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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 8544

FusionGeneSummary for CRYAB_UNKL

check button Fusion gene summary
Fusion gene informationFusion gene name: CRYAB_UNKL
Fusion gene ID: 8544
HgeneTgene
Gene symbol

CRYAB

UNKL

Gene ID

1410

64718

Gene namecrystallin alpha Bunkempt family like zinc finger
SynonymsCMD1II|CRYA2|CTPP2|CTRCT16|HEL-S-101|HSPB5|MFM2C16orf28|ZC3H5L|ZC3HDC5L
Cytomap

11q23.1

16p13.3

Type of geneprotein-codingprotein-coding
Descriptionalpha-crystallin B chainepididymis secretory protein Li 101heat shock protein beta-5heat-shock 20 kD like-proteinrenal carcinoma antigen NY-REN-27rosenthal fiber componentputative E3 ubiquitin-protein ligase UNKLRING finger protein unkempt-likeunkempt family zinc finger-likeunkempt homolog-likezinc finger CCCH domain-containing protein 5-like
Modification date2018051920180519
UniProtAcc

P02511

Q9H9P5

Ensembl transtripts involved in fusion geneENST00000526180, ENST00000533280, 
ENST00000525823, ENST00000533475, 
ENST00000527950, ENST00000227251, 
ENST00000531198, ENST00000533971, 
ENST00000389221, ENST00000508903, 
ENST00000397462, ENST00000391893, 
ENST00000403703, ENST00000248104, 
ENST00000397464, ENST00000402641, 
ENST00000301712, ENST00000503648, 
Fusion gene scores* DoF score2 X 2 X 1=43 X 3 X 2=18
# samples 23
** MAII scorelog2(2/4*10)=2.32192809488736log2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: CRYAB [Title/Abstract] AND UNKL [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneCRYAB

GO:0032387

negative regulation of intracellular transport

14752512

HgeneCRYAB

GO:0032463

negative regulation of protein homooligomerization

23106396

HgeneCRYAB

GO:0043066

negative regulation of apoptotic process

14752512

HgeneCRYAB

GO:0051260

protein homooligomerization

16303126

HgeneCRYAB

GO:1905907

negative regulation of amyloid fibril formation

23106396


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BI041332CRYABchr11

111782492

+UNKLchr16

1416195

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3UTRENST00000526180ENST00000389221CRYABchr11

111782492

+UNKLchr16

1416195

-
intron-3UTRENST00000526180ENST00000508903CRYABchr11

111782492

+UNKLchr16

1416195

-
intron-intronENST00000526180ENST00000397462CRYABchr11

111782492

+UNKLchr16

1416195

-
intron-3UTRENST00000526180ENST00000391893CRYABchr11

111782492

+UNKLchr16

1416195

-
intron-3UTRENST00000526180ENST00000403703CRYABchr11

111782492

+UNKLchr16

1416195

-
intron-3UTRENST00000526180ENST00000248104CRYABchr11

111782492

+UNKLchr16

1416195

-
intron-3UTRENST00000526180ENST00000397464CRYABchr11

111782492

+UNKLchr16

1416195

-
intron-3UTRENST00000526180ENST00000402641CRYABchr11

111782492

+UNKLchr16

1416195

-
intron-intronENST00000526180ENST00000301712CRYABchr11

111782492

+UNKLchr16

1416195

-
intron-intronENST00000526180ENST00000503648CRYABchr11

111782492

+UNKLchr16

1416195

-
intron-3UTRENST00000533280ENST00000389221CRYABchr11

111782492

+UNKLchr16

1416195

-
intron-3UTRENST00000533280ENST00000508903CRYABchr11

111782492

+UNKLchr16

1416195

-
intron-intronENST00000533280ENST00000397462CRYABchr11

111782492

+UNKLchr16

1416195

-
intron-3UTRENST00000533280ENST00000391893CRYABchr11

111782492

+UNKLchr16

1416195

-
intron-3UTRENST00000533280ENST00000403703CRYABchr11

111782492

+UNKLchr16

1416195

-
intron-3UTRENST00000533280ENST00000248104CRYABchr11

111782492

+UNKLchr16

1416195

-
intron-3UTRENST00000533280ENST00000397464CRYABchr11

111782492

+UNKLchr16

1416195

-
intron-3UTRENST00000533280ENST00000402641CRYABchr11

111782492

+UNKLchr16

1416195

-
intron-intronENST00000533280ENST00000301712CRYABchr11

111782492

+UNKLchr16

1416195

-
intron-intronENST00000533280ENST00000503648CRYABchr11

111782492

+UNKLchr16

1416195

-
intron-3UTRENST00000525823ENST00000389221CRYABchr11

111782492

+UNKLchr16

1416195

-
intron-3UTRENST00000525823ENST00000508903CRYABchr11

111782492

+UNKLchr16

1416195

-
intron-intronENST00000525823ENST00000397462CRYABchr11

111782492

+UNKLchr16

1416195

-
intron-3UTRENST00000525823ENST00000391893CRYABchr11

111782492

+UNKLchr16

1416195

-
intron-3UTRENST00000525823ENST00000403703CRYABchr11

111782492

+UNKLchr16

1416195

-
intron-3UTRENST00000525823ENST00000248104CRYABchr11

111782492

+UNKLchr16

1416195

-
intron-3UTRENST00000525823ENST00000397464CRYABchr11

111782492

+UNKLchr16

1416195

-
intron-3UTRENST00000525823ENST00000402641CRYABchr11

111782492

+UNKLchr16

1416195

-
intron-intronENST00000525823ENST00000301712CRYABchr11

111782492

+UNKLchr16

1416195

-
intron-intronENST00000525823ENST00000503648CRYABchr11

111782492

+UNKLchr16

1416195

-
intron-3UTRENST00000533475ENST00000389221CRYABchr11

111782492

+UNKLchr16

1416195

-
intron-3UTRENST00000533475ENST00000508903CRYABchr11

111782492

+UNKLchr16

1416195

-
intron-intronENST00000533475ENST00000397462CRYABchr11

111782492

+UNKLchr16

1416195

-
intron-3UTRENST00000533475ENST00000391893CRYABchr11

111782492

+UNKLchr16

1416195

-
intron-3UTRENST00000533475ENST00000403703CRYABchr11

111782492

+UNKLchr16

1416195

-
intron-3UTRENST00000533475ENST00000248104CRYABchr11

111782492

+UNKLchr16

1416195

-
intron-3UTRENST00000533475ENST00000397464CRYABchr11

111782492

+UNKLchr16

1416195

-
intron-3UTRENST00000533475ENST00000402641CRYABchr11

111782492

+UNKLchr16

1416195

-
intron-intronENST00000533475ENST00000301712CRYABchr11

111782492

+UNKLchr16

1416195

-
intron-intronENST00000533475ENST00000503648CRYABchr11

111782492

+UNKLchr16

1416195

-
intron-3UTRENST00000527950ENST00000389221CRYABchr11

111782492

+UNKLchr16

1416195

-
intron-3UTRENST00000527950ENST00000508903CRYABchr11

111782492

+UNKLchr16

1416195

-
intron-intronENST00000527950ENST00000397462CRYABchr11

111782492

+UNKLchr16

1416195

-
intron-3UTRENST00000527950ENST00000391893CRYABchr11

111782492

+UNKLchr16

1416195

-
intron-3UTRENST00000527950ENST00000403703CRYABchr11

111782492

+UNKLchr16

1416195

-
intron-3UTRENST00000527950ENST00000248104CRYABchr11

111782492

+UNKLchr16

1416195

-
intron-3UTRENST00000527950ENST00000397464CRYABchr11

111782492

+UNKLchr16

1416195

-
intron-3UTRENST00000527950ENST00000402641CRYABchr11

111782492

+UNKLchr16

1416195

-
intron-intronENST00000527950ENST00000301712CRYABchr11

111782492

+UNKLchr16

1416195

-
intron-intronENST00000527950ENST00000503648CRYABchr11

111782492

+UNKLchr16

1416195

-
intron-3UTRENST00000227251ENST00000389221CRYABchr11

111782492

+UNKLchr16

1416195

-
intron-3UTRENST00000227251ENST00000508903CRYABchr11

111782492

+UNKLchr16

1416195

-
intron-intronENST00000227251ENST00000397462CRYABchr11

111782492

+UNKLchr16

1416195

-
intron-3UTRENST00000227251ENST00000391893CRYABchr11

111782492

+UNKLchr16

1416195

-
intron-3UTRENST00000227251ENST00000403703CRYABchr11

111782492

+UNKLchr16

1416195

-
intron-3UTRENST00000227251ENST00000248104CRYABchr11

111782492

+UNKLchr16

1416195

-
intron-3UTRENST00000227251ENST00000397464CRYABchr11

111782492

+UNKLchr16

1416195

-
intron-3UTRENST00000227251ENST00000402641CRYABchr11

111782492

+UNKLchr16

1416195

-
intron-intronENST00000227251ENST00000301712CRYABchr11

111782492

+UNKLchr16

1416195

-
intron-intronENST00000227251ENST00000503648CRYABchr11

111782492

+UNKLchr16

1416195

-
intron-3UTRENST00000531198ENST00000389221CRYABchr11

111782492

+UNKLchr16

1416195

-
intron-3UTRENST00000531198ENST00000508903CRYABchr11

111782492

+UNKLchr16

1416195

-
intron-intronENST00000531198ENST00000397462CRYABchr11

111782492

+UNKLchr16

1416195

-
intron-3UTRENST00000531198ENST00000391893CRYABchr11

111782492

+UNKLchr16

1416195

-
intron-3UTRENST00000531198ENST00000403703CRYABchr11

111782492

+UNKLchr16

1416195

-
intron-3UTRENST00000531198ENST00000248104CRYABchr11

111782492

+UNKLchr16

1416195

-
intron-3UTRENST00000531198ENST00000397464CRYABchr11

111782492

+UNKLchr16

1416195

-
intron-3UTRENST00000531198ENST00000402641CRYABchr11

111782492

+UNKLchr16

1416195

-
intron-intronENST00000531198ENST00000301712CRYABchr11

111782492

+UNKLchr16

1416195

-
intron-intronENST00000531198ENST00000503648CRYABchr11

111782492

+UNKLchr16

1416195

-
intron-3UTRENST00000533971ENST00000389221CRYABchr11

111782492

+UNKLchr16

1416195

-
intron-3UTRENST00000533971ENST00000508903CRYABchr11

111782492

+UNKLchr16

1416195

-
intron-intronENST00000533971ENST00000397462CRYABchr11

111782492

+UNKLchr16

1416195

-
intron-3UTRENST00000533971ENST00000391893CRYABchr11

111782492

+UNKLchr16

1416195

-
intron-3UTRENST00000533971ENST00000403703CRYABchr11

111782492

+UNKLchr16

1416195

-
intron-3UTRENST00000533971ENST00000248104CRYABchr11

111782492

+UNKLchr16

1416195

-
intron-3UTRENST00000533971ENST00000397464CRYABchr11

111782492

+UNKLchr16

1416195

-
intron-3UTRENST00000533971ENST00000402641CRYABchr11

111782492

+UNKLchr16

1416195

-
intron-intronENST00000533971ENST00000301712CRYABchr11

111782492

+UNKLchr16

1416195

-
intron-intronENST00000533971ENST00000503648CRYABchr11

111782492

+UNKLchr16

1416195

-

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FusionProtFeatures for CRYAB_UNKL


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CRYAB

P02511

UNKL

Q9H9P5

May contribute to the transparency and refractive indexof the lens. Has chaperone-like activity, preventing aggregationof various proteins under a wide range of stress conditions. May participate in a protein complex showing an E3ligase activity regulated by RAC1. Ubiquitination is directedtowards itself and possibly other substrates, such asSMARCD2/BAF60b. Intrinsic E3 ligase activity has not been proven.{ECO:0000269|PubMed:20148946}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for CRYAB_UNKL


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for CRYAB_UNKL


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for CRYAB_UNKL


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for CRYAB_UNKL


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneCRYABC1837317Alpha-B Crystallinopathy3CTD_human;ORPHANET;UNIPROT
HgeneCRYABC3554649CARDIOMYOPATHY, DILATED, 1II2UNIPROT
HgeneCRYABC0007134Renal Cell Carcinoma1CTD_human
HgeneCRYABC0007137Squamous cell carcinoma1CTD_human
HgeneCRYABC0009375Colonic Neoplasms1CTD_human
HgeneCRYABC0014859Esophageal Neoplasms1CTD_human
HgeneCRYABC0023893Liver Cirrhosis, Experimental1CTD_human
HgeneCRYABC0026640Mouth Neoplasms1CTD_human
HgeneCRYABC0033578Prostatic Neoplasms1CTD_human
HgeneCRYABC0040411Tongue Neoplasms1CTD_human
HgeneCRYABC0086543Cataract1CTD_human;HPO
HgeneCRYABC0524851Neurodegenerative Disorders1CTD_human