FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 8492

FusionGeneSummary for CRK_GTF2I

check button Fusion gene summary
Fusion gene informationFusion gene name: CRK_GTF2I
Fusion gene ID: 8492
HgeneTgene
Gene symbol

CRK

GTF2I

Gene ID

1398

2969

Gene nameCRK proto-oncogene, adaptor proteingeneral transcription factor IIi
SynonymsCRKII|p38BAP135|BTKAP1|DIWS|GTFII-I|IB291|SPIN|TFII-I|WBS|WBSCR6
Cytomap

17p13.3

7q11.23

Type of geneprotein-codingprotein-coding
Descriptionadapter molecule crkproto-oncogene c-Crkv-crk avian sarcoma virus CT10 oncogene homologv-crk sarcoma virus CT10 oncogene-like proteingeneral transcription factor II-IBTK-associated protein, 135kDBruton tyrosine kinase-associated protein 135SRF-Phox1-interacting proteinWilliams-Beuren syndrome chromosome region 6
Modification date2018052220180522
UniProtAcc

P46108

P78347

Ensembl transtripts involved in fusion geneENST00000398970, ENST00000300574, 
ENST00000574295, ENST00000572145, 
ENST00000324896, ENST00000353920, 
ENST00000346152, ENST00000416070, 
ENST00000443166, ENST00000438130, 
Fusion gene scores* DoF score10 X 5 X 6=3004 X 5 X 5=100
# samples 106
** MAII scorelog2(10/300*10)=-1.58496250072116
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(6/100*10)=-0.736965594166206
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CRK [Title/Abstract] AND GTF2I [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneCRK

GO:0009966

regulation of signal transduction

17515907

HgeneCRK

GO:0032956

regulation of actin cytoskeleton organization

11870224

HgeneCRK

GO:0043087

regulation of GTPase activity

11870224

HgeneCRK

GO:0048013

ephrin receptor signaling pathway

11870224

HgeneCRK

GO:0061045

negative regulation of wound healing

17515907

HgeneCRK

GO:0071538

SH2 domain-mediated complex assembly

12384576

HgeneCRK

GO:2000146

negative regulation of cell motility

17515907

TgeneGTF2I

GO:0016525

negative regulation of angiogenesis

19242469


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVLIHCTCGA-BC-A10T-01ACRKchr17

1359171

-GTF2Ichr7

74113291

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shitENST00000398970ENST00000324896CRKchr17

