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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 8490

FusionGeneSummary for CRK_CRK

check button Fusion gene summary
Fusion gene informationFusion gene name: CRK_CRK
Fusion gene ID: 8490
HgeneTgene
Gene symbol

CRK

CRK

Gene ID

1398

1398

Gene nameCRK proto-oncogene, adaptor proteinCRK proto-oncogene, adaptor protein
SynonymsCRKII|p38CRKII|p38
Cytomap

17p13.3

17p13.3

Type of geneprotein-codingprotein-coding
Descriptionadapter molecule crkproto-oncogene c-Crkv-crk avian sarcoma virus CT10 oncogene homologv-crk sarcoma virus CT10 oncogene-like proteinadapter molecule crkproto-oncogene c-Crkv-crk avian sarcoma virus CT10 oncogene homologv-crk sarcoma virus CT10 oncogene-like protein
Modification date2018052220180522
UniProtAcc

P46108

P46108

Ensembl transtripts involved in fusion geneENST00000398970, ENST00000300574, 
ENST00000574295, ENST00000572145, 
ENST00000398970, ENST00000300574, 
ENST00000574295, ENST00000572145, 
Fusion gene scores* DoF score10 X 5 X 6=3008 X 8 X 2=128
# samples 108
** MAII scorelog2(10/300*10)=-1.58496250072116
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(8/128*10)=-0.678071905112638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CRK [Title/Abstract] AND CRK [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneCRK

GO:0009966

regulation of signal transduction

17515907

HgeneCRK

GO:0032956

regulation of actin cytoskeleton organization

11870224

HgeneCRK

GO:0043087

regulation of GTPase activity

11870224

HgeneCRK

GO:0048013

ephrin receptor signaling pathway

11870224

HgeneCRK

GO:0061045

negative regulation of wound healing

17515907

HgeneCRK

GO:0071538

SH2 domain-mediated complex assembly

12384576

HgeneCRK

GO:2000146

negative regulation of cell motility

17515907

TgeneCRK

GO:0009966

regulation of signal transduction

17515907

TgeneCRK

GO:0032956

regulation of actin cytoskeleton organization

11870224

TgeneCRK

GO:0043087

regulation of GTPase activity

11870224

TgeneCRK

GO:0048013

ephrin receptor signaling pathway

11870224

TgeneCRK

GO:0061045

negative regulation of wound healing

17515907

TgeneCRK

GO:0071538

SH2 domain-mediated complex assembly

12384576

TgeneCRK

GO:2000146

negative regulation of cell motility

17515907


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AI368616CRKchr17

1334758

+CRKchr17

1333956

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000398970ENST00000398970CRKchr17

1334758

+CRKchr17

1333956

+
intron-intronENST00000398970ENST00000300574CRKchr17

1334758

+CRKchr17

1333956

+
intron-intronENST00000398970ENST00000574295CRKchr17

1334758

+CRKchr17

1333956

+
intron-intronENST00000398970ENST00000572145CRKchr17

1334758

+CRKchr17

1333956

+
intron-intronENST00000300574ENST00000398970CRKchr17

1334758

+CRKchr17

1333956

+
intron-intronENST00000300574ENST00000300574CRKchr17

1334758

+CRKchr17

1333956

+
intron-intronENST00000300574ENST00000574295CRKchr17

1334758

+CRKchr17

1333956

+
intron-intronENST00000300574ENST00000572145CRKchr17

1334758

+CRKchr17

1333956

+
intron-intronENST00000574295ENST00000398970CRKchr17

1334758

+CRKchr17

1333956

+
intron-intronENST00000574295ENST00000300574CRKchr17

1334758

+CRKchr17

1333956

+
intron-intronENST00000574295ENST00000574295CRKchr17

1334758

+CRKchr17

1333956

+
intron-intronENST00000574295ENST00000572145CRKchr17

1334758

+CRKchr17

1333956

+
intron-intronENST00000572145ENST00000398970CRKchr17

1334758

+CRKchr17

1333956

+
intron-intronENST00000572145ENST00000300574CRKchr17

1334758

+CRKchr17

1333956

+
intron-intronENST00000572145ENST00000574295CRKchr17

1334758

+CRKchr17

1333956

+
intron-intronENST00000572145ENST00000572145CRKchr17

1334758

+CRKchr17

1333956

+

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FusionProtFeatures for CRK_CRK


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CRK

P46108

CRK

P46108

Isoform Crk-II: Regulates cell adhesion, spreading andmigration. Mediates attachment-induced MAPK8 activation, membraneruffling and cell motility in a Rac-dependent manner. Involved inphagocytosis of apoptotic cells and cell motility via itsinteraction with DOCK1 and DOCK4. May regulate the EFNA5-EPHA3signaling. {ECO:0000269|PubMed:11870224,ECO:0000269|PubMed:1630456, ECO:0000269|PubMed:17515907,ECO:0000269|PubMed:19004829}. Isoform Crk-II: Regulates cell adhesion, spreading andmigration. Mediates attachment-induced MAPK8 activation, membraneruffling and cell motility in a Rac-dependent manner. Involved inphagocytosis of apoptotic cells and cell motility via itsinteraction with DOCK1 and DOCK4. May regulate the EFNA5-EPHA3signaling. {ECO:0000269|PubMed:11870224,ECO:0000269|PubMed:1630456, ECO:0000269|PubMed:17515907,ECO:0000269|PubMed:19004829}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for CRK_CRK


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for CRK_CRK


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for CRK_CRK


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for CRK_CRK


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneCRKC0151744Myocardial Ischemia1CTD_human
TgeneCRKC0151744Myocardial Ischemia1CTD_human