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Fusion gene ID: 8517 |
FusionGeneSummary for CRTAC1_CCT5 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: CRTAC1_CCT5 | Fusion gene ID: 8517 | Hgene | Tgene | Gene symbol | CRTAC1 | CCT5 | Gene ID | 55118 | 22948 |
| Gene name | cartilage acidic protein 1 | chaperonin containing TCP1 subunit 5 | |
| Synonyms | ASPIC|ASPIC1|CEP-68 | CCT-epsilon|CCTE|HEL-S-69|PNAS-102|TCP-1-epsilon | |
| Cytomap | 10q24.2 | 5p15.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | cartilage acidic protein 1acidic secreted protein in cartilagechondrocyte expressed protein 68 kDa CEP-68 | T-complex protein 1 subunit epsilonchaperonin containing TCP1, subunit 5 (epsilon)epididymis secretory protein Li 69 | |
| Modification date | 20180519 | 20180523 | |
| UniProtAcc | Q9NQ79 | P48643 | |
| Ensembl transtripts involved in fusion gene | ENST00000370597, ENST00000298819, ENST00000370591, ENST00000468549, | ENST00000280326, ENST00000503026, ENST00000515390, ENST00000515676, ENST00000506600, | |
| Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 49 X 6 X 16=4704 |
| # samples | 1 | 53 | |
| ** MAII score | log2(1/1*10)=3.32192809488736 | log2(53/4704*10)=-3.1498237953858 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: CRTAC1 [Title/Abstract] AND CCT5 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | UVM | TCGA-VD-A8KD-01A | CRTAC1 | chr10 | 99624758 | - | CCT5 | chr5 | 10250033 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000370597 | ENST00000280326 | CRTAC1 | chr10 | 99624758 | - | CCT5 | chr5 | 10250033 | + |
| 5CDS-intron | ENST00000370597 | ENST00000503026 | CRTAC1 | chr10 | 99624758 | - | CCT5 | chr5 | 10250033 | + |
| 5CDS-intron | ENST00000370597 | ENST00000515390 | CRTAC1 | chr10 | 99624758 | - | CCT5 | chr5 | 10250033 | + |
| 5CDS-intron | ENST00000370597 | ENST00000515676 | CRTAC1 | chr10 | 99624758 | - | CCT5 | chr5 | 10250033 | + |
| 5CDS-intron | ENST00000370597 | ENST00000506600 | CRTAC1 | chr10 | 99624758 | - | CCT5 | chr5 | 10250033 | + |
| In-frame | ENST00000298819 | ENST00000280326 | CRTAC1 | chr10 | 99624758 | - | CCT5 | chr5 | 10250033 | + |
| 5CDS-intron | ENST00000298819 | ENST00000503026 | CRTAC1 | chr10 | 99624758 | - | CCT5 | chr5 | 10250033 | + |
| 5CDS-intron | ENST00000298819 | ENST00000515390 | CRTAC1 | chr10 | 99624758 | - | CCT5 | chr5 | 10250033 | + |
| 5CDS-intron | ENST00000298819 | ENST00000515676 | CRTAC1 | chr10 | 99624758 | - | CCT5 | chr5 | 10250033 | + |
| 5CDS-intron | ENST00000298819 | ENST00000506600 | CRTAC1 | chr10 | 99624758 | - | CCT5 | chr5 | 10250033 | + |
| intron-3CDS | ENST00000370591 | ENST00000280326 | CRTAC1 | chr10 | 99624758 | - | CCT5 | chr5 | 10250033 | + |
| intron-intron | ENST00000370591 | ENST00000503026 | CRTAC1 | chr10 | 99624758 | - | CCT5 | chr5 | 10250033 | + |
| intron-intron | ENST00000370591 | ENST00000515390 | CRTAC1 | chr10 | 99624758 | - | CCT5 | chr5 | 10250033 | + |
| intron-intron | ENST00000370591 | ENST00000515676 | CRTAC1 | chr10 | 99624758 | - | CCT5 | chr5 | 10250033 | + |
| intron-intron | ENST00000370591 | ENST00000506600 | CRTAC1 | chr10 | 99624758 | - | CCT5 | chr5 | 10250033 | + |
| intron-3CDS | ENST00000468549 | ENST00000280326 | CRTAC1 | chr10 | 99624758 | - | CCT5 | chr5 | 10250033 | + |
| intron-intron | ENST00000468549 | ENST00000503026 | CRTAC1 | chr10 | 99624758 | - | CCT5 | chr5 | 10250033 | + |
| intron-intron | ENST00000468549 | ENST00000515390 | CRTAC1 | chr10 | 99624758 | - | CCT5 | chr5 | 10250033 | + |
| intron-intron | ENST00000468549 | ENST00000515676 | CRTAC1 | chr10 | 99624758 | - | CCT5 | chr5 | 10250033 | + |
| intron-intron | ENST00000468549 | ENST00000506600 | CRTAC1 | chr10 | 99624758 | - | CCT5 | chr5 | 10250033 | + |
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FusionProtFeatures for CRTAC1_CCT5 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| CRTAC1 | CCT5 |
| Molecular chaperone; assists the folding of proteinsupon ATP hydrolysis. As part of the BBS/CCT complex may play arole in the assembly of BBSome, a complex involved in ciliogenesisregulating transports vesicles to the cilia. Known to play a role,in vitro, in the folding of actin and tubulin.{ECO:0000269|PubMed:20080638}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for CRTAC1_CCT5 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_CRTAC1_ENST00000298819_chr10_99624758_-_CCT5_ENST00000280326_chr5_10250033_+_682aa KKKKNRKWVLPSSRSRSAKKXRNSALSQXIPPWDPLSRNYQWXRFKKXQIQSALDLCVLRFPLSVFKPPPPRLPGXXKFPKAADSRRYCL AXNXSQXKHKSRASCAARAQAFGPSREREVHSRFRSGLRRLGGSNSGCCTMASMGTLAFDEYGRPFLIIKDQDRKSRLMGLEALKSHIMA AKAVANTMRTSLGPNGLDKMMVDKDGDVTVTNDGATILSMMDVDHQIAKLMVELSKSQDDEIGDGTTGVVVLAGALLEEAEQLLDRGIHP IRIADGYEQAARVAIEHLDKISDSVLVDIKDTEPLIQTAKTTLGSKVVNSCHRQMAEIAVNAVLTVADMERRDVDFELIKVEGKVGGRLE DTKLIKGVIVDKDFSHPQMPKKVEDAKIAILTCPFEPPKPKTKHKLDVTSVEDYKALQKYEKEKFEEMIQQIKETGANLAICQWGFDDEA NHLLLQNNLPAVRWVGGPEIELIAIATGGRIVPRFSELTAEKLGFAGLVQEISFGTTKDKMLVIEQCKNSRAVTIFIRGGNKMIIEEAKR SLHDALCVIRNLIRDNRVVYGGGAAEISCALAVSQEADKCPTLEQYAMRAFADALEVIPMALSENSGMNPIQTMTEVRARQVKEMNPALG |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_CRTAC1_ENST00000298819_chr10_99624758_-_CCT5_ENST00000280326_chr5_10250033_+_2046nt AAAAAAAAAAAAAACCGGAAATGGGTCCTACCATCTTCTCGGAGCCGGAGTGCGAAGAAATAAAGAAATAGTGCTTTAAGTCAATGAATT CCTCCTTGGGACCCACTATCGAGAAACTATCAGTGGTAACGTTTTAAAAAATGACAAATTCAATCTGCTCTTGACTTGTGTGTCCTAAGA TTTCCACTAAGTGTCTTCAAACCTCCCCCTCCCCGGCTTCCTGGATAATAGAAGTTCCCGAAGGCCGCCGATTCCAGAAGATACTGTCTG GCGTGAAATTAGTCTCAGTAGAAACATAAGTCCCGCGCGTCTTGTGCTGCGCGTGCGCAAGCTTTTGGGCCCTCCCGAGAAAGGGAAGTG CATTCTCGCTTCCGTAGCGGTCTCCGCCGGTTGGGGGGAAGTAATTCCGGTTGTTGCACCATGGCGTCCATGGGGACCCTCGCCTTCGAT GAATATGGGCGCCCTTTCCTCATCATCAAGGATCAGGACCGCAAGTCCCGTCTTATGGGACTTGAGGCCCTCAAGTCTCATATAATGGCA GCAAAGGCTGTAGCAAATACAATGAGAACATCACTTGGACCAAATGGGCTTGATAAGATGATGGTGGATAAGGATGGAGATGTGACTGTA ACTAATGATGGGGCCACCATCTTAAGCATGATGGATGTTGATCATCAGATTGCCAAGCTGATGGTGGAACTGTCCAAGTCTCAGGATGAT GAAATTGGAGATGGAACCACAGGAGTGGTTGTCCTGGCTGGTGCCTTGTTAGAAGAAGCGGAGCAATTGCTAGACCGAGGCATTCACCCA ATCAGAATAGCCGATGGCTATGAGCAGGCTGCTCGTGTTGCTATTGAACACCTGGACAAGATCAGCGATAGCGTCCTTGTTGACATAAAG GACACCGAACCCCTGATTCAGACAGCAAAAACCACGCTGGGCTCCAAAGTGGTCAACAGTTGTCACCGACAGATGGCTGAGATTGCTGTG AATGCCGTCCTCACTGTAGCAGATATGGAGCGGAGAGACGTTGACTTTGAGCTTATCAAAGTAGAAGGCAAAGTGGGCGGCAGGCTGGAG GACACTAAACTGATTAAGGGCGTGATTGTGGACAAGGATTTCAGTCACCCACAGATGCCAAAAAAAGTGGAAGATGCGAAGATTGCAATT CTCACATGTCCATTTGAACCACCCAAACCAAAAACAAAGCATAAGCTGGATGTGACCTCTGTCGAAGATTATAAAGCCCTTCAGAAATAC GAAAAGGAGAAATTTGAAGAGATGATTCAACAAATTAAAGAGACTGGTGCTAACCTAGCAATTTGTCAGTGGGGCTTTGATGATGAAGCA AATCACTTACTTCTTCAGAACAACTTGCCTGCGGTTCGCTGGGTAGGAGGACCTGAAATTGAGCTGATTGCCATCGCAACAGGAGGGCGG ATCGTCCCCAGGTTCTCAGAGCTCACAGCCGAGAAGCTGGGCTTTGCTGGTCTTGTACAGGAGATCTCATTTGGGACAACTAAGGATAAA ATGCTGGTCATCGAGCAGTGTAAGAACTCCAGAGCTGTAACCATTTTTATTAGAGGAGGAAATAAGATGATCATTGAGGAGGCGAAACGA TCCCTTCACGATGCTTTGTGTGTCATCCGGAACCTCATCCGCGATAATCGTGTGGTGTATGGAGGAGGGGCTGCTGAGATATCCTGTGCC CTGGCAGTTAGCCAAGAGGCGGATAAGTGCCCCACCTTAGAACAGTATGCCATGAGAGCGTTTGCCGACGCACTGGAGGTCATCCCCATG GCCCTCTCTGAAAACAGTGGCATGAATCCCATCCAGACTATGACCGAAGTCCGAGCCAGACAGGTGAAGGAGATGAACCCTGCTCTTGGC ATCGACTGTTTGCACAAGGGGACAAATGATATGAAGCAACAGCATGTCATAGAAACCTTGATTGGCAAAAAGCAACAGATATCTCTTGCA |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_CRTAC1_ENST00000298819_chr10_99624758_-_CCT5_ENST00000280326_chr5_10250033_+_6521nt CTGGCTGCCGGCTGCTGCCACCGCAATCCCGGCTCCTAAATCAGCGCGGGGAGGCGCTCCCTCCCCACGCCCGGCTCTCCGGGCTCTCGG GGCCGCGATTGGCCGCGCCGGCGCCCCCCACCCCGGGCCCCCGGCTCCAGCTGCCGCGCCATTGGCTGCGGGCCTCCGCCAGCCTTTACA TAAGACCGGGCGCGCTCGAGTGGAGTTGTATAAAGCGAGCGCGCGGCGTCGGGGCGGGAGGCTCGAGGCCAGCCCGGGACCGGGGCTGGG AGCAAGCAGGCGGCGGCGCCGGCGGCAGAGGCGGCAGCGAGCGCCCGCTTCCCACGCCCCTAGGCGGCGGGGCCGAGAGCGGGAGGATGG CTCCGAGCGCTGACCCCGGCATGTCCAGGATGTTACCGTTCCTGCTGCTGCTCTGGTTTCTGCCCATCACTGAGGGGTCCCAGCGGGCTG AACCCATGTTCACTGCAGTCACCAACTCAGTTCTGCCTCCTGACTATGACAGTAATCCCACCCAGCTCAACTATGGTGTGGCAGTTACTG ATGTGGACCATGATGGGGACTTTGAGATCGTCGTGGCGGGGTACAATGGACCCAACCTGGTTCTGAAGTATGACCGGGCCCAGAAGCGGC TGGTGAACATCGCGGTCGATGAGCGCAGCTCACCCTACTACGCGCTGCGGGACCGGCAGGGGAACGCCATCGGGGTCACAGCCTGCGACA TCGACGGGGACGGCCGGGAGGAGATCTACTTCCTCAACACCAATAATGCCTTCTCGGGGGTGGCCACGTACACCGACAAGTTGTTCAAGT TCCGCAATAACCGGTGGGAAGACATCCTGAGCGATGAGGTCAACGTGGCCCGTGGTGTGGCCAGCCTCTTTGCCGGACGCTCTGTGGCCT GTGTGGACAGAAAGGGCTCTGGACGCTACTCTATCTACATTGCCAATTACGCCTACGGTAATGTGGGCCCTGATGCCCTCATTGAAATGG ACCCTGAGGCCAGTGACCTCTCCCGGGGCATTCTGGCGCTCAGAGATGTGGCTGCTGAGGCTGGGGTCAGCAAATATACAGGGGGCCGAG GCGTCAGCGTGGGCCCCATCCTCAGCAGCAGTGCCTCGGATATCTTCTGCGACAATGAGAATGGGCCTAACTTCCTTTTCCACAACCGGG GCGATGGCACCTTTGTGGACGCTGCGGCCAGTGCTGGTGTGGACGACCCCCACCAGCATGGGCGAGGTGTCGCCCTGGCTGACTTCAACC GTGATGGCAAAGTGGACATCGTCTATGGCAACTGGAATGGCCCCCACCGCCTCTATCTGCAAATGAGCACCCATGGGAAGGTCCGCTTCC GGGACATCGCCTCACCCAAGTTCTCCATGCCCTCCCCTGTCCGCACGGTCATCACCGCCGACTTTGACAATGACCAGGAGCTGGAGATCT TCTTCAACAACATTGCCTACCGCAGCTCCTCAGCCAACCGCCTCTTCCGCGTCATCCGTAGAGAGCACGGAGACCCCCTCATCGAGGAGC TCAATCCCGGCGACGCCTTGGAGCCTGAGGGCCGGGGCACAGGGGGTGTGGTGACCGACTTCGACGGAGACGGGATGCTGGACCTCATCT TGTCCCATGGAGAGTCCATGGCTCAGCCGCTGTCCGTCTTCCGGGGCAATCAGGGCTTCAACAACAACTGGCTGCGAGTGGTGCCACGCA CCCGGTTTGGGGCCTTTGCCAGGGGAGCTAAGGTCGTGCTCTACACCAAGAAGAGTGGGGCCCACCTGAGGATCATCGACGGGGGCTCAG GCTACCTGTGTGAGATGGAGCCCGTGGCACACTTTGGCCTGGGGAAGGATGAAGCCAGCAGTGTGGAGGTGACGTGGCCAGATGGCAAGA TGGTGAGCCGGAACGTGGCCAGCGGGGAGATGAACTCAGTGCTGGAGATCCTCTACCCCCGGGATGAGGACACACTTCAGGACCCAGCCC CACTGGAGACACCAATGAATGCATCCAGTTCCCATTCGTGTGCCCTCGAGACAAGCCCGTATGTGTCAACACCTATGGAAGCTACAGGTG CCGGACCAACAAGAAGTGCAGTCGGGGCTACGAGCCCAACGAGGATGGCACAGCCTGCGTGGGGACTCTCGGCCAGTCACCGGGCCCCCG CCCCACCACCCCCACCGCTGCTGCTGCCACTGCCGCTGCTGCTGCCGCTGCTGGAGCTGCCACTGCTGCACCGGTCCTCGTAGATGGAGA TCTCAATCTGGGGTCGGTGGTTAAGGAGAGCTGCGAGCCCAGCTGCTGAGCAGGGGTGGGACATGAACCAGCGGATGGAGTCCAGCAGGG GAGTGGGAAAGTGGGCTTGTGCTGCTGCCTAGACAGTAGGGATGTAAAGGCCTGGGAGCTAGACCCTCCCCAAGCCCATCCATGCACATT ACTTAGCTAACAATTAGGGAGACTCGTAAGGCCAGGCCCTGTGCTGGGCACATAGCTGTGATCACAGCAGACAGGGTCGCTGCCCTGATG GCGCTTACATTCCAGTGGGTCTAATGACCATATCTTAGGACACAGATGTGCCCAGGGAGGTGGTGTCACTGCACAGGAAGTATGAGGACT TTAGTGTCCTGAGTTCAAATCCTGATTCAGGAACTCACAAAGCTATGTGACCTTACACCAGTCACTTAACTTGTTAGCCATCCATTATCG CATCTGCAAAATGGGGATTAAGAATAGAATCTTGGGGTTAGTGTGGAGATTAGATTAAATGTATGTAAGACACTTGGCACAAAACCTGGC ACATAGTAAAGGCTCAATAAAAACAAGTGCCTCTCACTGGGCTTTGTCAACACGTGAAAAAAAAAAAAAACCGGAAATGGGTCCTACCAT CTTCTCGGAGCCGGAGTGCGAAGAAATAAAGAAATAGTGCTTTAAGTCAATGAATTCCTCCTTGGGACCCACTATCGAGAAACTATCAGT GGTAACGTTTTAAAAAATGACAAATTCAATCTGCTCTTGACTTGTGTGTCCTAAGATTTCCACTAAGTGTCTTCAAACCTCCCCCTCCCC GGCTTCCTGGATAATAGAAGTTCCCGAAGGCCGCCGATTCCAGAAGATACTGTCTGGCGTGAAATTAGTCTCAGTAGAAACATAAGTCCC GCGCGTCTTGTGCTGCGCGTGCGCAAGCTTTTGGGCCCTCCCGAGAAAGGGAAGTGCATTCTCGCTTCCGTAGCGGTCTCCGCCGGTTGG GGGGAAGTAATTCCGGTTGTTGCACCATGGCGTCCATGGGGACCCTCGCCTTCGATGAATATGGGCGCCCTTTCCTCATCATCAAGGATC AGGACCGCAAGTCCCGTCTTATGGGACTTGAGGCCCTCAAGTCTCATATAATGGCAGCAAAGGCTGTAGCAAATACAATGAGAACATCAC TTGGACCAAATGGGCTTGATAAGATGATGGTGGATAAGGATGGAGATGTGACTGTAACTAATGATGGGGCCACCATCTTAAGCATGATGG ATGTTGATCATCAGATTGCCAAGCTGATGGTGGAACTGTCCAAGTCTCAGGATGATGAAATTGGAGATGGAACCACAGGAGTGGTTGTCC TGGCTGGTGCCTTGTTAGAAGAAGCGGAGCAATTGCTAGACCGAGGCATTCACCCAATCAGAATAGCCGATGGCTATGAGCAGGCTGCTC GTGTTGCTATTGAACACCTGGACAAGATCAGCGATAGCGTCCTTGTTGACATAAAGGACACCGAACCCCTGATTCAGACAGCAAAAACCA CGCTGGGCTCCAAAGTGGTCAACAGTTGTCACCGACAGATGGCTGAGATTGCTGTGAATGCCGTCCTCACTGTAGCAGATATGGAGCGGA GAGACGTTGACTTTGAGCTTATCAAAGTAGAAGGCAAAGTGGGCGGCAGGCTGGAGGACACTAAACTGATTAAGGGCGTGATTGTGGACA AGGATTTCAGTCACCCACAGATGCCAAAAAAAGTGGAAGATGCGAAGATTGCAATTCTCACATGTCCATTTGAACCACCCAAACCAAAAA CAAAGCATAAGCTGGATGTGACCTCTGTCGAAGATTATAAAGCCCTTCAGAAATACGAAAAGGAGAAATTTGAAGAGATGATTCAACAAA TTAAAGAGACTGGTGCTAACCTAGCAATTTGTCAGTGGGGCTTTGATGATGAAGCAAATCACTTACTTCTTCAGAACAACTTGCCTGCGG TTCGCTGGGTAGGAGGACCTGAAATTGAGCTGATTGCCATCGCAACAGGAGGGCGGATCGTCCCCAGGTTCTCAGAGCTCACAGCCGAGA AGCTGGGCTTTGCTGGTCTTGTACAGGAGATCTCATTTGGGACAACTAAGGATAAAATGCTGGTCATCGAGCAGTGTAAGAACTCCAGAG CTGTAACCATTTTTATTAGAGGAGGAAATAAGATGATCATTGAGGAGGCGAAACGATCCCTTCACGATGCTTTGTGTGTCATCCGGAACC TCATCCGCGATAATCGTGTGGTGTATGGAGGAGGGGCTGCTGAGATATCCTGTGCCCTGGCAGTTAGCCAAGAGGCGGATAAGTGCCCCA CCTTAGAACAGTATGCCATGAGAGCGTTTGCCGACGCACTGGAGGTCATCCCCATGGCCCTCTCTGAAAACAGTGGCATGAATCCCATCC AGACTATGACCGAAGTCCGAGCCAGACAGGTGAAGGAGATGAACCCTGCTCTTGGCATCGACTGTTTGCACAAGGGGACAAATGATATGA AGCAACAGCATGTCATAGAAACCTTGATTGGCAAAAAGCAACAGATATCTCTTGCAACACAAATGGTTAGAATGATTTTGAAGATTGATG ACATTCGTAAGCCTGGAGAATCTGAAGAATGAAGACATTGAGAAAACTATGTAGCAAGATCCACTTCTGTGATTAAGTAAATGGATGTCT CGTGATGCATCTACAGTTATTTATTGTTACATCCTTTTCCAGACACTGTAGATGCTATAATAAAAATAGCTGTTTGGTAACCATAGTTTC ACTTGTTCAAAGCTGTGTAATCGTGGGGGTACCATCTCAACTGCTTTTGTATTCATTGTATTAAAAGAATCTGTTTAAACAACCTTTATC TTCTCTTCGGGTTTAAGAAACGTTTATTGTAACAGTAATTAAATGCTGCCTTAATTGAAGGGGTTTGGGTGGATTTTTTTTTCTCAAAAT AAGCTGTAGGGACTATTTTAACAGCTTAAACAGGAGCTCTCAAGATGCACTTTCATATTGAGAGGAATATGGGCTTGATCCTCTTCCTAT CTAAATGGGTGGGCCATTTGATTGTAGAGGGTCCACCACAGAATTATGGGATGCCTTAAGTGCTGTTACTAGGTTGCTCACAGCCTAACC TGGCGTGTTGTTTAGGGCTGATGGAGACCCATGTGAGCCTTTGCTTTCCTCTGGCCCCGGCCCCACCCTGAACACAGCTCATACACAGAA TCAGGACCAGCATGTGCAGAGCTGGCCACCAGCACAGGCTTAGGGCAGTTCAGAACCCACTTGTTTCCCTATCAGAGGGACACAGTGAAG TGGAGGTTAAAGTAAATTACAGGAAATAAGGGAGAAATCTTGCAGTTACCATGTTCAGATAGAGTGACTGAAATTAATTGTACTTACTAA AGTATTAACTAGCTAACAGTGATGGGCCAAGACGCTCCGAGAACTCTACCGGGATTGTCTGTTCTGACAACCCAGTGAGGCAGATACACT TTCTTACTGCTCACATCTTACAGGTGAGTACTCATAATTGGCCAGCATCTCACCACCAGCAAGTAGTAGGGCCAGGTCAATCCCAGGCAG TCTGACCCCAGAGTGGCCCAGCTCATCCCCTACTCTGTTATTTGCTTGTTAATGATTCTCTAGATTTTCTAAAATAATGTTTCTTAGCAT TGTGATGATAAAGCTCATGATGAACTTTATCACTAGTTATGCCACCTTAACTAGTCAGATTTCCTAGAATTAGGAAATGGTGACTCTTGT CTAAATTTGGTTAAGTGATGAATTTGGGTTACCGTCTCATGTGAACCTGGAGATTCACCAGTCTTAACTTTTGGGTCATTGTGTTTTCTC TACATTCATGCATTGGATGTTTTGCTAAATAACTCCTGTGGATTTAGGAATGTGTGCTAATAGCAATCTTCCTAATTTTCATGTTTATAT GGAACTATGCAGTTGAGTATTGAAAGCTTTAAACTGAGTTTATTTACAAGGACTGAGTCTAGCCTACAGAGAACATACAGCAGCCTTCTT TGGACCACAGTCTTATCCGAGGGGTCTGTGGTTGTATCAGAAGAGCCACTAAACCAATCCCCCTTTCCAAAATTGAACCTCACAGACGTT CCTGTTTTTTGTGATTGAGAAACTGGTCAATGAACAGGAAGACTTAGAGATGTTTCACAAGCCTTTGATTTTTGTTTCATTTATTTGTAA |
