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Fusion gene ID: 8494 |
FusionGeneSummary for CRK_PITPNA |
Fusion gene summary |
Fusion gene information | Fusion gene name: CRK_PITPNA | Fusion gene ID: 8494 | Hgene | Tgene | Gene symbol | CRK | PITPNA | Gene ID | 1398 | 5306 |
Gene name | CRK proto-oncogene, adaptor protein | phosphatidylinositol transfer protein alpha | |
Synonyms | CRKII|p38 | HEL-S-36|PI-TPalpha|PITPN|VIB1A | |
Cytomap | 17p13.3 | 17p13.3 | |
Type of gene | protein-coding | protein-coding | |
Description | adapter molecule crkproto-oncogene c-Crkv-crk avian sarcoma virus CT10 oncogene homologv-crk sarcoma virus CT10 oncogene-like protein | phosphatidylinositol transfer protein alpha isoformPI-TP-alphaepididymis secretory protein Li 36ptdIns transfer protein alphaptdInsTP alpha | |
Modification date | 20180522 | 20180523 | |
UniProtAcc | P46108 | Q00169 | |
Ensembl transtripts involved in fusion gene | ENST00000398970, ENST00000300574, ENST00000574295, ENST00000572145, | ENST00000313486, ENST00000539476, | |
Fusion gene scores | * DoF score | 10 X 5 X 6=300 | 7 X 8 X 7=392 |
# samples | 10 | 8 | |
** MAII score | log2(10/300*10)=-1.58496250072116 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(8/392*10)=-2.29278174922785 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: CRK [Title/Abstract] AND PITPNA [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation | Oncogene involved fusion gene, in-frame and retained their domain. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | CRK | GO:0009966 | regulation of signal transduction | 17515907 |
Hgene | CRK | GO:0032956 | regulation of actin cytoskeleton organization | 11870224 |
Hgene | CRK | GO:0043087 | regulation of GTPase activity | 11870224 |
Hgene | CRK | GO:0048013 | ephrin receptor signaling pathway | 11870224 |
Hgene | CRK | GO:0061045 | negative regulation of wound healing | 17515907 |
Hgene | CRK | GO:0071538 | SH2 domain-mediated complex assembly | 12384576 |
Hgene | CRK | GO:2000146 | negative regulation of cell motility | 17515907 |
Tgene | PITPNA | GO:0015914 | phospholipid transport | 16274224|22822086 |
Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | OV | TCGA-09-1659-01B | CRK | chr17 | 1359171 | - | PITPNA | chr17 | 1442246 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
In-frame | ENST00000398970 | ENST00000313486 | CRK | chr17 | 1359171 | - | PITPNA | chr17 | 1442246 | - |
In-frame | ENST00000398970 | ENST00000539476 | CRK | chr17 | 1359171 | - | PITPNA | chr17 | 1442246 | - |
In-frame | ENST00000300574 | ENST00000313486 | CRK | chr17 | 1359171 | - | PITPNA | chr17 | 1442246 | - |
In-frame | ENST00000300574 | ENST00000539476 | CRK | chr17 | 1359171 | - | PITPNA | chr17 | 1442246 | - |
In-frame | ENST00000574295 | ENST00000313486 | CRK | chr17 | 1359171 | - | PITPNA | chr17 | 1442246 | - |
In-frame | ENST00000574295 | ENST00000539476 | CRK | chr17 | 1359171 | - | PITPNA | chr17 | 1442246 | - |
intron-3CDS | ENST00000572145 | ENST00000313486 | CRK | chr17 | 1359171 | - | PITPNA | chr17 | 1442246 | - |
intron-3CDS | ENST00000572145 | ENST00000539476 | CRK | chr17 | 1359171 | - | PITPNA | chr17 | 1442246 | - |
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FusionProtFeatures for CRK_PITPNA |
Main function of each fusion partner protein. (from UniProt) |
Hgene | Tgene |
CRK | PITPNA |
Isoform Crk-II: Regulates cell adhesion, spreading andmigration. Mediates attachment-induced MAPK8 activation, membraneruffling and cell motility in a Rac-dependent manner. Involved inphagocytosis of apoptotic cells and cell motility via itsinteraction with DOCK1 and DOCK4. May regulate the EFNA5-EPHA3signaling. {ECO:0000269|PubMed:11870224,ECO:0000269|PubMed:1630456, ECO:0000269|PubMed:17515907,ECO:0000269|PubMed:19004829}. | Catalyzes the transfer of PtdIns and phosphatidylcholinebetween membranes. |
Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | >CRK | chr17:1359171 | chr17:1442246 | ENST00000300574 | - | 1 | 3 | 132_192 | 80 | 305 | Domain | SH3 1 |
Hgene | >CRK | chr17:1359171 | chr17:1442246 | ENST00000300574 | - | 1 | 3 | 13_118 | 80 | 305 | Domain | SH2 |
Hgene | >CRK | chr17:1359171 | chr17:1442246 | ENST00000300574 | - | 1 | 3 | 235_296 | 80 | 305 | Domain | SH3 2 |
Hgene | >CRK | chr17:1359171 | chr17:1442246 | ENST00000398970 | - | 1 | 3 | 132_192 | 80 | 205 | Domain | SH3 1 |
Hgene | >CRK | chr17:1359171 | chr17:1442246 | ENST00000398970 | - | 1 | 3 | 13_118 | 80 | 205 | Domain | SH2 |
Hgene | >CRK | chr17:1359171 | chr17:1442246 | ENST00000398970 | - | 1 | 3 | 235_296 | 80 | 205 | Domain | SH3 2 |
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FusionGeneSequence for CRK_PITPNA |
For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for CRK_PITPNA |
Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
CRK | PLSCR1, DPPA4, BUB1, PSMC6, EGFR, ERBB4, BCAR1, SRCIN1, ARHGAP32, DOCK1, SRC, PTK2, MAP4K1, EPHA3, SH3KBP1, SOCS1, IRS4, MAPK8, KHDRBS1, ASAP1, PDGFRA, AVIL, GRB2, ARHGAP17, RET, PXN, PDGFRB, NEDD9, EPHB3, FRS2, MAP4K5, EPHB2, RAPGEF1, SH3BP1, SOS1, XPO1, WEE1, SHB, ZAP70, EPS15, CBL, PTPN1, CBLC, MICAL1, SYN1, PPP1CA, BCR, CSE1L, PIK3R1, TERF2IP, POT1, FASLG, EFS, ATXN1, KIT, ABL1, UBASH3B, PIK3R2, SHC1, PIK3CB, KRT1, PIK3CA, KRT2, KRT9, KRT10, HSPA8, KRT14, KRT5, KRT16, KRT6A, HSPA1B, KRT6B, PIK3C2B, TUBB, TUBB4B, CASS4, PTPN11, INPPL1, KRT17, ACTB, TUBB2A, SOS2, NCKIPSD, EDC4, HSPA1L, TUBB3, TUBA1A, CBLB, ABL2, HSPA9, RPS19, PIK3R3, PEAK1, GAB2, HSPA6, KRT3, KRT19, KRT15, HSPA5, AP2A1, KRT76, KRT77, PIK3CD, GAB1, KRT73, KRT8, AGO2, YWHAG, KRT79, KRT78, UBC, EEF1A1, YWHAQ, CORO1C, AP2B1, RPS5, DDX3X, DDX6, UBASH3A, KRT24, RPS25, SFN, ASAP3, KRT12, KRT4, AGO1, DNAJA3, RNGTT, RPL23, HSP90AB1, TUBA4B, LYZ, DDX5, RPS3, SERPINB6, HSPBP1, DSC1, AP2M1, GGA3, FUBP1, ATIC, SERPINH1, NANS, DHX9, HSPB1, SPR, DOK1, ERBB2, ERBB3, PPFIBP2, LMNA, BAG3, PTPN4, MAPK4, MET, SPRR2A, HUWE1, FAM154A, CAST, GFPT1, SRM, BEX5, RTCB, CHTF18, CNDP2, DOK2, DOK3, DOK7, ELK1, EPYC, EYA3, GAREM, FSTL1, GABPB2, HSH2D, KCTD13, KLHL20, LASP1, MAGEC3, MPG, MYLIP, MYOZ2, NUFIP2, OFCC1, PAFAH1B2, PHC2, PRKACA, PRRG2, RAB2B, SEMA4D, SH2D2A, SOCS6, STAT4, TCAP, TM4SF19, VAC14, ANKZF1, ANLN, ASB9, ASCL4, PRRC2B, BATF3, C4orf17, SETD9, C6orf141, CORO6, ESD, HABP4, IFT140, INO80E, ISL1, KCTD17, KLF15, LHX8, MNDA, PSMC1, PTTG1, RYBP, SEPT6, STRN4, TDG, TP53, TUBA1C, TWIST2, WDR83, ZKSCAN7, ZNF557, ATF3, FER, CLNK, RIN3, CCP110, CEP128, CEP89, ODF2, CEP19, COX6C, HIST1H1D, PPP1R12A, NUMA1, KAT6A, MPDZ, ARPC1B, SLC25A13, C10orf12, MRPL48, INF2, FLNA, STAT5A, FGFR1, TRIM15, TSG101, CDH1 | PITPNA | PMVK, MORF4L2, MLKL, SCP2, CSNK2B, ACP1, CCDC58, GOT1, HADH, HSPB1, NECAP1, VAPA, UBE2L3, PLK1, S1PR4 |
- Retained PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
- Lost PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
- Retained PPIs, but lost function due to frame-shift fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for CRK_PITPNA |
Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for CRK_PITPNA |
Diseases associated with fusion partners. (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | CRK | C0151744 | Myocardial Ischemia | 1 | CTD_human |