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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 8798

FusionGeneSummary for CTIF_LOXHD1

check button Fusion gene summary
Fusion gene informationFusion gene name: CTIF_LOXHD1
Fusion gene ID: 8798
HgeneTgene
Gene symbol

CTIF

LOXHD1

Gene ID

9811

125336

Gene namecap binding complex dependent translation initiation factorlipoxygenase homology domains 1
SynonymsGm672|KIAA0427DFNB77|LH2D1
Cytomap

18q21.1

18q21.1

Type of geneprotein-codingprotein-coding
DescriptionCBP80/20-dependent translation initiation factorlipoxygenase homology domain-containing protein 1
Modification date2018052320180519
UniProtAcc

O43310

Q8IVV2

Ensembl transtripts involved in fusion geneENST00000256413, ENST00000382998, 
ENST00000592658, 		ENST00000398722, 
ENST00000536736, ENST00000441551, 
ENST00000300591, ENST00000398705, 
ENST00000579038, ENST00000441893, 
ENST00000582408, ENST00000398686, 
Fusion gene scores* DoF score12 X 7 X 8=6722 X 2 X 2=8
# samples 122
** MAII scorelog2(12/672*10)=-2.48542682717024
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(2/8*10)=1.32192809488736
Context

PubMed: CTIF [Title/Abstract] AND LOXHD1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDBRCATCGA-AR-A0TV-01ACTIFchr18

46065683

+LOXHD1chr18

44089778

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3CDSENST00000256413ENST00000398722CTIFchr18

46065683

+LOXHD1chr18

44089778

-
5UTR-3CDSENST00000256413ENST00000536736CTIFchr18

46065683

+LOXHD1chr18

44089778

-
5UTR-3CDSENST00000256413ENST00000441551CTIFchr18

46065683

+LOXHD1chr18

44089778

-
5UTR-3CDSENST00000256413ENST00000300591CTIFchr18

46065683

+LOXHD1chr18

44089778

-
5UTR-3CDSENST00000256413ENST00000398705CTIFchr18

46065683

+LOXHD1chr18

44089778

-
5UTR-3CDSENST00000256413ENST00000579038CTIFchr18

46065683

+LOXHD1chr18

44089778

-
5UTR-3CDSENST00000256413ENST00000441893CTIFchr18

46065683

+LOXHD1chr18

44089778

-
5UTR-3CDSENST00000256413ENST00000582408CTIFchr18

46065683

+LOXHD1chr18

44089778

-
5UTR-3CDSENST00000256413ENST00000398686CTIFchr18

46065683

+LOXHD1chr18

44089778

-
5UTR-3CDSENST00000382998ENST00000398722CTIFchr18

46065683

+LOXHD1chr18

44089778

-
5UTR-3CDSENST00000382998ENST00000536736CTIFchr18

46065683

+LOXHD1chr18

44089778

-
5UTR-3CDSENST00000382998ENST00000441551CTIFchr18

46065683

+LOXHD1chr18

44089778

-
5UTR-3CDSENST00000382998ENST00000300591CTIFchr18

46065683

+LOXHD1chr18

44089778

-
5UTR-3CDSENST00000382998ENST00000398705CTIFchr18

46065683

+LOXHD1chr18

44089778

-
5UTR-3CDSENST00000382998ENST00000579038CTIFchr18

46065683

+LOXHD1chr18

44089778

-
5UTR-3CDSENST00000382998ENST00000441893CTIFchr18

46065683

+LOXHD1chr18

44089778

-
5UTR-3CDSENST00000382998ENST00000582408CTIFchr18

46065683

+LOXHD1chr18

44089778

-
5UTR-3CDSENST00000382998ENST00000398686CTIFchr18

46065683

+LOXHD1chr18

44089778

-
intron-3CDSENST00000592658ENST00000398722CTIFchr18

46065683

+LOXHD1chr18

44089778

-
intron-3CDSENST00000592658ENST00000536736CTIFchr18

46065683

+LOXHD1chr18

44089778

-
intron-3CDSENST00000592658ENST00000441551CTIFchr18

46065683

+LOXHD1chr18

44089778

-
intron-3CDSENST00000592658ENST00000300591CTIFchr18

46065683

+LOXHD1chr18

44089778

-
intron-3CDSENST00000592658ENST00000398705CTIFchr18

46065683

+LOXHD1chr18

44089778

-
intron-3CDSENST00000592658ENST00000579038CTIFchr18

46065683

+LOXHD1chr18

44089778

-
intron-3CDSENST00000592658ENST00000441893CTIFchr18

46065683

+LOXHD1chr18

44089778

-
intron-3CDSENST00000592658ENST00000582408CTIFchr18

46065683

+LOXHD1chr18

44089778

-
intron-3CDSENST00000592658ENST00000398686CTIFchr18

46065683

+LOXHD1chr18

44089778

-

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FusionProtFeatures for CTIF_LOXHD1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CTIF

O43310

LOXHD1

Q8IVV2

Specifically required for the pioneer round of mRNAtranslation mediated by the cap-binding complex (CBC), that takesplace during or right after mRNA export via the nuclear porecomplex (NPC). Acts via its interaction with the NCBP1/CBP80component of the CBC complex and recruits the 40S small subunit ofthe ribosome via eIF3. In contrast, it is not involved in steadystate translation, that takes place when the CBC complex isreplaced by cytoplasmic cap-binding protein eIF4E. Also requiredfor nonsense-mediated mRNA decay (NMD), the pioneer round of mRNAtranslation mediated by the cap-binding complex playing a centralrole in nonsense-mediated mRNA decay (NMD).{ECO:0000269|PubMed:19648179}. Involved in hearing. Required for normal function ofhair cells in the inner ear (By similarity). {ECO:0000250,ECO:0000269|PubMed:19732867}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for CTIF_LOXHD1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for CTIF_LOXHD1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
CTIFELAVL1, MIF4GD, DDX19A, FBXW7, SLBPLOXHD1FKBP4, TSC22D2


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for CTIF_LOXHD1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for CTIF_LOXHD1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource