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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionGeneSequence

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Fusion gene ID: 8526

FusionGeneSummary for CRTC1_HNRNPM

check button Fusion gene summary
Fusion gene informationFusion gene name: CRTC1_HNRNPM
Fusion gene ID: 8526
HgeneTgene
Gene symbol

CRTC1

HNRNPM

Gene ID

23373

4670

Gene nameCREB regulated transcription coactivator 1heterogeneous nuclear ribonucleoprotein M
SynonymsMECT1|TORC-1|TORC1|WAMTP1CEAR|HNRNPM4|HNRPM|HNRPM4|HTGR1|NAGR1|hnRNP M
Cytomap

19p13.11

19p13.2

Type of geneprotein-codingprotein-coding
DescriptionCREB-regulated transcription coactivator 1mucoepidermoid carcinoma translocated protein 1transducer of regulated cAMP response element-binding protein (CREB) 1heterogeneous nuclear ribonucleoprotein MCEA receptorN-acetylglucosamine receptor 1heterogenous nuclear ribonucleoprotein M4hnRNA-binding protein M4
Modification date2018052320180523
UniProtAcc

Q6UUV9

P52272

Ensembl transtripts involved in fusion geneENST00000321949, ENST00000338797, 
ENST00000594658, ENST00000601916, 
ENST00000348943, ENST00000325495, 
ENST00000602219, 
Fusion gene scores* DoF score7 X 4 X 4=11212 X 13 X 4=624
# samples 914
** MAII scorelog2(9/112*10)=-0.315501825727929
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(14/624*10)=-2.15611920191728
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CRTC1 [Title/Abstract] AND HNRNPM [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotationOncogene involved fusion gene, in-frame and retained their domain.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneCRTC1

GO:0045944

positive regulation of transcription by RNA polymerase II

14536081


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDGBMTCGA-19-A6J5-01ACRTC1chr19

18860685

+HNRNPMchr19

8548042

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000321949ENST00000348943CRTC1chr19

18860685

+HNRNPMchr19

8548042

+
In-frameENST00000321949ENST00000325495CRTC1chr19

18860685

+HNRNPMchr19

8548042

+
5CDS-intronENST00000321949ENST00000602219CRTC1chr19

18860685

+HNRNPMchr19

8548042

+
In-frameENST00000338797ENST00000348943CRTC1chr19

18860685

+HNRNPMchr19

8548042

+
In-frameENST00000338797ENST00000325495CRTC1chr19

18860685

+HNRNPMchr19

8548042

+
5CDS-intronENST00000338797ENST00000602219CRTC1chr19

18860685

+HNRNPMchr19

8548042

+
In-frameENST00000594658ENST00000348943CRTC1chr19

18860685

+HNRNPMchr19

8548042

+
In-frameENST00000594658ENST00000325495CRTC1chr19

18860685

+HNRNPMchr19

8548042

+
5CDS-intronENST00000594658ENST00000602219CRTC1chr19

18860685

+HNRNPMchr19

8548042

+
In-frameENST00000601916ENST00000348943CRTC1chr19

18860685

+HNRNPMchr19

8548042

+
In-frameENST00000601916ENST00000325495CRTC1chr19

18860685

+HNRNPMchr19

8548042

+
5CDS-intronENST00000601916ENST00000602219CRTC1chr19

18860685

+HNRNPMchr19

8548042

+

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FusionProtFeatures for CRTC1_HNRNPM


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CRTC1

Q6UUV9

HNRNPM

P52272

Pre-mRNA binding protein in vivo, binds avidly topoly(G) and poly(U) RNA homopolymers in vitro. Involved insplicing. Acts as a receptor for carcinoembryonic antigen inKupffer cells, may initiate a series of signaling events leadingto tyrosine phosphorylation of proteins and induction of IL-1alpha, IL-6, IL-10 and tumor necrosis factor alpha cytokines.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneHNRNPMchr19:18860685chr19:8548042ENST00000325495+1116390_396373731Compositional biasNote=Poly-Gly
TgeneHNRNPMchr19:18860685chr19:8548042ENST00000325495+1116612_616373731Compositional biasNote=Poly-Gly
TgeneHNRNPMchr19:18860685chr19:8548042ENST00000348943+1217390_396334692Compositional biasNote=Poly-Gly
TgeneHNRNPMchr19:18860685chr19:8548042ENST00000348943+1217612_616334692Compositional biasNote=Poly-Gly
TgeneHNRNPMchr19:18860685chr19:8548042ENST00000325495+1116653_729373731DomainRRM 3
TgeneHNRNPMchr19:18860685chr19:8548042ENST00000348943+1217653_729334692DomainRRM 3
TgeneHNRNPMchr19:18860685chr19:8548042ENST00000325495+1116400_608373731RegionNote=27 X 6 AA repeats of [GEVSTPAN]-[ILMV]-[DE]-[RH]-[MLVI]-[GAV]
TgeneHNRNPMchr19:18860685chr19:8548042ENST00000348943+1217400_608334692RegionNote=27 X 6 AA repeats of [GEVSTPAN]-[ILMV]-[DE]-[RH]-[MLVI]-[GAV]
TgeneHNRNPMchr19:18860685chr19:8548042ENST00000325495+1116400_405373731RepeatNote=1
TgeneHNRNPMchr19:18860685chr19:8548042ENST00000325495+1116407_412373731RepeatNote=2
TgeneHNRNPMchr19:18860685chr19:8548042ENST00000325495+1116415_420373731RepeatNote=3
TgeneHNRNPMchr19:18860685chr19:8548042ENST00000325495+1116426_431373731RepeatNote=4
TgeneHNRNPMchr19:18860685chr19:8548042ENST00000325495+1116433_438373731RepeatNote=5
TgeneHNRNPMchr19:18860685chr19:8548042ENST00000325495+1116440_445373731RepeatNote=6
TgeneHNRNPMchr19:18860685chr19:8548042ENST00000325495+1116446_451373731RepeatNote=7
TgeneHNRNPMchr19:18860685chr19:8548042ENST00000325495+1116453_458373731RepeatNote=8
TgeneHNRNPMchr19:18860685chr19:8548042ENST00000325495+1116461_466373731RepeatNote=9
TgeneHNRNPMchr19:18860685chr19:8548042ENST00000325495+1116468_473373731RepeatNote=10
TgeneHNRNPMchr19:18860685chr19:8548042ENST00000325495+1116475_480373731RepeatNote=11
TgeneHNRNPMchr19:18860685chr19:8548042ENST00000325495+1116482_487373731RepeatNote=12
TgeneHNRNPMchr19:18860685chr19:8548042ENST00000325495+1116493_498373731RepeatNote=13
TgeneHNRNPMchr19:18860685chr19:8548042ENST00000325495+1116500_505373731RepeatNote=14
TgeneHNRNPMchr19:18860685chr19:8548042ENST00000325495+1116507_512373731RepeatNote=15
TgeneHNRNPMchr19:18860685chr19:8548042ENST00000325495+1116514_519373731RepeatNote=16
TgeneHNRNPMchr19:18860685chr19:8548042ENST00000325495+1116521_526373731RepeatNote=17
TgeneHNRNPMchr19:18860685chr19:8548042ENST00000325495+1116528_533373731RepeatNote=18
TgeneHNRNPMchr19:18860685chr19:8548042ENST00000325495+1116540_545373731RepeatNote=19
TgeneHNRNPMchr19:18860685chr19:8548042ENST00000325495+1116547_552373731RepeatNote=20
TgeneHNRNPMchr19:18860685chr19:8548042ENST00000325495+1116554_559373731RepeatNote=21
TgeneHNRNPMchr19:18860685chr19:8548042ENST00000325495+1116562_566373731RepeatNote=22
TgeneHNRNPMchr19:18860685chr19:8548042ENST00000325495+1116567_572373731RepeatNote=23
TgeneHNRNPMchr19:18860685chr19:8548042ENST00000325495+1116575_579373731RepeatNote=24
TgeneHNRNPMchr19:18860685chr19:8548042ENST00000325495+1116580_585373731RepeatNote=25
TgeneHNRNPMchr19:18860685chr19:8548042ENST00000325495+1116588_593373731RepeatNote=26
TgeneHNRNPMchr19:18860685chr19:8548042ENST00000325495+1116603_608373731RepeatNote=27
TgeneHNRNPMchr19:18860685chr19:8548042ENST00000348943+1217400_405334692RepeatNote=1
TgeneHNRNPMchr19:18860685chr19:8548042ENST00000348943+1217407_412334692RepeatNote=2
TgeneHNRNPMchr19:18860685chr19:8548042ENST00000348943+1217415_420334692RepeatNote=3
TgeneHNRNPMchr19:18860685chr19:8548042ENST00000348943+1217426_431334692RepeatNote=4
TgeneHNRNPMchr19:18860685chr19:8548042ENST00000348943+1217433_438334692RepeatNote=5
TgeneHNRNPMchr19:18860685chr19:8548042ENST00000348943+1217440_445334692RepeatNote=6
TgeneHNRNPMchr19:18860685chr19:8548042ENST00000348943+1217446_451334692RepeatNote=7
TgeneHNRNPMchr19:18860685chr19:8548042ENST00000348943+1217453_458334692RepeatNote=8
TgeneHNRNPMchr19:18860685chr19:8548042ENST00000348943+1217461_466334692RepeatNote=9
TgeneHNRNPMchr19:18860685chr19:8548042ENST00000348943+1217468_473334692RepeatNote=10
TgeneHNRNPMchr19:18860685chr19:8548042ENST00000348943+1217475_480334692RepeatNote=11
TgeneHNRNPMchr19:18860685chr19:8548042ENST00000348943+1217482_487334692RepeatNote=12
TgeneHNRNPMchr19:18860685chr19:8548042ENST00000348943+1217493_498334692RepeatNote=13
TgeneHNRNPMchr19:18860685chr19:8548042ENST00000348943+1217500_505334692RepeatNote=14
TgeneHNRNPMchr19:18860685chr19:8548042ENST00000348943+1217507_512334692RepeatNote=15
TgeneHNRNPMchr19:18860685chr19:8548042ENST00000348943+1217514_519334692RepeatNote=16
TgeneHNRNPMchr19:18860685chr19:8548042ENST00000348943+1217521_526334692RepeatNote=17
TgeneHNRNPMchr19:18860685chr19:8548042ENST00000348943+1217528_533334692RepeatNote=18
TgeneHNRNPMchr19:18860685chr19:8548042ENST00000348943+1217540_545334692RepeatNote=19
TgeneHNRNPMchr19:18860685chr19:8548042ENST00000348943+1217547_552334692RepeatNote=20
TgeneHNRNPMchr19:18860685chr19:8548042ENST00000348943+1217554_559334692RepeatNote=21
TgeneHNRNPMchr19:18860685chr19:8548042ENST00000348943+1217562_566334692RepeatNote=22
TgeneHNRNPMchr19:18860685chr19:8548042ENST00000348943+1217567_572334692RepeatNote=23
TgeneHNRNPMchr19:18860685chr19:8548042ENST00000348943+1217575_579334692RepeatNote=24
TgeneHNRNPMchr19:18860685chr19:8548042ENST00000348943+1217580_585334692RepeatNote=25
TgeneHNRNPMchr19:18860685chr19:8548042ENST00000348943+1217588_593334692RepeatNote=26
TgeneHNRNPMchr19:18860685chr19:8548042ENST00000348943+1217603_608334692RepeatNote=27

- In-frame and not-retained protein feature among the 13 regional features.
>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCRTC1chr19:18860685chr19:8548042ENST00000321949+514299_366179635Compositional biasNote=Ser-rich
HgeneCRTC1chr19:18860685chr19:8548042ENST00000338797+615299_366195651Compositional biasNote=Ser-rich
HgeneCRTC1chr19:18860685chr19:8548042ENST00000321949+514242_258179635MotifNuclear export signal
HgeneCRTC1chr19:18860685chr19:8548042ENST00000338797+615242_258195651MotifNuclear export signal
TgeneHNRNPMchr19:18860685chr19:8548042ENST00000325495+1116204_281373731DomainRRM 2
TgeneHNRNPMchr19:18860685chr19:8548042ENST00000325495+111671_149373731DomainRRM 1
TgeneHNRNPMchr19:18860685chr19:8548042ENST00000348943+1217204_281334692DomainRRM 2
TgeneHNRNPMchr19:18860685chr19:8548042ENST00000348943+121771_149334692DomainRRM 1


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FusionGeneSequence for CRTC1_HNRNPM


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_CRTC1_ENST00000321949_chr19_18860685_+_HNRNPM_ENST00000348943_chr19_8548042_+_537aa
MATSNNPRKFSEKIALHNQKQAEETAAFEEVMKDLSLTRAARLQLQKSQYLQLGPSRGQYYGGSLPNVNQIGSGTMDLPFQTPFQSSGLD
TSRTTRHHGLVDRVYRERGRLGSPHRRPLSVDKHGRQADSCPYGTMYLSPPADTSWRRTNSDSALHQSTMTPTQPESFSSGSQDVHQKRE
ILSNALKRGEIIAKQGGGGGGGSVPGIERMGPGIDRLGGAGMERMGAGLGHGMDRVGSEIERMGLVMDRMGSVERMGSGIERMGPLGLDH
MASSIERMGQTMERIGSGVERMGAGMGFGLERMAAPIDRVGQTIERMGSGVERMGPAIERMGLSMERMVPAGMGAGLERMGPVMDRMATG
LERMGANNLERMGLERMGANSLERMGLERMGANSLERMGPAMGPALGAGIERMGLAMGGGGGASFDRAIEMERGNFGGSFAGSFGGAGGH

>In-frame_CRTC1_ENST00000321949_chr19_18860685_+_HNRNPM_ENST00000325495_chr19_8548042_+_537aa
MATSNNPRKFSEKIALHNQKQAEETAAFEEVMKDLSLTRAARLQLQKSQYLQLGPSRGQYYGGSLPNVNQIGSGTMDLPFQTPFQSSGLD
TSRTTRHHGLVDRVYRERGRLGSPHRRPLSVDKHGRQADSCPYGTMYLSPPADTSWRRTNSDSALHQSTMTPTQPESFSSGSQDVHQKRE
ILSNALKRGEIIAKQGGGGGGGSVPGIERMGPGIDRLGGAGMERMGAGLGHGMDRVGSEIERMGLVMDRMGSVERMGSGIERMGPLGLDH
MASSIERMGQTMERIGSGVERMGAGMGFGLERMAAPIDRVGQTIERMGSGVERMGPAIERMGLSMERMVPAGMGAGLERMGPVMDRMATG
LERMGANNLERMGLERMGANSLERMGLERMGANSLERMGPAMGPALGAGIERMGLAMGGGGGASFDRAIEMERGNFGGSFAGSFGGAGGH

>In-frame_CRTC1_ENST00000338797_chr19_18860685_+_HNRNPM_ENST00000348943_chr19_8548042_+_553aa
MATSNNPRKFSEKIALHNQKQAEETAAFEEVMKDLSLTRAARLQLQKSQYLQLGPSRGQYYGGSLPNVNQIGSGTMDLPFQPSGFLGEAL
AAAPVSLTPFQSSGLDTSRTTRHHGLVDRVYRERGRLGSPHRRPLSVDKHGRQADSCPYGTMYLSPPADTSWRRTNSDSALHQSTMTPTQ
PESFSSGSQDVHQKREILSNALKRGEIIAKQGGGGGGGSVPGIERMGPGIDRLGGAGMERMGAGLGHGMDRVGSEIERMGLVMDRMGSVE
RMGSGIERMGPLGLDHMASSIERMGQTMERIGSGVERMGAGMGFGLERMAAPIDRVGQTIERMGSGVERMGPAIERMGLSMERMVPAGMG
AGLERMGPVMDRMATGLERMGANNLERMGLERMGANSLERMGLERMGANSLERMGPAMGPALGAGIERMGLAMGGGGGASFDRAIEMERG
NFGGSFAGSFGGAGGHAPGVARKACQIFVRNLPFDFTWKMLKDKFNECGHVLYADIKMENGKSKGCGVVKFESPEVAERACRMMNGMKLS

>In-frame_CRTC1_ENST00000338797_chr19_18860685_+_HNRNPM_ENST00000325495_chr19_8548042_+_553aa
MATSNNPRKFSEKIALHNQKQAEETAAFEEVMKDLSLTRAARLQLQKSQYLQLGPSRGQYYGGSLPNVNQIGSGTMDLPFQPSGFLGEAL
AAAPVSLTPFQSSGLDTSRTTRHHGLVDRVYRERGRLGSPHRRPLSVDKHGRQADSCPYGTMYLSPPADTSWRRTNSDSALHQSTMTPTQ
PESFSSGSQDVHQKREILSNALKRGEIIAKQGGGGGGGSVPGIERMGPGIDRLGGAGMERMGAGLGHGMDRVGSEIERMGLVMDRMGSVE
RMGSGIERMGPLGLDHMASSIERMGQTMERIGSGVERMGAGMGFGLERMAAPIDRVGQTIERMGSGVERMGPAIERMGLSMERMVPAGMG
AGLERMGPVMDRMATGLERMGANNLERMGLERMGANSLERMGLERMGANSLERMGPAMGPALGAGIERMGLAMGGGGGASFDRAIEMERG
NFGGSFAGSFGGAGGHAPGVARKACQIFVRNLPFDFTWKMLKDKFNECGHVLYADIKMENGKSKGCGVVKFESPEVAERACRMMNGMKLS

>In-frame_CRTC1_ENST00000594658_chr19_18860685_+_HNRNPM_ENST00000348943_chr19_8548042_+_496aa
MLQLQKSQYLQLGPSRGQYYGGSLPNVNQIGSGTMDLPFQTPFQSSGLDTSRTTRHHGLVDRVYRERGRLGSPHRRPLSVDKHGRQADSC
PYGTMYLSPPADTSWRRTNSDSALHQSTMTPTQPESFSSGSQDVHQKREILSNALKRGEIIAKQGGGGGGGSVPGIERMGPGIDRLGGAG
MERMGAGLGHGMDRVGSEIERMGLVMDRMGSVERMGSGIERMGPLGLDHMASSIERMGQTMERIGSGVERMGAGMGFGLERMAAPIDRVG
QTIERMGSGVERMGPAIERMGLSMERMVPAGMGAGLERMGPVMDRMATGLERMGANNLERMGLERMGANSLERMGLERMGANSLERMGPA
MGPALGAGIERMGLAMGGGGGASFDRAIEMERGNFGGSFAGSFGGAGGHAPGVARKACQIFVRNLPFDFTWKMLKDKFNECGHVLYADIK

>In-frame_CRTC1_ENST00000594658_chr19_18860685_+_HNRNPM_ENST00000325495_chr19_8548042_+_496aa
MLQLQKSQYLQLGPSRGQYYGGSLPNVNQIGSGTMDLPFQTPFQSSGLDTSRTTRHHGLVDRVYRERGRLGSPHRRPLSVDKHGRQADSC
PYGTMYLSPPADTSWRRTNSDSALHQSTMTPTQPESFSSGSQDVHQKREILSNALKRGEIIAKQGGGGGGGSVPGIERMGPGIDRLGGAG
MERMGAGLGHGMDRVGSEIERMGLVMDRMGSVERMGSGIERMGPLGLDHMASSIERMGQTMERIGSGVERMGAGMGFGLERMAAPIDRVG
QTIERMGSGVERMGPAIERMGLSMERMVPAGMGAGLERMGPVMDRMATGLERMGANNLERMGLERMGANSLERMGLERMGANSLERMGPA
MGPALGAGIERMGLAMGGGGGASFDRAIEMERGNFGGSFAGSFGGAGGHAPGVARKACQIFVRNLPFDFTWKMLKDKFNECGHVLYADIK

>In-frame_CRTC1_ENST00000601916_chr19_18860685_+_HNRNPM_ENST00000348943_chr19_8548042_+_462aa
MDLPFQTPFQSSGLDTSRTTRHHGLVDRVYRERGRLGSPHRRPLSVDKHGRQADSCPYGTMYLSPPADTSWRRTNSDSALHQSTMTPTQP
ESFSSGSQDVHQKREILSNALKRGEIIAKQGGGGGGGSVPGIERMGPGIDRLGGAGMERMGAGLGHGMDRVGSEIERMGLVMDRMGSVER
MGSGIERMGPLGLDHMASSIERMGQTMERIGSGVERMGAGMGFGLERMAAPIDRVGQTIERMGSGVERMGPAIERMGLSMERMVPAGMGA
GLERMGPVMDRMATGLERMGANNLERMGLERMGANSLERMGLERMGANSLERMGPAMGPALGAGIERMGLAMGGGGGASFDRAIEMERGN
FGGSFAGSFGGAGGHAPGVARKACQIFVRNLPFDFTWKMLKDKFNECGHVLYADIKMENGKSKGCGVVKFESPEVAERACRMMNGMKLSG

>In-frame_CRTC1_ENST00000601916_chr19_18860685_+_HNRNPM_ENST00000325495_chr19_8548042_+_462aa
MDLPFQTPFQSSGLDTSRTTRHHGLVDRVYRERGRLGSPHRRPLSVDKHGRQADSCPYGTMYLSPPADTSWRRTNSDSALHQSTMTPTQP
ESFSSGSQDVHQKREILSNALKRGEIIAKQGGGGGGGSVPGIERMGPGIDRLGGAGMERMGAGLGHGMDRVGSEIERMGLVMDRMGSVER
MGSGIERMGPLGLDHMASSIERMGQTMERIGSGVERMGAGMGFGLERMAAPIDRVGQTIERMGSGVERMGPAIERMGLSMERMVPAGMGA
GLERMGPVMDRMATGLERMGANNLERMGLERMGANSLERMGLERMGANSLERMGPAMGPALGAGIERMGLAMGGGGGASFDRAIEMERGN
FGGSFAGSFGGAGGHAPGVARKACQIFVRNLPFDFTWKMLKDKFNECGHVLYADIKMENGKSKGCGVVKFESPEVAERACRMMNGMKLSG


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_CRTC1_ENST00000321949_chr19_18860685_+_HNRNPM_ENST00000348943_chr19_8548042_+_1611nt
ATGGCGACTTCGAACAATCCGCGGAAATTCAGCGAGAAGATCGCGCTGCACAATCAGAAGCAGGCGGAGGAGACGGCGGCCTTCGAGGAG
GTCATGAAGGACCTGAGCCTGACGCGGGCCGCGCGGCTCCAGCTCCAGAAATCCCAGTACCTGCAACTGGGCCCCAGCCGAGGCCAGTAC
TATGGCGGGTCCCTGCCCAACGTGAACCAGATCGGGAGTGGCACCATGGACCTGCCCTTCCAGACCCCCTTCCAATCCTCGGGCCTGGAC
ACCAGCCGGACCACCCGGCACCATGGGCTGGTGGACAGGGTGTACCGGGAGCGTGGCCGGCTCGGCTCCCCACACCGCCGGCCCCTGTCA
GTGGACAAACACGGACGGCAGGCCGACAGCTGCCCCTATGGCACCATGTACCTCTCACCACCCGCGGACACCAGCTGGAGAAGGACCAAT
TCTGACTCCGCCCTGCACCAGAGCACAATGACGCCCACGCAGCCAGAATCCTTTAGCAGTGGGTCCCAGGACGTGCACCAGAAAAGAGAA
ATCCTAAGTAATGCACTGAAGAGAGGAGAGATCATTGCAAAGCAGGGAGGAGGTGGAGGTGGAGGAAGCGTCCCTGGGATCGAGAGGATG
GGTCCTGGCATTGACCGCCTCGGGGGTGCCGGCATGGAGCGCATGGGCGCGGGCCTGGGCCACGGCATGGATCGCGTGGGCTCCGAGATC
GAGCGCATGGGCCTGGTCATGGACCGCATGGGCTCCGTGGAGCGCATGGGCTCCGGCATTGAGCGCATGGGCCCGCTGGGCCTCGACCAC
ATGGCCTCCAGCATTGAGCGCATGGGCCAGACCATGGAGCGCATTGGCTCTGGCGTGGAGCGCATGGGTGCCGGCATGGGCTTCGGCCTT
GAGCGCATGGCCGCTCCCATCGACCGTGTGGGCCAGACCATTGAGCGCATGGGCTCTGGCGTGGAGCGCATGGGCCCTGCCATCGAGCGC
ATGGGCCTGAGCATGGAGCGCATGGTGCCCGCAGGTATGGGAGCTGGCCTGGAGCGCATGGGCCCCGTGATGGATCGCATGGCCACCGGC
CTGGAGCGCATGGGCGCCAACAATCTGGAGCGGATGGGCCTGGAGCGCATGGGCGCCAACAGCCTCGAGCGCATGGGCCTGGAGCGCATG
GGTGCCAACAGCCTCGAGCGCATGGGCCCTGCCATGGGCCCGGCCCTGGGCGCTGGCATTGAGCGCATGGGCCTGGCCATGGGTGGCGGT
GGCGGTGCCAGCTTTGACCGTGCCATCGAGATGGAGCGTGGCAACTTCGGAGGAAGCTTCGCAGGTTCCTTTGGTGGAGCTGGAGGCCAT
GCTCCTGGGGTGGCCAGGAAGGCCTGCCAGATATTTGTGAGAAATCTGCCATTCGATTTCACATGGAAGATGCTAAAGGACAAATTCAAC
GAGTGCGGCCACGTGCTGTACGCCGACATCAAGATGGAGAATGGGAAGTCCAAGGGGTGTGGCGTGGTTAAGTTCGAGTCGCCAGAGGTG

>In-frame_CRTC1_ENST00000321949_chr19_18860685_+_HNRNPM_ENST00000325495_chr19_8548042_+_1611nt
ATGGCGACTTCGAACAATCCGCGGAAATTCAGCGAGAAGATCGCGCTGCACAATCAGAAGCAGGCGGAGGAGACGGCGGCCTTCGAGGAG
GTCATGAAGGACCTGAGCCTGACGCGGGCCGCGCGGCTCCAGCTCCAGAAATCCCAGTACCTGCAACTGGGCCCCAGCCGAGGCCAGTAC
TATGGCGGGTCCCTGCCCAACGTGAACCAGATCGGGAGTGGCACCATGGACCTGCCCTTCCAGACCCCCTTCCAATCCTCGGGCCTGGAC
ACCAGCCGGACCACCCGGCACCATGGGCTGGTGGACAGGGTGTACCGGGAGCGTGGCCGGCTCGGCTCCCCACACCGCCGGCCCCTGTCA
GTGGACAAACACGGACGGCAGGCCGACAGCTGCCCCTATGGCACCATGTACCTCTCACCACCCGCGGACACCAGCTGGAGAAGGACCAAT
TCTGACTCCGCCCTGCACCAGAGCACAATGACGCCCACGCAGCCAGAATCCTTTAGCAGTGGGTCCCAGGACGTGCACCAGAAAAGAGAA
ATCCTAAGTAATGCACTGAAGAGAGGAGAGATCATTGCAAAGCAGGGAGGAGGTGGAGGTGGAGGAAGCGTCCCTGGGATCGAGAGGATG
GGTCCTGGCATTGACCGCCTCGGGGGTGCCGGCATGGAGCGCATGGGCGCGGGCCTGGGCCACGGCATGGATCGCGTGGGCTCCGAGATC
GAGCGCATGGGCCTGGTCATGGACCGCATGGGCTCCGTGGAGCGCATGGGCTCCGGCATTGAGCGCATGGGCCCGCTGGGCCTCGACCAC
ATGGCCTCCAGCATTGAGCGCATGGGCCAGACCATGGAGCGCATTGGCTCTGGCGTGGAGCGCATGGGTGCCGGCATGGGCTTCGGCCTT
GAGCGCATGGCCGCTCCCATCGACCGTGTGGGCCAGACCATTGAGCGCATGGGCTCTGGCGTGGAGCGCATGGGCCCTGCCATCGAGCGC
ATGGGCCTGAGCATGGAGCGCATGGTGCCCGCAGGTATGGGAGCTGGCCTGGAGCGCATGGGCCCCGTGATGGATCGCATGGCCACCGGC
CTGGAGCGCATGGGCGCCAACAATCTGGAGCGGATGGGCCTGGAGCGCATGGGCGCCAACAGCCTCGAGCGCATGGGCCTGGAGCGCATG
GGTGCCAACAGCCTCGAGCGCATGGGCCCTGCCATGGGCCCGGCCCTGGGCGCTGGCATTGAGCGCATGGGCCTGGCCATGGGTGGCGGT
GGCGGTGCCAGCTTTGACCGTGCCATCGAGATGGAGCGTGGCAACTTCGGAGGAAGCTTCGCAGGTTCCTTTGGTGGAGCTGGAGGCCAT
GCTCCTGGGGTGGCCAGGAAGGCCTGCCAGATATTTGTGAGAAATCTGCCATTCGATTTCACATGGAAGATGCTAAAGGACAAATTCAAC
GAGTGCGGCCACGTGCTGTACGCCGACATCAAGATGGAGAATGGGAAGTCCAAGGGGTGTGGCGTGGTTAAGTTCGAGTCGCCAGAGGTG

>In-frame_CRTC1_ENST00000338797_chr19_18860685_+_HNRNPM_ENST00000348943_chr19_8548042_+_1659nt
ATGGCGACTTCGAACAATCCGCGGAAATTCAGCGAGAAGATCGCGCTGCACAATCAGAAGCAGGCGGAGGAGACGGCGGCCTTCGAGGAG
GTCATGAAGGACCTGAGCCTGACGCGGGCCGCGCGGCTCCAGCTCCAGAAATCCCAGTACCTGCAACTGGGCCCCAGCCGAGGCCAGTAC
TATGGCGGGTCCCTGCCCAACGTGAACCAGATCGGGAGTGGCACCATGGACCTGCCCTTCCAGCCCAGCGGATTTCTGGGGGAGGCCCTG
GCAGCGGCTCCTGTCTCTCTGACCCCCTTCCAATCCTCGGGCCTGGACACCAGCCGGACCACCCGGCACCATGGGCTGGTGGACAGGGTG
TACCGGGAGCGTGGCCGGCTCGGCTCCCCACACCGCCGGCCCCTGTCAGTGGACAAACACGGACGGCAGGCCGACAGCTGCCCCTATGGC
ACCATGTACCTCTCACCACCCGCGGACACCAGCTGGAGAAGGACCAATTCTGACTCCGCCCTGCACCAGAGCACAATGACGCCCACGCAG
CCAGAATCCTTTAGCAGTGGGTCCCAGGACGTGCACCAGAAAAGAGAAATCCTAAGTAATGCACTGAAGAGAGGAGAGATCATTGCAAAG
CAGGGAGGAGGTGGAGGTGGAGGAAGCGTCCCTGGGATCGAGAGGATGGGTCCTGGCATTGACCGCCTCGGGGGTGCCGGCATGGAGCGC
ATGGGCGCGGGCCTGGGCCACGGCATGGATCGCGTGGGCTCCGAGATCGAGCGCATGGGCCTGGTCATGGACCGCATGGGCTCCGTGGAG
CGCATGGGCTCCGGCATTGAGCGCATGGGCCCGCTGGGCCTCGACCACATGGCCTCCAGCATTGAGCGCATGGGCCAGACCATGGAGCGC
ATTGGCTCTGGCGTGGAGCGCATGGGTGCCGGCATGGGCTTCGGCCTTGAGCGCATGGCCGCTCCCATCGACCGTGTGGGCCAGACCATT
GAGCGCATGGGCTCTGGCGTGGAGCGCATGGGCCCTGCCATCGAGCGCATGGGCCTGAGCATGGAGCGCATGGTGCCCGCAGGTATGGGA
GCTGGCCTGGAGCGCATGGGCCCCGTGATGGATCGCATGGCCACCGGCCTGGAGCGCATGGGCGCCAACAATCTGGAGCGGATGGGCCTG
GAGCGCATGGGCGCCAACAGCCTCGAGCGCATGGGCCTGGAGCGCATGGGTGCCAACAGCCTCGAGCGCATGGGCCCTGCCATGGGCCCG
GCCCTGGGCGCTGGCATTGAGCGCATGGGCCTGGCCATGGGTGGCGGTGGCGGTGCCAGCTTTGACCGTGCCATCGAGATGGAGCGTGGC
AACTTCGGAGGAAGCTTCGCAGGTTCCTTTGGTGGAGCTGGAGGCCATGCTCCTGGGGTGGCCAGGAAGGCCTGCCAGATATTTGTGAGA
AATCTGCCATTCGATTTCACATGGAAGATGCTAAAGGACAAATTCAACGAGTGCGGCCACGTGCTGTACGCCGACATCAAGATGGAGAAT
GGGAAGTCCAAGGGGTGTGGCGTGGTTAAGTTCGAGTCGCCAGAGGTGGCCGAGAGAGCCTGCCGGATGATGAATGGCATGAAGCTGAGT

>In-frame_CRTC1_ENST00000338797_chr19_18860685_+_HNRNPM_ENST00000325495_chr19_8548042_+_1659nt
ATGGCGACTTCGAACAATCCGCGGAAATTCAGCGAGAAGATCGCGCTGCACAATCAGAAGCAGGCGGAGGAGACGGCGGCCTTCGAGGAG
GTCATGAAGGACCTGAGCCTGACGCGGGCCGCGCGGCTCCAGCTCCAGAAATCCCAGTACCTGCAACTGGGCCCCAGCCGAGGCCAGTAC
TATGGCGGGTCCCTGCCCAACGTGAACCAGATCGGGAGTGGCACCATGGACCTGCCCTTCCAGCCCAGCGGATTTCTGGGGGAGGCCCTG
GCAGCGGCTCCTGTCTCTCTGACCCCCTTCCAATCCTCGGGCCTGGACACCAGCCGGACCACCCGGCACCATGGGCTGGTGGACAGGGTG
TACCGGGAGCGTGGCCGGCTCGGCTCCCCACACCGCCGGCCCCTGTCAGTGGACAAACACGGACGGCAGGCCGACAGCTGCCCCTATGGC
ACCATGTACCTCTCACCACCCGCGGACACCAGCTGGAGAAGGACCAATTCTGACTCCGCCCTGCACCAGAGCACAATGACGCCCACGCAG
CCAGAATCCTTTAGCAGTGGGTCCCAGGACGTGCACCAGAAAAGAGAAATCCTAAGTAATGCACTGAAGAGAGGAGAGATCATTGCAAAG
CAGGGAGGAGGTGGAGGTGGAGGAAGCGTCCCTGGGATCGAGAGGATGGGTCCTGGCATTGACCGCCTCGGGGGTGCCGGCATGGAGCGC
ATGGGCGCGGGCCTGGGCCACGGCATGGATCGCGTGGGCTCCGAGATCGAGCGCATGGGCCTGGTCATGGACCGCATGGGCTCCGTGGAG
CGCATGGGCTCCGGCATTGAGCGCATGGGCCCGCTGGGCCTCGACCACATGGCCTCCAGCATTGAGCGCATGGGCCAGACCATGGAGCGC
ATTGGCTCTGGCGTGGAGCGCATGGGTGCCGGCATGGGCTTCGGCCTTGAGCGCATGGCCGCTCCCATCGACCGTGTGGGCCAGACCATT
GAGCGCATGGGCTCTGGCGTGGAGCGCATGGGCCCTGCCATCGAGCGCATGGGCCTGAGCATGGAGCGCATGGTGCCCGCAGGTATGGGA
GCTGGCCTGGAGCGCATGGGCCCCGTGATGGATCGCATGGCCACCGGCCTGGAGCGCATGGGCGCCAACAATCTGGAGCGGATGGGCCTG
GAGCGCATGGGCGCCAACAGCCTCGAGCGCATGGGCCTGGAGCGCATGGGTGCCAACAGCCTCGAGCGCATGGGCCCTGCCATGGGCCCG
GCCCTGGGCGCTGGCATTGAGCGCATGGGCCTGGCCATGGGTGGCGGTGGCGGTGCCAGCTTTGACCGTGCCATCGAGATGGAGCGTGGC
AACTTCGGAGGAAGCTTCGCAGGTTCCTTTGGTGGAGCTGGAGGCCATGCTCCTGGGGTGGCCAGGAAGGCCTGCCAGATATTTGTGAGA
AATCTGCCATTCGATTTCACATGGAAGATGCTAAAGGACAAATTCAACGAGTGCGGCCACGTGCTGTACGCCGACATCAAGATGGAGAAT
GGGAAGTCCAAGGGGTGTGGCGTGGTTAAGTTCGAGTCGCCAGAGGTGGCCGAGAGAGCCTGCCGGATGATGAATGGCATGAAGCTGAGT

>In-frame_CRTC1_ENST00000594658_chr19_18860685_+_HNRNPM_ENST00000348943_chr19_8548042_+_1488nt
ATGCTCCAGCTCCAGAAATCCCAGTACCTGCAACTGGGCCCCAGCCGAGGCCAGTACTATGGCGGGTCCCTGCCCAACGTGAACCAGATC
GGGAGTGGCACCATGGACCTGCCCTTCCAGACCCCCTTCCAATCCTCGGGCCTGGACACCAGCCGGACCACCCGGCACCATGGGCTGGTG
GACAGGGTGTACCGGGAGCGTGGCCGGCTCGGCTCCCCACACCGCCGGCCCCTGTCAGTGGACAAACACGGACGGCAGGCCGACAGCTGC
CCCTATGGCACCATGTACCTCTCACCACCCGCGGACACCAGCTGGAGAAGGACCAATTCTGACTCCGCCCTGCACCAGAGCACAATGACG
CCCACGCAGCCAGAATCCTTTAGCAGTGGGTCCCAGGACGTGCACCAGAAAAGAGAAATCCTAAGTAATGCACTGAAGAGAGGAGAGATC
ATTGCAAAGCAGGGAGGAGGTGGAGGTGGAGGAAGCGTCCCTGGGATCGAGAGGATGGGTCCTGGCATTGACCGCCTCGGGGGTGCCGGC
ATGGAGCGCATGGGCGCGGGCCTGGGCCACGGCATGGATCGCGTGGGCTCCGAGATCGAGCGCATGGGCCTGGTCATGGACCGCATGGGC
TCCGTGGAGCGCATGGGCTCCGGCATTGAGCGCATGGGCCCGCTGGGCCTCGACCACATGGCCTCCAGCATTGAGCGCATGGGCCAGACC
ATGGAGCGCATTGGCTCTGGCGTGGAGCGCATGGGTGCCGGCATGGGCTTCGGCCTTGAGCGCATGGCCGCTCCCATCGACCGTGTGGGC
CAGACCATTGAGCGCATGGGCTCTGGCGTGGAGCGCATGGGCCCTGCCATCGAGCGCATGGGCCTGAGCATGGAGCGCATGGTGCCCGCA
GGTATGGGAGCTGGCCTGGAGCGCATGGGCCCCGTGATGGATCGCATGGCCACCGGCCTGGAGCGCATGGGCGCCAACAATCTGGAGCGG
ATGGGCCTGGAGCGCATGGGCGCCAACAGCCTCGAGCGCATGGGCCTGGAGCGCATGGGTGCCAACAGCCTCGAGCGCATGGGCCCTGCC
ATGGGCCCGGCCCTGGGCGCTGGCATTGAGCGCATGGGCCTGGCCATGGGTGGCGGTGGCGGTGCCAGCTTTGACCGTGCCATCGAGATG
GAGCGTGGCAACTTCGGAGGAAGCTTCGCAGGTTCCTTTGGTGGAGCTGGAGGCCATGCTCCTGGGGTGGCCAGGAAGGCCTGCCAGATA
TTTGTGAGAAATCTGCCATTCGATTTCACATGGAAGATGCTAAAGGACAAATTCAACGAGTGCGGCCACGTGCTGTACGCCGACATCAAG
ATGGAGAATGGGAAGTCCAAGGGGTGTGGCGTGGTTAAGTTCGAGTCGCCAGAGGTGGCCGAGAGAGCCTGCCGGATGATGAATGGCATG

>In-frame_CRTC1_ENST00000594658_chr19_18860685_+_HNRNPM_ENST00000325495_chr19_8548042_+_1488nt
ATGCTCCAGCTCCAGAAATCCCAGTACCTGCAACTGGGCCCCAGCCGAGGCCAGTACTATGGCGGGTCCCTGCCCAACGTGAACCAGATC
GGGAGTGGCACCATGGACCTGCCCTTCCAGACCCCCTTCCAATCCTCGGGCCTGGACACCAGCCGGACCACCCGGCACCATGGGCTGGTG
GACAGGGTGTACCGGGAGCGTGGCCGGCTCGGCTCCCCACACCGCCGGCCCCTGTCAGTGGACAAACACGGACGGCAGGCCGACAGCTGC
CCCTATGGCACCATGTACCTCTCACCACCCGCGGACACCAGCTGGAGAAGGACCAATTCTGACTCCGCCCTGCACCAGAGCACAATGACG
CCCACGCAGCCAGAATCCTTTAGCAGTGGGTCCCAGGACGTGCACCAGAAAAGAGAAATCCTAAGTAATGCACTGAAGAGAGGAGAGATC
ATTGCAAAGCAGGGAGGAGGTGGAGGTGGAGGAAGCGTCCCTGGGATCGAGAGGATGGGTCCTGGCATTGACCGCCTCGGGGGTGCCGGC
ATGGAGCGCATGGGCGCGGGCCTGGGCCACGGCATGGATCGCGTGGGCTCCGAGATCGAGCGCATGGGCCTGGTCATGGACCGCATGGGC
TCCGTGGAGCGCATGGGCTCCGGCATTGAGCGCATGGGCCCGCTGGGCCTCGACCACATGGCCTCCAGCATTGAGCGCATGGGCCAGACC
ATGGAGCGCATTGGCTCTGGCGTGGAGCGCATGGGTGCCGGCATGGGCTTCGGCCTTGAGCGCATGGCCGCTCCCATCGACCGTGTGGGC
CAGACCATTGAGCGCATGGGCTCTGGCGTGGAGCGCATGGGCCCTGCCATCGAGCGCATGGGCCTGAGCATGGAGCGCATGGTGCCCGCA
GGTATGGGAGCTGGCCTGGAGCGCATGGGCCCCGTGATGGATCGCATGGCCACCGGCCTGGAGCGCATGGGCGCCAACAATCTGGAGCGG
ATGGGCCTGGAGCGCATGGGCGCCAACAGCCTCGAGCGCATGGGCCTGGAGCGCATGGGTGCCAACAGCCTCGAGCGCATGGGCCCTGCC
ATGGGCCCGGCCCTGGGCGCTGGCATTGAGCGCATGGGCCTGGCCATGGGTGGCGGTGGCGGTGCCAGCTTTGACCGTGCCATCGAGATG
GAGCGTGGCAACTTCGGAGGAAGCTTCGCAGGTTCCTTTGGTGGAGCTGGAGGCCATGCTCCTGGGGTGGCCAGGAAGGCCTGCCAGATA
TTTGTGAGAAATCTGCCATTCGATTTCACATGGAAGATGCTAAAGGACAAATTCAACGAGTGCGGCCACGTGCTGTACGCCGACATCAAG
ATGGAGAATGGGAAGTCCAAGGGGTGTGGCGTGGTTAAGTTCGAGTCGCCAGAGGTGGCCGAGAGAGCCTGCCGGATGATGAATGGCATG

>In-frame_CRTC1_ENST00000601916_chr19_18860685_+_HNRNPM_ENST00000348943_chr19_8548042_+_1386nt
ATGGACCTGCCCTTCCAGACCCCCTTCCAATCCTCGGGCCTGGACACCAGCCGGACCACCCGGCACCATGGGCTGGTGGACAGGGTGTAC
CGGGAGCGTGGCCGGCTCGGCTCCCCACACCGCCGGCCCCTGTCAGTGGACAAACACGGACGGCAGGCCGACAGCTGCCCCTATGGCACC
ATGTACCTCTCACCACCCGCGGACACCAGCTGGAGAAGGACCAATTCTGACTCCGCCCTGCACCAGAGCACAATGACGCCCACGCAGCCA
GAATCCTTTAGCAGTGGGTCCCAGGACGTGCACCAGAAAAGAGAAATCCTAAGTAATGCACTGAAGAGAGGAGAGATCATTGCAAAGCAG
GGAGGAGGTGGAGGTGGAGGAAGCGTCCCTGGGATCGAGAGGATGGGTCCTGGCATTGACCGCCTCGGGGGTGCCGGCATGGAGCGCATG
GGCGCGGGCCTGGGCCACGGCATGGATCGCGTGGGCTCCGAGATCGAGCGCATGGGCCTGGTCATGGACCGCATGGGCTCCGTGGAGCGC
ATGGGCTCCGGCATTGAGCGCATGGGCCCGCTGGGCCTCGACCACATGGCCTCCAGCATTGAGCGCATGGGCCAGACCATGGAGCGCATT
GGCTCTGGCGTGGAGCGCATGGGTGCCGGCATGGGCTTCGGCCTTGAGCGCATGGCCGCTCCCATCGACCGTGTGGGCCAGACCATTGAG
CGCATGGGCTCTGGCGTGGAGCGCATGGGCCCTGCCATCGAGCGCATGGGCCTGAGCATGGAGCGCATGGTGCCCGCAGGTATGGGAGCT
GGCCTGGAGCGCATGGGCCCCGTGATGGATCGCATGGCCACCGGCCTGGAGCGCATGGGCGCCAACAATCTGGAGCGGATGGGCCTGGAG
CGCATGGGCGCCAACAGCCTCGAGCGCATGGGCCTGGAGCGCATGGGTGCCAACAGCCTCGAGCGCATGGGCCCTGCCATGGGCCCGGCC
CTGGGCGCTGGCATTGAGCGCATGGGCCTGGCCATGGGTGGCGGTGGCGGTGCCAGCTTTGACCGTGCCATCGAGATGGAGCGTGGCAAC
TTCGGAGGAAGCTTCGCAGGTTCCTTTGGTGGAGCTGGAGGCCATGCTCCTGGGGTGGCCAGGAAGGCCTGCCAGATATTTGTGAGAAAT
CTGCCATTCGATTTCACATGGAAGATGCTAAAGGACAAATTCAACGAGTGCGGCCACGTGCTGTACGCCGACATCAAGATGGAGAATGGG
AAGTCCAAGGGGTGTGGCGTGGTTAAGTTCGAGTCGCCAGAGGTGGCCGAGAGAGCCTGCCGGATGATGAATGGCATGAAGCTGAGTGGC

>In-frame_CRTC1_ENST00000601916_chr19_18860685_+_HNRNPM_ENST00000325495_chr19_8548042_+_1386nt
ATGGACCTGCCCTTCCAGACCCCCTTCCAATCCTCGGGCCTGGACACCAGCCGGACCACCCGGCACCATGGGCTGGTGGACAGGGTGTAC
CGGGAGCGTGGCCGGCTCGGCTCCCCACACCGCCGGCCCCTGTCAGTGGACAAACACGGACGGCAGGCCGACAGCTGCCCCTATGGCACC
ATGTACCTCTCACCACCCGCGGACACCAGCTGGAGAAGGACCAATTCTGACTCCGCCCTGCACCAGAGCACAATGACGCCCACGCAGCCA
GAATCCTTTAGCAGTGGGTCCCAGGACGTGCACCAGAAAAGAGAAATCCTAAGTAATGCACTGAAGAGAGGAGAGATCATTGCAAAGCAG
GGAGGAGGTGGAGGTGGAGGAAGCGTCCCTGGGATCGAGAGGATGGGTCCTGGCATTGACCGCCTCGGGGGTGCCGGCATGGAGCGCATG
GGCGCGGGCCTGGGCCACGGCATGGATCGCGTGGGCTCCGAGATCGAGCGCATGGGCCTGGTCATGGACCGCATGGGCTCCGTGGAGCGC
ATGGGCTCCGGCATTGAGCGCATGGGCCCGCTGGGCCTCGACCACATGGCCTCCAGCATTGAGCGCATGGGCCAGACCATGGAGCGCATT
GGCTCTGGCGTGGAGCGCATGGGTGCCGGCATGGGCTTCGGCCTTGAGCGCATGGCCGCTCCCATCGACCGTGTGGGCCAGACCATTGAG
CGCATGGGCTCTGGCGTGGAGCGCATGGGCCCTGCCATCGAGCGCATGGGCCTGAGCATGGAGCGCATGGTGCCCGCAGGTATGGGAGCT
GGCCTGGAGCGCATGGGCCCCGTGATGGATCGCATGGCCACCGGCCTGGAGCGCATGGGCGCCAACAATCTGGAGCGGATGGGCCTGGAG
CGCATGGGCGCCAACAGCCTCGAGCGCATGGGCCTGGAGCGCATGGGTGCCAACAGCCTCGAGCGCATGGGCCCTGCCATGGGCCCGGCC
CTGGGCGCTGGCATTGAGCGCATGGGCCTGGCCATGGGTGGCGGTGGCGGTGCCAGCTTTGACCGTGCCATCGAGATGGAGCGTGGCAAC
TTCGGAGGAAGCTTCGCAGGTTCCTTTGGTGGAGCTGGAGGCCATGCTCCTGGGGTGGCCAGGAAGGCCTGCCAGATATTTGTGAGAAAT
CTGCCATTCGATTTCACATGGAAGATGCTAAAGGACAAATTCAACGAGTGCGGCCACGTGCTGTACGCCGACATCAAGATGGAGAATGGG
AAGTCCAAGGGGTGTGGCGTGGTTAAGTTCGAGTCGCCAGAGGTGGCCGAGAGAGCCTGCCGGATGATGAATGGCATGAAGCTGAGTGGC


* Fusion transcript sequences (Full-length transcript).
>In-frame_CRTC1_ENST00000321949_chr19_18860685_+_HNRNPM_ENST00000348943_chr19_8548042_+_1897nt
GAGGAGGAGGAGGTGGCGGCGAGAAGATGGCGACTTCGAACAATCCGCGGAAATTCAGCGAGAAGATCGCGCTGCACAATCAGAAGCAGG
CGGAGGAGACGGCGGCCTTCGAGGAGGTCATGAAGGACCTGAGCCTGACGCGGGCCGCGCGGCTCCAGCTCCAGAAATCCCAGTACCTGC
AACTGGGCCCCAGCCGAGGCCAGTACTATGGCGGGTCCCTGCCCAACGTGAACCAGATCGGGAGTGGCACCATGGACCTGCCCTTCCAGA
CCCCCTTCCAATCCTCGGGCCTGGACACCAGCCGGACCACCCGGCACCATGGGCTGGTGGACAGGGTGTACCGGGAGCGTGGCCGGCTCG
GCTCCCCACACCGCCGGCCCCTGTCAGTGGACAAACACGGACGGCAGGCCGACAGCTGCCCCTATGGCACCATGTACCTCTCACCACCCG
CGGACACCAGCTGGAGAAGGACCAATTCTGACTCCGCCCTGCACCAGAGCACAATGACGCCCACGCAGCCAGAATCCTTTAGCAGTGGGT
CCCAGGACGTGCACCAGAAAAGAGAAATCCTAAGTAATGCACTGAAGAGAGGAGAGATCATTGCAAAGCAGGGAGGAGGTGGAGGTGGAG
GAAGCGTCCCTGGGATCGAGAGGATGGGTCCTGGCATTGACCGCCTCGGGGGTGCCGGCATGGAGCGCATGGGCGCGGGCCTGGGCCACG
GCATGGATCGCGTGGGCTCCGAGATCGAGCGCATGGGCCTGGTCATGGACCGCATGGGCTCCGTGGAGCGCATGGGCTCCGGCATTGAGC
GCATGGGCCCGCTGGGCCTCGACCACATGGCCTCCAGCATTGAGCGCATGGGCCAGACCATGGAGCGCATTGGCTCTGGCGTGGAGCGCA
TGGGTGCCGGCATGGGCTTCGGCCTTGAGCGCATGGCCGCTCCCATCGACCGTGTGGGCCAGACCATTGAGCGCATGGGCTCTGGCGTGG
AGCGCATGGGCCCTGCCATCGAGCGCATGGGCCTGAGCATGGAGCGCATGGTGCCCGCAGGTATGGGAGCTGGCCTGGAGCGCATGGGCC
CCGTGATGGATCGCATGGCCACCGGCCTGGAGCGCATGGGCGCCAACAATCTGGAGCGGATGGGCCTGGAGCGCATGGGCGCCAACAGCC
TCGAGCGCATGGGCCTGGAGCGCATGGGTGCCAACAGCCTCGAGCGCATGGGCCCTGCCATGGGCCCGGCCCTGGGCGCTGGCATTGAGC
GCATGGGCCTGGCCATGGGTGGCGGTGGCGGTGCCAGCTTTGACCGTGCCATCGAGATGGAGCGTGGCAACTTCGGAGGAAGCTTCGCAG
GTTCCTTTGGTGGAGCTGGAGGCCATGCTCCTGGGGTGGCCAGGAAGGCCTGCCAGATATTTGTGAGAAATCTGCCATTCGATTTCACAT
GGAAGATGCTAAAGGACAAATTCAACGAGTGCGGCCACGTGCTGTACGCCGACATCAAGATGGAGAATGGGAAGTCCAAGGGGTGTGGCG
TGGTTAAGTTCGAGTCGCCAGAGGTGGCCGAGAGAGCCTGCCGGATGATGAATGGCATGAAGCTGAGTGGCCGAGAGATTGACGTTCGAA
TTGATAGAAACGCTTAAGCAGTTGCCTTTTTTAAACATCGATACGAGACCTCTGAATTTGTATTTTTTCTTGTTAACCATTTTAATTTGT
TGGCTGGATGTATAAAGATGTTTAAAAAATTCAGTTGCTTTTTGGGGTAATTTGAATTACTTTTTTAATGACTGGGGTTCCATTTGACTG
TTTGCATTGAGATTGCAATGTGCGCAATTTTTTTTGTAGTTGTGGCATCTTGTTGACATCGAATATGACTTTGATAATAAATACCGGTTC

>In-frame_CRTC1_ENST00000321949_chr19_18860685_+_HNRNPM_ENST00000325495_chr19_8548042_+_1897nt
GAGGAGGAGGAGGTGGCGGCGAGAAGATGGCGACTTCGAACAATCCGCGGAAATTCAGCGAGAAGATCGCGCTGCACAATCAGAAGCAGG
CGGAGGAGACGGCGGCCTTCGAGGAGGTCATGAAGGACCTGAGCCTGACGCGGGCCGCGCGGCTCCAGCTCCAGAAATCCCAGTACCTGC
AACTGGGCCCCAGCCGAGGCCAGTACTATGGCGGGTCCCTGCCCAACGTGAACCAGATCGGGAGTGGCACCATGGACCTGCCCTTCCAGA
CCCCCTTCCAATCCTCGGGCCTGGACACCAGCCGGACCACCCGGCACCATGGGCTGGTGGACAGGGTGTACCGGGAGCGTGGCCGGCTCG
GCTCCCCACACCGCCGGCCCCTGTCAGTGGACAAACACGGACGGCAGGCCGACAGCTGCCCCTATGGCACCATGTACCTCTCACCACCCG
CGGACACCAGCTGGAGAAGGACCAATTCTGACTCCGCCCTGCACCAGAGCACAATGACGCCCACGCAGCCAGAATCCTTTAGCAGTGGGT
CCCAGGACGTGCACCAGAAAAGAGAAATCCTAAGTAATGCACTGAAGAGAGGAGAGATCATTGCAAAGCAGGGAGGAGGTGGAGGTGGAG
GAAGCGTCCCTGGGATCGAGAGGATGGGTCCTGGCATTGACCGCCTCGGGGGTGCCGGCATGGAGCGCATGGGCGCGGGCCTGGGCCACG
GCATGGATCGCGTGGGCTCCGAGATCGAGCGCATGGGCCTGGTCATGGACCGCATGGGCTCCGTGGAGCGCATGGGCTCCGGCATTGAGC
GCATGGGCCCGCTGGGCCTCGACCACATGGCCTCCAGCATTGAGCGCATGGGCCAGACCATGGAGCGCATTGGCTCTGGCGTGGAGCGCA
TGGGTGCCGGCATGGGCTTCGGCCTTGAGCGCATGGCCGCTCCCATCGACCGTGTGGGCCAGACCATTGAGCGCATGGGCTCTGGCGTGG
AGCGCATGGGCCCTGCCATCGAGCGCATGGGCCTGAGCATGGAGCGCATGGTGCCCGCAGGTATGGGAGCTGGCCTGGAGCGCATGGGCC
CCGTGATGGATCGCATGGCCACCGGCCTGGAGCGCATGGGCGCCAACAATCTGGAGCGGATGGGCCTGGAGCGCATGGGCGCCAACAGCC
TCGAGCGCATGGGCCTGGAGCGCATGGGTGCCAACAGCCTCGAGCGCATGGGCCCTGCCATGGGCCCGGCCCTGGGCGCTGGCATTGAGC
GCATGGGCCTGGCCATGGGTGGCGGTGGCGGTGCCAGCTTTGACCGTGCCATCGAGATGGAGCGTGGCAACTTCGGAGGAAGCTTCGCAG
GTTCCTTTGGTGGAGCTGGAGGCCATGCTCCTGGGGTGGCCAGGAAGGCCTGCCAGATATTTGTGAGAAATCTGCCATTCGATTTCACAT
GGAAGATGCTAAAGGACAAATTCAACGAGTGCGGCCACGTGCTGTACGCCGACATCAAGATGGAGAATGGGAAGTCCAAGGGGTGTGGCG
TGGTTAAGTTCGAGTCGCCAGAGGTGGCCGAGAGAGCCTGCCGGATGATGAATGGCATGAAGCTGAGTGGCCGAGAGATTGACGTTCGAA
TTGATAGAAACGCTTAAGCAGTTGCCTTTTTTAAACATCGATACGAGACCTCTGAATTTGTATTTTTTCTTGTTAACCATTTTAATTTGT
TGGCTGGATGTATAAAGATGTTTAAAAAATTCAGTTGCTTTTTGGGGTAATTTGAATTACTTTTTTAATGACTGGGGTTCCATTTGACTG
TTTGCATTGAGATTGCAATGTGCGCAATTTTTTTTGTAGTTGTGGCATCTTGTTGACATCGAATATGACTTTGATAATAAATACCGGTTC

>In-frame_CRTC1_ENST00000338797_chr19_18860685_+_HNRNPM_ENST00000348943_chr19_8548042_+_1944nt
AGGAGGAGGAGGTGGCGGCGAGAAGATGGCGACTTCGAACAATCCGCGGAAATTCAGCGAGAAGATCGCGCTGCACAATCAGAAGCAGGC
GGAGGAGACGGCGGCCTTCGAGGAGGTCATGAAGGACCTGAGCCTGACGCGGGCCGCGCGGCTCCAGCTCCAGAAATCCCAGTACCTGCA
ACTGGGCCCCAGCCGAGGCCAGTACTATGGCGGGTCCCTGCCCAACGTGAACCAGATCGGGAGTGGCACCATGGACCTGCCCTTCCAGCC
CAGCGGATTTCTGGGGGAGGCCCTGGCAGCGGCTCCTGTCTCTCTGACCCCCTTCCAATCCTCGGGCCTGGACACCAGCCGGACCACCCG
GCACCATGGGCTGGTGGACAGGGTGTACCGGGAGCGTGGCCGGCTCGGCTCCCCACACCGCCGGCCCCTGTCAGTGGACAAACACGGACG
GCAGGCCGACAGCTGCCCCTATGGCACCATGTACCTCTCACCACCCGCGGACACCAGCTGGAGAAGGACCAATTCTGACTCCGCCCTGCA
CCAGAGCACAATGACGCCCACGCAGCCAGAATCCTTTAGCAGTGGGTCCCAGGACGTGCACCAGAAAAGAGAAATCCTAAGTAATGCACT
GAAGAGAGGAGAGATCATTGCAAAGCAGGGAGGAGGTGGAGGTGGAGGAAGCGTCCCTGGGATCGAGAGGATGGGTCCTGGCATTGACCG
CCTCGGGGGTGCCGGCATGGAGCGCATGGGCGCGGGCCTGGGCCACGGCATGGATCGCGTGGGCTCCGAGATCGAGCGCATGGGCCTGGT
CATGGACCGCATGGGCTCCGTGGAGCGCATGGGCTCCGGCATTGAGCGCATGGGCCCGCTGGGCCTCGACCACATGGCCTCCAGCATTGA
GCGCATGGGCCAGACCATGGAGCGCATTGGCTCTGGCGTGGAGCGCATGGGTGCCGGCATGGGCTTCGGCCTTGAGCGCATGGCCGCTCC
CATCGACCGTGTGGGCCAGACCATTGAGCGCATGGGCTCTGGCGTGGAGCGCATGGGCCCTGCCATCGAGCGCATGGGCCTGAGCATGGA
GCGCATGGTGCCCGCAGGTATGGGAGCTGGCCTGGAGCGCATGGGCCCCGTGATGGATCGCATGGCCACCGGCCTGGAGCGCATGGGCGC
CAACAATCTGGAGCGGATGGGCCTGGAGCGCATGGGCGCCAACAGCCTCGAGCGCATGGGCCTGGAGCGCATGGGTGCCAACAGCCTCGA
GCGCATGGGCCCTGCCATGGGCCCGGCCCTGGGCGCTGGCATTGAGCGCATGGGCCTGGCCATGGGTGGCGGTGGCGGTGCCAGCTTTGA
CCGTGCCATCGAGATGGAGCGTGGCAACTTCGGAGGAAGCTTCGCAGGTTCCTTTGGTGGAGCTGGAGGCCATGCTCCTGGGGTGGCCAG
GAAGGCCTGCCAGATATTTGTGAGAAATCTGCCATTCGATTTCACATGGAAGATGCTAAAGGACAAATTCAACGAGTGCGGCCACGTGCT
GTACGCCGACATCAAGATGGAGAATGGGAAGTCCAAGGGGTGTGGCGTGGTTAAGTTCGAGTCGCCAGAGGTGGCCGAGAGAGCCTGCCG
GATGATGAATGGCATGAAGCTGAGTGGCCGAGAGATTGACGTTCGAATTGATAGAAACGCTTAAGCAGTTGCCTTTTTTAAACATCGATA
CGAGACCTCTGAATTTGTATTTTTTCTTGTTAACCATTTTAATTTGTTGGCTGGATGTATAAAGATGTTTAAAAAATTCAGTTGCTTTTT
GGGGTAATTTGAATTACTTTTTTAATGACTGGGGTTCCATTTGACTGTTTGCATTGAGATTGCAATGTGCGCAATTTTTTTTGTAGTTGT

>In-frame_CRTC1_ENST00000338797_chr19_18860685_+_HNRNPM_ENST00000325495_chr19_8548042_+_1944nt
AGGAGGAGGAGGTGGCGGCGAGAAGATGGCGACTTCGAACAATCCGCGGAAATTCAGCGAGAAGATCGCGCTGCACAATCAGAAGCAGGC
GGAGGAGACGGCGGCCTTCGAGGAGGTCATGAAGGACCTGAGCCTGACGCGGGCCGCGCGGCTCCAGCTCCAGAAATCCCAGTACCTGCA
ACTGGGCCCCAGCCGAGGCCAGTACTATGGCGGGTCCCTGCCCAACGTGAACCAGATCGGGAGTGGCACCATGGACCTGCCCTTCCAGCC
CAGCGGATTTCTGGGGGAGGCCCTGGCAGCGGCTCCTGTCTCTCTGACCCCCTTCCAATCCTCGGGCCTGGACACCAGCCGGACCACCCG
GCACCATGGGCTGGTGGACAGGGTGTACCGGGAGCGTGGCCGGCTCGGCTCCCCACACCGCCGGCCCCTGTCAGTGGACAAACACGGACG
GCAGGCCGACAGCTGCCCCTATGGCACCATGTACCTCTCACCACCCGCGGACACCAGCTGGAGAAGGACCAATTCTGACTCCGCCCTGCA
CCAGAGCACAATGACGCCCACGCAGCCAGAATCCTTTAGCAGTGGGTCCCAGGACGTGCACCAGAAAAGAGAAATCCTAAGTAATGCACT
GAAGAGAGGAGAGATCATTGCAAAGCAGGGAGGAGGTGGAGGTGGAGGAAGCGTCCCTGGGATCGAGAGGATGGGTCCTGGCATTGACCG
CCTCGGGGGTGCCGGCATGGAGCGCATGGGCGCGGGCCTGGGCCACGGCATGGATCGCGTGGGCTCCGAGATCGAGCGCATGGGCCTGGT
CATGGACCGCATGGGCTCCGTGGAGCGCATGGGCTCCGGCATTGAGCGCATGGGCCCGCTGGGCCTCGACCACATGGCCTCCAGCATTGA
GCGCATGGGCCAGACCATGGAGCGCATTGGCTCTGGCGTGGAGCGCATGGGTGCCGGCATGGGCTTCGGCCTTGAGCGCATGGCCGCTCC
CATCGACCGTGTGGGCCAGACCATTGAGCGCATGGGCTCTGGCGTGGAGCGCATGGGCCCTGCCATCGAGCGCATGGGCCTGAGCATGGA
GCGCATGGTGCCCGCAGGTATGGGAGCTGGCCTGGAGCGCATGGGCCCCGTGATGGATCGCATGGCCACCGGCCTGGAGCGCATGGGCGC
CAACAATCTGGAGCGGATGGGCCTGGAGCGCATGGGCGCCAACAGCCTCGAGCGCATGGGCCTGGAGCGCATGGGTGCCAACAGCCTCGA
GCGCATGGGCCCTGCCATGGGCCCGGCCCTGGGCGCTGGCATTGAGCGCATGGGCCTGGCCATGGGTGGCGGTGGCGGTGCCAGCTTTGA
CCGTGCCATCGAGATGGAGCGTGGCAACTTCGGAGGAAGCTTCGCAGGTTCCTTTGGTGGAGCTGGAGGCCATGCTCCTGGGGTGGCCAG
GAAGGCCTGCCAGATATTTGTGAGAAATCTGCCATTCGATTTCACATGGAAGATGCTAAAGGACAAATTCAACGAGTGCGGCCACGTGCT
GTACGCCGACATCAAGATGGAGAATGGGAAGTCCAAGGGGTGTGGCGTGGTTAAGTTCGAGTCGCCAGAGGTGGCCGAGAGAGCCTGCCG
GATGATGAATGGCATGAAGCTGAGTGGCCGAGAGATTGACGTTCGAATTGATAGAAACGCTTAAGCAGTTGCCTTTTTTAAACATCGATA
CGAGACCTCTGAATTTGTATTTTTTCTTGTTAACCATTTTAATTTGTTGGCTGGATGTATAAAGATGTTTAAAAAATTCAGTTGCTTTTT
GGGGTAATTTGAATTACTTTTTTAATGACTGGGGTTCCATTTGACTGTTTGCATTGAGATTGCAATGTGCGCAATTTTTTTTGTAGTTGT

>In-frame_CRTC1_ENST00000594658_chr19_18860685_+_HNRNPM_ENST00000348943_chr19_8548042_+_1780nt
CCCTTAGGGGAAGAGTCCTGCTCTGGCTGTTGATGCTCCAGCTCCAGAAATCCCAGTACCTGCAACTGGGCCCCAGCCGAGGCCAGTACT
ATGGCGGGTCCCTGCCCAACGTGAACCAGATCGGGAGTGGCACCATGGACCTGCCCTTCCAGACCCCCTTCCAATCCTCGGGCCTGGACA
CCAGCCGGACCACCCGGCACCATGGGCTGGTGGACAGGGTGTACCGGGAGCGTGGCCGGCTCGGCTCCCCACACCGCCGGCCCCTGTCAG
TGGACAAACACGGACGGCAGGCCGACAGCTGCCCCTATGGCACCATGTACCTCTCACCACCCGCGGACACCAGCTGGAGAAGGACCAATT
CTGACTCCGCCCTGCACCAGAGCACAATGACGCCCACGCAGCCAGAATCCTTTAGCAGTGGGTCCCAGGACGTGCACCAGAAAAGAGAAA
TCCTAAGTAATGCACTGAAGAGAGGAGAGATCATTGCAAAGCAGGGAGGAGGTGGAGGTGGAGGAAGCGTCCCTGGGATCGAGAGGATGG
GTCCTGGCATTGACCGCCTCGGGGGTGCCGGCATGGAGCGCATGGGCGCGGGCCTGGGCCACGGCATGGATCGCGTGGGCTCCGAGATCG
AGCGCATGGGCCTGGTCATGGACCGCATGGGCTCCGTGGAGCGCATGGGCTCCGGCATTGAGCGCATGGGCCCGCTGGGCCTCGACCACA
TGGCCTCCAGCATTGAGCGCATGGGCCAGACCATGGAGCGCATTGGCTCTGGCGTGGAGCGCATGGGTGCCGGCATGGGCTTCGGCCTTG
AGCGCATGGCCGCTCCCATCGACCGTGTGGGCCAGACCATTGAGCGCATGGGCTCTGGCGTGGAGCGCATGGGCCCTGCCATCGAGCGCA
TGGGCCTGAGCATGGAGCGCATGGTGCCCGCAGGTATGGGAGCTGGCCTGGAGCGCATGGGCCCCGTGATGGATCGCATGGCCACCGGCC
TGGAGCGCATGGGCGCCAACAATCTGGAGCGGATGGGCCTGGAGCGCATGGGCGCCAACAGCCTCGAGCGCATGGGCCTGGAGCGCATGG
GTGCCAACAGCCTCGAGCGCATGGGCCCTGCCATGGGCCCGGCCCTGGGCGCTGGCATTGAGCGCATGGGCCTGGCCATGGGTGGCGGTG
GCGGTGCCAGCTTTGACCGTGCCATCGAGATGGAGCGTGGCAACTTCGGAGGAAGCTTCGCAGGTTCCTTTGGTGGAGCTGGAGGCCATG
CTCCTGGGGTGGCCAGGAAGGCCTGCCAGATATTTGTGAGAAATCTGCCATTCGATTTCACATGGAAGATGCTAAAGGACAAATTCAACG
AGTGCGGCCACGTGCTGTACGCCGACATCAAGATGGAGAATGGGAAGTCCAAGGGGTGTGGCGTGGTTAAGTTCGAGTCGCCAGAGGTGG
CCGAGAGAGCCTGCCGGATGATGAATGGCATGAAGCTGAGTGGCCGAGAGATTGACGTTCGAATTGATAGAAACGCTTAAGCAGTTGCCT
TTTTTAAACATCGATACGAGACCTCTGAATTTGTATTTTTTCTTGTTAACCATTTTAATTTGTTGGCTGGATGTATAAAGATGTTTAAAA
AATTCAGTTGCTTTTTGGGGTAATTTGAATTACTTTTTTAATGACTGGGGTTCCATTTGACTGTTTGCATTGAGATTGCAATGTGCGCAA

>In-frame_CRTC1_ENST00000594658_chr19_18860685_+_HNRNPM_ENST00000325495_chr19_8548042_+_1780nt
CCCTTAGGGGAAGAGTCCTGCTCTGGCTGTTGATGCTCCAGCTCCAGAAATCCCAGTACCTGCAACTGGGCCCCAGCCGAGGCCAGTACT
ATGGCGGGTCCCTGCCCAACGTGAACCAGATCGGGAGTGGCACCATGGACCTGCCCTTCCAGACCCCCTTCCAATCCTCGGGCCTGGACA
CCAGCCGGACCACCCGGCACCATGGGCTGGTGGACAGGGTGTACCGGGAGCGTGGCCGGCTCGGCTCCCCACACCGCCGGCCCCTGTCAG
TGGACAAACACGGACGGCAGGCCGACAGCTGCCCCTATGGCACCATGTACCTCTCACCACCCGCGGACACCAGCTGGAGAAGGACCAATT
CTGACTCCGCCCTGCACCAGAGCACAATGACGCCCACGCAGCCAGAATCCTTTAGCAGTGGGTCCCAGGACGTGCACCAGAAAAGAGAAA
TCCTAAGTAATGCACTGAAGAGAGGAGAGATCATTGCAAAGCAGGGAGGAGGTGGAGGTGGAGGAAGCGTCCCTGGGATCGAGAGGATGG
GTCCTGGCATTGACCGCCTCGGGGGTGCCGGCATGGAGCGCATGGGCGCGGGCCTGGGCCACGGCATGGATCGCGTGGGCTCCGAGATCG
AGCGCATGGGCCTGGTCATGGACCGCATGGGCTCCGTGGAGCGCATGGGCTCCGGCATTGAGCGCATGGGCCCGCTGGGCCTCGACCACA
TGGCCTCCAGCATTGAGCGCATGGGCCAGACCATGGAGCGCATTGGCTCTGGCGTGGAGCGCATGGGTGCCGGCATGGGCTTCGGCCTTG
AGCGCATGGCCGCTCCCATCGACCGTGTGGGCCAGACCATTGAGCGCATGGGCTCTGGCGTGGAGCGCATGGGCCCTGCCATCGAGCGCA
TGGGCCTGAGCATGGAGCGCATGGTGCCCGCAGGTATGGGAGCTGGCCTGGAGCGCATGGGCCCCGTGATGGATCGCATGGCCACCGGCC
TGGAGCGCATGGGCGCCAACAATCTGGAGCGGATGGGCCTGGAGCGCATGGGCGCCAACAGCCTCGAGCGCATGGGCCTGGAGCGCATGG
GTGCCAACAGCCTCGAGCGCATGGGCCCTGCCATGGGCCCGGCCCTGGGCGCTGGCATTGAGCGCATGGGCCTGGCCATGGGTGGCGGTG
GCGGTGCCAGCTTTGACCGTGCCATCGAGATGGAGCGTGGCAACTTCGGAGGAAGCTTCGCAGGTTCCTTTGGTGGAGCTGGAGGCCATG
CTCCTGGGGTGGCCAGGAAGGCCTGCCAGATATTTGTGAGAAATCTGCCATTCGATTTCACATGGAAGATGCTAAAGGACAAATTCAACG
AGTGCGGCCACGTGCTGTACGCCGACATCAAGATGGAGAATGGGAAGTCCAAGGGGTGTGGCGTGGTTAAGTTCGAGTCGCCAGAGGTGG
CCGAGAGAGCCTGCCGGATGATGAATGGCATGAAGCTGAGTGGCCGAGAGATTGACGTTCGAATTGATAGAAACGCTTAAGCAGTTGCCT
TTTTTAAACATCGATACGAGACCTCTGAATTTGTATTTTTTCTTGTTAACCATTTTAATTTGTTGGCTGGATGTATAAAGATGTTTAAAA
AATTCAGTTGCTTTTTGGGGTAATTTGAATTACTTTTTTAATGACTGGGGTTCCATTTGACTGTTTGCATTGAGATTGCAATGTGCGCAA

>In-frame_CRTC1_ENST00000601916_chr19_18860685_+_HNRNPM_ENST00000348943_chr19_8548042_+_1745nt
CTCCAGCTCCAGAAATCCCAGTACCTGCAACTGGGCCCCAGCCGAGGCCAGTACTATGGCGGGTCCCTGCCCAACGTGAACCAGATCGGG
AGTGGCACCATGGACCTGCCCTTCCAGACCCCCTTCCAATCCTCGGGCCTGGACACCAGCCGGACCACCCGGCACCATGGGCTGGTGGAC
AGGGTGTACCGGGAGCGTGGCCGGCTCGGCTCCCCACACCGCCGGCCCCTGTCAGTGGACAAACACGGACGGCAGGCCGACAGCTGCCCC
TATGGCACCATGTACCTCTCACCACCCGCGGACACCAGCTGGAGAAGGACCAATTCTGACTCCGCCCTGCACCAGAGCACAATGACGCCC
ACGCAGCCAGAATCCTTTAGCAGTGGGTCCCAGGACGTGCACCAGAAAAGAGAAATCCTAAGTAATGCACTGAAGAGAGGAGAGATCATT
GCAAAGCAGGGAGGAGGTGGAGGTGGAGGAAGCGTCCCTGGGATCGAGAGGATGGGTCCTGGCATTGACCGCCTCGGGGGTGCCGGCATG
GAGCGCATGGGCGCGGGCCTGGGCCACGGCATGGATCGCGTGGGCTCCGAGATCGAGCGCATGGGCCTGGTCATGGACCGCATGGGCTCC
GTGGAGCGCATGGGCTCCGGCATTGAGCGCATGGGCCCGCTGGGCCTCGACCACATGGCCTCCAGCATTGAGCGCATGGGCCAGACCATG
GAGCGCATTGGCTCTGGCGTGGAGCGCATGGGTGCCGGCATGGGCTTCGGCCTTGAGCGCATGGCCGCTCCCATCGACCGTGTGGGCCAG
ACCATTGAGCGCATGGGCTCTGGCGTGGAGCGCATGGGCCCTGCCATCGAGCGCATGGGCCTGAGCATGGAGCGCATGGTGCCCGCAGGT
ATGGGAGCTGGCCTGGAGCGCATGGGCCCCGTGATGGATCGCATGGCCACCGGCCTGGAGCGCATGGGCGCCAACAATCTGGAGCGGATG
GGCCTGGAGCGCATGGGCGCCAACAGCCTCGAGCGCATGGGCCTGGAGCGCATGGGTGCCAACAGCCTCGAGCGCATGGGCCCTGCCATG
GGCCCGGCCCTGGGCGCTGGCATTGAGCGCATGGGCCTGGCCATGGGTGGCGGTGGCGGTGCCAGCTTTGACCGTGCCATCGAGATGGAG
CGTGGCAACTTCGGAGGAAGCTTCGCAGGTTCCTTTGGTGGAGCTGGAGGCCATGCTCCTGGGGTGGCCAGGAAGGCCTGCCAGATATTT
GTGAGAAATCTGCCATTCGATTTCACATGGAAGATGCTAAAGGACAAATTCAACGAGTGCGGCCACGTGCTGTACGCCGACATCAAGATG
GAGAATGGGAAGTCCAAGGGGTGTGGCGTGGTTAAGTTCGAGTCGCCAGAGGTGGCCGAGAGAGCCTGCCGGATGATGAATGGCATGAAG
CTGAGTGGCCGAGAGATTGACGTTCGAATTGATAGAAACGCTTAAGCAGTTGCCTTTTTTAAACATCGATACGAGACCTCTGAATTTGTA
TTTTTTCTTGTTAACCATTTTAATTTGTTGGCTGGATGTATAAAGATGTTTAAAAAATTCAGTTGCTTTTTGGGGTAATTTGAATTACTT
TTTTAATGACTGGGGTTCCATTTGACTGTTTGCATTGAGATTGCAATGTGCGCAATTTTTTTTGTAGTTGTGGCATCTTGTTGACATCGA

>In-frame_CRTC1_ENST00000601916_chr19_18860685_+_HNRNPM_ENST00000325495_chr19_8548042_+_1745nt
CTCCAGCTCCAGAAATCCCAGTACCTGCAACTGGGCCCCAGCCGAGGCCAGTACTATGGCGGGTCCCTGCCCAACGTGAACCAGATCGGG
AGTGGCACCATGGACCTGCCCTTCCAGACCCCCTTCCAATCCTCGGGCCTGGACACCAGCCGGACCACCCGGCACCATGGGCTGGTGGAC
AGGGTGTACCGGGAGCGTGGCCGGCTCGGCTCCCCACACCGCCGGCCCCTGTCAGTGGACAAACACGGACGGCAGGCCGACAGCTGCCCC
TATGGCACCATGTACCTCTCACCACCCGCGGACACCAGCTGGAGAAGGACCAATTCTGACTCCGCCCTGCACCAGAGCACAATGACGCCC
ACGCAGCCAGAATCCTTTAGCAGTGGGTCCCAGGACGTGCACCAGAAAAGAGAAATCCTAAGTAATGCACTGAAGAGAGGAGAGATCATT
GCAAAGCAGGGAGGAGGTGGAGGTGGAGGAAGCGTCCCTGGGATCGAGAGGATGGGTCCTGGCATTGACCGCCTCGGGGGTGCCGGCATG
GAGCGCATGGGCGCGGGCCTGGGCCACGGCATGGATCGCGTGGGCTCCGAGATCGAGCGCATGGGCCTGGTCATGGACCGCATGGGCTCC
GTGGAGCGCATGGGCTCCGGCATTGAGCGCATGGGCCCGCTGGGCCTCGACCACATGGCCTCCAGCATTGAGCGCATGGGCCAGACCATG
GAGCGCATTGGCTCTGGCGTGGAGCGCATGGGTGCCGGCATGGGCTTCGGCCTTGAGCGCATGGCCGCTCCCATCGACCGTGTGGGCCAG
ACCATTGAGCGCATGGGCTCTGGCGTGGAGCGCATGGGCCCTGCCATCGAGCGCATGGGCCTGAGCATGGAGCGCATGGTGCCCGCAGGT
ATGGGAGCTGGCCTGGAGCGCATGGGCCCCGTGATGGATCGCATGGCCACCGGCCTGGAGCGCATGGGCGCCAACAATCTGGAGCGGATG
GGCCTGGAGCGCATGGGCGCCAACAGCCTCGAGCGCATGGGCCTGGAGCGCATGGGTGCCAACAGCCTCGAGCGCATGGGCCCTGCCATG
GGCCCGGCCCTGGGCGCTGGCATTGAGCGCATGGGCCTGGCCATGGGTGGCGGTGGCGGTGCCAGCTTTGACCGTGCCATCGAGATGGAG
CGTGGCAACTTCGGAGGAAGCTTCGCAGGTTCCTTTGGTGGAGCTGGAGGCCATGCTCCTGGGGTGGCCAGGAAGGCCTGCCAGATATTT
GTGAGAAATCTGCCATTCGATTTCACATGGAAGATGCTAAAGGACAAATTCAACGAGTGCGGCCACGTGCTGTACGCCGACATCAAGATG
GAGAATGGGAAGTCCAAGGGGTGTGGCGTGGTTAAGTTCGAGTCGCCAGAGGTGGCCGAGAGAGCCTGCCGGATGATGAATGGCATGAAG
CTGAGTGGCCGAGAGATTGACGTTCGAATTGATAGAAACGCTTAAGCAGTTGCCTTTTTTAAACATCGATACGAGACCTCTGAATTTGTA
TTTTTTCTTGTTAACCATTTTAATTTGTTGGCTGGATGTATAAAGATGTTTAAAAAATTCAGTTGCTTTTTGGGGTAATTTGAATTACTT
TTTTAATGACTGGGGTTCCATTTGACTGTTTGCATTGAGATTGCAATGTGCGCAATTTTTTTTGTAGTTGTGGCATCTTGTTGACATCGA


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FusionGenePPI for CRTC1_HNRNPM


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
CRTC1CREB1, MAP3K1, MEIS1, YWHAE, CREBBP, EP300, SRPK2, XPO1, KCTD3, KIF13B, CBY1HNRNPMPRRC2A, RBM4B, LMO3, TCERG1, GSTK1, PHLDA3, RFXANK, PTP4A3, TSC22D1, JUN, LYST, HNRNPA1, HNRNPH1, APC, SRRM1, SRRM2, TOPORS, MORF4L1, MORF4L2, MRGBP, DOT1L, NPM1, TADA2A, UBC, NOP56, VHL, SMARCAD1, ARRB1, ARRB2, ERG, KIAA0368, NFX1, CUL3, CUL2, CDK2, CUL1, COPS5, CAND1, PRAME, FBXO6, RBM8A, U2AF2, PRPF6, EFTUD2, NHP2L1, SNRPD1, RBMX, SF3B3, SF3A1, SNRPA1, SF3B1, U2AF1, HNRNPC, SNRPD3, SRSF1, HNRNPF, ALYREF, HNRNPR, HNRNPK, PRPF8, RNPS1, SRSF5, SRSF3, SYNCRIP, SFPQ, NONO, RBM25, HNRNPA0, HNRNPL, RPL10A, RPS6, RPL7, RALY, RPS24, RPS8, RPL11, RPL23A, RPS23, RPL7A, RPL12, DDX5, RPL31, RPS13, RPL6, RPL14, RPS15A, RPS16, RPLP0, DDX1, RPL18, RPL5, RPS11, TOP1, RPS7, RPS2, RPS14, PRPF19, RPL10, RPL19, RPL23, HNRNPDL, RPL18A, RPL30, RPL22, PUF60, RPS26, SRRT, RPS4X, PRPF40A, RPSA, RPS21, PRPF3, RPS5, RPS28, RPS25, RBM14, SND1, RANBP2, MRPL37, KRT16, STOM, MBD3, UQCR10, SLC25A24, SUPT16H, RPLP0P6, RRBP1, VTN, RCC1, RRS1, ZNF326, PCDHA2, LMNA, SMC3, SON, TRA2A, RAB31, RTN4, SMARCA5, LMNB1, MRPL55, MYH10, RAP1A, SSR1, FLNB, THRAP3, RRP7A, SEPT2, MRPS28, TOR1AIP1, SAMM50, TOMM70A, RCC2, ADAR, DHODH, MRPL23, MRPS9, TIMM9, MTA2, GTF3C1, ESR1, MAGOH, EIF4A3, FN1, VCAM1, ZNF207, RBM4, WDR77, MAP1LC3A, UBL4A, ITGA4, CTNNB1, AICDA, PAN2, CD81, IGSF8, LMO2, STAT3, SRPK2, CLK2, SRPK3, TARDBP, PARK2, ABCF1, RTCB, DHX9, EIF2B2, EIF2B3, FLII, IGF2BP3, NMT1, PSMB8, RFC4, RPL26L1, RPL27, MRE11A, RPA1, RPA2, RPA3, CDC37, IVNS1ABP, STAU1, MDM2, HAUS1, CEP250, TP53, AKAP9, GMCL1P1, TEKT4, ENO1, SHMT2, MOV10, NXF1, UBE2I, EED, ERLIN2, UBAC2, ABL1, ILK, MAST3, SRPK1, PLRG1, CDC5L, RPS6KB2, NTRK1, LRRC59, UQCRC2, SFN, SCARNA22, B9D2, XPO1, HNRNPH2, MATR3, SEC16A, MYEF2, GAN, SKI, CRY2, MCM2, SNW1, CRBN, C11orf30, ZNF746, CYLD, SMARCB1, BRCA1, RNF168, MTF1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for CRTC1_HNRNPM


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for CRTC1_HNRNPM


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneCRTC1C0279628Adenocarcinoma Of Esophagus1CTD_human
HgeneCRTC1C0525045Mood Disorders1PSYGENET