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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 8611

FusionGeneSummary for CSMD2_DNAH14

check button Fusion gene summary
Fusion gene informationFusion gene name: CSMD2_DNAH14
Fusion gene ID: 8611
HgeneTgene
Gene symbol

CSMD2

DNAH14

Gene ID

114784

127602

Gene nameCUB and Sushi multiple domains 2dynein axonemal heavy chain 14
SynonymsdJ1007G16.1|dJ1007G16.2|dJ947L8.1C1orf67|Dnahc14|HL-18|HL18
Cytomap

1p35.1

1q42.12

Type of geneprotein-codingprotein-coding
DescriptionCUB and sushi domain-containing protein 2CUB and Sushi (SCR repeat) domainCUB and sushi multiple domains protein 2dynein heavy chain 14, axonemalaxonemal beta dynein heavy chain 14ciliary dynein heavy chain 14dynein, axonemal, heavy polypeptide 14
Modification date2018040320180523
UniProtAcc

Q7Z408

Q0VDD8

Ensembl transtripts involved in fusion geneENST00000373381, ENST00000373380, 
ENST00000373377, ENST00000373388, 
ENST00000489419, ENST00000338325, 
ENST00000445597, ENST00000430092, 
ENST00000439375, ENST00000400952, 
ENST00000366849, ENST00000366850, 
ENST00000498360, ENST00000366848, 
Fusion gene scores* DoF score5 X 4 X 4=804 X 4 X 4=64
# samples 55
** MAII scorelog2(5/80*10)=-0.678071905112638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(5/64*10)=-0.356143810225275
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CSMD2 [Title/Abstract] AND DNAH14 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVSTADTCGA-VQ-A922-01ACSMD2chr1

34498195

-DNAH14chr1

225586222

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000373381ENST00000445597CSMD2chr1

