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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 8593

FusionGeneSummary for CSGALNACT2_ACKR3

check button Fusion gene summary
Fusion gene informationFusion gene name: CSGALNACT2_ACKR3
Fusion gene ID: 8593
HgeneTgene
Gene symbol

CSGALNACT2

ACKR3

Gene ID

55454

57007

Gene namechondroitin sulfate N-acetylgalactosaminyltransferase 2atypical chemokine receptor 3
SynonymsCHGN2|ChGn-2|GALNACT-2|GALNACT2|PRO0082|beta4GalNAcTCMKOR1|CXC-R7|CXCR-7|CXCR7|GPR159|RDC-1|RDC1
Cytomap

10q11.21

2q37.3

Type of geneprotein-codingprotein-coding
Descriptionchondroitin sulfate N-acetylgalactosaminyltransferase 2beta 4 GalNAcT-2chondroitin beta1,4 N-acetylgalactosaminyltransferase 2glucuronylgalactosylproteoglycan 4-beta-N-acetylgalactosaminyltransferase 2atypical chemokine receptor 3C-X-C chemokine receptor type 7G protein-coupled receptorG-protein coupled receptor 159G-protein coupled receptor RDC1 homologchemokine (C-X-C motif) receptor 7chemokine orphan receptor 1
Modification date2018052220180523
UniProtAcc

Q8N6G5

P25106

Ensembl transtripts involved in fusion geneENST00000374464, ENST00000374466, 
ENST00000272928, 
Fusion gene scores* DoF score5 X 4 X 3=603 X 3 X 2=18
# samples 53
** MAII scorelog2(5/60*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: CSGALNACT2 [Title/Abstract] AND ACKR3 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneCSGALNACT2

GO:0030166

proteoglycan biosynthetic process

11788602

HgeneCSGALNACT2

GO:0050650

chondroitin sulfate proteoglycan biosynthetic process

11788602

HgeneCSGALNACT2

GO:0050651

dermatan sulfate proteoglycan biosynthetic process

11788602


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1DA381927CSGALNACT2chr10

43654362

+ACKR3chr2

237478468

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000374464ENST00000272928CSGALNACT2chr10

43654362

+ACKR3chr2

237478468

+
5CDS-5UTRENST00000374466ENST00000272928CSGALNACT2chr10

43654362

+ACKR3chr2

237478468

+

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FusionProtFeatures for CSGALNACT2_ACKR3


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CSGALNACT2

Q8N6G5

ACKR3

P25106

Transfers 1,4-N-acetylgalactosamine (GalNAc) from UDP-GalNAc to the non-reducing end of glucuronic acid (GlcUA).Required for addition of the first GalNAc to the coretetrasaccharide linker and for elongation of chondroitin chains.{ECO:0000269|PubMed:12433924, ECO:0000269|PubMed:12446672}. Atypical chemokine receptor that controls chemokinelevels and localization via high-affinity chemokine binding thatis uncoupled from classic ligand-driven signal transductioncascades, resulting instead in chemokine sequestration,degradation, or transcytosis. Also known as interceptor(internalizing receptor) or chemokine-scavenging receptor orchemokine decoy receptor. Acts as a receptor for chemokines CXCL11and CXCL12/SDF1. Chemokine binding does not activate G-protein-mediated signal transduction but instead induces beta-arrestinrecruitment, leading to ligand internalization and activation ofMAPK signaling pathway. Required for regulation of CXCR4 proteinlevels in migrating interneurons, thereby adapting their chemokineresponsiveness. In glioma cells, transduces signals via MEK/ERKpathway, mediating resistance to apoptosis. Promotes cell growthand survival. Not involved in cell migration, adhesion orproliferation of normal hematopoietic progenitors but activated byCXCL11 in malignant hemapoietic cells, leading to phosphorylationof ERK1/2 (MAPK3/MAPK1) and enhanced cell adhesion and migration.Plays a regulatory role in CXCR4-mediated activation of cellsurface integrins by CXCL12. Required for heart valve development.Acts as coreceptor with CXCR4 for a restricted number of HIVisolates. {ECO:0000269|PubMed:16107333,ECO:0000269|PubMed:16940167, ECO:0000269|PubMed:17804806,ECO:0000269|PubMed:18653785, ECO:0000269|PubMed:19255243,ECO:0000269|PubMed:19380869, ECO:0000269|PubMed:19641136,ECO:0000269|PubMed:20018651, ECO:0000269|PubMed:20161793,ECO:0000269|PubMed:20388803, ECO:0000269|PubMed:20887389,ECO:0000269|PubMed:22300987}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for CSGALNACT2_ACKR3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for CSGALNACT2_ACKR3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for CSGALNACT2_ACKR3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for CSGALNACT2_ACKR3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneACKR3C0003873Rheumatoid Arthritis1CTD_human
TgeneACKR3C0009404Colorectal Neoplasms1CTD_human
TgeneACKR3C0022658Kidney Diseases1CTD_human
TgeneACKR3C0023893Liver Cirrhosis, Experimental1CTD_human
TgeneACKR3C0027627Neoplasm Metastasis1CTD_human