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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 8674

FusionGeneSummary for CSPP1_MAN1A2

check button Fusion gene summary
Fusion gene informationFusion gene name: CSPP1_MAN1A2
Fusion gene ID: 8674
HgeneTgene
Gene symbol

CSPP1

MAN1A2

Gene ID

79848

10905

Gene namecentrosome and spindle pole associated protein 1mannosidase alpha class 1A member 2
SynonymsCSPP|JBTS21MAN1B
Cytomap

8q13.1-q13.2

1p12

Type of geneprotein-codingprotein-coding
Descriptioncentrosome and spindle pole-associated protein 1mannosyl-oligosaccharide 1,2-alpha-mannosidase IBalpha-1,2-mannosidase IBalpha1,2-mannosidaseprocessing alpha-1,2-mannosidase IB
Modification date2018052320180523
UniProtAcc

Q1MSJ5

O60476

Ensembl transtripts involved in fusion geneENST00000412460, ENST00000262210, 
ENST00000521168, 
ENST00000356554, 
ENST00000482811, 
Fusion gene scores* DoF score7 X 7 X 7=34310 X 8 X 5=400
# samples 816
** MAII scorelog2(8/343*10)=-2.10013667128545
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(16/400*10)=-1.32192809488736
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CSPP1 [Title/Abstract] AND MAN1A2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVLUADTCGA-78-7167-01ACSPP1chr8

68071372

+MAN1A2chr1

117944808

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000412460ENST00000356554CSPP1chr8

68071372

+MAN1A2chr1

117944808

+
5CDS-intronENST00000412460ENST00000482811CSPP1chr8

68071372

+MAN1A2chr1

117944808

+
Frame-shiftENST00000262210ENST00000356554CSPP1chr8

68071372

+MAN1A2chr1

117944808

+
5CDS-intronENST00000262210ENST00000482811CSPP1chr8

68071372

+MAN1A2chr1

117944808

+
3UTR-3CDSENST00000521168ENST00000356554CSPP1chr8

68071372

+MAN1A2chr1

117944808

+
3UTR-intronENST00000521168ENST00000482811CSPP1chr8

68071372

+MAN1A2chr1

117944808

+

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FusionProtFeatures for CSPP1_MAN1A2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CSPP1

Q1MSJ5

MAN1A2

O60476

May play a role in cell-cycle-dependent microtubuleorganization. {ECO:0000269|PubMed:16826565}. Involved in the maturation of Asn-linkedoligosaccharides. Progressively trim alpha-1,2-linked mannoseresidues from Man(9)GlcNAc(2) to produce Man(5)GlcNAc(2).

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for CSPP1_MAN1A2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for CSPP1_MAN1A2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
CSPP1LATS2, GOLGA2, RPGRIP1, RINT1, MRFAP1L1, ACTR1B, DCTN3, KLHL13, CPNE8, DCTN4, CAPZA2, DCTN2, GAN, ACTR10, DCTN5, DCTN6, KLHL26, PCM1, XRCC6BP1, HOMER2, HOMER1, NME7, PXDNL, PLK4, CEP63, CCDC67, KIAA0753, MED4, CEP162, RPGRIP1L, SSX2IP, OFD1, CEP104, CEP290, CEP120, SPICE1, CEP128, CEP135, CEP89, CNTRL, FBF1, NINL, NIN, ODF2, POC5, LCA5, CENPJ, FGFR1OP, CCDC14, CDC14A, SPC25, SNAPC1MAN1A2SMAD9, CLDND1, CD1B, SCARA3, CLU, C5AR2, CD1E, SCGB2A2, TMEM30B, IL13RA2, ADAM32, PMEL, B4GAT1, TLR5, TRHDE, PTPRO


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for CSPP1_MAN1A2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for CSPP1_MAN1A2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource