENST00000526357ENST00000432829CTNND1chr11

57574455

+DOCK8chr9

304581

+
Frame-shitENST00000526357ENST00000469391CTNND1chr11

57574455

+DOCK8chr9

304581

+
5CDS-intronENST00000526357ENST00000382331CTNND1chr11

57574455

+DOCK8chr9

304581

+
5CDS-intronENST00000526357ENST00000382329CTNND1chr11

57574455

+DOCK8chr9

304581

+
5CDS-intronENST00000526357ENST00000493666CTNND1chr11

57574455

+DOCK8chr9

304581

+
Frame-shitENST00000530748ENST00000453981CTNND1chr11

57574455

+DOCK8chr9

304581

+
Frame-shitENST00000530748ENST00000432829CTNND1chr11

57574455

+DOCK8chr9

304581

+
Frame-shitENST00000530748ENST00000469391CTNND1chr11

57574455

+DOCK8chr9

304581

+
5CDS-intronENST00000530748ENST00000382331CTNND1chr11

57574455

+DOCK8chr9

304581

+
5CDS-intronENST00000530748ENST00000382329CTNND1chr11

57574455

+DOCK8chr9

304581

+
5CDS-intronENST00000530748ENST00000493666CTNND1chr11

57574455

+DOCK8chr9

304581

+
Frame-shitENST00000534579ENST00000453981CTNND1chr11

57574455

+DOCK8chr9

304581

+
Frame-shitENST00000534579ENST00000432829CTNND1chr11

57574455

+DOCK8chr9

304581

+
Frame-shitENST00000534579ENST00000469391CTNND1chr11

57574455

+DOCK8chr9

304581

+
5CDS-intronENST00000534579ENST00000382331CTNND1chr11

57574455

+DOCK8chr9

304581

+
5CDS-intronENST00000534579ENST00000382329CTNND1chr11

57574455

+DOCK8chr9

304581

+
5CDS-intronENST00000534579ENST00000493666CTNND1chr11

57574455

+DOCK8chr9

304581

+
Frame-shitENST00000526938ENST00000453981CTNND1chr11

57574455

+DOCK8chr9

304581

+
Frame-shitENST00000526938ENST00000432829CTNND1chr11

57574455

+DOCK8chr9

304581

+
Frame-shitENST00000526938ENST00000469391CTNND1chr11

57574455

+DOCK8chr9

304581

+
5CDS-intronENST00000526938ENST00000382331CTNND1chr11

57574455

+DOCK8chr9

304581

+
5CDS-intronENST00000526938ENST00000382329CTNND1chr11

57574455

+DOCK8chr9

304581

+
5CDS-intronENST00000526938ENST00000493666CTNND1chr11

57574455

+DOCK8chr9

304581

+

Top

FusionProtFeatures for CTNND1_DOCK8


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CTNND1

O60716

DOCK8

Q8NF50


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for CTNND1_DOCK8


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for CTNND1_DOCK8


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
CTNND1CDH1, CTNNB1, EGFR, CTNNA1, CDH2, ACTG1, CTTN, FYN, LCK, SRC, YES1, PTPRJ, ZBTB33, CDH3, CDH5, MUC1, PSEN1, PTPN6, PTPRM, COL17A1, ERBB2IP, WDR48, SQSTM1, SNCA, RIPK3, ARRB2, CUL3, CSNK1E, APP, VCP, MYC, ATF2, SOX2, ATP4A, AP2M1, AURKA, KCTD6, NXF1, CCDC8, BMI1, SUMO2, NTRK1, IFI16, CEP135, TMEM17, TMEM216, XPO1, PPP4R1, FOXB1, MCM2, CDC5L, OTUB1, PPAP2B, BTRC, GSK3B, CTDSPL, MTMR7, CDH8, CTNNA3, G3BP1DOCK8CDC42, RAC1, SMAD2, CRLF3, DOCK6, DOCK7, LRCH1, LRCH2, LRCH3, MOB1A, MOB1B, DGCR6, BYSL, HBZ, MEOX2, CARHSP1, CHMP2A, ZNF581, FBXL12, FANCL, EXOSC5, MRPL38, DOCK8, FAM161A, MED30, MTG1, KRT40, ZFC3H1, FAM124A, RTP5, ARPC3, PFKFB2, NSMAF, BAG3, MORC3, CDC5L, LRCH4, APPBP2, CPNE7


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for CTNND1_DOCK8


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for CTNND1_DOCK8


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneDOCK8C0008073Developmental Disabilities1CTD_human
TgeneDOCK8C0027819Neuroblastoma1CTD_human
TgeneDOCK8C1968689Hyper-Immunoglobulin E Syndrome, Autosomal Recessive1ORPHANET;UNIPROT
TgeneDOCK8C3714756Intellectual Disability1CTD_human