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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 8638

FusionGeneSummary for CSNK1D_WNK1

check button Fusion gene summary
Fusion gene informationFusion gene name: CSNK1D_WNK1
Fusion gene ID: 8638
HgeneTgene
Gene symbol

CSNK1D

WNK1

Gene ID

1453

65125

Gene namecasein kinase 1 deltaWNK lysine deficient protein kinase 1
SynonymsASPS|CKI-delta|CKId|CKIdelta|FASPS2|HCKIDHSAN2|HSN2|KDP|PPP1R167|PRKWNK1|PSK|p65
Cytomap

17q25.3

12p13.33

Type of geneprotein-codingprotein-coding
Descriptioncasein kinase I isoform deltacasein kinase Itau-protein kinase CSNK1Dserine/threonine-protein kinase WNK1WNK lysine deficient protein kinase 1 isoformerythrocyte 65 kDa proteinprostate-derived sterile 20-like kinaseprotein kinase with no lysine 1protein phosphatase 1, regulatory subunit 167serine/threonine-protein ki
Modification date2018052920180523
UniProtAcc

P48730

Q9H4A3

Ensembl transtripts involved in fusion geneENST00000398519, ENST00000314028, 
ENST00000392334, ENST00000578904, 
ENST00000535572, ENST00000537687, 
ENST00000315939, ENST00000447667, 
ENST00000530271, ENST00000540360, 
ENST00000340908, ENST00000574564, 
Fusion gene scores* DoF score10 X 8 X 9=72010 X 10 X 5=500
# samples 1315
** MAII scorelog2(13/720*10)=-2.46948528330122
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(15/500*10)=-1.73696559416621
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CSNK1D [Title/Abstract] AND WNK1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneCSNK1D

GO:0006468

protein phosphorylation

16618118

HgeneCSNK1D

GO:0018105

peptidyl-serine phosphorylation

25500533

HgeneCSNK1D

GO:0051225

spindle assembly

10826492

TgeneWNK1

GO:0006468

protein phosphorylation

10660600

TgeneWNK1

GO:0010923

negative regulation of phosphatase activity

19389623

TgeneWNK1

GO:0023016

signal transduction by trans-phosphorylation

16669787

TgeneWNK1

GO:0035556

intracellular signal transduction

10660600


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BE837509CSNK1Dchr17

80218223

-WNK1chr12

994278

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000398519ENST00000535572CSNK1Dchr17

80218223

-WNK1chr12

994278

+
intron-3CDSENST00000398519ENST00000537687CSNK1Dchr17

80218223

-WNK1chr12

994278

+
intron-3CDSENST00000398519ENST00000315939CSNK1Dchr17

80218223

-WNK1chr12

994278

+
intron-intronENST00000398519ENST00000447667CSNK1Dchr17

80218223

-WNK1chr12

994278

+
intron-intronENST00000398519ENST00000530271CSNK1Dchr17

80218223

-WNK1chr12

994278

+
intron-intronENST00000398519ENST00000540360CSNK1Dchr17

80218223

-WNK1chr12

994278

+
intron-intronENST00000398519ENST00000340908CSNK1Dchr17

80218223

-WNK1chr12

994278

+
intron-intronENST00000398519ENST00000574564CSNK1Dchr17

80218223

-WNK1chr12

994278

+
intron-3CDSENST00000314028ENST00000535572CSNK1Dchr17

80218223

-WNK1chr12

994278

+
intron-3CDSENST00000314028ENST00000537687CSNK1Dchr17

80218223

-WNK1chr12

994278

+
intron-3CDSENST00000314028ENST00000315939CSNK1Dchr17

80218223

-WNK1chr12

994278

+
intron-intronENST00000314028ENST00000447667CSNK1Dchr17

80218223

-WNK1chr12

994278

+
intron-intronENST00000314028ENST00000530271CSNK1Dchr17

80218223

-WNK1chr12

994278

+
intron-intronENST00000314028ENST00000540360CSNK1Dchr17

80218223

-WNK1chr12

994278

+
intron-intronENST00000314028ENST00000340908CSNK1Dchr17

80218223

-WNK1chr12

994278

+
intron-intronENST00000314028ENST00000574564CSNK1Dchr17

80218223

-WNK1chr12

994278

+
intron-3CDSENST00000392334ENST00000535572CSNK1Dchr17

80218223

-WNK1chr12

994278

+
intron-3CDSENST00000392334ENST00000537687CSNK1Dchr17

80218223

-WNK1chr12

994278

+
intron-3CDSENST00000392334ENST00000315939CSNK1Dchr17

80218223

-WNK1chr12

994278

+
intron-intronENST00000392334ENST00000447667CSNK1Dchr17

80218223

-WNK1chr12

994278

+
intron-intronENST00000392334ENST00000530271CSNK1Dchr17

80218223

-WNK1chr12

994278

+
intron-intronENST00000392334ENST00000540360CSNK1Dchr17

80218223

-WNK1chr12

994278

+
intron-intronENST00000392334ENST00000340908CSNK1Dchr17

80218223

-WNK1chr12

994278

+
intron-intronENST00000392334ENST00000574564CSNK1Dchr17

80218223

-WNK1chr12

994278

+
intron-3CDSENST00000578904ENST00000535572CSNK1Dchr17

80218223

-WNK1chr12

994278

+
intron-3CDSENST00000578904ENST00000537687CSNK1Dchr17

80218223

-WNK1chr12

994278

+
intron-3CDSENST00000578904ENST00000315939CSNK1Dchr17

80218223

-WNK1chr12

994278

+
intron-intronENST00000578904ENST00000447667CSNK1Dchr17

80218223

-WNK1chr12

994278

+
intron-intronENST00000578904ENST00000530271CSNK1Dchr17

80218223

-WNK1chr12

994278

+
intron-intronENST00000578904ENST00000540360CSNK1Dchr17

80218223

-WNK1chr12

994278

+
intron-intronENST00000578904ENST00000340908CSNK1Dchr17

80218223

-WNK1chr12

994278

+
intron-intronENST00000578904ENST00000574564CSNK1Dchr17

80218223

-WNK1chr12

994278

+

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FusionProtFeatures for CSNK1D_WNK1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CSNK1D

P48730

WNK1

Q9H4A3

Essential serine/threonine-protein kinase that regulatesdiverse cellular growth and survival processes including Wntsignaling, DNA repair and circadian rhythms. It can phosphorylatea large number of proteins. Casein kinases are operationallydefined by their preferential utilization of acidic proteins suchas caseins as substrates. Phosphorylates connexin-43/GJA1, MAP1A,SNAPIN, MAPT/TAU, TOP2A, DCK, HIF1A, EIF6, p53/TP53, DVL2, DVL3,ESR1, AIB1/NCOA3, DNMT1, PKD2, YAP1, PER1 and PER2. Centralcomponent of the circadian clock. In balance with PP1, determinesthe circadian period length through the regulation of the speedand rhythmicity of PER1 and PER2 phosphorylation. Controls PER1and PER2 nuclear transport and degradation. YAP1 phosphorylationpromotes its SCF(beta-TRCP) E3 ubiquitin ligase-mediatedubiquitination and subsequent degradation. DNMT1 phosphorylationreduces its DNA-binding activity. Phosphorylation of ESR1 andAIB1/NCOA3 stimulates their activity and coactivation.Phosphorylation of DVL2 and DVL3 regulates WNT3A signaling pathwaythat controls neurite outgrowth. EIF6 phosphorylation promotes itsnuclear export. Triggers down-regulation of dopamine receptors inthe forebrain. Activates DCK in vitro by phosphorylation. TOP2Aphosphorylation favors DNA cleavable complex formation. Mayregulate the formation of the mitotic spindle apparatus inextravillous trophoblast. Modulates connexin-43/GJA1 gap junctionassembly by phosphorylation. Probably involved in lymphocytephysiology. Regulates fast synaptic transmission mediated byglutamate. {ECO:0000269|PubMed:10606744,ECO:0000269|PubMed:12270943, ECO:0000269|PubMed:14761950,ECO:0000269|PubMed:16027726, ECO:0000269|PubMed:17562708,ECO:0000269|PubMed:17962809, ECO:0000269|PubMed:19043076,ECO:0000269|PubMed:19339517, ECO:0000269|PubMed:20041275,ECO:0000269|PubMed:20048001, ECO:0000269|PubMed:20407760,ECO:0000269|PubMed:20637175, ECO:0000269|PubMed:20696890,ECO:0000269|PubMed:20699359, ECO:0000269|PubMed:21084295,ECO:0000269|PubMed:21422228, ECO:0000269|PubMed:23636092}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for CSNK1D_WNK1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for CSNK1D_WNK1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for CSNK1D_WNK1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for CSNK1D_WNK1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneCSNK1DC0005586Bipolar Disorder1PSYGENET
HgeneCSNK1DC0036341Schizophrenia1PSYGENET
HgeneCSNK1DC0041696Unipolar Depression1PSYGENET
HgeneCSNK1DC1269683Major Depressive Disorder1PSYGENET
HgeneCSNK1DC3808874ADVANCED SLEEP PHASE SYNDROME, FAMILIAL, 21UNIPROT
TgeneWNK1C0020538Hypertensive disease1CTD_human
TgeneWNK1C0022658Kidney Diseases1CTD_human
TgeneWNK1C0033805Pseudohypoaldosteronism1CTD_human