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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 8613

FusionGeneSummary for CSMD2_IFI44L

check button Fusion gene summary
Fusion gene informationFusion gene name: CSMD2_IFI44L
Fusion gene ID: 8613
HgeneTgene
Gene symbol

CSMD2

IFI44L

Gene ID

114784

10964

Gene nameCUB and Sushi multiple domains 2interferon induced protein 44 like
SynonymsdJ1007G16.1|dJ1007G16.2|dJ947L8.1C1orf29|GS3686
Cytomap

1p35.1

1p31.1

Type of geneprotein-codingprotein-coding
DescriptionCUB and sushi domain-containing protein 2CUB and Sushi (SCR repeat) domainCUB and sushi multiple domains protein 2interferon-induced protein 44-like
Modification date2018040320180519
UniProtAcc

Q7Z408

Q53G44

Ensembl transtripts involved in fusion geneENST00000373381, ENST00000373380, 
ENST00000373377, ENST00000373388, 
ENST00000489419, ENST00000338325, 
ENST00000476521, ENST00000370751, 
ENST00000342282, 
Fusion gene scores* DoF score5 X 4 X 4=802 X 2 X 2=8
# samples 52
** MAII scorelog2(5/80*10)=-0.678071905112638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(2/8*10)=1.32192809488736
Context

PubMed: CSMD2 [Title/Abstract] AND IFI44L [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneIFI44L

GO:0051607

defense response to virus

21478870


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVBRCATCGA-BH-A1EV-01ACSMD2chr1

34052104

-IFI44Lchr1

79102717

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000373381ENST00000476521CSMD2chr1

34052104

-IFI44Lchr1

79102717

+
5CDS-intronENST00000373381ENST00000370751CSMD2chr1

34052104

-IFI44Lchr1

79102717

+
5CDS-intronENST00000373381ENST00000342282CSMD2chr1

34052104

-IFI44Lchr1

79102717

+
intron-intronENST00000373380ENST00000476521CSMD2chr1

34052104

-IFI44Lchr1

79102717

+
intron-intronENST00000373380ENST00000370751CSMD2chr1

34052104

-IFI44Lchr1

79102717

+
intron-intronENST00000373380ENST00000342282CSMD2chr1

34052104

-IFI44Lchr1

79102717

+
intron-intronENST00000373377ENST00000476521CSMD2chr1

34052104

-IFI44Lchr1

79102717

+
intron-intronENST00000373377ENST00000370751CSMD2chr1

34052104

-IFI44Lchr1

79102717

+
intron-intronENST00000373377ENST00000342282CSMD2chr1

34052104

-IFI44Lchr1

79102717

+
intron-intronENST00000373388ENST00000476521CSMD2chr1

34052104

-IFI44Lchr1

79102717

+
intron-intronENST00000373388ENST00000370751CSMD2chr1

34052104

-IFI44Lchr1

79102717

+
intron-intronENST00000373388ENST00000342282CSMD2chr1

34052104

-IFI44Lchr1

79102717

+
intron-intronENST00000489419ENST00000476521CSMD2chr1

34052104

-IFI44Lchr1

79102717

+
intron-intronENST00000489419ENST00000370751CSMD2chr1

34052104

-IFI44Lchr1

79102717

+
intron-intronENST00000489419ENST00000342282CSMD2chr1

34052104

-IFI44Lchr1

79102717

+
intron-intronENST00000338325ENST00000476521CSMD2chr1

34052104

-IFI44Lchr1

79102717

+
intron-intronENST00000338325ENST00000370751CSMD2chr1

34052104

-IFI44Lchr1

79102717

+
intron-intronENST00000338325ENST00000342282CSMD2chr1

34052104

-IFI44Lchr1

79102717

+

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FusionProtFeatures for CSMD2_IFI44L


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CSMD2

Q7Z408

IFI44L

Q53G44

Exhibits a low antiviral activity against hepatitis Cvirus. {ECO:0000269|PubMed:21478870}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for CSMD2_IFI44L


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for CSMD2_IFI44L


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
CSMD2IFI44LIFNA5, IFNA21


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for CSMD2_IFI44L


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for CSMD2_IFI44L


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneCSMD2C0011570Mental Depression1PSYGENET
HgeneCSMD2C0011581Depressive disorder1PSYGENET
HgeneCSMD2C0036341Schizophrenia1PSYGENET
TgeneIFI44LC0021400Influenza1CTD_human