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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 8675

FusionGeneSummary for CSPP1_PPP1R42

check button Fusion gene summary
Fusion gene informationFusion gene name: CSPP1_PPP1R42
Fusion gene ID: 8675
HgeneTgene
Gene symbol

CSPP1

PPP1R42

Gene ID

79848

286187

Gene namecentrosome and spindle pole associated protein 1protein phosphatase 1 regulatory subunit 42
SynonymsCSPP|JBTS21LRRC67|TLLR|TLRR|dtr
Cytomap

8q13.1-q13.2

8q13.1

Type of geneprotein-codingprotein-coding
Descriptioncentrosome and spindle pole-associated protein 1protein phosphatase 1 regulatory subunit 42leucine rich repeat containing 67leucine-rich repeat-containing protein 67testis leucine-rich repeat
Modification date2018052320180408
UniProtAcc

Q1MSJ5

Q7Z4L9

Ensembl transtripts involved in fusion geneENST00000412460, ENST00000262210, 
ENST00000521168, 
ENST00000522909, 
ENST00000324682, ENST00000517834, 
Fusion gene scores* DoF score7 X 7 X 7=3433 X 3 X 3=27
# samples 83
** MAII scorelog2(8/343*10)=-2.10013667128545
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(3/27*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: CSPP1 [Title/Abstract] AND PPP1R42 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDBLCATCGA-DK-A1A6-01ACSPP1chr8

67976731

+PPP1R42chr8

67883375

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3CDSENST00000412460ENST00000522909CSPP1chr8

67976731

+PPP1R42chr8

67883375

-
5UTR-intronENST00000412460ENST00000324682CSPP1chr8

67976731

+PPP1R42chr8

67883375

-
5UTR-intronENST00000412460ENST00000517834CSPP1chr8

67976731

+PPP1R42chr8

67883375

-
In-frameENST00000262210ENST00000522909CSPP1chr8

67976731

+PPP1R42chr8

67883375

-
5CDS-intronENST00000262210ENST00000324682CSPP1chr8

67976731

+PPP1R42chr8

67883375

-
5CDS-intronENST00000262210ENST00000517834CSPP1chr8

67976731

+PPP1R42chr8

67883375

-
intron-3CDSENST00000521168ENST00000522909CSPP1chr8

67976731

+PPP1R42chr8

67883375

-
intron-intronENST00000521168ENST00000324682CSPP1chr8

67976731

+PPP1R42chr8

67883375

-
intron-intronENST00000521168ENST00000517834CSPP1chr8

67976731

+PPP1R42chr8

67883375

-

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FusionProtFeatures for CSPP1_PPP1R42


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CSPP1

Q1MSJ5

PPP1R42

Q7Z4L9

May play a role in cell-cycle-dependent microtubuleorganization. {ECO:0000269|PubMed:16826565}. Regulates phosphatase activity of protein phosphatase 1(PP1) complexes in the testis. {ECO:0000250|UniProtKB:Q8R1Z4}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for CSPP1_PPP1R42


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for CSPP1_PPP1R42


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
CSPP1LATS2, GOLGA2, RPGRIP1, RINT1, MRFAP1L1, ACTR1B, DCTN3, KLHL13, CPNE8, DCTN4, CAPZA2, DCTN2, GAN, ACTR10, DCTN5, DCTN6, KLHL26, PCM1, XRCC6BP1, HOMER2, HOMER1, NME7, PXDNL, PLK4, CEP63, CCDC67, KIAA0753, MED4, CEP162, RPGRIP1L, SSX2IP, OFD1, CEP104, CEP290, CEP120, SPICE1, CEP128, CEP135, CEP89, CNTRL, FBF1, NINL, NIN, ODF2, POC5, LCA5, CENPJ, FGFR1OP, CCDC14, CDC14A, SPC25, SNAPC1PPP1R42


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for CSPP1_PPP1R42


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for CSPP1_PPP1R42


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource