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Fusion gene ID: 8820 |
FusionGeneSummary for CTNNA3_C14orf166B |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: CTNNA3_C14orf166B | Fusion gene ID: 8820 | Hgene | Tgene | Gene symbol | CTNNA3 | C14orf166B | Gene ID | 29119 | 145497 |
| Gene name | catenin alpha 3 | leucine rich repeat containing 74A | |
| Synonyms | ARVD13|VR22 | C14orf166B|LRRC74 | |
| Cytomap | 10q21.3 | 14q24.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | catenin alpha-3alpha-T-cateninalpha-catenin-like proteincatenin (cadherin-associated protein), alpha 3 | leucine-rich repeat-containing protein 74Aleucine rich repeat containing 74leucine-rich repeat-containing protein 74 | |
| Modification date | 20180519 | 20180403 | |
| UniProtAcc | Q9UI47 | ||
| Ensembl transtripts involved in fusion gene | ENST00000433211, ENST00000373744, ENST00000545309, ENST00000373735, | ENST00000393774, ENST00000460005, ENST00000450042, ENST00000216453, | |
| Fusion gene scores | * DoF score | 5 X 4 X 3=60 | 2 X 3 X 3=18 |
| # samples | 5 | 3 | |
| ** MAII score | log2(5/60*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: CTNNA3 [Title/Abstract] AND C14orf166B [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Tumor suppressor gene involved fusion gene, retained protein feature but frameshift. DDR (DNA damage repair) gene involved fusion gene, in-frame but not retained their domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | BRCA | TCGA-C8-A26Y-01A | CTNNA3 | chr10 | 69281600 | - | C14orf166B | chr14 | 77302550 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000433211 | ENST00000393774 | CTNNA3 | chr10 | 69281600 | - | C14orf166B | chr14 | 77302550 | + |
| 5CDS-3UTR | ENST00000433211 | ENST00000460005 | CTNNA3 | chr10 | 69281600 | - | C14orf166B | chr14 | 77302550 | + |
| 5CDS-3UTR | ENST00000433211 | ENST00000450042 | CTNNA3 | chr10 | 69281600 | - | C14orf166B | chr14 | 77302550 | + |
| 5CDS-intron | ENST00000433211 | ENST00000216453 | CTNNA3 | chr10 | 69281600 | - | C14orf166B | chr14 | 77302550 | + |
| In-frame | ENST00000373744 | ENST00000393774 | CTNNA3 | chr10 | 69281600 | - | C14orf166B | chr14 | 77302550 | + |
| 5CDS-3UTR | ENST00000373744 | ENST00000460005 | CTNNA3 | chr10 | 69281600 | - | C14orf166B | chr14 | 77302550 | + |
| 5CDS-3UTR | ENST00000373744 | ENST00000450042 | CTNNA3 | chr10 | 69281600 | - | C14orf166B | chr14 | 77302550 | + |
| 5CDS-intron | ENST00000373744 | ENST00000216453 | CTNNA3 | chr10 | 69281600 | - | C14orf166B | chr14 | 77302550 | + |
| In-frame | ENST00000545309 | ENST00000393774 | CTNNA3 | chr10 | 69281600 | - | C14orf166B | chr14 | 77302550 | + |
| 5CDS-3UTR | ENST00000545309 | ENST00000460005 | CTNNA3 | chr10 | 69281600 | - | C14orf166B | chr14 | 77302550 | + |
| 5CDS-3UTR | ENST00000545309 | ENST00000450042 | CTNNA3 | chr10 | 69281600 | - | C14orf166B | chr14 | 77302550 | + |
| 5CDS-intron | ENST00000545309 | ENST00000216453 | CTNNA3 | chr10 | 69281600 | - | C14orf166B | chr14 | 77302550 | + |
| intron-3CDS | ENST00000373735 | ENST00000393774 | CTNNA3 | chr10 | 69281600 | - | C14orf166B | chr14 | 77302550 | + |
| intron-3UTR | ENST00000373735 | ENST00000460005 | CTNNA3 | chr10 | 69281600 | - | C14orf166B | chr14 | 77302550 | + |
| intron-3UTR | ENST00000373735 | ENST00000450042 | CTNNA3 | chr10 | 69281600 | - | C14orf166B | chr14 | 77302550 | + |
| intron-intron | ENST00000373735 | ENST00000216453 | CTNNA3 | chr10 | 69281600 | - | C14orf166B | chr14 | 77302550 | + |
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FusionProtFeatures for CTNNA3_C14orf166B |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| CTNNA3 | C14orf166B |
| May be involved in formation of stretch-resistant cell-cell adhesion complexes. {ECO:0000303|PubMed:11590244}. | Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for CTNNA3_C14orf166B |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_CTNNA3_ENST00000373744_chr10_69281600_-_C14orf166B_ENST00000393774_chr14_77302550_+_552aa MSAETPITLNIDPQDLQVQTFTVEKLLEPLIIQVTTLVNCPQNPSSRKKGRSKRASVLLASVEEATWNLLDKGEKIAQEATVLKDELTAS LEEVRKESEALKVSAERFTDDPCFLPKREAVVQAARALLAAVTRLLILADMIDVMCLLQHVSAFQRTFESLKNVANKSDLQKTYQKLGKE LENLDYLAFKRQQSNMAVTKLELEDNCIMEEGVLSLVEMLQENYYLQEMNISNNHLGLEGARIISDFFERNSSSIWSLELSGNDFKEDSA ALLCQALSTNYQIKKLDLSHNQFSDVGGEHLGQMLAINVGLTSLDLSWNNFHTRGAVALCNGLRGNVTLTKLDLSMNGFGNEVALALGEV LRLNRCLVYLDIGGNDIGNEGASKISKGLESNESLRVLKLFLNPINMDGAILLILAIKRNPKSRMEELDISNVLVSEQFMKTLDGVYAVH PQLDVVFKAVQGLSPKKTIFLLTNPMKLIQSYADQHKITIVDFFKSLNPTGTMKMSVDEFQKVMIEQNKVPLNQYQVREVIKKLDEKTGM >In-frame_CTNNA3_ENST00000545309_chr10_69281600_-_C14orf166B_ENST00000393774_chr14_77302550_+_552aa MSAETPITLNIDPQDLQVQTFTVEKLLEPLIIQVTTLVNCPQNPSSRKKGRSKRASVLLASVEEATWNLLDKGEKIAQEATVLKDELTAS LEEVRKESEALKVSAERFTDDPCFLPKREAVVQAARALLAAVTRLLILADMIDVMCLLQHVSAFQRTFESLKNVANKSDLQKTYQKLGKE LENLDYLAFKRQQSNMAVTKLELEDNCIMEEGVLSLVEMLQENYYLQEMNISNNHLGLEGARIISDFFERNSSSIWSLELSGNDFKEDSA ALLCQALSTNYQIKKLDLSHNQFSDVGGEHLGQMLAINVGLTSLDLSWNNFHTRGAVALCNGLRGNVTLTKLDLSMNGFGNEVALALGEV LRLNRCLVYLDIGGNDIGNEGASKISKGLESNESLRVLKLFLNPINMDGAILLILAIKRNPKSRMEELDISNVLVSEQFMKTLDGVYAVH PQLDVVFKAVQGLSPKKTIFLLTNPMKLIQSYADQHKITIVDFFKSLNPTGTMKMSVDEFQKVMIEQNKVPLNQYQVREVIKKLDEKTGM |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_CTNNA3_ENST00000373744_chr10_69281600_-_C14orf166B_ENST00000393774_chr14_77302550_+_1656nt ATGTCAGCTGAAACACCAATCACATTGAATATCGATCCTCAGGATCTGCAGGTCCAAACATTCACCGTGGAGAAGCTACTGGAGCCTCTC ATAATCCAGGTTACCACACTTGTAAACTGTCCCCAGAACCCTTCCAGCAGGAAAAAAGGACGTTCGAAAAGAGCCAGTGTCCTTCTAGCT TCTGTGGAGGAAGCAACTTGGAATTTATTAGACAAGGGAGAGAAGATTGCCCAGGAAGCTACAGTTTTAAAGGATGAGCTTACGGCTTCA CTTGAGGAAGTTCGCAAAGAAAGTGAAGCTCTGAAAGTATCAGCTGAGAGATTTACAGATGACCCCTGTTTTCTCCCAAAAAGGGAGGCT GTGGTTCAAGCTGCCCGTGCCTTGCTGGCTGCGGTGACGAGACTCCTTATCCTTGCGGACATGATTGATGTCATGTGCCTCTTGCAACAT GTGTCAGCTTTTCAAAGGACATTTGAGTCTCTCAAAAATGTTGCCAACAAATCTGACCTCCAGAAAACCTACCAGAAGCTTGGGAAGGAG CTGGAAAATTTGGATTATTTAGCCTTCAAACGTCAGCAGTCCAACATGGCTGTTACCAAACTGGAGCTGGAAGACAATTGCATCATGGAG GAGGGCGTCTTGAGCCTGGTGGAGATGCTACAAGAGAACTACTACCTCCAGGAGATGAATATTTCCAACAATCACCTTGGTTTGGAGGGG GCCAGAATCATCTCAGATTTCTTTGAGAGAAACAGTTCTTCTATCTGGAGCCTTGAGCTTTCAGGAAATGACTTCAAGGAAGACTCCGCA GCACTGCTCTGCCAAGCCCTGTCGACCAATTACCAAATTAAAAAGCTGGATCTCAGTCACAACCAATTCTCTGATGTAGGAGGGGAGCAC CTGGGCCAGATGCTGGCCATCAACGTGGGGCTCACGTCACTGGATCTGAGCTGGAATAACTTCCACACAAGGGGAGCTGTGGCCTTGTGC AATGGTCTCCGGGGTAATGTGACCCTGACAAAGCTGGATCTCTCCATGAATGGCTTTGGGAATGAGGTGGCTCTGGCCCTAGGGGAAGTC CTCCGACTCAACCGCTGCCTGGTCTACCTGGATATCGGTGGCAATGACATCGGCAATGAAGGGGCCTCCAAAATCAGCAAAGGACTGGAA TCCAATGAAAGCCTCAGAGTTCTGAAGCTTTTCCTGAATCCCATAAATATGGATGGGGCTATTTTACTTATCCTGGCTATCAAGAGGAAC CCCAAATCCAGGATGGAAGAGCTTGATATTTCCAACGTGCTGGTGTCCGAGCAGTTCATGAAAACGTTGGACGGAGTGTATGCCGTTCAC CCGCAGCTGGACGTGGTATTCAAGGCAGTACAAGGCCTCTCTCCCAAGAAAACCATCTTCTTGTTGACAAACCCCATGAAACTGATCCAG AGCTATGCAGACCAACACAAAATCACGATCGTGGACTTCTTCAAGAGCTTGAACCCCACTGGGACAATGAAGATGTCTGTGGATGAGTTC CAGAAAGTGATGATAGAGCAAAACAAGGTCCCCCTGAACCAGTACCAGGTCAGGGAGGTGATAAAGAAGCTCGATGAGAAGACAGGCATG >In-frame_CTNNA3_ENST00000545309_chr10_69281600_-_C14orf166B_ENST00000393774_chr14_77302550_+_1656nt ATGTCAGCTGAAACACCAATCACATTGAATATCGATCCTCAGGATCTGCAGGTCCAAACATTCACCGTGGAGAAGCTACTGGAGCCTCTC ATAATCCAGGTTACCACACTTGTAAACTGTCCCCAGAACCCTTCCAGCAGGAAAAAAGGACGTTCGAAAAGAGCCAGTGTCCTTCTAGCT TCTGTGGAGGAAGCAACTTGGAATTTATTAGACAAGGGAGAGAAGATTGCCCAGGAAGCTACAGTTTTAAAGGATGAGCTTACGGCTTCA CTTGAGGAAGTTCGCAAAGAAAGTGAAGCTCTGAAAGTATCAGCTGAGAGATTTACAGATGACCCCTGTTTTCTCCCAAAAAGGGAGGCT GTGGTTCAAGCTGCCCGTGCCTTGCTGGCTGCGGTGACGAGACTCCTTATCCTTGCGGACATGATTGATGTCATGTGCCTCTTGCAACAT GTGTCAGCTTTTCAAAGGACATTTGAGTCTCTCAAAAATGTTGCCAACAAATCTGACCTCCAGAAAACCTACCAGAAGCTTGGGAAGGAG CTGGAAAATTTGGATTATTTAGCCTTCAAACGTCAGCAGTCCAACATGGCTGTTACCAAACTGGAGCTGGAAGACAATTGCATCATGGAG GAGGGCGTCTTGAGCCTGGTGGAGATGCTACAAGAGAACTACTACCTCCAGGAGATGAATATTTCCAACAATCACCTTGGTTTGGAGGGG GCCAGAATCATCTCAGATTTCTTTGAGAGAAACAGTTCTTCTATCTGGAGCCTTGAGCTTTCAGGAAATGACTTCAAGGAAGACTCCGCA GCACTGCTCTGCCAAGCCCTGTCGACCAATTACCAAATTAAAAAGCTGGATCTCAGTCACAACCAATTCTCTGATGTAGGAGGGGAGCAC CTGGGCCAGATGCTGGCCATCAACGTGGGGCTCACGTCACTGGATCTGAGCTGGAATAACTTCCACACAAGGGGAGCTGTGGCCTTGTGC AATGGTCTCCGGGGTAATGTGACCCTGACAAAGCTGGATCTCTCCATGAATGGCTTTGGGAATGAGGTGGCTCTGGCCCTAGGGGAAGTC CTCCGACTCAACCGCTGCCTGGTCTACCTGGATATCGGTGGCAATGACATCGGCAATGAAGGGGCCTCCAAAATCAGCAAAGGACTGGAA TCCAATGAAAGCCTCAGAGTTCTGAAGCTTTTCCTGAATCCCATAAATATGGATGGGGCTATTTTACTTATCCTGGCTATCAAGAGGAAC CCCAAATCCAGGATGGAAGAGCTTGATATTTCCAACGTGCTGGTGTCCGAGCAGTTCATGAAAACGTTGGACGGAGTGTATGCCGTTCAC CCGCAGCTGGACGTGGTATTCAAGGCAGTACAAGGCCTCTCTCCCAAGAAAACCATCTTCTTGTTGACAAACCCCATGAAACTGATCCAG AGCTATGCAGACCAACACAAAATCACGATCGTGGACTTCTTCAAGAGCTTGAACCCCACTGGGACAATGAAGATGTCTGTGGATGAGTTC CAGAAAGTGATGATAGAGCAAAACAAGGTCCCCCTGAACCAGTACCAGGTCAGGGAGGTGATAAAGAAGCTCGATGAGAAGACAGGCATG |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_CTNNA3_ENST00000373744_chr10_69281600_-_C14orf166B_ENST00000393774_chr14_77302550_+_1713nt ATGTCAGCTGAAACACCAATCACATTGAATATCGATCCTCAGGATCTGCAGGTCCAAACATTCACCGTGGAGAAGCTACTGGAGCCTCTC ATAATCCAGGTTACCACACTTGTAAACTGTCCCCAGAACCCTTCCAGCAGGAAAAAAGGACGTTCGAAAAGAGCCAGTGTCCTTCTAGCT TCTGTGGAGGAAGCAACTTGGAATTTATTAGACAAGGGAGAGAAGATTGCCCAGGAAGCTACAGTTTTAAAGGATGAGCTTACGGCTTCA CTTGAGGAAGTTCGCAAAGAAAGTGAAGCTCTGAAAGTATCAGCTGAGAGATTTACAGATGACCCCTGTTTTCTCCCAAAAAGGGAGGCT GTGGTTCAAGCTGCCCGTGCCTTGCTGGCTGCGGTGACGAGACTCCTTATCCTTGCGGACATGATTGATGTCATGTGCCTCTTGCAACAT GTGTCAGCTTTTCAAAGGACATTTGAGTCTCTCAAAAATGTTGCCAACAAATCTGACCTCCAGAAAACCTACCAGAAGCTTGGGAAGGAG CTGGAAAATTTGGATTATTTAGCCTTCAAACGTCAGCAGTCCAACATGGCTGTTACCAAACTGGAGCTGGAAGACAATTGCATCATGGAG GAGGGCGTCTTGAGCCTGGTGGAGATGCTACAAGAGAACTACTACCTCCAGGAGATGAATATTTCCAACAATCACCTTGGTTTGGAGGGG GCCAGAATCATCTCAGATTTCTTTGAGAGAAACAGTTCTTCTATCTGGAGCCTTGAGCTTTCAGGAAATGACTTCAAGGAAGACTCCGCA GCACTGCTCTGCCAAGCCCTGTCGACCAATTACCAAATTAAAAAGCTGGATCTCAGTCACAACCAATTCTCTGATGTAGGAGGGGAGCAC CTGGGCCAGATGCTGGCCATCAACGTGGGGCTCACGTCACTGGATCTGAGCTGGAATAACTTCCACACAAGGGGAGCTGTGGCCTTGTGC AATGGTCTCCGGGGTAATGTGACCCTGACAAAGCTGGATCTCTCCATGAATGGCTTTGGGAATGAGGTGGCTCTGGCCCTAGGGGAAGTC CTCCGACTCAACCGCTGCCTGGTCTACCTGGATATCGGTGGCAATGACATCGGCAATGAAGGGGCCTCCAAAATCAGCAAAGGACTGGAA TCCAATGAAAGCCTCAGAGTTCTGAAGCTTTTCCTGAATCCCATAAATATGGATGGGGCTATTTTACTTATCCTGGCTATCAAGAGGAAC CCCAAATCCAGGATGGAAGAGCTTGATATTTCCAACGTGCTGGTGTCCGAGCAGTTCATGAAAACGTTGGACGGAGTGTATGCCGTTCAC CCGCAGCTGGACGTGGTATTCAAGGCAGTACAAGGCCTCTCTCCCAAGAAAACCATCTTCTTGTTGACAAACCCCATGAAACTGATCCAG AGCTATGCAGACCAACACAAAATCACGATCGTGGACTTCTTCAAGAGCTTGAACCCCACTGGGACAATGAAGATGTCTGTGGATGAGTTC CAGAAAGTGATGATAGAGCAAAACAAGGTCCCCCTGAACCAGTACCAGGTCAGGGAGGTGATAAAGAAGCTCGATGAGAAGACAGGCATG GTGAACTTCAGTTTCTTGAACACGATGAAGCCATAGCAACAAGTCTGGTCTAGAAAGAAGTCTCGGCGAGAGGAGTCCTCGCAAGTCGGA >In-frame_CTNNA3_ENST00000545309_chr10_69281600_-_C14orf166B_ENST00000393774_chr14_77302550_+_1713nt ATGTCAGCTGAAACACCAATCACATTGAATATCGATCCTCAGGATCTGCAGGTCCAAACATTCACCGTGGAGAAGCTACTGGAGCCTCTC ATAATCCAGGTTACCACACTTGTAAACTGTCCCCAGAACCCTTCCAGCAGGAAAAAAGGACGTTCGAAAAGAGCCAGTGTCCTTCTAGCT TCTGTGGAGGAAGCAACTTGGAATTTATTAGACAAGGGAGAGAAGATTGCCCAGGAAGCTACAGTTTTAAAGGATGAGCTTACGGCTTCA CTTGAGGAAGTTCGCAAAGAAAGTGAAGCTCTGAAAGTATCAGCTGAGAGATTTACAGATGACCCCTGTTTTCTCCCAAAAAGGGAGGCT GTGGTTCAAGCTGCCCGTGCCTTGCTGGCTGCGGTGACGAGACTCCTTATCCTTGCGGACATGATTGATGTCATGTGCCTCTTGCAACAT GTGTCAGCTTTTCAAAGGACATTTGAGTCTCTCAAAAATGTTGCCAACAAATCTGACCTCCAGAAAACCTACCAGAAGCTTGGGAAGGAG CTGGAAAATTTGGATTATTTAGCCTTCAAACGTCAGCAGTCCAACATGGCTGTTACCAAACTGGAGCTGGAAGACAATTGCATCATGGAG GAGGGCGTCTTGAGCCTGGTGGAGATGCTACAAGAGAACTACTACCTCCAGGAGATGAATATTTCCAACAATCACCTTGGTTTGGAGGGG GCCAGAATCATCTCAGATTTCTTTGAGAGAAACAGTTCTTCTATCTGGAGCCTTGAGCTTTCAGGAAATGACTTCAAGGAAGACTCCGCA GCACTGCTCTGCCAAGCCCTGTCGACCAATTACCAAATTAAAAAGCTGGATCTCAGTCACAACCAATTCTCTGATGTAGGAGGGGAGCAC CTGGGCCAGATGCTGGCCATCAACGTGGGGCTCACGTCACTGGATCTGAGCTGGAATAACTTCCACACAAGGGGAGCTGTGGCCTTGTGC AATGGTCTCCGGGGTAATGTGACCCTGACAAAGCTGGATCTCTCCATGAATGGCTTTGGGAATGAGGTGGCTCTGGCCCTAGGGGAAGTC CTCCGACTCAACCGCTGCCTGGTCTACCTGGATATCGGTGGCAATGACATCGGCAATGAAGGGGCCTCCAAAATCAGCAAAGGACTGGAA TCCAATGAAAGCCTCAGAGTTCTGAAGCTTTTCCTGAATCCCATAAATATGGATGGGGCTATTTTACTTATCCTGGCTATCAAGAGGAAC CCCAAATCCAGGATGGAAGAGCTTGATATTTCCAACGTGCTGGTGTCCGAGCAGTTCATGAAAACGTTGGACGGAGTGTATGCCGTTCAC CCGCAGCTGGACGTGGTATTCAAGGCAGTACAAGGCCTCTCTCCCAAGAAAACCATCTTCTTGTTGACAAACCCCATGAAACTGATCCAG AGCTATGCAGACCAACACAAAATCACGATCGTGGACTTCTTCAAGAGCTTGAACCCCACTGGGACAATGAAGATGTCTGTGGATGAGTTC CAGAAAGTGATGATAGAGCAAAACAAGGTCCCCCTGAACCAGTACCAGGTCAGGGAGGTGATAAAGAAGCTCGATGAGAAGACAGGCATG GTGAACTTCAGTTTCTTGAACACGATGAAGCCATAGCAACAAGTCTGGTCTAGAAAGAAGTCTCGGCGAGAGGAGTCCTCGCAAGTCGGA |
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FusionGenePPI for CTNNA3_C14orf166B |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| CTNNA3 | CTNNB1, CTNNA1, JUP, EHMT2, SPRY2, EPS8, CDH3, CDH12, CDH1, APC, CDH24, BLZF1, CDH10, ARVCF, PKP4, CDH4, CTNNBIP1, OSBPL1A, VMA21, RELL1, CDH2, GIMAP8, CTNND1, AMER1, FAM162A, PRKAA2, MYCBP2, ATP5B, TPD52, TRIM25 | C14orf166B |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for CTNNA3_C14orf166B |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for CTNNA3_C14orf166B |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | CTNNA3 | C0004096 | Asthma | 1 | CTD_human |
| Hgene | CTNNA3 | C0236969 | Substance-Related Disorders | 1 | CTD_human |
| Hgene | CTNNA3 | C3810138 | ARRHYTHMOGENIC RIGHT VENTRICULAR DYSPLASIA, FAMILIAL, 13 | 1 | UNIPROT |
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