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FusionGenePPI for CRTAC1_CCT5 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| CRTAC1 | AQP1, MAPRE2, MORN4, ZMYM6, A2M, CFP, WFDC2, RUVBL1, MTO1, TRAPPC10, BRIP1, TRAPPC9, MOCOS, ASPM, KLHDC3, VPS13A, RUVBL2, EFEMP1, CCRN4L | CCT5 | XRN1, THEG, SSSCA1, HDAC3, ACTB, TBC1D17, IKBKAP, IMMT, TP53, PPP4C, CTTNBP2, MOB4, PPP2CA, STK24, STRN, STRN3, TRAF3IP3, PPP2CB, PPP2R2C, IGBP1, TCP1, ACTA2, ACTA1, GPN1, HNRNPH1, RPAP2, RPAP3, CDK9, RFWD2, SRRM2, SRRM1, WDR82, H2AFX, UBC, MYC, PPP2R2A, PPP2R2B, PPP2R2D, PPP2R4, AGO4, HDAC5, PCK1, VHL, SIRT7, FBXO25, CUL3, CUL4A, CDK2, GNB5, GNB1, RGS7, PDCL, GRB2, PACRG, CCT2, CCT3, CCT8, CCT6A, CCT4, CCT7, CCT6B, AHCYL1, IARS, TARS, PSMA6, PSMB1, VCP, SSR1, XPO1, SLU7, TXNL1, SRSF2, ATXN2, TRIM28, FN1, VCAM1, ATF2, PEX14, NOS2, FAM86B2, METTL21B, ITGA4, PAN2, HDAC6, FBXW4, TERT, FBXO6, CDK5, ILK, CDC20, LGALS3BP, NEDD1, TUBG1, HUWE1, FUS, CUL7, OBSL1, RNF2, SIRT6, IKBKE, IRAK1, SGK2, TSSK6, TYK2, WDR76, POC1A, PEX7, RPS6KB2, DCAF7, UNK, ACTR2, AHNAK, HSPE1, PIN4, STUB1, NTRK1, BTRC, B9D1, MKS1, CETN2, CDK1, DDB2, HDAC1, PDK3, NSMAF, NIPSNAP1, PRPF4, BUB3, WRAP53, RFWD3, KIF21A, SEH1L, KBTBD7, TUBA1C, ARMC6, GAN, CRY2, ALKBH3, MCM2, SNW1, CDC5L, TTC27, NLE1, CDC73, CRBN, PPM1J, KLHDC8A, DNAI2, HCFC2, WDR77, DCAF11, KDM4B, KLHL33, KLHDC2, TXNDC9, WDR86, TBL1Y, DCAF8, THOC3, WDTC1, GANAB, ODF1, DCAF5, SEC31B, TSSC1, WDR83, CYLD, WDR92, TRIM25, MCPH1, HEY1, BRCA1, YAP1 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for CRTAC1_CCT5 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for CRTAC1_CCT5 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Tgene | CCT5 | C0019693 | HIV Infections | 1 | CTD_human |
| Tgene | CCT5 | C1458155 | Mammary Neoplasms | 1 | CTD_human |
| Tgene | CCT5 | C1850395 | Neuropathy, Hereditary Sensory, with Spastic Paraplegia, Autosomal Recessive | 1 | CTD_human;ORPHANET;UNIPROT |
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