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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 8782

FusionGeneSummary for CTDSPL2_FBXO42

check button Fusion gene summary
Fusion gene informationFusion gene name: CTDSPL2_FBXO42
Fusion gene ID: 8782
HgeneTgene
Gene symbol

CTDSPL2

FBXO42

Gene ID

51496

54455

Gene nameCTD small phosphatase like 2F-box protein 42
SynonymsHSPC058|HSPC129Fbx42|JFK
Cytomap

15q15.3-q21.1

1p36.13

Type of geneprotein-codingprotein-coding
DescriptionCTD small phosphatase-like protein 2CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase like 2CTDSP-like 2F-box only protein 42just one F-box and Kelch domain-containing protein
Modification date2018052320180519
UniProtAcc

Q05D32

Q6P3S6

Ensembl transtripts involved in fusion geneENST00000260327, ENST00000396780, 
ENST00000558966, ENST00000558373, 
ENST00000561189, 
ENST00000375592, 
ENST00000478089, 
Fusion gene scores* DoF score5 X 6 X 4=1206 X 6 X 5=180
# samples 119
** MAII scorelog2(11/120*10)=-0.125530882083859
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(9/180*10)=-1
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CTDSPL2 [Title/Abstract] AND FBXO42 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVUCECTCGA-AX-A3G4-01ACTDSPL2chr15

44719970

+FBXO42chr1

16621412

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3CDSENST00000260327ENST00000375592CTDSPL2chr15

44719970

+FBXO42chr1

16621412

-
5UTR-5UTRENST00000260327ENST00000478089CTDSPL2chr15

44719970

+FBXO42chr1

16621412

-
5UTR-3CDSENST00000396780ENST00000375592CTDSPL2chr15

44719970

+FBXO42chr1

16621412

-
5UTR-5UTRENST00000396780ENST00000478089CTDSPL2chr15

44719970

+FBXO42chr1

16621412

-
intron-3CDSENST00000558966ENST00000375592CTDSPL2chr15

44719970

+FBXO42chr1

16621412

-
intron-5UTRENST00000558966ENST00000478089CTDSPL2chr15

44719970

+FBXO42chr1

16621412

-
intron-3CDSENST00000558373ENST00000375592CTDSPL2chr15

44719970

+FBXO42chr1

16621412

-
intron-5UTRENST00000558373ENST00000478089CTDSPL2chr15

44719970

+FBXO42chr1

16621412

-
intron-3CDSENST00000561189ENST00000375592CTDSPL2chr15

44719970

+FBXO42chr1

16621412

-
intron-5UTRENST00000561189ENST00000478089CTDSPL2chr15

44719970

+FBXO42chr1

16621412

-

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FusionProtFeatures for CTDSPL2_FBXO42


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CTDSPL2

Q05D32

FBXO42

Q6P3S6

Probable phosphatase. {ECO:0000250}. Substrate-recognition component of some SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Specificallyrecognizes p53/TP53, promoting its ubiquitination and degradation.{ECO:0000269|PubMed:19509332}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for CTDSPL2_FBXO42


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for CTDSPL2_FBXO42


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
CTDSPL2ELAVL1, ATP5E, IPP, JAK1, MYBL2, RPL10, TCEB1, CDC42BPA, SLC27A2, MED15, FBXL19, SCYL1, KLF16, CPNE8, PTAR1, KPNA2, KPNA3, KPNA4, KPNB1, NUP153, NUP93, RANBP2, RANGAP1, PDIK1L, STK35FBXO42TP53, CUL1, SKP1, RBX1, COPS6, SMURF1, RBPJ, GSK3A, ROCK2, RAB28, CCDC6, CST1, KLK6


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for CTDSPL2_FBXO42


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for CTDSPL2_FBXO42


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource