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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 8846

FusionGeneSummary for CTNND1_BTBD18

check button Fusion gene summary
Fusion gene informationFusion gene name: CTNND1_BTBD18
Fusion gene ID: 8846
HgeneTgene
Gene symbol

CTNND1

BTBD18

Gene ID

1500

643376

Gene namecatenin delta 1BTB domain containing 18
SynonymsBCDS2|CAS|CTNND|P120CAS|P120CTN|p120|p120(CAS)|p120(CTN)-
Cytomap

11q12.1

11q12.1

Type of geneprotein-codingprotein-coding
Descriptioncatenin delta-1cadherin-associated Src substratecatenin (cadherin-associated protein), delta 1p120 cateninBTB/POZ domain-containing protein 18BTB (POZ) domain containing 18hCG1730474
Modification date2018052320180522
UniProtAcc

O60716

B2RXH4

Ensembl transtripts involved in fusion geneENST00000524630, ENST00000529919, 
ENST00000399039, ENST00000360682, 
ENST00000361796, ENST00000361391, 
ENST00000530094, ENST00000428599, 
ENST00000361332, ENST00000527467, 
ENST00000415361, ENST00000532245, 
ENST00000532463, ENST00000528232, 
ENST00000529986, ENST00000531014, 
ENST00000358694, ENST00000526772, 
ENST00000532787, ENST00000533667, 
ENST00000529873, ENST00000525902, 
ENST00000529526, ENST00000532649, 
ENST00000426142, ENST00000532844, 
ENST00000528621, ENST00000399050, 
ENST00000526357, ENST00000530748, 
ENST00000534579, ENST00000526938, 
ENST00000436147, ENST00000422652, 
Fusion gene scores* DoF score17 X 11 X 12=22441 X 1 X 1=1
# samples 191
** MAII scorelog2(19/2244*10)=-3.56200135227784
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(1/1*10)=3.32192809488736
Context

PubMed: CTNND1 [Title/Abstract] AND BTBD18 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVCOADTCGA-A6-A566-01ACTNND1chr11

57529591

+BTBD18chr11

57518708

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-5UTRENST00000524630ENST00000436147CTNND1chr11

57529591

+BTBD18chr11

57518708

-
intron-5UTRENST00000524630ENST00000422652CTNND1chr11

57529591

+BTBD18chr11

57518708

-
intron-5UTRENST00000529919ENST00000436147CTNND1chr11

57529591

+BTBD18chr11

57518708

-
intron-5UTRENST00000529919ENST00000422652CTNND1chr11

57529591

+BTBD18chr11

57518708

-
intron-5UTRENST00000399039ENST00000436147CTNND1chr11

57529591

+BTBD18chr11

57518708

-
intron-5UTRENST00000399039ENST00000422652CTNND1chr11

57529591

+BTBD18chr11

57518708

-
5UTR-5UTRENST00000360682ENST00000436147CTNND1chr11

57529591

+BTBD18chr11

57518708

-
5UTR-5UTRENST00000360682ENST00000422652CTNND1chr11

57529591

+BTBD18chr11

57518708

-
5UTR-5UTRENST00000361796ENST00000436147CTNND1chr11

57529591

+BTBD18chr11

57518708

-
5UTR-5UTRENST00000361796ENST00000422652CTNND1chr11

57529591

+BTBD18chr11

57518708

-
5UTR-5UTRENST00000361391ENST00000436147CTNND1chr11

57529591

+BTBD18chr11

57518708

-
5UTR-5UTRENST00000361391ENST00000422652CTNND1chr11

57529591

+BTBD18chr11

57518708

-
intron-5UTRENST00000530094ENST00000436147CTNND1chr11

57529591

+BTBD18chr11

57518708

-
intron-5UTRENST00000530094ENST00000422652CTNND1chr11

57529591

+BTBD18chr11

57518708

-
intron-5UTRENST00000428599ENST00000436147CTNND1chr11

57529591

+BTBD18chr11

57518708

-
intron-5UTRENST00000428599ENST00000422652CTNND1chr11

57529591

+BTBD18chr11

57518708

-
5UTR-5UTRENST00000361332ENST00000436147CTNND1chr11

57529591

+BTBD18chr11

57518708

-
5UTR-5UTRENST00000361332ENST00000422652CTNND1chr11

57529591

+BTBD18chr11

57518708

-
intron-5UTRENST00000527467ENST00000436147CTNND1chr11

57529591

+BTBD18chr11

57518708

-
intron-5UTRENST00000527467ENST00000422652CTNND1chr11

57529591

+BTBD18chr11

57518708

-
intron-5UTRENST00000415361ENST00000436147CTNND1chr11

57529591

+BTBD18chr11

57518708

-
intron-5UTRENST00000415361ENST00000422652CTNND1chr11

57529591

+BTBD18chr11

57518708

-
intron-5UTRENST00000532245ENST00000436147CTNND1chr11

57529591

+BTBD18chr11

57518708

-
intron-5UTRENST00000532245ENST00000422652CTNND1chr11

57529591

+BTBD18chr11

57518708

-
intron-5UTRENST00000532463ENST00000436147CTNND1chr11

57529591

+BTBD18chr11

57518708

-
intron-5UTRENST00000532463ENST00000422652CTNND1chr11

57529591

+BTBD18chr11

57518708

-
intron-5UTRENST00000528232ENST00000436147CTNND1chr11

57529591

+BTBD18chr11

57518708

-
intron-5UTRENST00000528232ENST00000422652CTNND1chr11

57529591

+BTBD18chr11

57518708

-
intron-5UTRENST00000529986ENST00000436147CTNND1chr11

57529591

+BTBD18chr11

57518708

-
intron-5UTRENST00000529986ENST00000422652CTNND1chr11

57529591

+BTBD18chr11

57518708

-
intron-5UTRENST00000531014ENST00000436147CTNND1chr11

57529591

+BTBD18chr11

57518708

-
intron-5UTRENST00000531014ENST00000422652CTNND1chr11

57529591

+BTBD18chr11

57518708

-
intron-5UTRENST00000358694ENST00000436147CTNND1chr11

57529591

+BTBD18chr11

57518708

-
intron-5UTRENST00000358694ENST00000422652CTNND1chr11

57529591

+BTBD18chr11

57518708

-
intron-5UTRENST00000526772ENST00000436147CTNND1chr11

57529591

+BTBD18chr11

57518708

-
intron-5UTRENST00000526772ENST00000422652CTNND1chr11

57529591

+BTBD18chr11

57518708

-
intron-5UTRENST00000532787ENST00000436147CTNND1chr11

57529591

+BTBD18chr11

57518708

-
intron-5UTRENST00000532787ENST00000422652CTNND1chr11

57529591

+BTBD18chr11

57518708

-
intron-5UTRENST00000533667ENST00000436147CTNND1chr11

57529591

+BTBD18chr11

57518708

-
intron-5UTRENST00000533667ENST00000422652CTNND1chr11

57529591

+BTBD18chr11

57518708

-
intron-5UTRENST00000529873ENST00000436147CTNND1chr11

57529591

+BTBD18chr11

57518708

-
intron-5UTRENST00000529873ENST00000422652CTNND1chr11

57529591

+BTBD18chr11

57518708

-
intron-5UTRENST00000525902ENST00000436147CTNND1chr11

57529591

+BTBD18chr11

57518708

-
intron-5UTRENST00000525902ENST00000422652CTNND1chr11

57529591

+BTBD18chr11

57518708

-
5UTR-5UTRENST00000529526ENST00000436147CTNND1chr11

57529591

+BTBD18chr11

57518708

-
5UTR-5UTRENST00000529526ENST00000422652CTNND1chr11

57529591

+BTBD18chr11

57518708

-
intron-5UTRENST00000532649ENST00000436147CTNND1chr11

57529591

+BTBD18chr11

57518708

-
intron-5UTRENST00000532649ENST00000422652CTNND1chr11

57529591

+BTBD18chr11

57518708

-
5UTR-5UTRENST00000426142ENST00000436147CTNND1chr11

57529591

+BTBD18chr11

57518708

-
5UTR-5UTRENST00000426142ENST00000422652CTNND1chr11

57529591

+BTBD18chr11

57518708

-
intron-5UTRENST00000532844ENST00000436147CTNND1chr11

57529591

+BTBD18chr11

57518708

-
intron-5UTRENST00000532844ENST00000422652CTNND1chr11

57529591

+BTBD18chr11

57518708

-
intron-5UTRENST00000528621ENST00000436147CTNND1chr11

57529591

+BTBD18chr11

57518708

-
intron-5UTRENST00000528621ENST00000422652CTNND1chr11

57529591

+BTBD18chr11

57518708

-
5UTR-5UTRENST00000399050ENST00000436147CTNND1chr11

57529591

+BTBD18chr11

57518708

-
5UTR-5UTRENST00000399050ENST00000422652CTNND1chr11

57529591

+BTBD18chr11

57518708

-
intron-5UTRENST00000526357ENST00000436147CTNND1chr11

57529591

+BTBD18chr11

57518708

-
intron-5UTRENST00000526357ENST00000422652CTNND1chr11

57529591

+BTBD18chr11

57518708

-
intron-5UTRENST00000530748ENST00000436147CTNND1chr11

57529591

+BTBD18chr11

57518708

-
intron-5UTRENST00000530748ENST00000422652CTNND1chr11

57529591

+BTBD18chr11

57518708

-
intron-5UTRENST00000534579ENST00000436147CTNND1chr11

57529591

+BTBD18chr11

57518708

-
intron-5UTRENST00000534579ENST00000422652CTNND1chr11

57529591

+BTBD18chr11

57518708

-
intron-5UTRENST00000526938ENST00000436147CTNND1chr11

57529591

+BTBD18chr11

57518708

-
intron-5UTRENST00000526938ENST00000422652CTNND1chr11

57529591

+BTBD18chr11

57518708

-

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FusionProtFeatures for CTNND1_BTBD18


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CTNND1

O60716

BTBD18

B2RXH4

Specifically required during spermatogenesis to promoteexpression of piRNA precursors. The piRNA metabolic processmediates the repression of transposable elements during meiosis byforming complexes composed of piRNAs and Piwi proteins and governsthe methylation and subsequent repression of transposons, which isessential for the germline integrity. Acts by facilitatingtranscription elongation at piRNA loci during pachytene.{ECO:0000250|UniProtKB:A0A0A6YY25}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for CTNND1_BTBD18


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for CTNND1_BTBD18


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
CTNND1CDH1, CTNNB1, EGFR, CTNNA1, CDH2, ACTG1, CTTN, FYN, LCK, SRC, YES1, PTPRJ, ZBTB33, CDH3, CDH5, MUC1, PSEN1, PTPN6, PTPRM, COL17A1, ERBB2IP, WDR48, SQSTM1, SNCA, RIPK3, ARRB2, CUL3, CSNK1E, APP, VCP, MYC, ATF2, SOX2, ATP4A, AP2M1, AURKA, KCTD6, NXF1, CCDC8, BMI1, SUMO2, NTRK1, IFI16, CEP135, TMEM17, TMEM216, XPO1, PPP4R1, FOXB1, MCM2, CDC5L, OTUB1, PPAP2B, BTRC, GSK3B, CTDSPL, MTMR7, CDH8, CTNNA3, G3BP1BTBD18EGFR


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for CTNND1_BTBD18


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for CTNND1_BTBD18


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource