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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 8663

FusionGeneSummary for CSNK2A1_CSNK2A1

check button Fusion gene summary
Fusion gene informationFusion gene name: CSNK2A1_CSNK2A1
Fusion gene ID: 8663
HgeneTgene
Gene symbol

CSNK2A1

CSNK2A1

Gene ID

1459

1459

Gene namecasein kinase 2 alpha 2casein kinase 2 alpha 2
SynonymsCK2A2|CK2alpha'|CSNK2A1CK2A2|CK2alpha'|CSNK2A1
Cytomap

16q21

16q21

Type of geneprotein-codingprotein-coding
Descriptioncasein kinase II subunit alpha'CK II alpha'casein kinase 2 alpha'casein kinase 2, alpha prime polypeptidecasein kinase II subunit alpha'CK II alpha'casein kinase 2 alpha'casein kinase 2, alpha prime polypeptide
Modification date2018052920180529
UniProtAcc

P68400

P68400

Ensembl transtripts involved in fusion geneENST00000400227, ENST00000349736, 
ENST00000217244, ENST00000400217, 
ENST00000400227, ENST00000349736, 
ENST00000217244, ENST00000400217, 
Fusion gene scores* DoF score2 X 2 X 2=84 X 4 X 2=32
# samples 34
** MAII scorelog2(3/8*10)=1.90689059560852log2(4/32*10)=0.321928094887362
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: CSNK2A1 [Title/Abstract] AND CSNK2A1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AA659846CSNK2A1chr20

519670

-CSNK2A1chr20

519490

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000400227ENST00000400227CSNK2A1chr20

519670

-CSNK2A1chr20

519490

+
intron-intronENST00000400227ENST00000349736CSNK2A1chr20

519670

-CSNK2A1chr20

519490

+
intron-intronENST00000400227ENST00000217244CSNK2A1chr20

519670

-CSNK2A1chr20

519490

+
intron-intronENST00000400227ENST00000400217CSNK2A1chr20

519670

-CSNK2A1chr20

519490

+
intron-intronENST00000349736ENST00000400227CSNK2A1chr20

519670

-CSNK2A1chr20

519490

+
intron-intronENST00000349736ENST00000349736CSNK2A1chr20

519670

-CSNK2A1chr20

519490

+
intron-intronENST00000349736ENST00000217244CSNK2A1chr20

519670

-CSNK2A1chr20

519490

+
intron-intronENST00000349736ENST00000400217CSNK2A1chr20

519670

-CSNK2A1chr20

519490

+
intron-intronENST00000217244ENST00000400227CSNK2A1chr20

519670

-CSNK2A1chr20

519490

+
intron-intronENST00000217244ENST00000349736CSNK2A1chr20

519670

-CSNK2A1chr20

519490

+
intron-intronENST00000217244ENST00000217244CSNK2A1chr20

519670

-CSNK2A1chr20

519490

+
intron-intronENST00000217244ENST00000400217CSNK2A1chr20

519670

-CSNK2A1chr20

519490

+
intron-intronENST00000400217ENST00000400227CSNK2A1chr20

519670

-CSNK2A1chr20

519490

+
intron-intronENST00000400217ENST00000349736CSNK2A1chr20

519670

-CSNK2A1chr20

519490

+
intron-intronENST00000400217ENST00000217244CSNK2A1chr20

519670

-CSNK2A1chr20

519490

+
intron-intronENST00000400217ENST00000400217CSNK2A1chr20

519670

-CSNK2A1chr20

519490

+

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FusionProtFeatures for CSNK2A1_CSNK2A1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CSNK2A1

