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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 8773

FusionGeneSummary for CTDSP2_TMEM200A

check button Fusion gene summary
Fusion gene informationFusion gene name: CTDSP2_TMEM200A
Fusion gene ID: 8773
HgeneTgene
Gene symbol

CTDSP2

TMEM200A

Gene ID

10106

114801

Gene nameCTD small phosphatase 2transmembrane protein 200A
SynonymsOS4|PSR2|SCP2KIAA1913|TTMA|TTMC
Cytomap

12q14.1

6q23.1

Type of geneprotein-codingprotein-coding
Descriptioncarboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 2CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 2NLI-interacting factor 2conserved gene amplified in osteosarcomanuclear LIM interactor-interatransmembrane protein 200Atwo transmembrane C
Modification date2018052320180519
UniProtAcc

O14595

Q86VY9

Ensembl transtripts involved in fusion geneENST00000398073, ENST00000548823, 
ENST00000547701, 
ENST00000296978, 
ENST00000545622, ENST00000392429, 
Fusion gene scores* DoF score26 X 5 X 7=9103 X 2 X 2=12
# samples 223
** MAII scorelog2(22/910*10)=-2.0483630215614
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(3/12*10)=1.32192809488736
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: CTDSP2 [Title/Abstract] AND TMEM200A [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneCTDSP2

GO:0006470

protein dephosphorylation

12721286


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDSARCTCGA-FX-A3NK-01ACTDSP2chr12

58217812

-TMEM200Achr6

130761552

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-5UTRENST00000398073ENST00000296978CTDSP2chr12

58217812

-TMEM200Achr6

130761552

+
intron-5UTRENST00000398073ENST00000545622CTDSP2chr12

58217812

-TMEM200Achr6

130761552

+
intron-5UTRENST00000398073ENST00000392429CTDSP2chr12

58217812

-TMEM200Achr6

130761552

+
intron-5UTRENST00000548823ENST00000296978CTDSP2chr12

58217812

-TMEM200Achr6

130761552

+
intron-5UTRENST00000548823ENST00000545622CTDSP2chr12

58217812

-TMEM200Achr6

130761552

+
intron-5UTRENST00000548823ENST00000392429CTDSP2chr12

58217812

-TMEM200Achr6

130761552

+
intron-5UTRENST00000547701ENST00000296978CTDSP2chr12

58217812

-TMEM200Achr6

130761552

+
intron-5UTRENST00000547701ENST00000545622CTDSP2chr12

58217812

-TMEM200Achr6

130761552

+
intron-5UTRENST00000547701ENST00000392429CTDSP2chr12

58217812

-TMEM200Achr6

130761552

+

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FusionProtFeatures for CTDSP2_TMEM200A


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CTDSP2

O14595

TMEM200A

Q86VY9

Preferentially catalyzes the dephosphorylation of 'Ser-5' within the tandem 7 residue repeats in the C-terminal domain(CTD) of the largest RNA polymerase II subunit POLR2A. Negativelyregulates RNA polymerase II transcription, possibly by controllingthe transition from initiation/capping to processive transcriptelongation. Recruited by REST to neuronal genes that contain RE-1elements, leading to neuronal gene silencing in non-neuronalcells. May contribute to the development of sarcomas.{ECO:0000269|PubMed:12721286, ECO:0000269|PubMed:15681389}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for CTDSP2_TMEM200A


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for CTDSP2_TMEM200A


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
CTDSP2POLR2A, SNAI1, CDCA3, CTDSP1, PLEKHH3, POM121, ZC3H3, ZMYM6, MAP7D1, INTS6, PRR14, ATP2B3, CWC22, SETD1A, UBTF, NEK4, ENDOD1, MAP7, SLC25A20, ATP12A, ANKRD13A, TBC1D4, BSG, DNAJA3, HAX1, P4HA1, RPS27L, TIMM50, TUBB6, ANKRD13D, NEK1, CSF1R, TYRO3, INSRR, PTK7, EPHA3, EPHA1, AKT1TMEM200ATP53, PPP3CC, FHOD1, PPP3CB, PPP3R1, MYADM, STX6, STX10, PPP3CA, GOSR1, STX7


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for CTDSP2_TMEM200A


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for CTDSP2_TMEM200A


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource