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Fusion gene ID: 8645 |
FusionGeneSummary for CSNK1E_MB |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: CSNK1E_MB | Fusion gene ID: 8645 | Hgene | Tgene | Gene symbol | CSNK1E | MB | Gene ID | 1454 | 4151 |
| Gene name | casein kinase 1 epsilon | myoglobin | |
| Synonyms | CKIe|CKIepsilon|HCKIE | PVALB|myoglobgin | |
| Cytomap | 22q13.1 | 22q12.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | casein kinase I isoform epsilon | myoglobin | |
| Modification date | 20180523 | 20180519 | |
| UniProtAcc | P49674 | P02144 | |
| Ensembl transtripts involved in fusion gene | ENST00000359867, ENST00000396832, ENST00000400206, ENST00000403904, ENST00000413574, ENST00000405675, ENST00000498529, | ENST00000401702, ENST00000397326, ENST00000397328, ENST00000359787, ENST00000406324, ENST00000472240, | |
| Fusion gene scores | * DoF score | 11 X 8 X 10=880 | 6 X 3 X 6=108 |
| # samples | 11 | 6 | |
| ** MAII score | log2(11/880*10)=-3 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(6/108*10)=-0.84799690655495 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: CSNK1E [Title/Abstract] AND MB [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | CSNK1E | GO:0006468 | protein phosphorylation | 15917222|17244647 |
| Hgene | CSNK1E | GO:0018105 | peptidyl-serine phosphorylation | 25500533 |
| Hgene | CSNK1E | GO:0032091 | negative regulation of protein binding | 23109420 |
| Hgene | CSNK1E | GO:0060070 | canonical Wnt signaling pathway | 14722104 |
| Hgene | CSNK1E | GO:1903827 | regulation of cellular protein localization | 17244647 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | PAAD | TCGA-HZ-8005-01A | CSNK1E | chr22 | 38794443 | - | MB | chr22 | 36033255 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-intron | ENST00000359867 | ENST00000401702 | CSNK1E | chr22 | 38794443 | - | MB | chr22 | 36033255 | - |
| intron-intron | ENST00000359867 | ENST00000397326 | CSNK1E | chr22 | 38794443 | - | MB | chr22 | 36033255 | - |
| intron-intron | ENST00000359867 | ENST00000397328 | CSNK1E | chr22 | 38794443 | - | MB | chr22 | 36033255 | - |
| intron-intron | ENST00000359867 | ENST00000359787 | CSNK1E | chr22 | 38794443 | - | MB | chr22 | 36033255 | - |
| intron-intron | ENST00000359867 | ENST00000406324 | CSNK1E | chr22 | 38794443 | - | MB | chr22 | 36033255 | - |
| intron-intron | ENST00000359867 | ENST00000472240 | CSNK1E | chr22 | 38794443 | - | MB | chr22 | 36033255 | - |
| intron-intron | ENST00000396832 | ENST00000401702 | CSNK1E | chr22 | 38794443 | - | MB | chr22 | 36033255 | - |
| intron-intron | ENST00000396832 | ENST00000397326 | CSNK1E | chr22 | 38794443 | - | MB | chr22 | 36033255 | - |
| intron-intron | ENST00000396832 | ENST00000397328 | CSNK1E | chr22 | 38794443 | - | MB | chr22 | 36033255 | - |
| intron-intron | ENST00000396832 | ENST00000359787 | CSNK1E | chr22 | 38794443 | - | MB | chr22 | 36033255 | - |
| intron-intron | ENST00000396832 | ENST00000406324 | CSNK1E | chr22 | 38794443 | - | MB | chr22 | 36033255 | - |
| intron-intron | ENST00000396832 | ENST00000472240 | CSNK1E | chr22 | 38794443 | - | MB | chr22 | 36033255 | - |