P68400

CSNK2A1

P68400

Catalytic subunit of a constitutively activeserine/threonine-protein kinase complex that phosphorylates alarge number of substrates containing acidic residues C-terminalto the phosphorylated serine or threonine. Regulates numerouscellular processes, such as cell cycle progression, apoptosis andtranscription, as well as viral infection. May act as a regulatorynode which integrates and coordinates numerous signals leading toan appropriate cellular response. During mitosis, functions as acomponent of the p53/TP53-dependent spindle assembly checkpoint(SAC) that maintains cyclin-B-CDK1 activity and G2 arrest inresponse to spindle damage. Also required for p53/TP53-mediatedapoptosis, phosphorylating 'Ser-392' of p53/TP53 following UVirradiation. Can also negatively regulate apoptosis.Phosphorylates the caspases CASP9 and CASP2 and the apoptoticregulator NOL3. Phosphorylation protects CASP9 from cleavage andactivation by CASP8, and inhibits the dimerization of CASP2 andactivation of CASP8. Regulates transcription by directphosphorylation of RNA polymerases I, II, III and IV. Alsophosphorylates and regulates numerous transcription factorsincluding NF-kappa-B, STAT1, CREB1, IRF1, IRF2, ATF1, SRF, MAX,JUN, FOS, MYC and MYB. Phosphorylates Hsp90 and its co-chaperonesFKBP4 and CDC37, which is essential for chaperone function.Regulates Wnt signaling by phosphorylating CTNNB1 and thetranscription factor LEF1. Acts as an ectokinase thatphosphorylates several extracellular proteins. During viralinfection, phosphorylates various proteins involved in the virallife cycles of EBV, HSV, HBV, HCV, HIV, CMV and HPV.Phosphorylates PML at 'Ser-565' and primes it for ubiquitin-mediated degradation. Plays an important role in the circadianclock function by phosphorylating ARNTL/BMAL1 at 'Ser-90' which ispivotal for its interaction with CLOCK and which controls CLOCKnuclear entry (PubMed:11239457, PubMed:11704824, PubMed:16193064,PubMed:19188443, PubMed:20625391, PubMed:22406621). PhosphorylatesCCAR2 at 'Thr-454' in gastric carcinoma tissue (PubMed:24962073).{ECO:0000269|PubMed:11239457, ECO:0000269|PubMed:11704824,ECO:0000269|PubMed:16193064, ECO:0000269|PubMed:19188443,ECO:0000269|PubMed:20625391, ECO:0000269|PubMed:22406621,ECO:0000269|PubMed:24962073}. Catalytic subunit of a constitutively activeserine/threonine-protein kinase complex that phosphorylates alarge number of substrates containing acidic residues C-terminalto the phosphorylated serine or threonine. Regulates numerouscellular processes, such as cell cycle progression, apoptosis andtranscription, as well as viral infection. May act as a regulatorynode which integrates and coordinates numerous signals leading toan appropriate cellular response. During mitosis, functions as acomponent of the p53/TP53-dependent spindle assembly checkpoint(SAC) that maintains cyclin-B-CDK1 activity and G2 arrest inresponse to spindle damage. Also required for p53/TP53-mediatedapoptosis, phosphorylating 'Ser-392' of p53/TP53 following UVirradiation. Can also negatively regulate apoptosis.Phosphorylates the caspases CASP9 and CASP2 and the apoptoticregulator NOL3. Phosphorylation protects CASP9 from cleavage andactivation by CASP8, and inhibits the dimerization of CASP2 andactivation of CASP8. Regulates transcription by directphosphorylation of RNA polymerases I, II, III and IV. Alsophosphorylates and regulates numerous transcription factorsincluding NF-kappa-B, STAT1, CREB1, IRF1, IRF2, ATF1, SRF, MAX,JUN, FOS, MYC and MYB. Phosphorylates Hsp90 and its co-chaperonesFKBP4 and CDC37, which is essential for chaperone function.Regulates Wnt signaling by phosphorylating CTNNB1 and thetranscription factor LEF1. Acts as an ectokinase thatphosphorylates several extracellular proteins. During viralinfection, phosphorylates various proteins involved in the virallife cycles of EBV, HSV, HBV, HCV, HIV, CMV and HPV.Phosphorylates PML at 'Ser-565' and primes it for ubiquitin-mediated degradation. Plays an important role in the circadianclock function by phosphorylating ARNTL/BMAL1 at 'Ser-90' which ispivotal for its interaction with CLOCK and which controls CLOCKnuclear entry (PubMed:11239457, PubMed:11704824, PubMed:16193064,PubMed:19188443, PubMed:20625391, PubMed:22406621). PhosphorylatesCCAR2 at 'Thr-454' in gastric carcinoma tissue (PubMed:24962073).{ECO:0000269|PubMed:11239457, ECO:0000269|PubMed:11704824,ECO:0000269|PubMed:16193064, ECO:0000269|PubMed:19188443,ECO:0000269|PubMed:20625391, ECO:0000269|PubMed:22406621,ECO:0000269|PubMed:24962073}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for CSNK2A1_CSNK2A1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for CSNK2A1_CSNK2A1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for CSNK2A1_CSNK2A1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for CSNK2A1_CSNK2A1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneCSNK2A1C0007137Squamous cell carcinoma1CTD_human
HgeneCSNK2A1C0023493Adult T-Cell Lymphoma/Leukemia1CTD_human
HgeneCSNK2A1C0037286Skin Neoplasms1CTD_human
TgeneCSNK2A1C0007137Squamous cell carcinoma1CTD_human
TgeneCSNK2A1C0023493Adult T-Cell Lymphoma/Leukemia1CTD_human
TgeneCSNK2A1C0037286Skin Neoplasms1CTD_human