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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 8688

FusionGeneSummary for CSRP2_NAV3

check button Fusion gene summary
Fusion gene informationFusion gene name: CSRP2_NAV3
Fusion gene ID: 8688
HgeneTgene
Gene symbol

CSRP2

NAV3

Gene ID

1466

89795

Gene namecysteine and glycine rich protein 2neuron navigator 3
SynonymsCRP2|LMO5|SmLIMPOMFIL1|STEERIN3|unc53H3
Cytomap

12q21.2

12q21.2

Type of geneprotein-codingprotein-coding
Descriptioncysteine and glycine-rich protein 2LIM domain only 5, smooth muscleLIM domain only protein 5LMO-5cysteine-rich protein 2smooth muscle cell LIM proteinneuron navigator 3pore membrane and/or filament interacting like protein 1unc-53 homolog 3
Modification date2018051920180523
UniProtAcc

Q16527

Q8IVL0

Ensembl transtripts involved in fusion geneENST00000311083, ENST00000552330, 
ENST00000546966, ENST00000547435, 
ENST00000536525, ENST00000397909, 
ENST00000228327, ENST00000266692, 
ENST00000552300, ENST00000541270, 
Fusion gene scores* DoF score3 X 1 X 2=615 X 13 X 4=780
# samples 211
** MAII scorelog2(2/6*10)=1.73696559416621log2(11/780*10)=-2.82597060022495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CSRP2 [Title/Abstract] AND NAV3 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDSKCMTCGA-D3-A51H-06ACSRP2chr12

77272718

-NAV3chr12

78334099

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3CDSENST00000311083ENST00000536525CSRP2chr12

77272718

-NAV3chr12

78334099

+
5UTR-3CDSENST00000311083ENST00000397909CSRP2chr12

77272718

-NAV3chr12

78334099

+
5UTR-3CDSENST00000311083ENST00000228327CSRP2chr12

77272718

-NAV3chr12

78334099

+
5UTR-3CDSENST00000311083ENST00000266692CSRP2chr12

77272718

-NAV3chr12

78334099

+
5UTR-intronENST00000311083ENST00000552300CSRP2chr12

77272718

-NAV3chr12

78334099

+
5UTR-intronENST00000311083ENST00000541270CSRP2chr12

77272718

-NAV3chr12

78334099

+
5UTR-3CDSENST00000552330ENST00000536525CSRP2chr12

77272718

-NAV3chr12

78334099

+
5UTR-3CDSENST00000552330ENST00000397909CSRP2chr12

77272718

-NAV3chr12

78334099

+
5UTR-3CDSENST00000552330ENST00000228327CSRP2chr12

77272718

-NAV3chr12

78334099

+
5UTR-3CDSENST00000552330ENST00000266692CSRP2chr12

77272718

-NAV3chr12

78334099

+
5UTR-intronENST00000552330ENST00000552300CSRP2chr12

77272718

-NAV3chr12

78334099

+
5UTR-intronENST00000552330ENST00000541270CSRP2chr12

77272718

-NAV3chr12

78334099

+
intron-3CDSENST00000546966ENST00000536525CSRP2chr12

77272718

-NAV3chr12

78334099

+
intron-3CDSENST00000546966ENST00000397909CSRP2chr12

77272718

-NAV3chr12

78334099

+
intron-3CDSENST00000546966ENST00000228327CSRP2chr12

77272718

-NAV3chr12

78334099

+
intron-3CDSENST00000546966ENST00000266692CSRP2chr12

77272718

-NAV3chr12

78334099

+
intron-intronENST00000546966ENST00000552300CSRP2chr12

77272718

-NAV3chr12

78334099

+
intron-intronENST00000546966ENST00000541270CSRP2chr12

77272718

-NAV3chr12

78334099

+
5UTR-3CDSENST00000547435ENST00000536525CSRP2chr12

77272718

-NAV3chr12

78334099

+
5UTR-3CDSENST00000547435ENST00000397909CSRP2chr12

77272718

-NAV3chr12

78334099

+
5UTR-3CDSENST00000547435ENST00000228327CSRP2chr12

77272718

-NAV3chr12

78334099

+
5UTR-3CDSENST00000547435ENST00000266692CSRP2chr12

77272718

-NAV3chr12

78334099

+
5UTR-intronENST00000547435ENST00000552300CSRP2chr12

77272718

-NAV3chr12

78334099

+
5UTR-intronENST00000547435ENST00000541270CSRP2chr12

77272718

-NAV3chr12

78334099

+

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FusionProtFeatures for CSRP2_NAV3


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CSRP2

Q16527

NAV3

Q8IVL0

Drastically down-regulated in response to PDGF-BB orcell injury, that promote smooth muscle cell proliferation anddedifferentiation. Seems to play a role in the development of theembryonic vascular system. May regulate IL2 production by T-cells. May be involvedin neuron regeneration. {ECO:0000269|PubMed:16166283}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for CSRP2_NAV3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for CSRP2_NAV3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
CSRP2PIAS1, CSRP2BP, AGPS, MDC1, TRIM27, RNF2, BMI1, LUZP4, EWSR1, CEP164, MCM2, OTUB1, TESNAV3APC, TFAP4, MAPRE1, TRIO, KRAS


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for CSRP2_NAV3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for CSRP2_NAV3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneNAV3C0007134Renal Cell Carcinoma1CTD_human
TgeneNAV3C0027412Opioid-Related Disorders1CTD_human