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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 8717

FusionGeneSummary for CT45A4_FRMD4A

check button Fusion gene summary
Fusion gene informationFusion gene name: CT45A4_FRMD4A
Fusion gene ID: 8717
HgeneTgene
Gene symbol

CT45A4

FRMD4A

Gene ID

55691

Gene nameFERM domain containing 4A
SynonymsCCAFCA|FRMD4|bA295P9.4
Cytomap

10p13

Type of geneprotein-coding
DescriptionFERM domain-containing protein 4AFERM domain containing 4
Modification date20180519
UniProtAcc

Q9P2Q2

Ensembl transtripts involved in fusion geneENST00000487941, ENST00000434966, 
ENST00000420087, ENST00000494421, 
ENST00000358621, ENST00000357447, 
ENST00000378503, ENST00000342409, 
ENST00000493380, ENST00000475141, 
ENST00000492155, 
Fusion gene scores* DoF score1 X 1 X 1=19 X 7 X 6=378
# samples 110
** MAII scorelog2(1/1*10)=3.32192809488736log2(10/378*10)=-1.91838623444635
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CT45A4 [Title/Abstract] AND FRMD4A [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AI133694CT45A4chrX

134874737

-FRMD4Achr10

13720471

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000487941ENST00000358621CT45A4chrX

134874737

-FRMD4Achr10

13720471

-
intron-intronENST00000487941ENST00000357447CT45A4chrX

134874737

-FRMD4Achr10

13720471

-
intron-intronENST00000487941ENST00000378503CT45A4chrX

134874737

-FRMD4Achr10

13720471

-
intron-intronENST00000487941ENST00000342409CT45A4chrX

134874737

-FRMD4Achr10

13720471

-
intron-intronENST00000487941ENST00000493380CT45A4chrX

134874737

-FRMD4Achr10

13720471

-
intron-intronENST00000487941ENST00000475141CT45A4chrX

134874737

-FRMD4Achr10

13720471

-
intron-intronENST00000487941ENST00000492155CT45A4chrX

134874737

-FRMD4Achr10

13720471

-
intron-intronENST00000434966ENST00000358621CT45A4chrX

134874737

-FRMD4Achr10

13720471

-
intron-intronENST00000434966ENST00000357447CT45A4chrX

134874737

-FRMD4Achr10

13720471

-
intron-intronENST00000434966ENST00000378503CT45A4chrX

134874737

-FRMD4Achr10

13720471

-
intron-intronENST00000434966ENST00000342409CT45A4chrX

134874737

-FRMD4Achr10

13720471

-
intron-intronENST00000434966ENST00000493380CT45A4chrX

134874737

-FRMD4Achr10

13720471

-
intron-intronENST00000434966ENST00000475141CT45A4chrX

134874737

-FRMD4Achr10

13720471

-
intron-intronENST00000434966ENST00000492155CT45A4chrX

134874737

-FRMD4Achr10

13720471

-
intron-intronENST00000420087ENST00000358621CT45A4chrX

134874737

-FRMD4Achr10

13720471

-
intron-intronENST00000420087ENST00000357447CT45A4chrX

134874737

-FRMD4Achr10

13720471

-
intron-intronENST00000420087ENST00000378503CT45A4chrX

134874737

-FRMD4Achr10

13720471

-
intron-intronENST00000420087ENST00000342409CT45A4chrX

134874737

-FRMD4Achr10

13720471

-
intron-intronENST00000420087ENST00000493380CT45A4chrX

134874737

-FRMD4Achr10

13720471

-
intron-intronENST00000420087ENST00000475141CT45A4chrX

134874737

-FRMD4Achr10

13720471

-
intron-intronENST00000420087ENST00000492155CT45A4chrX

134874737

-FRMD4Achr10

13720471

-
intron-intronENST00000494421ENST00000358621CT45A4chrX

134874737

-FRMD4Achr10

13720471

-
intron-intronENST00000494421ENST00000357447CT45A4chrX

134874737

-FRMD4Achr10

13720471

-
intron-intronENST00000494421ENST00000378503CT45A4chrX

134874737

-FRMD4Achr10

13720471

-
intron-intronENST00000494421ENST00000342409CT45A4chrX

134874737

-FRMD4Achr10

13720471

-
intron-intronENST00000494421ENST00000493380CT45A4chrX

134874737

-FRMD4Achr10

13720471

-
intron-intronENST00000494421ENST00000475141CT45A4chrX

134874737

-FRMD4Achr10

13720471

-
intron-intronENST00000494421ENST00000492155CT45A4chrX

134874737

-FRMD4Achr10

13720471

-

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FusionProtFeatures for CT45A4_FRMD4A


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CT45A4

FRMD4A

Q9P2Q2

Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}. Scaffolding protein that regulates epithelial cellpolarity by connecting ARF6 activation with the PAR3 complex (Bysimilarity). Plays a redundant role with FRMD4B in epithelialpolarization (By similarity). May regulate MAPT secretion byactivating ARF6-signaling (PubMed:27044754).{ECO:0000250|UniProtKB:Q8BIE6, ECO:0000269|PubMed:27044754}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for CT45A4_FRMD4A


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for CT45A4_FRMD4A


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for CT45A4_FRMD4A


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for CT45A4_FRMD4A


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneFRMD4AC0236969Substance-Related Disorders1CTD_human