	FusionGeneSummary
	FusionProtFeature
	FusionGeneSequence
	FusionGenePPI
	RelatedDrugs
	RelatedDiseases

Fusion gene ID: 8573

FusionGeneSummary for CSDE1_CLASP1

Fusion gene summary

Fusion gene information	Fusion gene name: CSDE1_CLASP1
	Fusion gene ID: 8573
		Hgene	Tgene
	Gene symbol	CSDE1	CLASP1
	Gene ID	7812	23332
	Gene name	cold shock domain containing E1	cytoplasmic linker associated protein 1
	Synonyms	D1S155E\|UNR	MAST1
	Cytomap	1p13.2	2q14.2-q14.3
	Type of gene	protein-coding	protein-coding
	Description	cold shock domain-containing protein E1N-ras upstream gene proteinNRAS-relatedcold shock domain containing E1, RNA bindingupstream of NRAS	CLIP-associating protein 1multiple asters 1multiple asters homolog 1protein Orbit homolog 1
	Modification date	20180519	20180522
	UniProtAcc	O75534	Q7Z460
	Ensembl transtripts involved in fusion gene	ENST00000339438, ENST00000438362, ENST00000358528, ENST00000261443, ENST00000530886, ENST00000369530, ENST00000483407, ENST00000534699,	ENST00000409078, ENST00000541859, ENST00000541377, ENST00000455322, ENST00000397587, ENST00000263710, ENST00000545861, ENST00000430234,
Fusion gene scores	* DoF score	8 X 7 X 6=336	5 X 5 X 3=75
	# samples	9	6
	** MAII score	log2(9/336*10)=-1.90046432644909 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(6/75*10)=-0.321928094887362 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: CSDE1 [Title/Abstract] AND CLASP1 [Title/Abstract] AND fusion [Title/Abstract]
Functional or gene categories assigned by FusionGDB annotation

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	CLASP1	GO:0051294	establishment of spindle orientation	21822276
Tgene	CLASP1	GO:0051301	cell division	21822276

Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Data type	Source	Cancer type	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChiTaRS3.1			AW995806	CSDE1	chr1	115273251	+	CLASP1	chr2	122357878	+
ChiTaRS3.1			AW995863	CSDE1	chr1	115273251	+	CLASP1	chr2	122357878	+

* LD: Li Ding group's fusion gene list
RV: Roel Verhaak group's fusion gene list
ChiTaRs fusion database

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
intron-intron	ENST00000339438	ENST00000409078	CSDE1	chr1	115273251	+	CLASP1	chr2	122357878	+
intron-intron	ENST00000339438	ENST00000541859	CSDE1	chr1	115273251	+	CLASP1	chr2	122357878	+
intron-intron	ENST00000339438	ENST00000541377	CSDE1	chr1	115273251	+	CLASP1	chr2	122357878	+
intron-intron	ENST00000339438	ENST00000455322	CSDE1	chr1	115273251	+	CLASP1	chr2	122357878	+
intron-intron	ENST00000339438	ENST00000397587	CSDE1	chr1	115273251	+	CLASP1	chr2	122357878	+
intron-intron	ENST00000339438	ENST00000263710	CSDE1	chr1	115273251	+	CLASP1	chr2	122357878	+
intron-intron	ENST00000339438	ENST00000545861	CSDE1	chr1	115273251	+	CLASP1	chr2	122357878	+
intron-intron	ENST00000339438	ENST00000430234	CSDE1	chr1	115273251	+	CLASP1	chr2	122357878	+
intron-intron	ENST00000438362	ENST00000409078	CSDE1	chr1	115273251	+	CLASP1	chr2	122357878	+
intron-intron	ENST00000438362	ENST00000541859	CSDE1	chr1	115273251	+	CLASP1	chr2	122357878	+
intron-intron	ENST00000438362	ENST00000541377	CSDE1	chr1	115273251	+	CLASP1	chr2	122357878	+
intron-intron	ENST00000438362	ENST00000455322	CSDE1	chr1	115273251	+	CLASP1	chr2	122357878	+
intron-intron	ENST00000438362	ENST00000397587	CSDE1	chr1	115273251	+	CLASP1	chr2	122357878	+
intron-intron	ENST00000438362	ENST00000263710	CSDE1	chr1	115273251	+	CLASP1	chr2	122357878	+
intron-intron	ENST00000438362	ENST00000545861	CSDE1	chr1	115273251	+	CLASP1	chr2	122357878	+
intron-intron	ENST00000438362	ENST00000430234	CSDE1	chr1	115273251	+	CLASP1	chr2	122357878	+
intron-intron	ENST00000358528	ENST00000409078	CSDE1	chr1	115273251	+	CLASP1	chr2	122357878	+
intron-intron	ENST00000358528	ENST00000541859	CSDE1	chr1	115273251	+	CLASP1	chr2	122357878	+
intron-intron	ENST00000358528	ENST00000541377	CSDE1	chr1	115273251	+	CLASP1	chr2	122357878	+
intron-intron	ENST00000358528	ENST00000455322	CSDE1	chr1	115273251	+	CLASP1	chr2	122357878	+
intron-intron	ENST00000358528	ENST00000397587	CSDE1	chr1	115273251	+	CLASP1	chr2	122357878	+
intron-intron	ENST00000358528	ENST00000263710	CSDE1	chr1	115273251	+	CLASP1	chr2	122357878	+
intron-intron	ENST00000358528	ENST00000545861	CSDE1	chr1	115273251	+	CLASP1	chr2	122357878	+
intron-intron	ENST00000358528	ENST00000430234	CSDE1	chr1	115273251	+	CLASP1	chr2	122357878	+
intron-intron	ENST00000261443	ENST00000409078	CSDE1	chr1	115273251	+	CLASP1	chr2	122357878	+
intron-intron	ENST00000261443	ENST00000541859	CSDE1	chr1	115273251	+	CLASP1	chr2	122357878	+
intron-intron	ENST00000261443	ENST00000541377	CSDE1	chr1	115273251	+	CLASP1	chr2	122357878	+
intron-intron	ENST00000261443	ENST00000455322	CSDE1	chr1	115273251	+	CLASP1	chr2	122357878	+
intron-intron	ENST00000261443	ENST00000397587	CSDE1	chr1	115273251	+	CLASP1	chr2	122357878	+
intron-intron	ENST00000261443	ENST00000263710	CSDE1	chr1	115273251	+	CLASP1	chr2	122357878	+
intron-intron	ENST00000261443	ENST00000545861	CSDE1	chr1	115273251	+	CLASP1	chr2	122357878	+
intron-intron	ENST00000261443	ENST00000430234	CSDE1	chr1	115273251	+	CLASP1	chr2	122357878	+
intron-intron	ENST00000530886	ENST00000409078	CSDE1	chr1	115273251	+	CLASP1	chr2	122357878	+
intron-intron	ENST00000530886	ENST00000541859	CSDE1	chr1	115273251	+	CLASP1	chr2	122357878	+
intron-intron	ENST00000530886	ENST00000541377	CSDE1	chr1	115273251	+	CLASP1	chr2	122357878	+
intron-intron	ENST00000530886	ENST00000455322	CSDE1	chr1	115273251	+	CLASP1	chr2	122357878	+
intron-intron	ENST00000530886	ENST00000397587	CSDE1	chr1	115273251	+	CLASP1	chr2	122357878	+
intron-intron	ENST00000530886	ENST00000263710	CSDE1	chr1	115273251	+	CLASP1	chr2	122357878	+
intron-intron	ENST00000530886	ENST00000545861	CSDE1	chr1	115273251	+	CLASP1	chr2	122357878	+
intron-intron	ENST00000530886	ENST00000430234	CSDE1	chr1	115273251	+	CLASP1	chr2	122357878	+
intron-intron	ENST00000369530	ENST00000409078	CSDE1	chr1	115273251	+	CLASP1	chr2	122357878	+
intron-intron	ENST00000369530	ENST00000541859	CSDE1	chr1	115273251	+	CLASP1	chr2	122357878	+
intron-intron	ENST00000369530	ENST00000541377	CSDE1	chr1	115273251	+	CLASP1	chr2	122357878	+
intron-intron	ENST00000369530	ENST00000455322	CSDE1	chr1	115273251	+	CLASP1	chr2	122357878	+
intron-intron	ENST00000369530	ENST00000397587	CSDE1	chr1	115273251	+	CLASP1	chr2	122357878	+
intron-intron	ENST00000369530	ENST00000263710	CSDE1	chr1	115273251	+	CLASP1	chr2	122357878	+
intron-intron	ENST00000369530	ENST00000545861	CSDE1	chr1	115273251	+	CLASP1	chr2	122357878	+
intron-intron	ENST00000369530	ENST00000430234	CSDE1	chr1	115273251	+	CLASP1	chr2	122357878	+
intron-intron	ENST00000483407	ENST00000409078	CSDE1	chr1	115273251	+	CLASP1	chr2	122357878	+
intron-intron	ENST00000483407	ENST00000541859	CSDE1	chr1	115273251	+	CLASP1	chr2	122357878	+
intron-intron	ENST00000483407	ENST00000541377	CSDE1	chr1	115273251	+	CLASP1	chr2	122357878	+
intron-intron	ENST00000483407	ENST00000455322	CSDE1	chr1	115273251	+	CLASP1	chr2	122357878	+
intron-intron	ENST00000483407	ENST00000397587	CSDE1	chr1	115273251	+	CLASP1	chr2	122357878	+
intron-intron	ENST00000483407	ENST00000263710	CSDE1	chr1	115273251	+	CLASP1	chr2	122357878	+
intron-intron	ENST00000483407	ENST00000545861	CSDE1	chr1	115273251	+	CLASP1	chr2	122357878	+
intron-intron	ENST00000483407	ENST00000430234	CSDE1	chr1	115273251	+	CLASP1	chr2	122357878	+
intron-intron	ENST00000534699	ENST00000409078	CSDE1	chr1	115273251	+	CLASP1	chr2	122357878	+
intron-intron	ENST00000534699	ENST00000541859	CSDE1	chr1	115273251	+	CLASP1	chr2	122357878	+
intron-intron	ENST00000534699	ENST00000541377	CSDE1	chr1	115273251	+	CLASP1	chr2	122357878	+
intron-intron	ENST00000534699	ENST00000455322	CSDE1	chr1	115273251	+	CLASP1	chr2	122357878	+
intron-intron	ENST00000534699	ENST00000397587	CSDE1	chr1	115273251	+	CLASP1	chr2	122357878	+
intron-intron	ENST00000534699	ENST00000263710	CSDE1	chr1	115273251	+	CLASP1	chr2	122357878	+
intron-intron	ENST00000534699	ENST00000545861	CSDE1	chr1	115273251	+	CLASP1	chr2	122357878	+
intron-intron	ENST00000534699	ENST00000430234	CSDE1	chr1	115273251	+	CLASP1	chr2	122357878	+

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FusionProtFeatures for CSDE1_CLASP1

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
CSDE1 O75534	CLASP1 Q7Z460

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
.

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

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FusionGeneSequence for CSDE1_CLASP1

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for CSDE1_CLASP1

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page
.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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RelatedDrugs for CSDE1_CLASP1

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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RelatedDiseases for CSDE1_CLASP1

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source

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Fusion gene ID: 8573

FusionGeneSummary for CSDE1_CLASP1

FusionProtFeatures for CSDE1_CLASP1

FusionGeneSequence for CSDE1_CLASP1

FusionGenePPI for CSDE1_CLASP1

RelatedDrugs for CSDE1_CLASP1

RelatedDiseases for CSDE1_CLASP1