FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 8637

FusionGeneSummary for CSNK1D_SECTM1

check button Fusion gene summary
Fusion gene informationFusion gene name: CSNK1D_SECTM1
Fusion gene ID: 8637
HgeneTgene
Gene symbol

CSNK1D

SECTM1

Gene ID

1453

6398

Gene namecasein kinase 1 deltasecreted and transmembrane 1
SynonymsASPS|CKI-delta|CKId|CKIdelta|FASPS2|HCKIDK12
Cytomap

17q25.3

17q25.3

Type of geneprotein-codingprotein-coding
Descriptioncasein kinase I isoform deltacasein kinase Itau-protein kinase CSNK1Dsecreted and transmembrane protein 1type 1a transmembrane protein
Modification date2018052920180523
UniProtAcc

P48730

Q8WVN6

Ensembl transtripts involved in fusion geneENST00000398519, ENST00000314028, 
ENST00000392334, ENST00000578904, 
ENST00000269389, ENST00000580437, 
Fusion gene scores* DoF score10 X 8 X 9=7203 X 3 X 6=54
# samples 136
** MAII scorelog2(13/720*10)=-2.46948528330122
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(6/54*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: CSNK1D [Title/Abstract] AND SECTM1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneCSNK1D

GO:0006468

protein phosphorylation

16618118

HgeneCSNK1D

GO:0018105

peptidyl-serine phosphorylation

25500533

HgeneCSNK1D

GO:0051225

spindle assembly

10826492


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDBRCATCGA-A2-A04T-01ACSNK1Dchr17

80206751

-SECTM1chr17

80285168

-
TCGARVCOADTCGA-AZ-6601-01ACSNK1Dchr17

80223562

-SECTM1chr17

80280887

-
TCGARVHNSCTCGA-CV-5440-01ACSNK1Dchr17

80231182

-SECTM1chr17

80285168

-
TCGARVUCECTCGA-AJ-A3EJ-01ACSNK1Dchr17

80231182

-SECTM1chr17

80280887

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000398519ENST00000269389CSNK1Dchr17

80206751

-SECTM1chr17

80285168

-
5CDS-5UTRENST00000398519ENST00000580437CSNK1Dchr17

80206751

-SECTM1chr17

80285168

-
5CDS-5UTRENST00000314028ENST00000269389CSNK1Dchr17

80206751

-SECTM1chr17

80285168

-
5CDS-5UTRENST00000314028ENST00000580437CSNK1Dchr17

80206751

-SECTM1chr17

80285168

-
5CDS-5UTRENST00000392334ENST00000269389CSNK1Dchr17

80206751

-SECTM1chr17

80285168

-
5CDS-5UTRENST00000392334ENST00000580437CSNK1Dchr17

80206751

-SECTM1chr17

80285168

-
intron-5UTRENST00000578904ENST00000269389CSNK1Dchr17

80206751

-SECTM1chr17

80285168

-
intron-5UTRENST00000578904ENST00000580437CSNK1Dchr17

80206751

-SECTM1chr17

80285168

-
In-frameENST00000398519ENST00000269389CSNK1Dchr17

80223562

-SECTM1chr17

80280887

-
5CDS-intronENST00000398519ENST00000580437CSNK1Dchr17

80223562

-SECTM1chr17

80280887

-
In-frameENST00000314028ENST00000269389CSNK1Dchr17

80223562

-SECTM1chr17

80280887

-
5CDS-intronENST00000314028ENST00000580437CSNK1Dchr17

80223562

-SECTM1chr17

80280887

-
Frame-shiftENST00000392334ENST00000269389CSNK1Dchr17

80223562

-SECTM1chr17

80280887

-
5CDS-intronENST00000392334ENST00000580437CSNK1Dchr17

80223562

-SECTM1chr17

80280887

-
intron-3CDSENST00000578904ENST00000269389CSNK1Dchr17

80223562

-SECTM1chr17

80280887

-
intron-intronENST00000578904ENST00000580437CSNK1Dchr17

80223562

-SECTM1chr17

80280887

-
5CDS-5UTRENST00000398519ENST00000269389CSNK1Dchr17

80231182

-SECTM1chr17

80285168

-
5CDS-5UTRENST00000398519ENST00000580437CSNK1Dchr17

80231182

-SECTM1chr17

80285168

-
5CDS-5UTRENST00000314028ENST00000269389CSNK1Dchr17

80231182

-SECTM1chr17

80285168

-
5CDS-5UTRENST00000314028ENST00000580437CSNK1Dchr17

80231182

-SECTM1chr17

80285168

-
5CDS-5UTRENST00000392334ENST00000269389CSNK1Dchr17

80231182

-SECTM1chr17

80285168

-
5CDS-5UTRENST00000392334ENST00000580437CSNK1Dchr17

80231182

-SECTM1chr17

80285168

-
intron-5UTRENST00000578904ENST00000269389CSNK1Dchr17

80231182

-SECTM1chr17

80285168

-
intron-5UTRENST00000578904ENST00000580437CSNK1Dchr17

80231182

-SECTM1chr17

80285168

-
Frame-shiftENST00000398519ENST00000269389CSNK1Dchr17

80231182

-SECTM1chr17

80280887

-
5CDS-intronENST00000398519ENST00000580437CSNK1Dchr17

80231182

-SECTM1chr17

80280887

-
Frame-shiftENST00000314028ENST00000269389CSNK1Dchr17

80231182

-SECTM1chr17

80280887

-
5CDS-intronENST00000314028ENST00000580437CSNK1Dchr17

80231182

-SECTM1chr17

80280887

-
Frame-shiftENST00000392334ENST00000269389CSNK1Dchr17

80231182

-SECTM1chr17

80280887

-
5CDS-intronENST00000392334ENST00000580437CSNK1Dchr17

80231182

-SECTM1chr17

80280887

-
intron-3CDSENST00000578904ENST00000269389CSNK1Dchr17

80231182

-SECTM1chr17

80280887

-
intron-intronENST00000578904ENST00000580437CSNK1Dchr17

80231182

-SECTM1chr17

80280887

-

Top

FusionProtFeatures for CSNK1D_SECTM1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CSNK1D

