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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 8720

FusionGeneSummary for CTAGE5_PNN

check button Fusion gene summary
Fusion gene informationFusion gene name: CTAGE5_PNN
Fusion gene ID: 8720
HgeneTgene
Gene symbol

CTAGE5

PNN

Gene ID

4253

5411

Gene nameMIA SH3 domain ER export factor 2pinin, desmosome associated protein
SynonymsCTAGE5|MEA6|MGEA|MGEA11|MGEA6|TALIDRS|DRSP|SDK3|memA
Cytomap

14q21.1

14q21.1

Type of geneprotein-codingprotein-coding
DescriptioncTAGE family member 5melanoma inhibitory activity protein 2CTAGE family member 5, ER export factorCTAGE family, member 5TANGO1-likecutaneous T-cell lymphoma-associated antigen 5melanoma inhibitory activity 2meningioma expressed antigen 6 (coiled-copinin140 kDa nuclear and cell adhesion-related phosphoproteinSR-like proteindesmosome-associated proteindomain-rich serine proteinmelanoma metastasis clone A proteinneutrophil proteinnuclear protein SDK3
Modification date2018052320180523
UniProtAcc

O15320

Q9H307

Ensembl transtripts involved in fusion geneENST00000341502, ENST00000341749, 
ENST00000557038, ENST00000396165, 
ENST00000396158, ENST00000280083, 
ENST00000556148, ENST00000348007, 
ENST00000553352, ENST00000553383, 
ENST00000553331, ENST00000216832, 
ENST00000556530, ENST00000557680, 
Fusion gene scores* DoF score3 X 3 X 3=275 X 6 X 3=90
# samples 36
** MAII scorelog2(3/27*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(6/90*10)=-0.584962500721156
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CTAGE5 [Title/Abstract] AND PNN [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneCTAGE5

GO:1905097

regulation of guanyl-nucleotide exchange factor activity

25202031


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDUCECTCGA-EO-A1Y7-01ACTAGE5chr14

39818181

+PNNchr14

39648295

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000341502ENST00000553331CTAGE5chr14

