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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 8747

FusionGeneSummary for CTDNEP1_SHBG

check button Fusion gene summary
Fusion gene informationFusion gene name: CTDNEP1_SHBG
Fusion gene ID: 8747
HgeneTgene
Gene symbol

CTDNEP1

SHBG

Gene ID

23399

6462

Gene nameCTD nuclear envelope phosphatase 1sex hormone binding globulin
SynonymsDULLARD|HSA011916|NET56ABP|SBP|TEBG
Cytomap

17p13.1

17p13.1

Type of geneprotein-codingprotein-coding
DescriptionCTD nuclear envelope phosphatase 1C-terminal domain nuclear envelope phosphatase 1dullard homologserine/threonine-protein phosphatase dullardsex hormone-binding globulinsex steroid-binding proteintestis-specific androgen-binding proteintestosterone-binding beta-globulintestosterone-estradiol-binding globulintestosterone-estrogen-binding globulin
Modification date2018052320180519
UniProtAcc

O95476

P04278

Ensembl transtripts involved in fusion geneENST00000574322, ENST00000573600, 
ENST00000318988, ENST00000572043, 
ENST00000572262, ENST00000575314, 
ENST00000574539, ENST00000576478, 
ENST00000570547, ENST00000572182, 
ENST00000576728, ENST00000340624, 
ENST00000441599, ENST00000380450, 
ENST00000575903, ENST00000416273, 
Fusion gene scores* DoF score2 X 1 X 2=41 X 1 X 1=1
# samples 21
** MAII scorelog2(2/4*10)=2.32192809488736log2(1/1*10)=3.32192809488736
Context

PubMed: CTDNEP1 [Title/Abstract] AND SHBG [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneCTDNEP1

GO:0006470

protein dephosphorylation

17420445|22134922

HgeneCTDNEP1

GO:0006998

nuclear envelope organization

17420445

HgeneCTDNEP1

GO:0034504

protein localization to nucleus

22134922


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDACCTCGA-OR-A5KY-01ACTDNEP1chr17

7149345

-SHBGchr17

7533734

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000574322ENST00000572262CTDNEP1chr17

7149345

-SHBGchr17

7533734

+
5CDS-5UTRENST00000574322ENST00000575314CTDNEP1chr17

7149345

-SHBGchr17

7533734

+
5CDS-5UTRENST00000574322ENST00000574539CTDNEP1chr17

7149345

-SHBGchr17

7533734

+
5CDS-5UTRENST00000574322ENST00000576478CTDNEP1chr17

7149345

-SHBGchr17

7533734

+
5CDS-5UTRENST00000574322ENST00000570547CTDNEP1chr17

7149345

-SHBGchr17

7533734

+
5CDS-5UTRENST00000574322ENST00000572182CTDNEP1chr17

7149345

-SHBGchr17

7533734

+
5CDS-5UTRENST00000574322ENST00000576728CTDNEP1chr17

7149345

-SHBGchr17

7533734

+
5CDS-5UTRENST00000574322ENST00000340624CTDNEP1chr17

7149345

-SHBGchr17

7533734

+
5CDS-5UTRENST00000574322ENST00000441599CTDNEP1chr17

7149345

-SHBGchr17

7533734

+
5CDS-5UTRENST00000574322ENST00000380450CTDNEP1chr17

7149345

-SHBGchr17

7533734

+
5CDS-5UTRENST00000574322ENST00000575903CTDNEP1chr17

7149345

-SHBGchr17

7533734

+
5CDS-5UTRENST00000574322ENST00000416273CTDNEP1chr17

7149345

-SHBGchr17

7533734

+
5CDS-5UTRENST00000573600ENST00000572262CTDNEP1chr17

7149345

-SHBGchr17

7533734

+
5CDS-5UTRENST00000573600ENST00000575314CTDNEP1chr17

7149345

-SHBGchr17

7533734

+
5CDS-5UTRENST00000573600ENST00000574539CTDNEP1chr17

7149345

-SHBGchr17

7533734

+
5CDS-5UTRENST00000573600ENST00000576478CTDNEP1chr17

7149345

-SHBGchr17

7533734

+
5CDS-5UTRENST00000573600ENST00000570547CTDNEP1chr17

7149345

-SHBGchr17

7533734

+
5CDS-5UTRENST00000573600ENST00000572182CTDNEP1chr17

7149345

-SHBGchr17

7533734

+
5CDS-5UTRENST00000573600ENST00000576728CTDNEP1chr17

7149345

-SHBGchr17

7533734

+
5CDS-5UTRENST00000573600ENST00000340624CTDNEP1chr17

7149345

-SHBGchr17

7533734

+
5CDS-5UTRENST00000573600ENST00000441599CTDNEP1chr17

7149345

-SHBGchr17

7533734

+
5CDS-5UTRENST00000573600ENST00000380450CTDNEP1chr17

7149345

-SHBGchr17

7533734

+
5CDS-5UTRENST00000573600ENST00000575903CTDNEP1chr17

7149345

-SHBGchr17

7533734

+
5CDS-5UTRENST00000573600ENST00000416273CTDNEP1chr17

7149345

-SHBGchr17

7533734

+
5CDS-5UTRENST00000318988ENST00000572262CTDNEP1chr17

7149345

-SHBGchr17

7533734

+
5CDS-5UTRENST00000318988ENST00000575314CTDNEP1chr17

7149345

-SHBGchr17

7533734

+
5CDS-5UTRENST00000318988ENST00000574539CTDNEP1chr17

7149345

-SHBGchr17

7533734

+
5CDS-5UTRENST00000318988ENST00000576478CTDNEP1chr17

7149345

-SHBGchr17

7533734

+
5CDS-5UTRENST00000318988ENST00000570547CTDNEP1chr17

7149345

-SHBGchr17

7533734

+
5CDS-5UTRENST00000318988ENST00000572182CTDNEP1chr17

7149345

-SHBGchr17

7533734

+
5CDS-5UTRENST00000318988ENST00000576728CTDNEP1chr17

7149345

-SHBGchr17

7533734

+
5CDS-5UTRENST00000318988ENST00000340624CTDNEP1chr17

7149345

-SHBGchr17

7533734

+
5CDS-5UTRENST00000318988ENST00000441599CTDNEP1chr17

7149345

-SHBGchr17

7533734

+
5CDS-5UTRENST00000318988ENST00000380450CTDNEP1chr17

7149345

-SHBGchr17

7533734

+
5CDS-5UTRENST00000318988ENST00000575903CTDNEP1chr17

7149345

-SHBGchr17

7533734

+
5CDS-5UTRENST00000318988ENST00000416273CTDNEP1chr17

7149345

-SHBGchr17

7533734

+
5CDS-5UTRENST00000572043ENST00000572262CTDNEP1chr17

7149345

-SHBGchr17

7533734

+
5CDS-5UTRENST00000572043ENST00000575314CTDNEP1chr17

7149345

-SHBGchr17

7533734

+
5CDS-5UTRENST00000572043ENST00000574539CTDNEP1chr17

7149345

-SHBGchr17

7533734

+
5CDS-5UTRENST00000572043ENST00000576478CTDNEP1chr17

7149345

-SHBGchr17

7533734

+
5CDS-5UTRENST00000572043ENST00000570547CTDNEP1chr17

7149345

-SHBGchr17

7533734

+
5CDS-5UTRENST00000572043ENST00000572182CTDNEP1chr17

7149345

-SHBGchr17

7533734

+
5CDS-5UTRENST00000572043ENST00000576728CTDNEP1chr17

7149345

-SHBGchr17

7533734

+
5CDS-5UTRENST00000572043ENST00000340624CTDNEP1chr17

7149345

-SHBGchr17

7533734

+
5CDS-5UTRENST00000572043ENST00000441599CTDNEP1chr17

7149345

-SHBGchr17

7533734

+
5CDS-5UTRENST00000572043ENST00000380450CTDNEP1chr17

7149345

-SHBGchr17

7533734

+
5CDS-5UTRENST00000572043ENST00000575903CTDNEP1chr17

7149345

-SHBGchr17

7533734

+
5CDS-5UTRENST00000572043ENST00000416273CTDNEP1chr17

7149345

-SHBGchr17

7533734

+

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FusionProtFeatures for CTDNEP1_SHBG


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CTDNEP1

O95476

SHBG

P04278

Serine/threonine protein phosphatase forming withCNEP1R1 an active phosphatase complex that dephosphorylates andmay activate LPIN1 and LPIN2. LPIN1 and LPIN2 are phosphatidatephosphatases that catalyze the conversion of phosphatidic acid todiacylglycerol and control the metabolism of fatty acids atdifferent levels. May indirectly modulate the lipid composition ofnuclear and/or endoplasmic reticulum membranes and be required forproper nuclear membrane morphology and/or dynamics. May alsoindirectly regulate the production of lipid droplets andtriacylglycerol. May antagonize BMP signaling.{ECO:0000269|PubMed:17420445, ECO:0000269|PubMed:22134922}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for CTDNEP1_SHBG


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for CTDNEP1_SHBG


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
CTDNEP1CNEP1R1, MOV10, NXF1, SRPRB, CDCA3, IL20RB, TEX264, TGFBR2, GNAI1, FAM189A2, EVA1C, TMEM92, ATP2A2, HAX1, TUBB6, ACBD5, ITPR1, ITPR2, POR, ITPR3, VPS13A, SUN2, LEMD3, SENP2, TRIM13, ABCD3, VRK2, OCIAD1, SYNE2, ATP6AP1, PGRMC2, EMC3, SMPD4, VEZT, AAAS, GRAMD1A, PDZD8, NDC1, SUN1, ALDH3A2, PTPN1, EMC1, CCDC47, CCDC107, OLFM2, FAM189B, HLA-DRB1, SLC17A2, TLR5, PDGFRB, PLXDC2, TRIM25SHBGGRB2, CLEC4G, ASB16-AS1, FYTTD1, HYI, RMND5B, CECR5, AKR1B1, SORD, CTSD, KLK4, ACPP, PLA2G4A, AZGP1, AK2, PKM, ATP5A1, APEH, SHBG, APOD, A2M, SRI, TINAGL1, PTGDS, MT1F, MT1G, MT2A, UBE3A, UBE2O, PACSIN2, SEMA3F, PLP2, SLC37A4, FLOT1, CD177, CLDN4, MPDU1, AP1B1, AP2A1, ACTA2, ACTB, ACTG2, COL1A2, DSTN, DES, PSTPIP1, FLNA, NOMO1, EEF1A1, EIF3E, SRF, MXD4, APOBEC3C, SNRNP70, DDX3Y, TMEM236, CNTNAP3B, GNB2


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for CTDNEP1_SHBG


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgeneSHBGP04278DB00421SpironolactoneSex hormone-binding globulinsmall moleculeapproved
TgeneSHBGP04278DB00655EstroneSex hormone-binding globulinsmall moleculeapproved
TgeneSHBGP04278DB00675TamoxifenSex hormone-binding globulinsmall moleculeapproved
TgeneSHBGP04278DB00977Ethinyl EstradiolSex hormone-binding globulinsmall moleculeapproved
TgeneSHBGP04278DB09371NorethynodrelSex hormone-binding globulinsmall moleculeapproved
TgeneSHBGP04278DB11619GestrinoneSex hormone-binding globulinsmall moleculeapproved
TgeneSHBGP04278DB00179MasoprocolSex hormone-binding globulinsmall moleculeapproved|investigational
TgeneSHBGP04278DB00255DiethylstilbestrolSex hormone-binding globulinsmall moleculeapproved|investigational
TgeneSHBGP04278DB00367LevonorgestrelSex hormone-binding globulinsmall moleculeapproved|investigational
TgeneSHBGP04278DB00539ToremifeneSex hormone-binding globulinsmall moleculeapproved|investigational
TgeneSHBGP04278DB00882ClomifeneSex hormone-binding globulinsmall moleculeapproved|investigational
TgeneSHBGP04278DB00890DienestrolSex hormone-binding globulinsmall moleculeapproved|investigational
TgeneSHBGP04278DB01593ZincSex hormone-binding globulinsmall moleculeapproved|investigational
TgeneSHBGP04278DB04573EstriolSex hormone-binding globulinsmall moleculeapproved|investigational|vet_approved
TgeneSHBGP04278DB00396ProgesteroneSex hormone-binding globulinsmall moleculeapproved|vet_approved
TgeneSHBGP04278DB04824PhenolphthaleinSex hormone-binding globulinsmall moleculeapproved|withdrawn

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RelatedDiseases for CTDNEP1_SHBG


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneSHBGC0001973Alcoholic Intoxication, Chronic2CTD_human;PSYGENET
TgeneSHBGC0033578Prostatic Neoplasms2CTD_human
TgeneSHBGC0524620Metabolic Syndrome X2CTD_human
TgeneSHBGC0011860Diabetes Mellitus, Non-Insulin-Dependent1CTD_human
TgeneSHBGC0024232Lymphatic Metastasis1CTD_human
TgeneSHBGC0027626Neoplasm Invasiveness1CTD_human
TgeneSHBGC0242350Erectile dysfunction1CTD_human