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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 8844

FusionGeneSummary for CTNNBL1_TTI1

check button Fusion gene summary
Fusion gene informationFusion gene name: CTNNBL1_TTI1
Fusion gene ID: 8844
HgeneTgene
Gene symbol

CTNNBL1

TTI1

Gene ID

56259

9675

Gene namecatenin beta like 1TELO2 interacting protein 1
SynonymsC20orf33|NAP|P14L|PP8304|dJ633O20.1KIAA0406|smg-10
Cytomap

20q11.23

20q11.23

Type of geneprotein-codingprotein-coding
Descriptionbeta-catenin-like protein 1nuclear associated proteintestis development protein NYD-SP19TELO2-interacting protein 1 homologTEL2-interacting protein 1 homologTel two interacting protein 1smg-10 homolog, nonsense mediated mRNA decay factor
Modification date2018052320180519
UniProtAcc

Q8WYA6

O43156

Ensembl transtripts involved in fusion geneENST00000361383, ENST00000405275, 
ENST00000373473, ENST00000473857, 
ENST00000373469, 
ENST00000373448, 
ENST00000373447, ENST00000449821, 
ENST00000487362, 
Fusion gene scores* DoF score4 X 3 X 3=363 X 3 X 3=27
# samples 43
** MAII scorelog2(4/36*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(3/27*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: CTNNBL1 [Title/Abstract] AND TTI1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneCTNNBL1

GO:0043065

positive regulation of apoptotic process

12659813


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDBRCATCGA-C8-A1HN-01ACTNNBL1chr20

36322554

+TTI1chr20

36642259

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000361383ENST00000373448CTNNBL1chr20

36322554

+TTI1chr20

36642259

-
5CDS-5UTRENST00000361383ENST00000373447CTNNBL1chr20

36322554

+TTI1chr20

36642259

-
5CDS-5UTRENST00000361383ENST00000449821CTNNBL1chr20

36322554

+TTI1chr20

36642259

-
5CDS-5UTRENST00000361383ENST00000487362CTNNBL1chr20

36322554

+TTI1chr20

36642259

-
5UTR-5UTRENST00000405275ENST00000373448CTNNBL1chr20

36322554

+TTI1chr20

36642259

-
5UTR-5UTRENST00000405275ENST00000373447CTNNBL1chr20

36322554

+TTI1chr20

36642259

-
5UTR-5UTRENST00000405275ENST00000449821CTNNBL1chr20

36322554

+TTI1chr20

36642259

-
5UTR-5UTRENST00000405275ENST00000487362CTNNBL1chr20

36322554

+TTI1chr20

36642259

-
intron-5UTRENST00000373473ENST00000373448CTNNBL1chr20

36322554

+TTI1chr20

36642259

-
intron-5UTRENST00000373473ENST00000373447CTNNBL1chr20

36322554

+TTI1chr20

36642259

-
intron-5UTRENST00000373473ENST00000449821CTNNBL1chr20

36322554

+TTI1chr20

36642259

-
intron-5UTRENST00000373473ENST00000487362CTNNBL1chr20

36322554

+TTI1chr20

36642259

-
intron-5UTRENST00000473857ENST00000373448CTNNBL1chr20

36322554

+TTI1chr20

36642259

-
intron-5UTRENST00000473857ENST00000373447CTNNBL1chr20

36322554

+TTI1chr20

36642259

-
intron-5UTRENST00000473857ENST00000449821CTNNBL1chr20

36322554

+TTI1chr20

36642259

-
intron-5UTRENST00000473857ENST00000487362CTNNBL1chr20

36322554

+TTI1chr20

36642259

-
intron-5UTRENST00000373469ENST00000373448CTNNBL1chr20

36322554

+TTI1chr20

36642259

-
intron-5UTRENST00000373469ENST00000373447CTNNBL1chr20

36322554

+TTI1chr20

36642259

-
intron-5UTRENST00000373469ENST00000449821CTNNBL1chr20

36322554

+TTI1chr20

36642259

-
intron-5UTRENST00000373469ENST00000487362CTNNBL1chr20

36322554

+TTI1chr20

36642259

-

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FusionProtFeatures for CTNNBL1_TTI1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CTNNBL1

Q8WYA6

TTI1

O43156

Regulator of the DNA damage response (DDR). Part of theTTT complex that is required to stabilize protein levels of thephosphatidylinositol 3-kinase-related protein kinase (PIKK) familyproteins. The TTT complex is involved in the cellular resistanceto DNA damage stresses, like ionizing radiation (IR), ultraviolet(UV) and mitomycin C (MMC). Together with the TTT complex andHSP90 may participate in the proper folding of newly synthesizedPIKKs. Promotes assembly, stabilizes and maintains the activity ofmTORC1 and mTORC2 complexes, which regulate cell growth andsurvival in response to nutrient and hormonal signals.{ECO:0000269|PubMed:20427287, ECO:0000269|PubMed:20801936,ECO:0000269|PubMed:20810650}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for CTNNBL1_TTI1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for CTNNBL1_TTI1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
CTNNBL1SPP1, CDC5L, PRPF19, HSPA4, PRPF31, KPNA2, DDX21, PLRG1, PRMT5, ACTA1, NPM1, RBM39, STAT1, WDR77, HIST4H4, AICDA, KPNA1, SF3A2, STAMBP, BCAS2, CWC15, VCP, U2SURP, PRPF3, WBP11, SNW1, BUD31, IK, PPP1R8, HNRNPK, NSRP1, ZCCHC10, SRPK2, LUC7L, HECW2, MEOX2, PRDM4, LDOC1, NGFRAP1, MED4, CDCA7L, CREBZF, CATIP, CTNNBL1, THAP2, HOXB5, CYP1A1, MAPK8IP2, EWSR1, G3BP1, KIF3A, RBM45, TBK1, ZNF394, ZNF331, CLEC3A, FGB, USP47, SNRNP27, DUSP23TTI1RUVBL2, RUVBL1, MTOR, TELO2, ATM, ATR, PRKDC, SMG1, TRRAP, TTI2, HSPA4, PIH1D1, POLR2E, RPAP3, URI1, TUBA1A, RBM8A, EGFR, FBXO6, PSME4, COPB2, COPG1, COPZ1, NUP50, RUFY1, TSC22D1, TMEM51, CD274, VSIG2, CD68, LPAR6, ARL13B, SCN2B, HTR6, API5, NTRK1, NCSTN, POU5F1, PTPRF, VSIG1, SIGLECL1, CD70, CHRM3, STOM, ZNHIT2


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for CTNNBL1_TTI1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for CTNNBL1_TTI1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource