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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 8497

FusionGeneSummary for CRK_STX8

check button Fusion gene summary
Fusion gene informationFusion gene name: CRK_STX8
Fusion gene ID: 8497
HgeneTgene
Gene symbol

CRK

STX8

Gene ID

1398

9482

Gene nameCRK proto-oncogene, adaptor proteinsyntaxin 8
SynonymsCRKII|p38CARB
Cytomap

17p13.3

17p13.1

Type of geneprotein-codingprotein-coding
Descriptionadapter molecule crkproto-oncogene c-Crkv-crk avian sarcoma virus CT10 oncogene homologv-crk sarcoma virus CT10 oncogene-like proteinsyntaxin-8CIP-1-associated regulator of cyclin B
Modification date2018052220180523
UniProtAcc

P46108

Q9UNK0

Ensembl transtripts involved in fusion geneENST00000398970, ENST00000300574, 
ENST00000574295, ENST00000572145, 
ENST00000306357, ENST00000574431, 
ENST00000573373, 
Fusion gene scores* DoF score10 X 5 X 6=3009 X 4 X 7=252
# samples 109
** MAII scorelog2(10/300*10)=-1.58496250072116
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(9/252*10)=-1.48542682717024
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CRK [Title/Abstract] AND STX8 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotationOncogene involved fusion gene, in-frame and retained their domain.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneCRK

GO:0009966

regulation of signal transduction

17515907

HgeneCRK

GO:0032956

regulation of actin cytoskeleton organization

11870224

HgeneCRK

GO:0043087

regulation of GTPase activity

11870224

HgeneCRK

GO:0048013

ephrin receptor signaling pathway

11870224

HgeneCRK

GO:0061045

negative regulation of wound healing

17515907

HgeneCRK

GO:0071538

SH2 domain-mediated complex assembly

12384576

HgeneCRK

GO:2000146

negative regulation of cell motility

17515907

TgeneSTX8

GO:0045022

early endosome to late endosome transport

10564279

TgeneSTX8

GO:1903076

regulation of protein localization to plasma membrane

18570918


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVLUSCTCGA-85-A4CN-01ACRKchr17

1359171

-STX8chr17

9153962

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000398970ENST00000306357CRKchr17

1359171

-STX8chr17

9153962

-
In-frameENST00000398970ENST00000574431CRKchr17

1359171

-STX8chr17

9153962

-
5CDS-intronENST00000398970ENST00000573373CRKchr17

1359171

-STX8chr17

9153962

-
In-frameENST00000300574ENST00000306357CRKchr17

1359171

-STX8chr17

9153962

-
In-frameENST00000300574ENST00000574431CRKchr17

1359171

-STX8chr17

9153962

-
5CDS-intronENST00000300574ENST00000573373CRKchr17

1359171

-STX8chr17

9153962

-
In-frameENST00000574295ENST00000306357CRKchr17

1359171

-STX8chr17

9153962

-
In-frameENST00000574295ENST00000574431CRKchr17

1359171

-STX8chr17

9153962

-
5CDS-intronENST00000574295ENST00000573373CRKchr17

1359171

-STX8chr17

9153962

-
intron-3CDSENST00000572145ENST00000306357CRKchr17

1359171

-STX8chr17

9153962

-
intron-3CDSENST00000572145ENST00000574431CRKchr17

1359171

-STX8chr17

9153962

-
intron-intronENST00000572145ENST00000573373CRKchr17

1359171

-STX8chr17

9153962

-

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FusionProtFeatures for CRK_STX8


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CRK

P46108

STX8

Q9UNK0

Isoform Crk-II: Regulates cell adhesion, spreading andmigration. Mediates attachment-induced MAPK8 activation, membraneruffling and cell motility in a Rac-dependent manner. Involved inphagocytosis of apoptotic cells and cell motility via itsinteraction with DOCK1 and DOCK4. May regulate the EFNA5-EPHA3signaling. {ECO:0000269|PubMed:11870224,ECO:0000269|PubMed:1630456, ECO:0000269|PubMed:17515907,ECO:0000269|PubMed:19004829}. Vesicle trafficking protein that functions in the earlysecretory pathway, possibly by mediating retrograde transport fromcis-Golgi membranes to the ER.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneSTX8chr17:1359171chr17:9153962ENST00000306357-68233_236214237Topological domainVesicular
TgeneSTX8chr17:1359171chr17:9153962ENST00000306357-68216_232214237TransmembraneHelical%3B Anchor for type IV membrane protein

- In-frame and not-retained protein feature among the 13 regional features.
>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCRKchr17:1359171chr17:9153962ENST00000300574-13132_19280305DomainSH3 1
HgeneCRKchr17:1359171chr17:9153962ENST00000300574-1313_11880305DomainSH2
HgeneCRKchr17:1359171chr17:9153962ENST00000300574-13235_29680305DomainSH3 2
HgeneCRKchr17:1359171chr17:9153962ENST00000398970-13132_19280205DomainSH3 1
HgeneCRKchr17:1359171chr17:9153962ENST00000398970-1313_11880205DomainSH2
HgeneCRKchr17:1359171chr17:9153962ENST00000398970-13235_29680205DomainSH3 2
TgeneSTX8chr17:1359171chr17:9153962ENST00000306357-6842_65214237Coiled coilOntology_term=ECO:0000255
TgeneSTX8chr17:1359171chr17:9153962ENST00000306357-68145_207214237Domaint-SNARE coiled-coil homology
TgeneSTX8chr17:1359171chr17:9153962ENST00000306357-681_215214237Topological domainCytoplasmic


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FusionGeneSequence for CRK_STX8


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_CRK_ENST00000398970_chr17_1359171_-_STX8_ENST00000306357_chr17_9153962_-_103aa
MAGNFDSEERSSWYWGRLSRQEAVALLQGQRHGVFLVRDSSTSPGDTVLSVSENSRVSHYIINSSGPRPPVPPSPAQPPPGMIMVILLLL

>In-frame_CRK_ENST00000398970_chr17_1359171_-_STX8_ENST00000574431_chr17_9153962_-_103aa
MAGNFDSEERSSWYWGRLSRQEAVALLQGQRHGVFLVRDSSTSPGDTVLSVSENSRVSHYIINSSGPRPPVPPSPAQPPPGMIMVILLLL

>In-frame_CRK_ENST00000300574_chr17_1359171_-_STX8_ENST00000306357_chr17_9153962_-_103aa
MAGNFDSEERSSWYWGRLSRQEAVALLQGQRHGVFLVRDSSTSPGDTVLSVSENSRVSHYIINSSGPRPPVPPSPAQPPPGMIMVILLLL

>In-frame_CRK_ENST00000300574_chr17_1359171_-_STX8_ENST00000574431_chr17_9153962_-_103aa
MAGNFDSEERSSWYWGRLSRQEAVALLQGQRHGVFLVRDSSTSPGDTVLSVSENSRVSHYIINSSGPRPPVPPSPAQPPPGMIMVILLLL

>In-frame_CRK_ENST00000574295_chr17_1359171_-_STX8_ENST00000306357_chr17_9153962_-_103aa
MAGNFDSEERSSWYWGRLSRQEAVALLQGQRHGVFLVRDSSTSPGDTVLSVSENSRVSHYIINSSGPRPPVPPSPAQPPPGMIMVILLLL

>In-frame_CRK_ENST00000574295_chr17_1359171_-_STX8_ENST00000574431_chr17_9153962_-_103aa
MAGNFDSEERSSWYWGRLSRQEAVALLQGQRHGVFLVRDSSTSPGDTVLSVSENSRVSHYIINSSGPRPPVPPSPAQPPPGMIMVILLLL


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_CRK_ENST00000398970_chr17_1359171_-_STX8_ENST00000306357_chr17_9153962_-_309nt
ATGGCGGGCAACTTCGACTCGGAGGAGCGGAGTAGCTGGTACTGGGGGAGGTTGAGTCGGCAGGAGGCGGTGGCGCTGCTGCAGGGCCAG
CGGCACGGGGTGTTCCTGGTGCGGGACTCGAGCACCAGCCCCGGGGACTATGTGCTCAGCGTCTCAGAGAACTCGCGCGTCTCCCACTAC
ATCATCAACAGCAGCGGCCCGCGCCCGCCGGTGCCACCGTCGCCCGCCCAGCCTCCGCCCGGGATGATCATGGTGATTTTACTGCTGCTT

>In-frame_CRK_ENST00000398970_chr17_1359171_-_STX8_ENST00000574431_chr17_9153962_-_309nt
ATGGCGGGCAACTTCGACTCGGAGGAGCGGAGTAGCTGGTACTGGGGGAGGTTGAGTCGGCAGGAGGCGGTGGCGCTGCTGCAGGGCCAG
CGGCACGGGGTGTTCCTGGTGCGGGACTCGAGCACCAGCCCCGGGGACTATGTGCTCAGCGTCTCAGAGAACTCGCGCGTCTCCCACTAC
ATCATCAACAGCAGCGGCCCGCGCCCGCCGGTGCCACCGTCGCCCGCCCAGCCTCCGCCCGGGATGATCATGGTGATTTTACTGCTGCTT

>In-frame_CRK_ENST00000300574_chr17_1359171_-_STX8_ENST00000306357_chr17_9153962_-_309nt
ATGGCGGGCAACTTCGACTCGGAGGAGCGGAGTAGCTGGTACTGGGGGAGGTTGAGTCGGCAGGAGGCGGTGGCGCTGCTGCAGGGCCAG
CGGCACGGGGTGTTCCTGGTGCGGGACTCGAGCACCAGCCCCGGGGACTATGTGCTCAGCGTCTCAGAGAACTCGCGCGTCTCCCACTAC
ATCATCAACAGCAGCGGCCCGCGCCCGCCGGTGCCACCGTCGCCCGCCCAGCCTCCGCCCGGGATGATCATGGTGATTTTACTGCTGCTT

>In-frame_CRK_ENST00000300574_chr17_1359171_-_STX8_ENST00000574431_chr17_9153962_-_309nt
ATGGCGGGCAACTTCGACTCGGAGGAGCGGAGTAGCTGGTACTGGGGGAGGTTGAGTCGGCAGGAGGCGGTGGCGCTGCTGCAGGGCCAG
CGGCACGGGGTGTTCCTGGTGCGGGACTCGAGCACCAGCCCCGGGGACTATGTGCTCAGCGTCTCAGAGAACTCGCGCGTCTCCCACTAC
ATCATCAACAGCAGCGGCCCGCGCCCGCCGGTGCCACCGTCGCCCGCCCAGCCTCCGCCCGGGATGATCATGGTGATTTTACTGCTGCTT

>In-frame_CRK_ENST00000574295_chr17_1359171_-_STX8_ENST00000306357_chr17_9153962_-_309nt
ATGGCGGGCAACTTCGACTCGGAGGAGCGGAGTAGCTGGTACTGGGGGAGGTTGAGTCGGCAGGAGGCGGTGGCGCTGCTGCAGGGCCAG
CGGCACGGGGTGTTCCTGGTGCGGGACTCGAGCACCAGCCCCGGGGACTATGTGCTCAGCGTCTCAGAGAACTCGCGCGTCTCCCACTAC
ATCATCAACAGCAGCGGCCCGCGCCCGCCGGTGCCACCGTCGCCCGCCCAGCCTCCGCCCGGGATGATCATGGTGATTTTACTGCTGCTT

>In-frame_CRK_ENST00000574295_chr17_1359171_-_STX8_ENST00000574431_chr17_9153962_-_309nt
ATGGCGGGCAACTTCGACTCGGAGGAGCGGAGTAGCTGGTACTGGGGGAGGTTGAGTCGGCAGGAGGCGGTGGCGCTGCTGCAGGGCCAG
CGGCACGGGGTGTTCCTGGTGCGGGACTCGAGCACCAGCCCCGGGGACTATGTGCTCAGCGTCTCAGAGAACTCGCGCGTCTCCCACTAC
ATCATCAACAGCAGCGGCCCGCGCCCGCCGGTGCCACCGTCGCCCGCCCAGCCTCCGCCCGGGATGATCATGGTGATTTTACTGCTGCTT


* Fusion transcript sequences (Full-length transcript).
>In-frame_CRK_ENST00000398970_chr17_1359171_-_STX8_ENST00000306357_chr17_9153962_-_522nt
GCTGCTGTGAAGCTGAAACCGGAGCCGGTCCGCTGGGCGGCGGGCGCCGGGGGCCGGAGGGGCGCGCGCGGCGGCGGCACCCCAGCGTTT
AGGCGCGGAGGCAGCCATGGCGGGCAACTTCGACTCGGAGGAGCGGAGTAGCTGGTACTGGGGGAGGTTGAGTCGGCAGGAGGCGGTGGC
GCTGCTGCAGGGCCAGCGGCACGGGGTGTTCCTGGTGCGGGACTCGAGCACCAGCCCCGGGGACTATGTGCTCAGCGTCTCAGAGAACTC
GCGCGTCTCCCACTACATCATCAACAGCAGCGGCCCGCGCCCGCCGGTGCCACCGTCGCCCGCCCAGCCTCCGCCCGGGATGATCATGGT
GATTTTACTGCTGCTTGTGGCTATCGTGGTTGTTGCAGTCTGGCCGACCAACTGATGGCAGTAAAGAGACCACCAGCAGTGACACCTGCC

>In-frame_CRK_ENST00000398970_chr17_1359171_-_STX8_ENST00000574431_chr17_9153962_-_506nt
GCTGCTGTGAAGCTGAAACCGGAGCCGGTCCGCTGGGCGGCGGGCGCCGGGGGCCGGAGGGGCGCGCGCGGCGGCGGCACCCCAGCGTTT
AGGCGCGGAGGCAGCCATGGCGGGCAACTTCGACTCGGAGGAGCGGAGTAGCTGGTACTGGGGGAGGTTGAGTCGGCAGGAGGCGGTGGC
GCTGCTGCAGGGCCAGCGGCACGGGGTGTTCCTGGTGCGGGACTCGAGCACCAGCCCCGGGGACTATGTGCTCAGCGTCTCAGAGAACTC
GCGCGTCTCCCACTACATCATCAACAGCAGCGGCCCGCGCCCGCCGGTGCCACCGTCGCCCGCCCAGCCTCCGCCCGGGATGATCATGGT
GATTTTACTGCTGCTTGTGGCTATCGTGGTTGTTGCAGTCTGGCCGACCAACTGATGGCAGTAAAGAGACCACCAGCAGTGACACCTGCC

>In-frame_CRK_ENST00000300574_chr17_1359171_-_STX8_ENST00000306357_chr17_9153962_-_557nt
GGGGGAGGCCCGCGGCTGCCGCCGCCATTTCGGGCGCTGCTGTGAAGCTGAAACCGGAGCCGGTCCGCTGGGCGGCGGGCGCCGGGGGCC
GGAGGGGCGCGCGCGGCGGCGGCACCCCAGCGTTTAGGCGCGGAGGCAGCCATGGCGGGCAACTTCGACTCGGAGGAGCGGAGTAGCTGG
TACTGGGGGAGGTTGAGTCGGCAGGAGGCGGTGGCGCTGCTGCAGGGCCAGCGGCACGGGGTGTTCCTGGTGCGGGACTCGAGCACCAGC
CCCGGGGACTATGTGCTCAGCGTCTCAGAGAACTCGCGCGTCTCCCACTACATCATCAACAGCAGCGGCCCGCGCCCGCCGGTGCCACCG
TCGCCCGCCCAGCCTCCGCCCGGGATGATCATGGTGATTTTACTGCTGCTTGTGGCTATCGTGGTTGTTGCAGTCTGGCCGACCAACTGA
TGGCAGTAAAGAGACCACCAGCAGTGACACCTGCCAATGACAGATGCAAGCCCAACACCCTTTTGGTACGCAAAACCTGCTCTCAATAAA

>In-frame_CRK_ENST00000300574_chr17_1359171_-_STX8_ENST00000574431_chr17_9153962_-_541nt
GGGGGAGGCCCGCGGCTGCCGCCGCCATTTCGGGCGCTGCTGTGAAGCTGAAACCGGAGCCGGTCCGCTGGGCGGCGGGCGCCGGGGGCC
GGAGGGGCGCGCGCGGCGGCGGCACCCCAGCGTTTAGGCGCGGAGGCAGCCATGGCGGGCAACTTCGACTCGGAGGAGCGGAGTAGCTGG
TACTGGGGGAGGTTGAGTCGGCAGGAGGCGGTGGCGCTGCTGCAGGGCCAGCGGCACGGGGTGTTCCTGGTGCGGGACTCGAGCACCAGC
CCCGGGGACTATGTGCTCAGCGTCTCAGAGAACTCGCGCGTCTCCCACTACATCATCAACAGCAGCGGCCCGCGCCCGCCGGTGCCACCG
TCGCCCGCCCAGCCTCCGCCCGGGATGATCATGGTGATTTTACTGCTGCTTGTGGCTATCGTGGTTGTTGCAGTCTGGCCGACCAACTGA
TGGCAGTAAAGAGACCACCAGCAGTGACACCTGCCAATGACAGATGCAAGCCCAACACCCTTTTGGTACGCAAAACCTGCTCTCAATAAA

>In-frame_CRK_ENST00000574295_chr17_1359171_-_STX8_ENST00000306357_chr17_9153962_-_448nt
CGGCACCCCAGCGTTTAGGCGCGGAGGCAGCCATGGCGGGCAACTTCGACTCGGAGGAGCGGAGTAGCTGGTACTGGGGGAGGTTGAGTC
GGCAGGAGGCGGTGGCGCTGCTGCAGGGCCAGCGGCACGGGGTGTTCCTGGTGCGGGACTCGAGCACCAGCCCCGGGGACTATGTGCTCA
GCGTCTCAGAGAACTCGCGCGTCTCCCACTACATCATCAACAGCAGCGGCCCGCGCCCGCCGGTGCCACCGTCGCCCGCCCAGCCTCCGC
CCGGGATGATCATGGTGATTTTACTGCTGCTTGTGGCTATCGTGGTTGTTGCAGTCTGGCCGACCAACTGATGGCAGTAAAGAGACCACC

>In-frame_CRK_ENST00000574295_chr17_1359171_-_STX8_ENST00000574431_chr17_9153962_-_432nt
CGGCACCCCAGCGTTTAGGCGCGGAGGCAGCCATGGCGGGCAACTTCGACTCGGAGGAGCGGAGTAGCTGGTACTGGGGGAGGTTGAGTC
GGCAGGAGGCGGTGGCGCTGCTGCAGGGCCAGCGGCACGGGGTGTTCCTGGTGCGGGACTCGAGCACCAGCCCCGGGGACTATGTGCTCA
GCGTCTCAGAGAACTCGCGCGTCTCCCACTACATCATCAACAGCAGCGGCCCGCGCCCGCCGGTGCCACCGTCGCCCGCCCAGCCTCCGC
CCGGGATGATCATGGTGATTTTACTGCTGCTTGTGGCTATCGTGGTTGTTGCAGTCTGGCCGACCAACTGATGGCAGTAAAGAGACCACC


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FusionGenePPI for CRK_STX8


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
CRKPLSCR1, DPPA4, BUB1, PSMC6, EGFR, ERBB4, BCAR1, SRCIN1, ARHGAP32, DOCK1, SRC, PTK2, MAP4K1, EPHA3, SH3KBP1, SOCS1, IRS4, MAPK8, KHDRBS1, ASAP1, PDGFRA, AVIL, GRB2, ARHGAP17, RET, PXN, PDGFRB, NEDD9, EPHB3, FRS2, MAP4K5, EPHB2, RAPGEF1, SH3BP1, SOS1, XPO1, WEE1, SHB, ZAP70, EPS15, CBL, PTPN1, CBLC, MICAL1, SYN1, PPP1CA, BCR, CSE1L, PIK3R1, TERF2IP, POT1, FASLG, EFS, ATXN1, KIT, ABL1, UBASH3B, PIK3R2, SHC1, PIK3CB, KRT1, PIK3CA, KRT2, KRT9, KRT10, HSPA8, KRT14, KRT5, KRT16, KRT6A, HSPA1B, KRT6B, PIK3C2B, TUBB, TUBB4B, CASS4, PTPN11, INPPL1, KRT17, ACTB, TUBB2A, SOS2, NCKIPSD, EDC4, HSPA1L, TUBB3, TUBA1A, CBLB, ABL2, HSPA9, RPS19, PIK3R3, PEAK1, GAB2, HSPA6, KRT3, KRT19, KRT15, HSPA5, AP2A1, KRT76, KRT77, PIK3CD, GAB1, KRT73, KRT8, AGO2, YWHAG, KRT79, KRT78, UBC, EEF1A1, YWHAQ, CORO1C, AP2B1, RPS5, DDX3X, DDX6, UBASH3A, KRT24, RPS25, SFN, ASAP3, KRT12, KRT4, AGO1, DNAJA3, RNGTT, RPL23, HSP90AB1, TUBA4B, LYZ, DDX5, RPS3, SERPINB6, HSPBP1, DSC1, AP2M1, GGA3, FUBP1, ATIC, SERPINH1, NANS, DHX9, HSPB1, SPR, DOK1, ERBB2, ERBB3, PPFIBP2, LMNA, BAG3, PTPN4, MAPK4, MET, SPRR2A, HUWE1, FAM154A, CAST, GFPT1, SRM, BEX5, RTCB, CHTF18, CNDP2, DOK2, DOK3, DOK7, ELK1, EPYC, EYA3, GAREM, FSTL1, GABPB2, HSH2D, KCTD13, KLHL20, LASP1, MAGEC3, MPG, MYLIP, MYOZ2, NUFIP2, OFCC1, PAFAH1B2, PHC2, PRKACA, PRRG2, RAB2B, SEMA4D, SH2D2A, SOCS6, STAT4, TCAP, TM4SF19, VAC14, ANKZF1, ANLN, ASB9, ASCL4, PRRC2B, BATF3, C4orf17, SETD9, C6orf141, CORO6, ESD, HABP4, IFT140, INO80E, ISL1, KCTD17, KLF15, LHX8, MNDA, PSMC1, PTTG1, RYBP, SEPT6, STRN4, TDG, TP53, TUBA1C, TWIST2, WDR83, ZKSCAN7, ZNF557, ATF3, FER, CLNK, RIN3, CCP110, CEP128, CEP89, ODF2, CEP19, COX6C, HIST1H1D, PPP1R12A, NUMA1, KAT6A, MPDZ, ARPC1B, SLC25A13, C10orf12, MRPL48, INF2, FLNA, STAT5A, FGFR1, TRIM15, TSG101, CDH1STX8VTI1B, CREB3, NAPA, VTI1A, STX7, VAMP8, HECTD3, NSF, CALM1, ATP6V1B1, CLN8, STX4, VAMP4, VAMP3, VAMP7, STX6, SRPRB, STX12, CLEC12A, STX3, CEP170, NAPG, TMEM171, STX18, DTNBP1, AP2M1, LPAR1, CEP164, TMEM17, TMEM216, ERRFI1, SEC22B, STX11, STXBP6, CLINT1, STAMBPL1, AP1S2, IPPK, GDPD5, ASPH, MED21, MAP7D2, GPR156, TRDN, LMNA


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for CRK_STX8


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for CRK_STX8


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneCRKC0151744Myocardial Ischemia1CTD_human