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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 874

FusionGeneSummary for ADD2_ANTXR1

check button Fusion gene summary
Fusion gene informationFusion gene name: ADD2_ANTXR1
Fusion gene ID: 874
HgeneTgene
Gene symbol

ADD2

ANTXR1

Gene ID

119

84168

Gene nameadducin 2ANTXR cell adhesion molecule 1
SynonymsADDBATR|GAPO|TEM8
Cytomap

2p13.3

2p13.3

Type of geneprotein-codingprotein-coding
Descriptionbeta-adducinadducin 2 (beta)erythrocyte adducin subunit betaanthrax toxin receptor 12310008J16Rik2810405N18Riktumor endothelial marker 8
Modification date2018052320180523
UniProtAcc

P35612

Q9H6X2

Ensembl transtripts involved in fusion geneENST00000264436, ENST00000407644, 
ENST00000355733, ENST00000413157, 
ENST00000430656, ENST00000473232, 
ENST00000303714, ENST00000409829, 
ENST00000409349, 
Fusion gene scores* DoF score1 X 1 X 1=15 X 5 X 3=75
# samples 16
** MAII scorelog2(1/1*10)=3.32192809488736log2(6/75*10)=-0.321928094887362
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ADD2 [Title/Abstract] AND ANTXR1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneADD2

GO:0032092

positive regulation of protein binding

3693401|7642559

HgeneADD2

GO:0051016

barbed-end actin filament capping

8626479

HgeneADD2

GO:0051017

actin filament bundle assembly

3693401

HgeneADD2

GO:0065003

protein-containing complex assembly

18347014

TgeneANTXR1

GO:0031532

actin cytoskeleton reorganization

16762926

TgeneANTXR1

GO:0034446

substrate adhesion-dependent cell spreading

16762926


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDOVTCGA-09-1673-01AADD2chr2

70995018

-ANTXR1chr2

69329974

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3CDSENST00000264436ENST00000303714ADD2chr2

70995018

-ANTXR1chr2

69329974

+
5UTR-3CDSENST00000264436ENST00000409829ADD2chr2

70995018

-ANTXR1chr2

69329974

+
5UTR-3CDSENST00000264436ENST00000409349ADD2chr2

70995018

-ANTXR1chr2

69329974

+
intron-3CDSENST00000407644ENST00000303714ADD2chr2

70995018

-ANTXR1chr2

69329974

+
intron-3CDSENST00000407644ENST00000409829ADD2chr2

70995018

-ANTXR1chr2

69329974

+
intron-3CDSENST00000407644ENST00000409349ADD2chr2

70995018

-ANTXR1chr2

69329974

+
5UTR-3CDSENST00000355733ENST00000303714ADD2chr2

70995018

-ANTXR1chr2

69329974

+
5UTR-3CDSENST00000355733ENST00000409829ADD2chr2

70995018

-ANTXR1chr2

69329974

+
5UTR-3CDSENST00000355733ENST00000409349ADD2chr2

70995018

-ANTXR1chr2

69329974

+
5UTR-3CDSENST00000413157ENST00000303714ADD2chr2

70995018

-ANTXR1chr2

69329974

+
5UTR-3CDSENST00000413157ENST00000409829ADD2chr2

70995018

-ANTXR1chr2

69329974

+
5UTR-3CDSENST00000413157ENST00000409349ADD2chr2

70995018

-ANTXR1chr2

69329974

+
Frame-shiftENST00000430656ENST00000303714ADD2chr2

70995018

-ANTXR1chr2

69329974

+
Frame-shiftENST00000430656ENST00000409829ADD2chr2

70995018

-ANTXR1chr2

69329974

+
Frame-shiftENST00000430656ENST00000409349ADD2chr2

70995018

-ANTXR1chr2

69329974

+
5UTR-3CDSENST00000473232ENST00000303714ADD2chr2

70995018

-ANTXR1chr2

69329974

+
5UTR-3CDSENST00000473232ENST00000409829ADD2chr2

70995018

-ANTXR1chr2

69329974

+
5UTR-3CDSENST00000473232ENST00000409349ADD2chr2

70995018

-ANTXR1chr2

69329974

+

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FusionProtFeatures for ADD2_ANTXR1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ADD2

P35612

ANTXR1

Q9H6X2

Plays a role in cell attachment and migration. Interactswith extracellular matrix proteins and with the actincytoskeleton. Mediates adhesion of cells to type 1 collagen andgelatin, reorganization of the actin cytoskeleton and promotescell spreading. Plays a role in the angiogenic response ofcultured umbilical vein endothelial cells.{ECO:0000269|PubMed:15777794, ECO:0000269|PubMed:16762926}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for ADD2_ANTXR1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for ADD2_ANTXR1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
ADD2FYN, RPH3A, APP, NUFIP1, DPPA4, ANKRD29, DEF6, CTDSPL, PTPRG, NUDT12, ADD1, ADD3, ROCK1, ROCK2, SERPINB13, ALDH16A1, DUSP23ANTXR1ELAVL1, SPACA1, TUBB3, RSAD1, CA11, ZNF146, POTEF, TUBB8, HSPA5, KANK2, RICTOR, LRP11, PDIA5, TUBA4A, TUBA1A, PC, DNAJC12, OBSL1, RPL23, H6PD, KIRREL, GALNT7, WFS1, PCYOX1, CNTNAP3, FOXF2, TUBB4A, DMXL2, MAP2K7, ETV3, MANEA, ERF, TRMT44, PAM16, GDF11, SAMD1, WNT5A, SLAMF1, PRMT2, FLNA, GJB2, MYH9, SYN1, KLF8, MYO19, B4GALNT4, OCLN, IL13RA2, FCGRT, PMEL, TMEM30A, UBC, TRIM25


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ADD2_ANTXR1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for ADD2_ANTXR1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource