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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 8487

FusionGeneSummary for CRKL_SLC25A18

check button Fusion gene summary
Fusion gene informationFusion gene name: CRKL_SLC25A18
Fusion gene ID: 8487
HgeneTgene
Gene symbol

CRKL

SLC25A18

Gene ID

1399

83733

Gene nameCRK like proto-oncogene, adaptor proteinsolute carrier family 25 member 18
Synonyms-GC2
Cytomap

22q11.21

22q11.21

Type of geneprotein-codingprotein-coding
Descriptioncrk-like proteinv-crk avian sarcoma virus CT10 oncogene homolog-likemitochondrial glutamate carrier 2glutamate/H(+) symporter 2solute carrier family 25 (glutamate carrier), member 18solute carrier family 25 (mitochondrial carrier), member 18
Modification date2018052220180523
UniProtAcc

P46109

Q9H1K4

Ensembl transtripts involved in fusion geneENST00000354336, ENST00000327451, 
ENST00000399813, ENST00000497401, 
Fusion gene scores* DoF score5 X 3 X 4=602 X 2 X 1=4
# samples 52
** MAII scorelog2(5/60*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(2/4*10)=2.32192809488736
Context

PubMed: CRKL [Title/Abstract] AND SLC25A18 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDLUADTCGA-86-8358-01ACRKLchr22

21288532

+SLC25A18chr22

18062511

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000354336ENST00000327451CRKLchr22

21288532

+SLC25A18chr22

18062511

+
5CDS-5UTRENST00000354336ENST00000399813CRKLchr22

21288532

+SLC25A18chr22

18062511

+
5CDS-3UTRENST00000354336ENST00000497401CRKLchr22

21288532

+SLC25A18chr22

18062511

+

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FusionProtFeatures for CRKL_SLC25A18


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CRKL

P46109

SLC25A18

Q9H1K4

May mediate the transduction of intracellular signals. Involved in the transport of glutamate across the innermitochondrial membrane. Glutamate is cotransported with H(+).{ECO:0000269|PubMed:11897791}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for CRKL_SLC25A18


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for CRKL_SLC25A18


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
CRKLBCR, BCAR1, PXN, CBL, ETV6, ABL1, MAP4K1, RAPGEF1, NEDD9, FCGR1A, DOK1, KIT, TYK2, STAT5A, SYK, WAS, PDGFRA, BLNK, ARHGAP32, CD34, IRS4, GRB2, MAP4K5, PIK3R2, PIK3R1, SHC1, PTPN11, EPOR, INPP5D, GAB2, DOCK2, GAB1, CBLB, USP7, PTEN, MSL1, PLEKHA1, MEGF6, LTBP4, GRN, PLSCR1, LAMA5, NOTCH2, ELAVL1, EPS15, EGFR, ERBB2, ERBB3, LMNA, BAG3, WAC, AOX1, BIK, PHC2, RPL31, YY1, ARHGEF5, PPFIBP2, KHDRBS1, TENC1, POLR1D, GAREM, SHANK3, HUWE1, MOV10, NXF1, CUL7, CLIC4, OGT, SEPHS1, HIP1R, HNRNPH2, PDCD6, NTRK1, AREL1, SOCS1, TMEM168, DOK2, RIN3, CEP170, NINL, ODF2, APOB, DDX6, DOCK1, SOS1, MPZL1, KIAA0430, TELO2, TRAP1, PNRC1, EDC4, IMPACT, DCP1A, UBL5, ELMO2, PEAK1, DOCK5, EDC3, PRR3, GORAB, SGK223, DCP2, C15orf54, IGF1R, CRY2, MCM2, OTUB1, CDH1, IFIT5, PTPN4, TNK2SLC25A18ICT1, GOPC, SLC25A22


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for CRKL_SLC25A18


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgeneSLC25A18Q9H1K4DB00142Glutamic AcidMitochondrial glutamate carrier 2small moleculeapproved|nutraceutical

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RelatedDiseases for CRKL_SLC25A18


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneCRKLC0012236DiGeorge Syndrome1CTD_human