1359171

-GTF2Ichr7

74113291

+
Frame-shitENST00000398970ENST00000353920CRKchr17

1359171

-GTF2Ichr7

74113291

+
Frame-shitENST00000398970ENST00000346152CRKchr17

1359171

-GTF2Ichr7

74113291

+
Frame-shitENST00000398970ENST00000416070CRKchr17

1359171

-GTF2Ichr7

74113291

+
Frame-shitENST00000398970ENST00000443166CRKchr17

1359171

-GTF2Ichr7

74113291

+
5CDS-intronENST00000398970ENST00000438130CRKchr17

1359171

-GTF2Ichr7

74113291

+
Frame-shitENST00000300574ENST00000324896CRKchr17

1359171

-GTF2Ichr7

74113291

+
Frame-shitENST00000300574ENST00000353920CRKchr17

1359171

-GTF2Ichr7

74113291

+
Frame-shitENST00000300574ENST00000346152CRKchr17

1359171

-GTF2Ichr7

74113291

+
Frame-shitENST00000300574ENST00000416070CRKchr17

1359171

-GTF2Ichr7

74113291

+
Frame-shitENST00000300574ENST00000443166CRKchr17

1359171

-GTF2Ichr7

74113291

+
5CDS-intronENST00000300574ENST00000438130CRKchr17

1359171

-GTF2Ichr7

74113291

+
Frame-shitENST00000574295ENST00000324896CRKchr17

1359171

-GTF2Ichr7

74113291

+
Frame-shitENST00000574295ENST00000353920CRKchr17

1359171

-GTF2Ichr7

74113291

+
Frame-shitENST00000574295ENST00000346152CRKchr17

1359171

-GTF2Ichr7

74113291

+
Frame-shitENST00000574295ENST00000416070CRKchr17

1359171

-GTF2Ichr7

74113291

+
Frame-shitENST00000574295ENST00000443166CRKchr17

1359171

-GTF2Ichr7

74113291

+
5CDS-intronENST00000574295ENST00000438130CRKchr17

1359171

-GTF2Ichr7

74113291

+
intron-3CDSENST00000572145ENST00000324896CRKchr17

1359171

-GTF2Ichr7

74113291

+
intron-3CDSENST00000572145ENST00000353920CRKchr17

1359171

-GTF2Ichr7

74113291

+
intron-3CDSENST00000572145ENST00000346152CRKchr17

1359171

-GTF2Ichr7

74113291

+
intron-3CDSENST00000572145ENST00000416070CRKchr17

1359171

-GTF2Ichr7

74113291

+
intron-3CDSENST00000572145ENST00000443166CRKchr17

1359171

-GTF2Ichr7

74113291

+
intron-intronENST00000572145ENST00000438130CRKchr17

1359171

-GTF2Ichr7

74113291

+

Top

FusionProtFeatures for CRK_GTF2I


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CRK

P46108

GTF2I

P78347

Isoform Crk-II: Regulates cell adhesion, spreading andmigration. Mediates attachment-induced MAPK8 activation, membraneruffling and cell motility in a Rac-dependent manner. Involved inphagocytosis of apoptotic cells and cell motility via itsinteraction with DOCK1 and DOCK4. May regulate the EFNA5-EPHA3signaling. {ECO:0000269|PubMed:11870224,ECO:0000269|PubMed:1630456, ECO:0000269|PubMed:17515907,ECO:0000269|PubMed:19004829}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for CRK_GTF2I


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for CRK_GTF2I


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
CRKPLSCR1, DPPA4, BUB1, PSMC6, EGFR, ERBB4, BCAR1, SRCIN1, ARHGAP32, DOCK1, SRC, PTK2, MAP4K1, EPHA3, SH3KBP1, SOCS1, IRS4, MAPK8, KHDRBS1, ASAP1, PDGFRA, AVIL, GRB2, ARHGAP17, RET, PXN, PDGFRB, NEDD9, EPHB3, FRS2, MAP4K5, EPHB2, RAPGEF1, SH3BP1, SOS1, XPO1, WEE1, SHB, ZAP70, EPS15, CBL, PTPN1, CBLC, MICAL1, SYN1, PPP1CA, BCR, CSE1L, PIK3R1, TERF2IP, POT1, FASLG, EFS, ATXN1, KIT, ABL1, UBASH3B, PIK3R2, SHC1, PIK3CB, KRT1, PIK3CA, KRT2, KRT9, KRT10, HSPA8, KRT14, KRT5, KRT16, KRT6A, HSPA1B, KRT6B, PIK3C2B, TUBB, TUBB4B, CASS4, PTPN11, INPPL1, KRT17, ACTB, TUBB2A, SOS2, NCKIPSD, EDC4, HSPA1L, TUBB3, TUBA1A, CBLB, ABL2, HSPA9, RPS19, PIK3R3, PEAK1, GAB2, HSPA6, KRT3, KRT19, KRT15, HSPA5, AP2A1, KRT76, KRT77, PIK3CD, GAB1, KRT73, KRT8, AGO2, YWHAG, KRT79, KRT78, UBC, EEF1A1, YWHAQ, CORO1C, AP2B1, RPS5, DDX3X, DDX6, UBASH3A, KRT24, RPS25, SFN, ASAP3, KRT12, KRT4, AGO1, DNAJA3, RNGTT, RPL23, HSP90AB1, TUBA4B, LYZ, DDX5, RPS3, SERPINB6, HSPBP1, DSC1, AP2M1, GGA3, FUBP1, ATIC, SERPINH1, NANS, DHX9, HSPB1, SPR, DOK1, ERBB2, ERBB3, PPFIBP2, LMNA, BAG3, PTPN4, MAPK4, MET, SPRR2A, HUWE1, FAM154A, CAST, GFPT1, SRM, BEX5, RTCB, CHTF18, CNDP2, DOK2, DOK3, DOK7, ELK1, EPYC, EYA3, GAREM, FSTL1, GABPB2, HSH2D, KCTD13, KLHL20, LASP1, MAGEC3, MPG, MYLIP, MYOZ2, NUFIP2, OFCC1, PAFAH1B2, PHC2, PRKACA, PRRG2, RAB2B, SEMA4D, SH2D2A, SOCS6, STAT4, TCAP, TM4SF19, VAC14, ANKZF1, ANLN, ASB9, ASCL4, PRRC2B, BATF3, C4orf17, SETD9, C6orf141, CORO6, ESD, HABP4, IFT140, INO80E, ISL1, KCTD17, KLF15, LHX8, MNDA, PSMC1, PTTG1, RYBP, SEPT6, STRN4, TDG, TP53, TUBA1C, TWIST2, WDR83, ZKSCAN7, ZNF557, ATF3, FER, CLNK, RIN3, CCP110, CEP128, CEP89, ODF2, CEP19, COX6C, HIST1H1D, PPP1R12A, NUMA1, KAT6A, MPDZ, ARPC1B, SLC25A13, C10orf12, MRPL48, INF2, FLNA, STAT5A, FGFR1, TRIM15, TSG101, CDH1GTF2ILSM8, PTP4A3, BTK, HDAC2, KDM1A, PHF21A, HDAC3, HDAC1, MYC, USF1, PRKG1, ATF6, PRRX1, SRF, STAT1, STAT3, MAPK3, STX7, SUZ12, OTUB2, USP7, MEPCE, SUV420H2, SRRM1, SRRM2, SMAD2, BCL2L11, TOPORS, CHAF1A, CALM1, MAPK1, JAK2, POU2AF1, POLR2A, SIRT7, TFAP4, CUL3, CDK2, BRCA1, INPPL1, LGALS3, LGALS1, SLU7, SNRPN, EEF1A1, SRSF9, PDHA1, HNRNPH1, CBX2, CBX4, C4BPA, MAP3K3, MAPK12, AP4S1, TAB2, FBXO6, ADSL, CTPS2, METTL1, NUCB1, PRKDC, WARS, PRPS2, RAD23B, RPL28, RPA1, RPA2, RPA3, MDM2, PIAS2, ZMYM3, AP2B1, DPY30, GCC1, MTUS2, TRAF6, TUBG1, TP53, MAD2L2, EED, RNF2, UBE2I, SIRT6, MAGEA1, GTF2IRD2B, CYP1A1, PGPEP1, RPS6KB2, HNRNPA1, FBXW11, CCT2, CCT3, NFATC2IP, TCP1, TRMT1L, XRCC6, NTRK1, EWSR1, HIST1H3E, VPS11, PRDM1, USP37, DNMT3L, PTAR1, CDC25A, MTMR7, TIGD6, SOST, ZNF428, UBC, TULP3, STYX, FOXA1, ZMYM2


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for CRK_GTF2I


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for CRK_GTF2I


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneCRKC0151744Myocardial Ischemia1CTD_human
TgeneGTF2IC0175702Williams Syndrome2CTD_human;ORPHANET
TgeneGTF2IC0023467Leukemia, Myelocytic, Acute1CTD_human
TgeneGTF2IC1266101Thymic epithelial tumor1CTD_human
TgeneGTF2IC1510586Autism Spectrum Disorders1CTD_human
TgeneGTF2IC1527336Sjogren's Syndrome1CTD_human