39818181

+PNNchr14

39648295

+
5CDS-3UTRENST00000341502ENST00000216832CTAGE5chr14

39818181

+PNNchr14

39648295

+
5CDS-intronENST00000341502ENST00000556530CTAGE5chr14

39818181

+PNNchr14

39648295

+
5CDS-intronENST00000341502ENST00000557680CTAGE5chr14

39818181

+PNNchr14

39648295

+
5CDS-3UTRENST00000341749ENST00000553331CTAGE5chr14

39818181

+PNNchr14

39648295

+
5CDS-3UTRENST00000341749ENST00000216832CTAGE5chr14

39818181

+PNNchr14

39648295

+
5CDS-intronENST00000341749ENST00000556530CTAGE5chr14

39818181

+PNNchr14

39648295

+
5CDS-intronENST00000341749ENST00000557680CTAGE5chr14

39818181

+PNNchr14

39648295

+
5CDS-3UTRENST00000557038ENST00000553331CTAGE5chr14

39818181

+PNNchr14

39648295

+
5CDS-3UTRENST00000557038ENST00000216832CTAGE5chr14

39818181

+PNNchr14

39648295

+
5CDS-intronENST00000557038ENST00000556530CTAGE5chr14

39818181

+PNNchr14

39648295

+
5CDS-intronENST00000557038ENST00000557680CTAGE5chr14

39818181

+PNNchr14

39648295

+
5CDS-3UTRENST00000396165ENST00000553331CTAGE5chr14

39818181

+PNNchr14

39648295

+
5CDS-3UTRENST00000396165ENST00000216832CTAGE5chr14

39818181

+PNNchr14

39648295

+
5CDS-intronENST00000396165ENST00000556530CTAGE5chr14

39818181

+PNNchr14

39648295

+
5CDS-intronENST00000396165ENST00000557680CTAGE5chr14

39818181

+PNNchr14

39648295

+
5CDS-3UTRENST00000396158ENST00000553331CTAGE5chr14

39818181

+PNNchr14

39648295

+
5CDS-3UTRENST00000396158ENST00000216832CTAGE5chr14

39818181

+PNNchr14

39648295

+
5CDS-intronENST00000396158ENST00000556530CTAGE5chr14

39818181

+PNNchr14

39648295

+
5CDS-intronENST00000396158ENST00000557680CTAGE5chr14

39818181

+PNNchr14

39648295

+
5CDS-3UTRENST00000280083ENST00000553331CTAGE5chr14

39818181

+PNNchr14

39648295

+
5CDS-3UTRENST00000280083ENST00000216832CTAGE5chr14

39818181

+PNNchr14

39648295

+
5CDS-intronENST00000280083ENST00000556530CTAGE5chr14

39818181

+PNNchr14

39648295

+
5CDS-intronENST00000280083ENST00000557680CTAGE5chr14

39818181

+PNNchr14

39648295

+
5CDS-3UTRENST00000556148ENST00000553331CTAGE5chr14

39818181

+PNNchr14

39648295

+
5CDS-3UTRENST00000556148ENST00000216832CTAGE5chr14

39818181

+PNNchr14

39648295

+
5CDS-intronENST00000556148ENST00000556530CTAGE5chr14

39818181

+PNNchr14

39648295

+
5CDS-intronENST00000556148ENST00000557680CTAGE5chr14

39818181

+PNNchr14

39648295

+
5CDS-3UTRENST00000348007ENST00000553331CTAGE5chr14

39818181

+PNNchr14

39648295

+
5CDS-3UTRENST00000348007ENST00000216832CTAGE5chr14

39818181

+PNNchr14

39648295

+
5CDS-intronENST00000348007ENST00000556530CTAGE5chr14

39818181

+PNNchr14

39648295

+
5CDS-intronENST00000348007ENST00000557680CTAGE5chr14

39818181

+PNNchr14

39648295

+
5CDS-3UTRENST00000553352ENST00000553331CTAGE5chr14

39818181

+PNNchr14

39648295

+
5CDS-3UTRENST00000553352ENST00000216832CTAGE5chr14

39818181

+PNNchr14

39648295

+
5CDS-intronENST00000553352ENST00000556530CTAGE5chr14

39818181

+PNNchr14

39648295

+
5CDS-intronENST00000553352ENST00000557680CTAGE5chr14

39818181

+PNNchr14

39648295

+
3UTR-3UTRENST00000553383ENST00000553331CTAGE5chr14

39818181

+PNNchr14

39648295

+
3UTR-3UTRENST00000553383ENST00000216832CTAGE5chr14

39818181

+PNNchr14

39648295

+
3UTR-intronENST00000553383ENST00000556530CTAGE5chr14

39818181

+PNNchr14

39648295

+
3UTR-intronENST00000553383ENST00000557680CTAGE5chr14

39818181

+PNNchr14

39648295

+

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FusionProtFeatures for CTAGE5_PNN


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CTAGE5

O15320

PNN

Q9H307


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for CTAGE5_PNN


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for CTAGE5_PNN


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
CTAGE5ALB, GRB2, DGCR6, AES, PSMA3, RASAL2, CEP57, EMILIN1, SS18L1, CCHCR1, TTC23L, MAGEB18, SRPRB, MIA3, CTAGE1, CTAGE8, CTAGE6, SLC39A5, ATF1, ANO6, RGPD8, SERPINA12, CREB1, ABCB10, TRAF4, OCLN, RGPD5, CD1E, HAO2, SERPINA5, MPRIP, CEP55, CREM, CCDC22, TMPRSS11B, BCHE, IDE, GPR21, ARSG, EEF1A2, GPRC5C, RGPD3, SERPINA10, LPAR1, MTFR1, COMMD3, EML4, FAM19A4, COMMD2, GPR114PNNSRRM2, RNPS1, NFKBIL1, CTBP1, PPIG, SRSF4, PNISR, ZCCHC17, PRPF4B, KRT19, KRT8, KRT18, TCEA2, SRRM1, RBM39, SF3A2, SIRT7, HNRNPA1, SAP18, CDK2, GRK5, BARD1, EIF4A3, MAGOH, CSNK2A1, KIAA0101, HDAC11, SRPK2, SRPK1, CLK2, CSNK2A2, CUL7, OBSL1, LUZP4, PRPF40A, TRA2A, RALYL, FAM9A, LUC7L, LUC7L2, EDA, SNIP1, PTGER3, PSMC3, C11orf57, DENND2D, SREK1, EPB41L3, ZMYND11, RPL6, ZC3H18, NTRK1, IFI16, NDUFAF1, USP37, SNW1, CDC5L, U2AF2, CCDC9, EPB41L2, ZC3H14, CAMKV, AKAP17A, CLK3, VANGL2, ACIN1, PIP4K2A, CASC3, SCAF1, C17orf85, VANGL1, RSBN1L, THRAP3, PES1, WSB2, DDX41, XAB2, MDK, RBM22, ELAVL2, CDC40, CFAP20, NKTR, FYTTD1, TOPORS, BCLAF1, NOS1AP, PPIE, NKAP, SMOC1, RSBN1, CRNKL1, ISY1, RBBP6, SARNP, GPALPP1, SRSF10, DHX8, AQR, COX15, DLD, DLST, DNM1L, PARK7, PDHA1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for CTAGE5_PNN


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for CTAGE5_PNN


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource