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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 8623

FusionGeneSummary for CSNK1A1_CSNK1A1

check button Fusion gene summary
Fusion gene informationFusion gene name: CSNK1A1_CSNK1A1
Fusion gene ID: 8623
HgeneTgene
Gene symbol

CSNK1A1

CSNK1A1

Gene ID

1452

1452

Gene namecasein kinase 1 alpha 1casein kinase 1 alpha 1
SynonymsCK1|CK1a|CKIa|HEL-S-77p|HLCDGP1|PRO2975CK1|CK1a|CKIa|HEL-S-77p|HLCDGP1|PRO2975
Cytomap

5q32

5q32

Type of geneprotein-codingprotein-coding
Descriptioncasein kinase I isoform alphaCKI-alphaclock regulator kinasedown-regulated in lung cancerepididymis secretory sperm binding protein Li 77pcasein kinase I isoform alphaCKI-alphaclock regulator kinasedown-regulated in lung cancerepididymis secretory sperm binding protein Li 77p
Modification date2018052320180523
UniProtAcc

P48729

P48729

Ensembl transtripts involved in fusion geneENST00000261798, ENST00000377843, 
ENST00000515435, ENST00000504676, 
ENST00000515768, ENST00000606719, 
ENST00000606299, ENST00000515748, 
ENST00000261798, ENST00000377843, 
ENST00000515435, ENST00000504676, 
ENST00000515768, ENST00000606719, 
ENST00000606299, ENST00000515748, 
Fusion gene scores* DoF score7 X 6 X 6=2527 X 5 X 6=210
# samples 97
** MAII scorelog2(9/252*10)=-1.48542682717024
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(7/210*10)=-1.58496250072116
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CSNK1A1 [Title/Abstract] AND CSNK1A1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneCSNK1A1

GO:0006468

protein phosphorylation

18305108

HgeneCSNK1A1

GO:0018105

peptidyl-serine phosphorylation

25500533

TgeneCSNK1A1

GO:0006468

protein phosphorylation

18305108

TgeneCSNK1A1

GO:0018105

peptidyl-serine phosphorylation

25500533


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AW265513CSNK1A1chr5

148896480

-CSNK1A1chr5

148896619

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000261798ENST00000261798CSNK1A1chr5