P48730

SECTM1

Q8WVN6

Essential serine/threonine-protein kinase that regulatesdiverse cellular growth and survival processes including Wntsignaling, DNA repair and circadian rhythms. It can phosphorylatea large number of proteins. Casein kinases are operationallydefined by their preferential utilization of acidic proteins suchas caseins as substrates. Phosphorylates connexin-43/GJA1, MAP1A,SNAPIN, MAPT/TAU, TOP2A, DCK, HIF1A, EIF6, p53/TP53, DVL2, DVL3,ESR1, AIB1/NCOA3, DNMT1, PKD2, YAP1, PER1 and PER2. Centralcomponent of the circadian clock. In balance with PP1, determinesthe circadian period length through the regulation of the speedand rhythmicity of PER1 and PER2 phosphorylation. Controls PER1and PER2 nuclear transport and degradation. YAP1 phosphorylationpromotes its SCF(beta-TRCP) E3 ubiquitin ligase-mediatedubiquitination and subsequent degradation. DNMT1 phosphorylationreduces its DNA-binding activity. Phosphorylation of ESR1 andAIB1/NCOA3 stimulates their activity and coactivation.Phosphorylation of DVL2 and DVL3 regulates WNT3A signaling pathwaythat controls neurite outgrowth. EIF6 phosphorylation promotes itsnuclear export. Triggers down-regulation of dopamine receptors inthe forebrain. Activates DCK in vitro by phosphorylation. TOP2Aphosphorylation favors DNA cleavable complex formation. Mayregulate the formation of the mitotic spindle apparatus inextravillous trophoblast. Modulates connexin-43/GJA1 gap junctionassembly by phosphorylation. Probably involved in lymphocytephysiology. Regulates fast synaptic transmission mediated byglutamate. {ECO:0000269|PubMed:10606744,ECO:0000269|PubMed:12270943, ECO:0000269|PubMed:14761950,ECO:0000269|PubMed:16027726, ECO:0000269|PubMed:17562708,ECO:0000269|PubMed:17962809, ECO:0000269|PubMed:19043076,ECO:0000269|PubMed:19339517, ECO:0000269|PubMed:20041275,ECO:0000269|PubMed:20048001, ECO:0000269|PubMed:20407760,ECO:0000269|PubMed:20637175, ECO:0000269|PubMed:20696890,ECO:0000269|PubMed:20699359, ECO:0000269|PubMed:21084295,ECO:0000269|PubMed:21422228, ECO:0000269|PubMed:23636092}. May be involved in thymocyte signaling.{ECO:0000269|PubMed:15742156}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCSNK1Dchr17:80223562chr17:80280887ENST00000314028-2915_2362416Nucleotide bindingATP
HgeneCSNK1Dchr17:80223562chr17:80280887ENST00000392334-21015_2362420Nucleotide bindingATP
TgeneSECTM1chr17:80223562chr17:80280887ENST00000269389-25167_248134249Topological domainCytoplasmic
TgeneSECTM1chr17:80223562chr17:80280887ENST00000269389-25146_166134249TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCSNK1Dchr17:80223562chr17:80280887ENST00000314028-299_27762416DomainProtein kinase
HgeneCSNK1Dchr17:80223562chr17:80280887ENST00000392334-2109_27762420DomainProtein kinase
HgeneCSNK1Dchr17:80223562chr17:80280887ENST00000314028-29278_36462416RegionNote=Centrosomal localization signal (CLS)
HgeneCSNK1Dchr17:80223562chr17:80280887ENST00000314028-29317_34262416RegionAutoinhibitory
HgeneCSNK1Dchr17:80223562chr17:80280887ENST00000392334-210278_36462420RegionNote=Centrosomal localization signal (CLS)
HgeneCSNK1Dchr17:80223562chr17:80280887ENST00000392334-210317_34262420RegionAutoinhibitory
TgeneSECTM1chr17:80223562chr17:80280887ENST00000269389-2529_145134249Topological domainExtracellular


Top

FusionGeneSequence for CSNK1D_SECTM1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for CSNK1D_SECTM1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
CSNK1DDVL3, MCC, PER1, GJA1, AKAP9, DVL1, MDM2, HN1L, KDR, PTPN14, TP53, SMAD2, SMAD3, ATM, PML, DBNDD2, SNCA, MAPT, APP, USP16, BYSL, PPP1R14A, YWHAZ, SMAD4, FHL1, MTSS1, NEDD4, CSNK1A1, CSNK1E, TRIM9, LURAP1, BRCA1, ZDHHC17, PPP6C, PER2, RHOJ, DRICH1, MAF1, CACNG2, TRA2A, KCTD17, TEX264, CACNG4, RP2, MICU2, LDLRAD4, NOB1, PPM1B, PCM1, CEP128, XPO1, KLC1, GEMIN7, FAM83H, PRKAR2B, DAP3, AXIN1, BACE1, NFATC1, NFATC2, SMURF1, RAB1A, ATOH1, CDH1, SNX24, FAM110B, ZNF618, GAPVD1, CRY2, CRY1, PDE4DIP, ANKRD49, TDP1, FAM199X, VPS13B, SSMEM1, NXF2, FKBPL, FAM83D, HMMR, HSPA8, CACNG5, APC, TRIM25SECTM1CD7


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for CSNK1D_SECTM1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for CSNK1D_SECTM1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneCSNK1DC0005586Bipolar Disorder1PSYGENET
HgeneCSNK1DC0036341Schizophrenia1PSYGENET
HgeneCSNK1DC0041696Unipolar Depression1PSYGENET
HgeneCSNK1DC1269683Major Depressive Disorder1PSYGENET
HgeneCSNK1DC3808874ADVANCED SLEEP PHASE SYNDROME, FAMILIAL, 21UNIPROT