| 5UTR-intron | ENST00000400206 | ENST00000401702 | CSNK1E | chr22 | 38794443 | - | MB | chr22 | 36033255 | - |
| 5UTR-intron | ENST00000400206 | ENST00000397326 | CSNK1E | chr22 | 38794443 | - | MB | chr22 | 36033255 | - |
| 5UTR-intron | ENST00000400206 | ENST00000397328 | CSNK1E | chr22 | 38794443 | - | MB | chr22 | 36033255 | - |
| 5UTR-intron | ENST00000400206 | ENST00000359787 | CSNK1E | chr22 | 38794443 | - | MB | chr22 | 36033255 | - |
| 5UTR-intron | ENST00000400206 | ENST00000406324 | CSNK1E | chr22 | 38794443 | - | MB | chr22 | 36033255 | - |
| 5UTR-intron | ENST00000400206 | ENST00000472240 | CSNK1E | chr22 | 38794443 | - | MB | chr22 | 36033255 | - |
| intron-intron | ENST00000403904 | ENST00000401702 | CSNK1E | chr22 | 38794443 | - | MB | chr22 | 36033255 | - |
| intron-intron | ENST00000403904 | ENST00000397326 | CSNK1E | chr22 | 38794443 | - | MB | chr22 | 36033255 | - |
| intron-intron | ENST00000403904 | ENST00000397328 | CSNK1E | chr22 | 38794443 | - | MB | chr22 | 36033255 | - |
| intron-intron | ENST00000403904 | ENST00000359787 | CSNK1E | chr22 | 38794443 | - | MB | chr22 | 36033255 | - |
| intron-intron | ENST00000403904 | ENST00000406324 | CSNK1E | chr22 | 38794443 | - | MB | chr22 | 36033255 | - |
| intron-intron | ENST00000403904 | ENST00000472240 | CSNK1E | chr22 | 38794443 | - | MB | chr22 | 36033255 | - |
| intron-intron | ENST00000413574 | ENST00000401702 | CSNK1E | chr22 | 38794443 | - | MB | chr22 | 36033255 | - |
| intron-intron | ENST00000413574 | ENST00000397326 | CSNK1E | chr22 | 38794443 | - | MB | chr22 | 36033255 | - |
| intron-intron | ENST00000413574 | ENST00000397328 | CSNK1E | chr22 | 38794443 | - | MB | chr22 | 36033255 | - |
| intron-intron | ENST00000413574 | ENST00000359787 | CSNK1E | chr22 | 38794443 | - | MB | chr22 | 36033255 | - |
| intron-intron | ENST00000413574 | ENST00000406324 | CSNK1E | chr22 | 38794443 | - | MB | chr22 | 36033255 | - |
| intron-intron | ENST00000413574 | ENST00000472240 | CSNK1E | chr22 | 38794443 | - | MB | chr22 | 36033255 | - |
| intron-intron | ENST00000405675 | ENST00000401702 | CSNK1E | chr22 | 38794443 | - | MB | chr22 | 36033255 | - |
| intron-intron | ENST00000405675 | ENST00000397326 | CSNK1E | chr22 | 38794443 | - | MB | chr22 | 36033255 | - |
| intron-intron | ENST00000405675 | ENST00000397328 | CSNK1E | chr22 | 38794443 | - | MB | chr22 | 36033255 | - |
| intron-intron | ENST00000405675 | ENST00000359787 | CSNK1E | chr22 | 38794443 | - | MB | chr22 | 36033255 | - |
| intron-intron | ENST00000405675 | ENST00000406324 | CSNK1E | chr22 | 38794443 | - | MB | chr22 | 36033255 | - |
| intron-intron | ENST00000405675 | ENST00000472240 | CSNK1E | chr22 | 38794443 | - | MB | chr22 | 36033255 | - |
| intron-intron | ENST00000498529 | ENST00000401702 | CSNK1E | chr22 | 38794443 | - | MB | chr22 | 36033255 | - |
| intron-intron | ENST00000498529 | ENST00000397326 | CSNK1E | chr22 | 38794443 | - | MB | chr22 | 36033255 | - |
| intron-intron | ENST00000498529 | ENST00000397328 | CSNK1E | chr22 | 38794443 | - | MB | chr22 | 36033255 | - |
| intron-intron | ENST00000498529 | ENST00000359787 | CSNK1E | chr22 | 38794443 | - | MB | chr22 | 36033255 | - |
| intron-intron | ENST00000498529 | ENST00000406324 | CSNK1E | chr22 | 38794443 | - | MB | chr22 | 36033255 | - |
| intron-intron | ENST00000498529 | ENST00000472240 | CSNK1E | chr22 | 38794443 | - | MB | chr22 | 36033255 | - |
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FusionProtFeatures for CSNK1E_MB |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| CSNK1E | MB |
| Casein kinases are operationally defined by theirpreferential utilization of acidic proteins such as caseins assubstrates. Can phosphorylate a large number of proteins.Participates in Wnt signaling. Phosphorylates DVL1 and DVL2.Central component of the circadian clock. In balance with PP1,determines the circadian period length, through the regulation ofthe speed and rhythmicity of PER1 and PER2 phosphorylation.Controls PER1 and PER2 nuclear transport and degradation. Inhibitscytokine-induced granuloytic differentiation.{ECO:0000269|PubMed:12556519, ECO:0000269|PubMed:15070676,ECO:0000269|PubMed:15917222, ECO:0000269|PubMed:16790549,ECO:0000269|PubMed:23413191}. | Serves as a reserve supply of oxygen and facilitates themovement of oxygen within muscles. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for CSNK1E_MB |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for CSNK1E_MB |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| CSNK1E | DVL2, RAD54B, MCC, PER3, PER1, ARNTL, AXIN1, DVL1, ANKRD6, NCOA3, CADM4, HES1, GTF3C1, RBX1, KAT7, TAOK1, BBS10, ZNF227, PNO1, C2orf44, FAM110A, FBP1, ARHGEF1, FAM83D, ZMYND8, ELAVL1, MYC, MYCN, TAZ, CTNND1, DBNDD2, APP, BYSL, PPP1R14A, PPP1CA, SDCCAG3, TENC1, FAM110C, SAV1, REST, CSNK1A1, ZSWIM8, USP9Y, PRMT5, SEC16A, AHCYL1, HMMR, MTA2, FARP2, CSNK1D, SEC13, WDR5, ACACA, PRDX4, STK3, CUL2, TCEB2, CRY1, PPP6R3, FAM83B, FAM199X, FAM83H, VPS13B, FAM110B, USP9X, AHCYL2, SNX22, KLHDC3, UNC45A, ADAM22, STOX2, RASAL2, SNX24, TIAM1, DVL3, OCLN, CSNK1E, DEC1, BHLHE41, PER2, PPP1CC, PPP2R5E, RORC, CSNK2B, FBXW11, NR1D2, CLOCK, PPP2R5D, RORA, UBE2S, DRICH1, CACNG2, TRA2A, TEX264, MRPL4, CACNG4, RP2, SGOL2, MAPK9, MICU2, LTBR, PCMT1, SMARCD1, LDLRAD4, NTRK1, ALYREF, DHX16, DTD1, NLRP1, NSUN2, USP39, NOB1, PPM1B, CEP290, CEP162, PCM1, CEP128, XPO1, CRY2, CLTC, JAK3, KIF2A, BAIAP2, GTSE1, CAMKK1, PRKAR2A, OFD1, KIAA0753, TRIM3, CEP131, GAPVD1, CEP72, MIER1, FOPNL, SPICE1, WDR90, CCDC61, APC, BID, TP53, UBXN7, TRAF3, MAVS, ATOH1, LPIN1, ZNF618, PDE4DIP, ANKRD49, SSMEM1, NXF2, RPS4Y2, FKBPL, UQCC1, POTEF, ARHGAP22, HSPA8, KLHL42, CACNG5, RNF43, TNFRSF1A, BTBD1, C7orf60, PRKAR2B, MTMR4, FOXP2, WWC1 | MB | PSMD4, APP, HSPB2, ANK1, CORT |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for CSNK1E_MB |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| Tgene | MB | P02144 | DB09112 | Nitrous acid | Myoglobin | small molecule | approved|investigational |
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RelatedDiseases for CSNK1E_MB |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | CSNK1E | C0005586 | Bipolar Disorder | 5 | PSYGENET |
| Hgene | CSNK1E | C0036341 | Schizophrenia | 2 | PSYGENET |
| Hgene | CSNK1E | C0033975 | Psychotic Disorders | 1 | PSYGENET |
| Hgene | CSNK1E | C0349204 | Nonorganic psychosis | 1 | PSYGENET |
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