148896480

-CSNK1A1chr5

148896619

+
intron-intronENST00000261798ENST00000377843CSNK1A1chr5

148896480

-CSNK1A1chr5

148896619

+
intron-intronENST00000261798ENST00000515435CSNK1A1chr5

148896480

-CSNK1A1chr5

148896619

+
intron-intronENST00000261798ENST00000504676CSNK1A1chr5

148896480

-CSNK1A1chr5

148896619

+
intron-intronENST00000261798ENST00000515768CSNK1A1chr5

148896480

-CSNK1A1chr5

148896619

+
intron-intronENST00000261798ENST00000606719CSNK1A1chr5

148896480

-CSNK1A1chr5

148896619

+
intron-intronENST00000261798ENST00000606299CSNK1A1chr5

148896480

-CSNK1A1chr5

148896619

+
intron-intronENST00000261798ENST00000515748CSNK1A1chr5

148896480

-CSNK1A1chr5

148896619

+
intron-intronENST00000377843ENST00000261798CSNK1A1chr5

148896480

-CSNK1A1chr5

148896619

+
intron-intronENST00000377843ENST00000377843CSNK1A1chr5

148896480

-CSNK1A1chr5

148896619

+
intron-intronENST00000377843ENST00000515435CSNK1A1chr5

148896480

-CSNK1A1chr5

148896619

+
intron-intronENST00000377843ENST00000504676CSNK1A1chr5

148896480

-CSNK1A1chr5

148896619

+
intron-intronENST00000377843ENST00000515768CSNK1A1chr5

148896480

-CSNK1A1chr5

148896619

+
intron-intronENST00000377843ENST00000606719CSNK1A1chr5

148896480

-CSNK1A1chr5

148896619

+
intron-intronENST00000377843ENST00000606299CSNK1A1chr5

148896480

-CSNK1A1chr5

148896619

+
intron-intronENST00000377843ENST00000515748CSNK1A1chr5

148896480

-CSNK1A1chr5

148896619

+
intron-intronENST00000515435ENST00000261798CSNK1A1chr5

148896480

-CSNK1A1chr5

148896619

+
intron-intronENST00000515435ENST00000377843CSNK1A1chr5

148896480

-CSNK1A1chr5

148896619

+
intron-intronENST00000515435ENST00000515435CSNK1A1chr5

148896480

-CSNK1A1chr5

148896619

+
intron-intronENST00000515435ENST00000504676CSNK1A1chr5

148896480

-CSNK1A1chr5

148896619

+
intron-intronENST00000515435ENST00000515768CSNK1A1chr5

148896480

-CSNK1A1chr5

148896619

+
intron-intronENST00000515435ENST00000606719CSNK1A1chr5

148896480

-CSNK1A1chr5

148896619

+
intron-intronENST00000515435ENST00000606299CSNK1A1chr5

148896480

-CSNK1A1chr5

148896619

+
intron-intronENST00000515435ENST00000515748CSNK1A1chr5

148896480

-CSNK1A1chr5

148896619

+
intron-intronENST00000504676ENST00000261798CSNK1A1chr5

148896480

-CSNK1A1chr5

148896619

+
intron-intronENST00000504676ENST00000377843CSNK1A1chr5

148896480

-CSNK1A1chr5

148896619

+
intron-intronENST00000504676ENST00000515435CSNK1A1chr5

148896480

-CSNK1A1chr5

148896619

+
intron-intronENST00000504676ENST00000504676CSNK1A1chr5

148896480

-CSNK1A1chr5

148896619

+
intron-intronENST00000504676ENST00000515768CSNK1A1chr5

148896480

-CSNK1A1chr5

148896619

+
intron-intronENST00000504676ENST00000606719CSNK1A1chr5

148896480

-CSNK1A1chr5

148896619

+
intron-intronENST00000504676ENST00000606299CSNK1A1chr5

148896480

-CSNK1A1chr5

148896619

+
intron-intronENST00000504676ENST00000515748CSNK1A1chr5

148896480

-CSNK1A1chr5

148896619

+
intron-intronENST00000515768ENST00000261798CSNK1A1chr5

148896480

-CSNK1A1chr5

148896619

+
intron-intronENST00000515768ENST00000377843CSNK1A1chr5

148896480

-CSNK1A1chr5

148896619

+
intron-intronENST00000515768ENST00000515435CSNK1A1chr5

148896480

-CSNK1A1chr5

148896619

+
intron-intronENST00000515768ENST00000504676CSNK1A1chr5

148896480

-CSNK1A1chr5

148896619

+
intron-intronENST00000515768ENST00000515768CSNK1A1chr5

148896480

-CSNK1A1chr5

148896619

+
intron-intronENST00000515768ENST00000606719CSNK1A1chr5

148896480

-CSNK1A1chr5

148896619

+
intron-intronENST00000515768ENST00000606299CSNK1A1chr5

148896480

-CSNK1A1chr5

148896619

+
intron-intronENST00000515768ENST00000515748CSNK1A1chr5

148896480

-CSNK1A1chr5

148896619

+
intron-intronENST00000606719ENST00000261798CSNK1A1chr5

148896480

-CSNK1A1chr5

148896619

+
intron-intronENST00000606719ENST00000377843CSNK1A1chr5

148896480

-CSNK1A1chr5

148896619

+
intron-intronENST00000606719ENST00000515435CSNK1A1chr5

148896480

-CSNK1A1chr5

148896619

+
intron-intronENST00000606719ENST00000504676CSNK1A1chr5

148896480

-CSNK1A1chr5

148896619

+
intron-intronENST00000606719ENST00000515768CSNK1A1chr5

148896480

-CSNK1A1chr5

148896619

+
intron-intronENST00000606719ENST00000606719CSNK1A1chr5

148896480

-CSNK1A1chr5

148896619

+
intron-intronENST00000606719ENST00000606299CSNK1A1chr5

148896480

-CSNK1A1chr5

148896619

+
intron-intronENST00000606719ENST00000515748CSNK1A1chr5

148896480

-CSNK1A1chr5

148896619

+
intron-intronENST00000606299ENST00000261798CSNK1A1chr5

148896480

-CSNK1A1chr5

148896619

+
intron-intronENST00000606299ENST00000377843CSNK1A1chr5

148896480

-CSNK1A1chr5

148896619

+
intron-intronENST00000606299ENST00000515435CSNK1A1chr5

148896480

-CSNK1A1chr5

148896619

+
intron-intronENST00000606299ENST00000504676CSNK1A1chr5

148896480

-CSNK1A1chr5

148896619

+
intron-intronENST00000606299ENST00000515768CSNK1A1chr5

148896480

-CSNK1A1chr5

148896619

+
intron-intronENST00000606299ENST00000606719CSNK1A1chr5

148896480

-CSNK1A1chr5

148896619

+
intron-intronENST00000606299ENST00000606299CSNK1A1chr5

148896480

-CSNK1A1chr5

148896619

+
intron-intronENST00000606299ENST00000515748CSNK1A1chr5

148896480

-CSNK1A1chr5

148896619

+
intron-intronENST00000515748ENST00000261798CSNK1A1chr5

148896480

-CSNK1A1chr5

148896619

+
intron-intronENST00000515748ENST00000377843CSNK1A1chr5

148896480

-CSNK1A1chr5

148896619

+
intron-intronENST00000515748ENST00000515435CSNK1A1chr5

148896480

-CSNK1A1chr5

148896619

+
intron-intronENST00000515748ENST00000504676CSNK1A1chr5

148896480

-CSNK1A1chr5

148896619

+
intron-intronENST00000515748ENST00000515768CSNK1A1chr5

148896480

-CSNK1A1chr5

148896619

+
intron-intronENST00000515748ENST00000606719CSNK1A1chr5

148896480

-CSNK1A1chr5

148896619

+
intron-intronENST00000515748ENST00000606299CSNK1A1chr5

148896480

-CSNK1A1chr5

148896619

+
intron-intronENST00000515748ENST00000515748CSNK1A1chr5

148896480

-CSNK1A1chr5

148896619

+

Top

FusionProtFeatures for CSNK1A1_CSNK1A1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CSNK1A1

P48729

CSNK1A1

P48729


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for CSNK1A1_CSNK1A1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for CSNK1A1_CSNK1A1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for CSNK1A1_CSNK1A1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for CSNK1A1_CSNK1A1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneCSNK1A1C0023493Adult T-Cell Lymphoma/Leukemia1CTD_human
HgeneCSNK1A1C0376634Craniofacial Abnormalities1CTD_human
TgeneCSNK1A1C0023493Adult T-Cell Lymphoma/Leukemia1CTD_human
TgeneCSNK1A1C0376634Craniofacial Abnormalities1CTD_human