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Fusion gene ID: 878 |
FusionGeneSummary for ADH1B_CES1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: ADH1B_CES1 | Fusion gene ID: 878 | Hgene | Tgene | Gene symbol | ADH1B | CES1 | Gene ID | 125 | 1066 |
| Gene name | alcohol dehydrogenase 1B (class I), beta polypeptide | carboxylesterase 1 | |
| Synonyms | ADH2|HEL-S-117 | ACAT|CE-1|CEH|CES2|HMSE|HMSE1|PCE-1|REH|SES1|TGH|hCE-1 | |
| Cytomap | 4q23 | 16q12.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | alcohol dehydrogenase 1BADH, beta subunitalcohol dehydrogenase 2 (class I), beta polypeptidealcohol dehydrogenase subunit betaaldehyde reductaseepididymis secretory protein Li 117 | liver carboxylesterase 1acyl coenzyme A:cholesterol acyltransferasebrain carboxylesterase hBr1carboxylesterase 1 (monocyte/macrophage serine esterase 1)carboxylesterase 2 (liver)cholesteryl ester hydrolasecocaine carboxylesteraseegasynhuman monocy | |
| Modification date | 20180519 | 20180523 | |
| UniProtAcc | P00325 | P23141 | |
| Ensembl transtripts involved in fusion gene | ENST00000305046, ENST00000394887, ENST00000504498, | ENST00000360526, ENST00000422046, ENST00000361503, ENST00000566555, | |
| Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 1 X 1 X 1=1 |
| # samples | 1 | 1 | |
| ** MAII score | log2(1/1*10)=3.32192809488736 | log2(1/1*10)=3.32192809488736 | |
| Context | PubMed: ADH1B [Title/Abstract] AND CES1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | ADH1B | GO:0006069 | ethanol oxidation | 2398055 |
| Tgene | CES1 | GO:0006695 | cholesterol biosynthetic process | 11015575 |
| Tgene | CES1 | GO:0030855 | epithelial cell differentiation | 21492153 |
| Tgene | CES1 | GO:0051791 | medium-chain fatty acid metabolic process | 11015575 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | LIHC | TCGA-DD-A39W-01A | ADH1B | chr4 | 100232678 | - | CES1 | chr16 | 55867008 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-5UTR | ENST00000305046 | ENST00000360526 | ADH1B | chr4 | 100232678 | - | CES1 | chr16 | 55867008 | - |
| 5CDS-5UTR | ENST00000305046 | ENST00000422046 | ADH1B | chr4 | 100232678 | - | CES1 | chr16 | 55867008 | - |
| 5CDS-5UTR | ENST00000305046 | ENST00000361503 | ADH1B | chr4 | 100232678 | - | CES1 | chr16 | 55867008 | - |
| 5CDS-intron | ENST00000305046 | ENST00000566555 | ADH1B | chr4 | 100232678 | - | CES1 | chr16 | 55867008 | - |
| 5CDS-5UTR | ENST00000394887 | ENST00000360526 | ADH1B | chr4 | 100232678 | - | CES1 | chr16 | 55867008 | - |
| 5CDS-5UTR | ENST00000394887 | ENST00000422046 | ADH1B | chr4 | 100232678 | - | CES1 | chr16 | 55867008 | - |
| 5CDS-5UTR | ENST00000394887 | ENST00000361503 | ADH1B | chr4 | 100232678 | - | CES1 | chr16 | 55867008 | - |
| 5CDS-intron | ENST00000394887 | ENST00000566555 | ADH1B | chr4 | 100232678 | - | CES1 | chr16 | 55867008 | - |
| intron-5UTR | ENST00000504498 | ENST00000360526 | ADH1B | chr4 | 100232678 | - | CES1 | chr16 | 55867008 | - |
| intron-5UTR | ENST00000504498 | ENST00000422046 | ADH1B | chr4 | 100232678 | - | CES1 | chr16 | 55867008 | - |
| intron-5UTR | ENST00000504498 | ENST00000361503 | ADH1B | chr4 | 100232678 | - | CES1 | chr16 | 55867008 | - |
| intron-intron | ENST00000504498 | ENST00000566555 | ADH1B | chr4 | 100232678 | - | CES1 | chr16 | 55867008 | - |
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FusionProtFeatures for ADH1B_CES1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| ADH1B | CES1 |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for ADH1B_CES1 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for ADH1B_CES1 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| ADH1B | YWHAE, PDE4DIP, GNB2L1, SERPINA3, PML, IRAK3, ADH1C | CES1 | CES1, GUSB, CREB3 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for ADH1B_CES1 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| Hgene | ADH1B | P00325 | DB09462 | Glycerin | Alcohol dehydrogenase 1B | small molecule | approved|investigational |
| Hgene | ADH1B | P00325 | DB01213 | Fomepizole | Alcohol dehydrogenase 1B | small molecule | approved|vet_approved |
| Tgene | CES1 | P23141 | DB00198 | Oseltamivir | Liver carboxylesterase 1 | small molecule | approved |
| Tgene | CES1 | P23141 | DB00454 | Pethidine | Liver carboxylesterase 1 | small molecule | approved |
| Tgene | CES1 | P23141 | DB02659 | Cholic Acid | Liver carboxylesterase 1 | small molecule | approved |
| Tgene | CES1 | P23141 | DB04838 | Cyclandelate | Liver carboxylesterase 1 | small molecule | approved |
| Tgene | CES1 | P23141 | DB11181 | Homatropine | Liver carboxylesterase 1 | small molecule | approved |
| Tgene | CES1 | P23141 | DB00907 | Cocaine | Liver carboxylesterase 1 | small molecule | approved|illicit |
| Tgene | CES1 | P23141 | DB01452 | Heroin | Liver carboxylesterase 1 | small molecule | approved|illicit|investigational |
| Tgene | CES1 | P23141 | DB00647 | Dextropropoxyphene | Liver carboxylesterase 1 | small molecule | approved|illicit|investigational|withdrawn |
| Tgene | CES1 | P23141 | DB00583 | L-Carnitine | Liver carboxylesterase 1 | small molecule | approved|investigational |
| Tgene | CES1 | P23141 | DB01599 | Probucol | Liver carboxylesterase 1 | small molecule | approved|investigational |
| Tgene | CES1 | P23141 | DB01183 | Naloxone | Liver carboxylesterase 1 | small molecule | approved|vet_approved |
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RelatedDiseases for ADH1B_CES1 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | ADH1B | C0001973 | Alcoholic Intoxication, Chronic | 8 | CTD_human;PSYGENET |
| Hgene | ADH1B | C0001969 | Alcoholic Intoxication | 5 | PSYGENET |
| Hgene | ADH1B | C0085762 | Alcohol abuse | 5 | PSYGENET |
| Hgene | ADH1B | C0007785 | Cerebral Infarction | 1 | CTD_human |
| Hgene | ADH1B | C0009404 | Colorectal Neoplasms | 1 | CTD_human |
| Hgene | ADH1B | C0014859 | Esophageal Neoplasms | 1 | CTD_human |
| Hgene | ADH1B | C0023055 | Laryngeal neoplasm | 1 | CTD_human |
| Hgene | ADH1B | C0026640 | Mouth Neoplasms | 1 | CTD_human |
| Hgene | ADH1B | C0028754 | Obesity | 1 | CTD_human |
| Hgene | ADH1B | C0031347 | Pharyngeal Neoplasms | 1 | CTD_human |
| Hgene | ADH1B | C0033975 | Psychotic Disorders | 1 | PSYGENET |
| Hgene | ADH1B | C0279626 | Squamous cell carcinoma of esophagus | 1 | CTD_human |
| Hgene | ADH1B | C0349464 | Wernicke-Korsakoff Syndrome | 1 | PSYGENET |
| Hgene | ADH1B | C0393756 | Hangover from alcohol | 1 | PSYGENET |
| Tgene | CES1 | C0024121 | Lung Neoplasms | 2 | CTD_human |
| Tgene | CES1 | C0236736 | Cocaine-Related Disorders | 2 | CTD_human |
| Tgene | CES1 | C0020443 | Hypercholesterolemia | 1 | CTD_human |
| Tgene | CES1 | C0025521 | Inborn Errors of Metabolism | 1 | CTD_human |
| Tgene | CES1 | C0027412 | Opioid-Related Disorders | 1 | CTD_human |
| Tgene | CES1 | C0028754 | Obesity | 1 | CTD_human |
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