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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 8676

FusionGeneSummary for CSPP1_TERF1

check button Fusion gene summary
Fusion gene informationFusion gene name: CSPP1_TERF1
Fusion gene ID: 8676
HgeneTgene
Gene symbol

CSPP1

TERF1

Gene ID

79848

7013

Gene namecentrosome and spindle pole associated protein 1telomeric repeat binding factor 1
SynonymsCSPP|JBTS21PIN2|TRBF1|TRF|TRF1|hTRF1-AS|t-TRF1
Cytomap

8q13.1-q13.2

8q21.11

Type of geneprotein-codingprotein-coding
Descriptioncentrosome and spindle pole-associated protein 1telomeric repeat-binding factor 1NIMA-interacting protein 2TTAGGG repeat-binding factor 1telomeric protein Pin2/TRF1telomeric repeat binding factor (NIMA-interacting) 1
Modification date2018052320180522
UniProtAcc

Q1MSJ5

P54274

Ensembl transtripts involved in fusion geneENST00000412460, ENST00000262210, 
ENST00000521168, 		ENST00000276603, 
ENST00000276602, ENST00000520783, 
Fusion gene scores* DoF score7 X 7 X 7=3434 X 3 X 3=36
# samples 84
** MAII scorelog2(8/343*10)=-2.10013667128545
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(4/36*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: CSPP1 [Title/Abstract] AND TERF1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotationTranscription factor involved fusion gene, inframe and retained DNA-binding domain.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneTERF1

GO:0007004

telomere maintenance via telomerase

23685356

TgeneTERF1

GO:0008156

negative regulation of DNA replication

11327863

TgeneTERF1

GO:1905778

negative regulation of exonuclease activity

15200954

TgeneTERF1

GO:1905839

negative regulation of telomeric D-loop disassembly

15200954


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDCOADTCGA-RU-A8FL-01ACSPP1chr8

68015370

+TERF1chr8

73958196

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000412460ENST00000276603CSPP1chr8

68015370

+TERF1chr8

73958196

+
Frame-shiftENST00000412460ENST00000276602CSPP1chr8

68015370

+TERF1chr8

73958196

+
5CDS-intronENST00000412460ENST00000520783CSPP1chr8

68015370

+TERF1chr8

73958196

+
In-frameENST00000262210ENST00000276603CSPP1chr8

68015370

+TERF1chr8

73958196

+
Frame-shiftENST00000262210ENST00000276602CSPP1chr8

68015370

+TERF1chr8

73958196

+
5CDS-intronENST00000262210ENST00000520783CSPP1chr8

68015370

+TERF1chr8

73958196

+
intron-3CDSENST00000521168ENST00000276603CSPP1chr8

68015370

+TERF1chr8

73958196

+
intron-3CDSENST00000521168ENST00000276602CSPP1chr8

68015370

+TERF1chr8

73958196

+
intron-intronENST00000521168ENST00000520783CSPP1chr8

68015370

+TERF1chr8

73958196

+

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FusionProtFeatures for CSPP1_TERF1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CSPP1

Q1MSJ5

TERF1

P54274

May play a role in cell-cycle-dependent microtubuleorganization. {ECO:0000269|PubMed:16826565}. Binds the telomeric double-stranded 5'-TTAGGG-3' repeatand negatively regulates telomere length. Involved in theregulation of the mitotic spindle. Component of the shelterincomplex (telosome) that is involved in the regulation of telomerelength and protection. Shelterin associates with arrays of double-stranded 5'-TTAGGG-3' repeats added by telomerase and protectschromosome ends; without its protective activity, telomeres are nolonger hidden from the DNA damage surveillance and chromosome endsare inappropriately processed by DNA repair pathways.{ECO:0000269|PubMed:16166375}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCSPP1chr8:68015370chr8:73958196ENST00000262210+729114_1353491222Coiled coilOntology_term=ECO:0000255
HgeneCSPP1chr8:68015370chr8:73958196ENST00000262210+729244_2703491222Coiled coilOntology_term=ECO:0000255
HgeneCSPP1chr8:68015370chr8:73958196ENST00000262210+72938_623491222Coiled coilOntology_term=ECO:0000255
TgeneTERF1chr8:68015370chr8:73958196ENST00000276602+79403_428361420DNA bindingH-T-H motif
TgeneTERF1chr8:68015370chr8:73958196ENST00000276603+810403_428381440DNA bindingH-T-H motif
TgeneTERF1chr8:68015370chr8:73958196ENST00000276602+79375_432361420DomainHTH myb-type

- In-frame and not-retained protein feature among the 13 regional features.
>>>>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCSPP1chr8:68015370chr8:73958196ENST00000262210+729417_4493491222Coiled coilOntology_term=ECO:0000255
HgeneCSPP1chr8:68015370chr8:73958196ENST00000262210+729625_6693491222Coiled coilOntology_term=ECO:0000255
HgeneCSPP1chr8:68015370chr8:73958196ENST00000262210+729925_9643491222Coiled coilOntology_term=ECO:0000255
HgeneCSPP1chr8:68015370chr8:73958196ENST00000412460+930114_13555877Coiled coilOntology_term=ECO:0000255
HgeneCSPP1chr8:68015370chr8:73958196ENST00000412460+930244_27055877Coiled coilOntology_term=ECO:0000255
HgeneCSPP1chr8:68015370chr8:73958196ENST00000412460+93038_6255877Coiled coilOntology_term=ECO:0000255
HgeneCSPP1chr8:68015370chr8:73958196ENST00000412460+930417_44955877Coiled coilOntology_term=ECO:0000255
HgeneCSPP1chr8:68015370chr8:73958196ENST00000412460+930625_66955877Coiled coilOntology_term=ECO:0000255
HgeneCSPP1chr8:68015370chr8:73958196ENST00000412460+930925_96455877Coiled coilOntology_term=ECO:0000255
HgeneCSPP1chr8:68015370chr8:73958196ENST00000262210+729478_5413491222Compositional biasNote=Pro-rich
HgeneCSPP1chr8:68015370chr8:73958196ENST00000262210+729672_6773491222Compositional biasNote=Poly-Gly
HgeneCSPP1chr8:68015370chr8:73958196ENST00000262210+729779_8553491222Compositional biasNote=Glu-rich
HgeneCSPP1chr8:68015370chr8:73958196ENST00000412460+930478_54155877Compositional biasNote=Pro-rich
HgeneCSPP1chr8:68015370chr8:73958196ENST00000412460+930672_67755877Compositional biasNote=Poly-Gly
HgeneCSPP1chr8:68015370chr8:73958196ENST00000412460+930779_85555877Compositional biasNote=Glu-rich
TgeneTERF1chr8:68015370chr8:73958196ENST00000276602+792_71361420Compositional biasNote=Asp/Glu-rich (acidic)
TgeneTERF1chr8:68015370chr8:73958196ENST00000276602+7955_62361420Compositional biasNote=Poly-Glu
TgeneTERF1chr8:68015370chr8:73958196ENST00000276603+8102_71381440Compositional biasNote=Asp/Glu-rich (acidic)
TgeneTERF1chr8:68015370chr8:73958196ENST00000276603+81055_62381440Compositional biasNote=Poly-Glu
TgeneTERF1chr8:68015370chr8:73958196ENST00000276603+810375_432381440DomainHTH myb-type
TgeneTERF1chr8:68015370chr8:73958196ENST00000276602+79337_356361420MotifNuclear localization signal
TgeneTERF1chr8:68015370chr8:73958196ENST00000276603+810337_356381440MotifNuclear localization signal
TgeneTERF1chr8:68015370chr8:73958196ENST00000276602+7958_268361420RegionNote=TRFH dimerization
TgeneTERF1chr8:68015370chr8:73958196ENST00000276603+81058_268381440RegionNote=TRFH dimerization


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FusionGeneSequence for CSPP1_TERF1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_CSPP1_ENST00000412460_chr8_68015370_+_TERF1_ENST00000276603_chr8_73958196_+_114aa
MDERFRYESDFDRRLSRVYTNDRMHRNKRGNMPPMEHDGDVIEQSNIRISSAENKRHGFGKKTRIXDLAXGNMERETGLKYCCIINSTTG

>In-frame_CSPP1_ENST00000262210_chr8_68015370_+_TERF1_ENST00000276603_chr8_73958196_+_408aa
MLFPLQVAAVTSSVRDDPLEHCVSPRTRARSPEICKMADNLDEFIEEQKARLAEDKAELESDPPYMEMKGKLSAKLSENSKILISMAKEN
IPPNSQQTRGSLGIDYGLSLPLGEDYERKKHKLKEELRQDYRRYLTQERLKLERNKEYNQFLRGKEESSEKFRQVEKSTEPKSQRNKKPI
GQVKPDLTSQIQTSCENSEGPRKDVLTPSEAYEELLNQRRLEEDRYRQLDDEIELRNRRIIKKANEEVGISNLKHQRFASKAGIPDRRFH
RFNEDRVFDRRYHRPDQDPEVSEEMDERFRYESDFDRRLSRVYTNDRMHRNKRGNMPPMEHDGDVIEQSNIRISSAENKRHGFGKKTRIX


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_CSPP1_ENST00000412460_chr8_68015370_+_TERF1_ENST00000276603_chr8_73958196_+_344nt
ATGGATGAGAGGTTTAGATATGAAAGTGATTTTGATAGAAGACTTTCGAGAGTGTATACAAATGACAGGATGCACAGGAACAAACGAGGG
AATATGCCTCCTATGGAACATGATGGGGATGTTATAGAACAGTCAAACATAAGAATTTCATCTGCTGAAAATAAAAGGCATGGCTTTGGG
AAGAAGACAAGAATTTGAGATCTGGCGTGAGGAAATATGGAGAGGGAAACTGGTCTAAAATACTGTTGCATTATAAATTCAACAACCGGA

>In-frame_CSPP1_ENST00000262210_chr8_68015370_+_TERF1_ENST00000276603_chr8_73958196_+_1226nt
ATGCTGTTCCCGCTCCAGGTGGCCGCTGTAACCTCTTCGGTCCGCGACGATCCTCTAGAGCACTGTGTGTCTCCCCGGACGCGAGCCCGC
TCCCCTGAAATCTGCAAAATGGCTGATAATTTGGATGAATTTATTGAAGAGCAAAAAGCCAGATTGGCCGAAGACAAAGCAGAGTTGGAA
AGTGATCCACCTTACATGGAAATGAAGGGAAAGTTGTCAGCGAAGCTTTCTGAAAACAGTAAGATACTGATCTCTATGGCTAAGGAAAAC
ATACCACCAAATAGTCAACAGACCAGGGGTTCCTTAGGAATTGATTATGGATTAAGTTTACCACTTGGAGAAGACTATGAACGGAAGAAA
CATAAATTAAAAGAAGAATTGCGGCAAGATTACAGACGTTATCTTACTCAGGAAAGGTTGAAACTTGAACGTAACAAAGAATACAATCAG
TTTCTCAGGGGTAAGGAAGAATCCAGTGAAAAGTTCAGGCAGGTGGAAAAGAGTACTGAGCCCAAGAGTCAGAGAAATAAAAAACCTATT
GGTCAAGTTAAGCCTGATCTAACTTCACAAATACAGACATCTTGTGAAAATTCAGAGGGTCCTAGAAAAGATGTCTTAACTCCTTCAGAG
GCATATGAAGAACTTCTGAACCAAAGACGACTAGAGGAGGACAGATACCGACAACTAGATGATGAAATCGAATTAAGGAATAGAAGAATT
ATTAAAAAAGCAAATGAAGAAGTGGGCATTTCCAACCTAAAACATCAAAGGTTTGCAAGCAAGGCTGGCATTCCAGATAGAAGATTTCAC
AGATTTAATGAGGATCGTGTTTTTGATAGACGGTATCATAGACCAGACCAAGATCCTGAAGTAAGTGAAGAAATGGATGAGAGGTTTAGA
TATGAAAGTGATTTTGATAGAAGACTTTCGAGAGTGTATACAAATGACAGGATGCACAGGAACAAACGAGGGAATATGCCTCCTATGGAA
CATGATGGGGATGTTATAGAACAGTCAAACATAAGAATTTCATCTGCTGAAAATAAAAGGCATGGCTTTGGGAAGAAGACAAGAATTTGA
GATCTGGCGTGAGGAAATATGGAGAGGGAAACTGGTCTAAAATACTGTTGCATTATAAATTCAACAACCGGACAAGTGTCATGTTAAAAG


* Fusion transcript sequences (Full-length transcript).
>In-frame_CSPP1_ENST00000412460_chr8_68015370_+_TERF1_ENST00000276603_chr8_73958196_+_1696nt
GAGGGGCGGAGCCCCGGCCCGGAGGTCTGTCATGCTGTTCCCGCTCCAGGTGGCCGCTGTAACCTCTTCGGTCCGCGACGATCCTCTAGA
GCACTGTGTGTCTCCCCGGACGCGAGCCCGCTCCCCTGAAATCTGCAAAATGGCTGATAATTTGGATGAATTTATTGAAGAGCAAAAAGC
CAGATTGGCCGAAGACAAAGCAGAGTTGGAAAGTGATCCACCTTACATGGAAATGAAGGGAAAGTTGTCAGCGAAGCTTTCTGAAAACAG
TAAGATACTGATCTCTATGGCTAAGGAAAACATACCACCAAATAGTCAACAGACCAGGGGTTCCTTAGGAATTGATTATGGATTAAGTTT
ACCACTTGGAGAAGACTATGAACGGAAGAAACATAAATTAAAAGAAGAATTGCGGCAAGATTACAGACGTTATCTTACTCAGGGCATTAC
ACAAGGGAAAAGAAAGAAAAATTTTCTATCTACGAGTGAAACAGATCCATCTACTTTGGGAGTTTCTCTTCCTATTGGTGAGAGGTTATC
TGCTAAGGAAAGGTTGAAACTTGAACGTAACAAAGAATACAATCAGTTTCTCAGGGGTAAGGAAGAATCCAGTGAAAAGTTCAGGCAGGT
GGAAAAGAGTACTGAGCCCAAGAGTCAGAGAAATAAAAAACCTATTGGTCAAGTTAAGCCTGATCTAACTTCACAAATACAGACATCTTG
TGAAAATTCAGAGGGTCCTAGAAAAGATGTCTTAACTCCTTCAGAGGCATATGAAGAACTTCTGAACCAAAGACGACTAGAGGAGGACAG
ATACCGACAACTAGATGATGAAATCGAATTAAGGAATAGAAGAATTATTAAAAAAGCAAATGAAGAAGTGGGCATTTCCAACCTAAAACA
TCAAAGGTTTGCAAGCAAGGCTGGCATTCCAGATAGAAGATTTCACAGATTTAATGAGGATCGTGTTTTTGATAGACGGTATCATAGACC
AGACCAAGATCCTGAAGTAAGTGAAGAAATGGATGAGAGGTTTAGATATGAAAGTGATTTTGATAGAAGACTTTCGAGAGTGTATACAAA
TGACAGGATGCACAGGAACAAACGAGGGAATATGCCTCCTATGGAACATGATGGGGATGTTATAGAACAGTCAAACATAAGAATTTCATC
TGCTGAAAATAAAAGGCATGGCTTTGGGAAGAAGACAAGAATTTGAGATCTGGCGTGAGGAAATATGGAGAGGGAAACTGGTCTAAAATA
CTGTTGCATTATAAATTCAACAACCGGACAAGTGTCATGTTAAAAGACAGATGGAGGACCATGAAGAAACTAAAACTGATTTCCTCAGAC
AGCGAAGACTGATTGTGTTTGTAAAAGCTTGATGAAAGGACAGTTAAGTATTTTGATCACTGCATTTTGTTTGAAACTTGTGTCATTGAT
GTAATTTAAAACTTTTGTTTAAAGCATTACAGTATTTTTCTGTGACCATCAATTAATGAGGGTTTGTGCTACCAGAGTTAAAGCATATGC
TATCATTGTATTCTTTAAGAACCTTATTTTGATAAAATGTAAATTTGTTGAACCCTGCCACATTTAGTATCCCCACCCCCAAATCCTGTT

