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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 878

FusionGeneSummary for ADH1B_CES1

check button Fusion gene summary
Fusion gene informationFusion gene name: ADH1B_CES1
Fusion gene ID: 878
HgeneTgene
Gene symbol

ADH1B

CES1

Gene ID

125

1066

Gene namealcohol dehydrogenase 1B (class I), beta polypeptidecarboxylesterase 1
SynonymsADH2|HEL-S-117ACAT|CE-1|CEH|CES2|HMSE|HMSE1|PCE-1|REH|SES1|TGH|hCE-1
Cytomap

4q23

16q12.2

Type of geneprotein-codingprotein-coding
Descriptionalcohol dehydrogenase 1BADH, beta subunitalcohol dehydrogenase 2 (class I), beta polypeptidealcohol dehydrogenase subunit betaaldehyde reductaseepididymis secretory protein Li 117liver carboxylesterase 1acyl coenzyme A:cholesterol acyltransferasebrain carboxylesterase hBr1carboxylesterase 1 (monocyte/macrophage serine esterase 1)carboxylesterase 2 (liver)cholesteryl ester hydrolasecocaine carboxylesteraseegasynhuman monocy
Modification date2018051920180523
UniProtAcc

P00325

P23141

Ensembl transtripts involved in fusion geneENST00000305046, ENST00000394887, 
ENST00000504498, 
ENST00000360526, 
ENST00000422046, ENST00000361503, 
ENST00000566555, 
Fusion gene scores* DoF score1 X 1 X 1=11 X 1 X 1=1
# samples 11
** MAII scorelog2(1/1*10)=3.32192809488736log2(1/1*10)=3.32192809488736
Context

PubMed: ADH1B [Title/Abstract] AND CES1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneADH1B

GO:0006069

ethanol oxidation

2398055

TgeneCES1

GO:0006695

cholesterol biosynthetic process

11015575

TgeneCES1

GO:0030855

epithelial cell differentiation

21492153

TgeneCES1

GO:0051791

medium-chain fatty acid metabolic process

11015575


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDLIHCTCGA-DD-A39W-01AADH1Bchr4

100232678

-CES1chr16

55867008

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000305046ENST00000360526ADH1Bchr4

100232678

-CES1chr16

55867008

-
5CDS-5UTRENST00000305046ENST00000422046ADH1Bchr4

100232678

-CES1chr16

55867008

-
5CDS-5UTRENST00000305046ENST00000361503ADH1Bchr4

100232678

-CES1chr16

55867008

-
5CDS-intronENST00000305046ENST00000566555ADH1Bchr4

100232678

-CES1chr16

55867008

-
5CDS-5UTRENST00000394887ENST00000360526ADH1Bchr4

100232678

-CES1chr16

55867008

-
5CDS-5UTRENST00000394887ENST00000422046ADH1Bchr4

100232678

-CES1chr16

55867008

-
5CDS-5UTRENST00000394887ENST00000361503ADH1Bchr4

100232678

-CES1chr16

55867008

-
5CDS-intronENST00000394887ENST00000566555ADH1Bchr4

100232678

-CES1chr16

55867008

-
intron-5UTRENST00000504498ENST00000360526ADH1Bchr4

100232678

-CES1chr16

55867008

-
intron-5UTRENST00000504498ENST00000422046ADH1Bchr4

100232678

-CES1chr16

55867008

-
intron-5UTRENST00000504498ENST00000361503ADH1Bchr4

100232678

-CES1chr16

55867008

-
intron-intronENST00000504498ENST00000566555ADH1Bchr4

100232678

-CES1chr16

55867008

-

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FusionProtFeatures for ADH1B_CES1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ADH1B

P00325

CES1

P23141


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for ADH1B_CES1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for ADH1B_CES1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
ADH1BYWHAE, PDE4DIP, GNB2L1, SERPINA3, PML, IRAK3, ADH1CCES1CES1, GUSB, CREB3


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ADH1B_CES1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneADH1BP00325DB09462GlycerinAlcohol dehydrogenase 1Bsmall moleculeapproved|investigational
HgeneADH1BP00325DB01213FomepizoleAlcohol dehydrogenase 1Bsmall moleculeapproved|vet_approved
TgeneCES1P23141DB00198OseltamivirLiver carboxylesterase 1small moleculeapproved
TgeneCES1P23141DB00454PethidineLiver carboxylesterase 1small moleculeapproved
TgeneCES1P23141DB02659Cholic AcidLiver carboxylesterase 1small moleculeapproved
TgeneCES1P23141DB04838CyclandelateLiver carboxylesterase 1small moleculeapproved
TgeneCES1P23141DB11181HomatropineLiver carboxylesterase 1small moleculeapproved
TgeneCES1P23141DB00907CocaineLiver carboxylesterase 1small moleculeapproved|illicit
TgeneCES1P23141DB01452HeroinLiver carboxylesterase 1small moleculeapproved|illicit|investigational
TgeneCES1P23141DB00647DextropropoxypheneLiver carboxylesterase 1small moleculeapproved|illicit|investigational|withdrawn
TgeneCES1P23141DB00583L-CarnitineLiver carboxylesterase 1small moleculeapproved|investigational
TgeneCES1P23141DB01599ProbucolLiver carboxylesterase 1small moleculeapproved|investigational
TgeneCES1P23141DB01183NaloxoneLiver carboxylesterase 1small moleculeapproved|vet_approved

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RelatedDiseases for ADH1B_CES1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneADH1BC0001973Alcoholic Intoxication, Chronic8CTD_human;PSYGENET
HgeneADH1BC0001969Alcoholic Intoxication5PSYGENET
HgeneADH1BC0085762Alcohol abuse5PSYGENET
HgeneADH1BC0007785Cerebral Infarction1CTD_human
HgeneADH1BC0009404Colorectal Neoplasms1CTD_human
HgeneADH1BC0014859Esophageal Neoplasms1CTD_human
HgeneADH1BC0023055Laryngeal neoplasm1CTD_human
HgeneADH1BC0026640Mouth Neoplasms1CTD_human
HgeneADH1BC0028754Obesity1CTD_human
HgeneADH1BC0031347Pharyngeal Neoplasms1CTD_human
HgeneADH1BC0033975Psychotic Disorders1PSYGENET
HgeneADH1BC0279626Squamous cell carcinoma of esophagus1CTD_human
HgeneADH1BC0349464Wernicke-Korsakoff Syndrome1PSYGENET
HgeneADH1BC0393756Hangover from alcohol1PSYGENET
TgeneCES1C0024121Lung Neoplasms2CTD_human
TgeneCES1C0236736Cocaine-Related Disorders2CTD_human
TgeneCES1C0020443Hypercholesterolemia1CTD_human
TgeneCES1C0025521Inborn Errors of Metabolism1CTD_human
TgeneCES1C0027412Opioid-Related Disorders1CTD_human
TgeneCES1C0028754Obesity1CTD_human