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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 8502

FusionGeneSummary for CRLF3_ATAD5

check button Fusion gene summary
Fusion gene informationFusion gene name: CRLF3_ATAD5
Fusion gene ID: 8502
HgeneTgene
Gene symbol

CRLF3

ATAD5

Gene ID

51379

79915

Gene namecytokine receptor like factor 3ATPase family, AAA domain containing 5
SynonymsCREME-9|CREME9|CRLM9|CYTOR4|FRWS|p48.2C17orf41|ELG1|FRAG1
Cytomap

17q11.2

17q11.2

Type of geneprotein-codingprotein-coding
Descriptioncytokine receptor-like factor 3cytokine receptor-like molecule 9cytokine receptor-related protein 4type I cytokine receptor-like factor p48ATPase family AAA domain-containing protein 5chromosome fragility associated gene 1chromosome fragility-associated gene 1 proteinenhanced level of genomic instability 1 homolog
Modification date2018052320180523
UniProtAcc

Q8IUI8

Q96QE3

Ensembl transtripts involved in fusion geneENST00000324238, ENST00000544695, 
ENST00000577725, 
ENST00000321990, 
Fusion gene scores* DoF score6 X 4 X 4=964 X 6 X 4=96
# samples 66
** MAII scorelog2(6/96*10)=-0.678071905112638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(6/96*10)=-0.678071905112638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CRLF3 [Title/Abstract] AND ATAD5 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneCRLF3

GO:0030308

negative regulation of cell growth

19427400

HgeneCRLF3

GO:0045893

positive regulation of transcription, DNA-templated

19427400

HgeneCRLF3

GO:0045944

positive regulation of transcription by RNA polymerase II

19427400

HgeneCRLF3

GO:0046427

positive regulation of JAK-STAT cascade

19427400

HgeneCRLF3

GO:0071158

positive regulation of cell cycle arrest

19427400


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVBRCATCGA-A2-A0CY-01ACRLF3chr17

29151541

-ATAD5chr17

29185179

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000324238ENST00000321990CRLF3chr17

29151541

-ATAD5chr17

29185179

+
5UTR-3CDSENST00000544695ENST00000321990CRLF3chr17

29151541

-ATAD5chr17

29185179

+
intron-3CDSENST00000577725ENST00000321990CRLF3chr17

29151541

-ATAD5chr17

29185179

+

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FusionProtFeatures for CRLF3_ATAD5


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CRLF3

Q8IUI8

ATAD5

Q96QE3

May play a role in the negative regulation of cell cycleprogression. {ECO:0000269|PubMed:19427400}. Involved in DNA damage response. Involved in a RAD9A-related damage checkpoint, a pathway that is important indetermining whether DNA damage is compatible with cell survival orwhether it requires cell elimination by apoptosis. Modulates theRAD9A interaction with BCL2 and thereby induces DNA damages-induced apoptosis. {ECO:0000269|PubMed:15983387}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneATAD5chr17:29151541chr17:29185179ENST00000321990+7231589_15999311845Compositional biasNote=Poly-Ser
TgeneATAD5chr17:29151541chr17:29185179ENST00000321990+7231428_14329311845MotifNote=LXCXE motif
TgeneATAD5chr17:29151541chr17:29185179ENST00000321990+7231132_11399311845Nucleotide bindingATP

- In-frame and not-retained protein feature among the 13 regional features.
>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCRLF3chr17:29151541chr17:29185179ENST00000324238-1810_5743443Coiled coilOntology_term=ECO:0000255
HgeneCRLF3chr17:29151541chr17:29185179ENST00000324238-18181_27443443DomainFibronectin type-III


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FusionGeneSequence for CRLF3_ATAD5


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for CRLF3_ATAD5


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
CRLF3ELAVL1, DOCK6, DOCK7, DOCK8, LRCH2, SNRPD2, LRCH3, MOB1A, MOB1B, KDM1A, CRLF3, LGALS14, VPS25, ENPP6, APPL2, PTPN14, ZBED8, TRIM25ATAD5USP1, WDR48, RFC4, PCNA, BRD4, CPVL, BAZ1B, HIST1H2BG, HIST1H3A, BAX, NOP56, MIS12, CDC14B, RFC5, CHEK2, CHEK1, CSNK2A1, ALDH2, WEE1, MAP2K1, RABGGTB, FNTA, TUBA1A


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for CRLF3_ATAD5


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for CRLF3_ATAD5


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneATAD5C0677886Epithelial ovarian cancer1CTD_human