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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 8565

FusionGeneSummary for CRYZ_VPS13D

check button Fusion gene summary
Fusion gene informationFusion gene name: CRYZ_VPS13D
Fusion gene ID: 8565
HgeneTgene
Gene symbol

CRYZ

VPS13D

Gene ID

1429

55187

Gene namecrystallin zetavacuolar protein sorting 13 homolog D
Synonyms--
Cytomap

1p31.1

1p36.22-p36.21

Type of geneprotein-codingprotein-coding
Descriptionquinone oxidoreductaseNADPH:quinone reductasecrystallin, zeta (quinone reductase)vacuolar protein sorting-associated protein 13Dvacuolar protein sorting 13D
Modification date2018052320180525
UniProtAcc

Q08257

Q5THJ4

Ensembl transtripts involved in fusion geneENST00000370872, ENST00000340866, 
ENST00000492102, ENST00000417775, 
ENST00000370871, 		ENST00000358136, 
ENST00000356315, ENST00000496628, 
ENST00000543766, ENST00000471923, 
ENST00000543710, 
Fusion gene scores* DoF score1 X 1 X 1=17 X 8 X 4=224
# samples 19
** MAII scorelog2(1/1*10)=3.32192809488736log2(9/224*10)=-1.31550182572793
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CRYZ [Title/Abstract] AND VPS13D [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneCRYZ

GO:0042178

xenobiotic catabolic process

17497241


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDOVTCGA-61-2095-01ACRYZchr1

75184893

-VPS13Dchr1

12475140

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000370872ENST00000358136CRYZchr1

75184893

-VPS13Dchr1

12475140

+
intron-3CDSENST00000370872ENST00000356315CRYZchr1

75184893

-VPS13Dchr1

12475140

+
intron-3UTRENST00000370872ENST00000496628CRYZchr1

75184893

-VPS13Dchr1

12475140

+
intron-3UTRENST00000370872ENST00000543766CRYZchr1

75184893

-VPS13Dchr1

12475140

+
intron-intronENST00000370872ENST00000471923CRYZchr1

75184893

-VPS13Dchr1

12475140

+
intron-intronENST00000370872ENST00000543710CRYZchr1

75184893

-VPS13Dchr1

12475140

+
Frame-shiftENST00000340866ENST00000358136CRYZchr1

75184893

-VPS13Dchr1

12475140

+
Frame-shiftENST00000340866ENST00000356315CRYZchr1

75184893

-VPS13Dchr1

12475140

+
5CDS-3UTRENST00000340866ENST00000496628CRYZchr1

75184893

-VPS13Dchr1

12475140

+
5CDS-3UTRENST00000340866ENST00000543766CRYZchr1

75184893

-VPS13Dchr1

12475140

+
5CDS-intronENST00000340866ENST00000471923CRYZchr1

75184893

-VPS13Dchr1

12475140

+
5CDS-intronENST00000340866ENST00000543710CRYZchr1

75184893

-VPS13Dchr1

12475140

+
intron-3CDSENST00000492102ENST00000358136CRYZchr1

75184893

-VPS13Dchr1

12475140

+
intron-3CDSENST00000492102ENST00000356315CRYZchr1

75184893

-VPS13Dchr1

12475140

+
intron-3UTRENST00000492102ENST00000496628CRYZchr1

75184893

-VPS13Dchr1

12475140

+
intron-3UTRENST00000492102ENST00000543766CRYZchr1

75184893

-VPS13Dchr1

12475140

+
intron-intronENST00000492102ENST00000471923CRYZchr1

75184893

-VPS13Dchr1

12475140

+
intron-intronENST00000492102ENST00000543710CRYZchr1

75184893

-VPS13Dchr1

12475140

+
Frame-shiftENST00000417775ENST00000358136CRYZchr1

75184893

-VPS13Dchr1

12475140

+
Frame-shiftENST00000417775ENST00000356315CRYZchr1

75184893

-VPS13Dchr1

12475140

+
5CDS-3UTRENST00000417775ENST00000496628CRYZchr1

75184893

-VPS13Dchr1

12475140

+
5CDS-3UTRENST00000417775ENST00000543766CRYZchr1

75184893

-VPS13Dchr1

12475140

+
5CDS-intronENST00000417775ENST00000471923CRYZchr1

75184893

-VPS13Dchr1

12475140

+
5CDS-intronENST00000417775ENST00000543710CRYZchr1

75184893

-VPS13Dchr1

12475140

+
Frame-shiftENST00000370871ENST00000358136CRYZchr1

75184893

-VPS13Dchr1

12475140

+
Frame-shiftENST00000370871ENST00000356315CRYZchr1

75184893

-VPS13Dchr1

12475140

+
5CDS-3UTRENST00000370871ENST00000496628CRYZchr1

75184893

-VPS13Dchr1

12475140

+
5CDS-3UTRENST00000370871ENST00000543766CRYZchr1

75184893

-VPS13Dchr1

12475140

+
5CDS-intronENST00000370871ENST00000471923CRYZchr1

75184893

-VPS13Dchr1

12475140

+
5CDS-intronENST00000370871ENST00000543710CRYZchr1

75184893

-VPS13Dchr1

12475140

+

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FusionProtFeatures for CRYZ_VPS13D


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CRYZ

Q08257

VPS13D

Q5THJ4

Does not have alcohol dehydrogenase activity. Binds NADPand acts through a one-electron transfer process. Orthoquinones,such as 1,2-naphthoquinone or 9,10-phenanthrenequinone, are thebest substrates (in vitro). May act in the detoxification ofxenobiotics. Interacts with (AU)-rich elements (ARE) in the 3'-UTRof target mRNA species. Enhances the stability of mRNA coding forBCL2. NADPH binding interferes with mRNA binding.{ECO:0000269|PubMed:17497241, ECO:0000269|PubMed:20103721}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for CRYZ_VPS13D


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for CRYZ_VPS13D


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
CRYZBASP1, IGF2BP3, KRT17, PFKP, SPTAN1, GAPDH, TUBA4A, TUBB, TXNRD1, CAB39, FKBP2, FSCN1, YKT6, DCXR, LGALS3, NNMT, SMAP2, CSNK2A2, ZNF526, ASPM, TRIP13, SOD1VPS13DMADD, ESR1, PPP2R1A, PSMC1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for CRYZ_VPS13D


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneCRYZQ08257DB00266DicoumarolQuinone oxidoreductasesmall moleculeapproved

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RelatedDiseases for CRYZ_VPS13D


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneCRYZC0036341Schizophrenia3PSYGENET
HgeneCRYZC0041696Unipolar Depression1PSYGENET
HgeneCRYZC0525045Mood Disorders1PSYGENET
HgeneCRYZC1269683Major Depressive Disorder1PSYGENET
TgeneVPS13DC0043094Weight Gain1CTD_human