34498195

-DNAH14chr1

225586222

+
Frame-shiftENST00000373381ENST00000430092CSMD2chr1

34498195

-DNAH14chr1

225586222

+
Frame-shiftENST00000373381ENST00000439375CSMD2chr1

34498195

-DNAH14chr1

225586222

+
5CDS-intronENST00000373381ENST00000400952CSMD2chr1

34498195

-DNAH14chr1

225586222

+
5CDS-intronENST00000373381ENST00000366849CSMD2chr1

34498195

-DNAH14chr1

225586222

+
5CDS-intronENST00000373381ENST00000366850CSMD2chr1

34498195

-DNAH14chr1

225586222

+
5CDS-intronENST00000373381ENST00000498360CSMD2chr1

34498195

-DNAH14chr1

225586222

+
5CDS-intronENST00000373381ENST00000366848CSMD2chr1

34498195

-DNAH14chr1

225586222

+
intron-3CDSENST00000373380ENST00000445597CSMD2chr1

34498195

-DNAH14chr1

225586222

+
intron-3CDSENST00000373380ENST00000430092CSMD2chr1

34498195

-DNAH14chr1

225586222

+
intron-3CDSENST00000373380ENST00000439375CSMD2chr1

34498195

-DNAH14chr1

225586222

+
intron-intronENST00000373380ENST00000400952CSMD2chr1

34498195

-DNAH14chr1

225586222

+
intron-intronENST00000373380ENST00000366849CSMD2chr1

34498195

-DNAH14chr1

225586222

+
intron-intronENST00000373380ENST00000366850CSMD2chr1

34498195

-DNAH14chr1

225586222

+
intron-intronENST00000373380ENST00000498360CSMD2chr1

34498195

-DNAH14chr1

225586222

+
intron-intronENST00000373380ENST00000366848CSMD2chr1

34498195

-DNAH14chr1

225586222

+
intron-3CDSENST00000373377ENST00000445597CSMD2chr1

34498195

-DNAH14chr1

225586222

+
intron-3CDSENST00000373377ENST00000430092CSMD2chr1

34498195

-DNAH14chr1

225586222

+
intron-3CDSENST00000373377ENST00000439375CSMD2chr1

34498195

-DNAH14chr1

225586222

+
intron-intronENST00000373377ENST00000400952CSMD2chr1

34498195

-DNAH14chr1

225586222

+
intron-intronENST00000373377ENST00000366849CSMD2chr1

34498195

-DNAH14chr1

225586222

+
intron-intronENST00000373377ENST00000366850CSMD2chr1

34498195

-DNAH14chr1

225586222

+
intron-intronENST00000373377ENST00000498360CSMD2chr1

34498195

-DNAH14chr1

225586222

+
intron-intronENST00000373377ENST00000366848CSMD2chr1

34498195

-DNAH14chr1

225586222

+
intron-3CDSENST00000373388ENST00000445597CSMD2chr1

34498195

-DNAH14chr1

225586222

+
intron-3CDSENST00000373388ENST00000430092CSMD2chr1

34498195

-DNAH14chr1

225586222

+
intron-3CDSENST00000373388ENST00000439375CSMD2chr1

34498195

-DNAH14chr1

225586222

+
intron-intronENST00000373388ENST00000400952CSMD2chr1

34498195

-DNAH14chr1

225586222

+
intron-intronENST00000373388ENST00000366849CSMD2chr1

34498195

-DNAH14chr1

225586222

+
intron-intronENST00000373388ENST00000366850CSMD2chr1

34498195

-DNAH14chr1

225586222

+
intron-intronENST00000373388ENST00000498360CSMD2chr1

34498195

-DNAH14chr1

225586222

+
intron-intronENST00000373388ENST00000366848CSMD2chr1

34498195

-DNAH14chr1

225586222

+
intron-3CDSENST00000489419ENST00000445597CSMD2chr1

34498195

-DNAH14chr1

225586222

+
intron-3CDSENST00000489419ENST00000430092CSMD2chr1

34498195

-DNAH14chr1

225586222

+
intron-3CDSENST00000489419ENST00000439375CSMD2chr1

34498195

-DNAH14chr1

225586222

+
intron-intronENST00000489419ENST00000400952CSMD2chr1

34498195

-DNAH14chr1

225586222

+
intron-intronENST00000489419ENST00000366849CSMD2chr1

34498195

-DNAH14chr1

225586222

+
intron-intronENST00000489419ENST00000366850CSMD2chr1

34498195

-DNAH14chr1

225586222

+
intron-intronENST00000489419ENST00000498360CSMD2chr1

34498195

-DNAH14chr1

225586222

+
intron-intronENST00000489419ENST00000366848CSMD2chr1

34498195

-DNAH14chr1

225586222

+
intron-3CDSENST00000338325ENST00000445597CSMD2chr1

34498195

-DNAH14chr1

225586222

+
intron-3CDSENST00000338325ENST00000430092CSMD2chr1

34498195

-DNAH14chr1

225586222

+
intron-3CDSENST00000338325ENST00000439375CSMD2chr1

34498195

-DNAH14chr1

225586222

+
intron-intronENST00000338325ENST00000400952CSMD2chr1

34498195

-DNAH14chr1

225586222

+
intron-intronENST00000338325ENST00000366849CSMD2chr1

34498195

-DNAH14chr1

225586222

+
intron-intronENST00000338325ENST00000366850CSMD2chr1

34498195

-DNAH14chr1

225586222

+
intron-intronENST00000338325ENST00000498360CSMD2chr1

34498195

-DNAH14chr1

225586222

+
intron-intronENST00000338325ENST00000366848CSMD2chr1

34498195

-DNAH14chr1

225586222

+

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FusionProtFeatures for CSMD2_DNAH14


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CSMD2

Q7Z408

DNAH14

Q0VDD8


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for CSMD2_DNAH14


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for CSMD2_DNAH14


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
CSMD2DNAH14APP, IGSF8, DLK1, CETN2, CAMK2D, SSSCA1, IKZF5, CETN1, RELL2, GFAP


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for CSMD2_DNAH14


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for CSMD2_DNAH14


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneCSMD2C0011570Mental Depression1PSYGENET
HgeneCSMD2C0011581Depressive disorder1PSYGENET
HgeneCSMD2C0036341Schizophrenia1PSYGENET