>In-frame_CSPP1_ENST00000262210_chr8_68015370_+_TERF1_ENST00000276603_chr8_73958196_+_1591nt
GAGGGGCGGAGCCCCGGCCCGGAGGTCTGTCATGCTGTTCCCGCTCCAGGTGGCCGCTGTAACCTCTTCGGTCCGCGACGATCCTCTAGA
GCACTGTGTGTCTCCCCGGACGCGAGCCCGCTCCCCTGAAATCTGCAAAATGGCTGATAATTTGGATGAATTTATTGAAGAGCAAAAAGC
CAGATTGGCCGAAGACAAAGCAGAGTTGGAAAGTGATCCACCTTACATGGAAATGAAGGGAAAGTTGTCAGCGAAGCTTTCTGAAAACAG
TAAGATACTGATCTCTATGGCTAAGGAAAACATACCACCAAATAGTCAACAGACCAGGGGTTCCTTAGGAATTGATTATGGATTAAGTTT
ACCACTTGGAGAAGACTATGAACGGAAGAAACATAAATTAAAAGAAGAATTGCGGCAAGATTACAGACGTTATCTTACTCAGGAAAGGTT
GAAACTTGAACGTAACAAAGAATACAATCAGTTTCTCAGGGGTAAGGAAGAATCCAGTGAAAAGTTCAGGCAGGTGGAAAAGAGTACTGA
GCCCAAGAGTCAGAGAAATAAAAAACCTATTGGTCAAGTTAAGCCTGATCTAACTTCACAAATACAGACATCTTGTGAAAATTCAGAGGG
TCCTAGAAAAGATGTCTTAACTCCTTCAGAGGCATATGAAGAACTTCTGAACCAAAGACGACTAGAGGAGGACAGATACCGACAACTAGA
TGATGAAATCGAATTAAGGAATAGAAGAATTATTAAAAAAGCAAATGAAGAAGTGGGCATTTCCAACCTAAAACATCAAAGGTTTGCAAG
CAAGGCTGGCATTCCAGATAGAAGATTTCACAGATTTAATGAGGATCGTGTTTTTGATAGACGGTATCATAGACCAGACCAAGATCCTGA
AGTAAGTGAAGAAATGGATGAGAGGTTTAGATATGAAAGTGATTTTGATAGAAGACTTTCGAGAGTGTATACAAATGACAGGATGCACAG
GAACAAACGAGGGAATATGCCTCCTATGGAACATGATGGGGATGTTATAGAACAGTCAAACATAAGAATTTCATCTGCTGAAAATAAAAG
GCATGGCTTTGGGAAGAAGACAAGAATTTGAGATCTGGCGTGAGGAAATATGGAGAGGGAAACTGGTCTAAAATACTGTTGCATTATAAA
TTCAACAACCGGACAAGTGTCATGTTAAAAGACAGATGGAGGACCATGAAGAAACTAAAACTGATTTCCTCAGACAGCGAAGACTGATTG
TGTTTGTAAAAGCTTGATGAAAGGACAGTTAAGTATTTTGATCACTGCATTTTGTTTGAAACTTGTGTCATTGATGTAATTTAAAACTTT
TGTTTAAAGCATTACAGTATTTTTCTGTGACCATCAATTAATGAGGGTTTGTGCTACCAGAGTTAAAGCATATGCTATCATTGTATTCTT
TAAGAACCTTATTTTGATAAAATGTAAATTTGTTGAACCCTGCCACATTTAGTATCCCCACCCCCAAATCCTGTTCCAATGAAAAAATTA


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FusionGenePPI for CSPP1_TERF1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
CSPP1LATS2, GOLGA2, RPGRIP1, RINT1, MRFAP1L1, ACTR1B, DCTN3, KLHL13, CPNE8, DCTN4, CAPZA2, DCTN2, GAN, ACTR10, DCTN5, DCTN6, KLHL26, PCM1, XRCC6BP1, HOMER2, HOMER1, NME7, PXDNL, PLK4, CEP63, CCDC67, KIAA0753, MED4, CEP162, RPGRIP1L, SSX2IP, OFD1, CEP104, CEP290, CEP120, SPICE1, CEP128, CEP135, CEP89, CNTRL, FBF1, NINL, NIN, ODF2, POC5, LCA5, CENPJ, FGFR1OP, CCDC14, CDC14A, SPC25, SNAPC1TERF1ACD, TINF2, POT1, CAPNS1, DLG5, RIC8A, SH3GL3, ZBTB16, UTP14A, GIT1, PFN2, ZHX1, TNKS, TNKS2, TERF1, ATM, ABL1, SALL1, NME1, PINX1, NBN, KPNB1, MAPRE1, CDC6, FBXO4, BRAF, YWHAG, BRCA1, PRMT1, FANCD2, ZC3HAV1L, RBM15B, KPNA2, STUB1, YY1, RBM33, PABPC4, MCCC2, CSNK2B, BMP2K, CYFIP1, S100A8, HSPA4, ACTN1, MCM7, DDB1, PRDX4, RASGEF1C, CDK9, FBXO21, BAIAP2L1, CHD8, TOX4, CLK3, SEC16A, S100A7, HSP90AB2P, USP9X, RPS2, CSNK2A2, PLOD2, RING1, ZNF281, FOXJ3, LARP7, IRS4, SAP30BP, DST, XRCC5, HSP90B1, ACLY, PRPS1L1, IDH3A, HSPH1, SPTAN1, MACROD2, BAG3, CCNT1, MYH9, TBPL1, RPS8, KCTD15, PLOD1, TBX1, RSBN1L, RAD50, TRPC5, CFAP58, GTF2A2, PCMT1, RPS7, PSMB5, GRPEL1, PSMA7, PSMA2, PPP2CA, PPP2CB, GANAB, PRMT5, KIAA2022, TDRD6, DOCK2, SYNE2, CENPF, RPS16, TAF2, RYR2, RNF2, ATN1, CDC37, ARHGEF18, CDK13, RNF40, UTRN, DMD, RALGAPA1, TERF2, GNL3, SKP1, GNL3L, TERT, STAG1, TERF2IP, PRKDC, MTOR, C19orf66, NAP1L1, WFS1, CASP7, RPAP3, PEPD, ACAT2, MSN, PRDX1, SUPT5H, RBMY1A1, RNF10, LRSAM1, TRMT1, SOAT1, JSRP1, C12orf43, PGD, HSPA6, TNPO2, TUBB3, TKT, PA2G4, KEAP1, RTN3, AMPH, HGD, PAICS, NOL12, RPL19, WARS, C1orf35, ALDOA, SH3GL2, KLHDC4, KIAA1279, CEP85, SIRPD, GSS, THG1L, SYK, MAPK12, NEFL, PTPN5, CORO1B, CRYM, DNAJB1, SRM, HCLS1, EPHX2, FKBP8, FEN1, MDH1, LDHB, MAP4, MAP7, PRDX6, ASS1, AMPD2, SMARCC2, WDR4, PKM, RTN4, PAK4, CRYBB1, SH3BP1, MCM2, TPI1, DDX23, EPB41L1, PNMT, FBP1, PAFAH1B3, DNPH1, EVL, DDX19B, AKR1A1, LYAR, PRKCB, ANXA2, TBL1X, CFL1, DDX21, HDGFRP2, AHCY, NUDT14, ACY1, ZC3H18, FES, ARPP21, HEXIM1, HMOX1, HEXIM2, HIST1H1A, OGFR, MVK, BCL7B, SRSF6, SET, PTMA, PACSIN2, TALDO1, CALD1, TUBB2A, IPO5, APEX1, DPYSL3, SARS, DDX24, PGLS, GAMT, TBCD, HOXA3, HNMT, OCM2, ACOT7, BIN2, EEF1D, ARHGDIA, PPM1G, HMGN4, SNCG, TBC1D10A, TRIP10, SP100, NUMA1, TMSB4Y, MT1X, AK1, CCDC9, HMGN3, DDX39A, PCP4, HSP90AB1, RECQL4, ZNF790, DPP3, EIF4B, DBN1, TUBB4B, DCX, ANXA5, DBNL, PGM1, NOL3, SULT1C2, ENO2, ANXA8L1, LDHA, TRIM16, TOMM34, PGM2, LASP1, PFKP, CKB, ZFP36L1, NUDCD2, PAGE2, TMSB10, SBDS, NXNL1, GAPDH, CPNE3, AFAP1L2, GNMT, RLIM, BLM, SMAD9, BTRC, TCIRG1, KDM1A, U2AF2, U2AF1, EP300, FOXM1, HSP90AA1, THOC2, DCLRE1B, XPO1, MRPS9, BRWD3, AKTIP, NUB1, PSMD4, UBE2M, SENP8, NAGK, NEK7


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
TgeneTERF1chr8:68015370chr8:73958196ENST00000276602+79265_378361420RLIM
TgeneTERF1chr8:68015370chr8:73958196ENST00000276603+810265_378381440RLIM


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for CSPP1_TERF1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for CSPP1_TERF1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource