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Fusion gene ID: 8469 |
FusionGeneSummary for CRIM1_TBC1D25 |
Fusion gene summary |
Fusion gene information | Fusion gene name: CRIM1_TBC1D25 | Fusion gene ID: 8469 | Hgene | Tgene | Gene symbol | CRIM1 | TBC1D25 | Gene ID | 51232 | 4943 |
Gene name | cysteine rich transmembrane BMP regulator 1 | TBC1 domain family member 25 | |
Synonyms | CRIM-1|S52 | MG81|OATL1 | |
Cytomap | 2p22.2 | Xp11.23 | |
Type of gene | protein-coding | protein-coding | |
Description | cysteine-rich motor neuron 1 proteincysteine rich transmembrane BMP regulator 1 (chordin-like)cysteine-rich repeat-containing protein S52 | TBC1 domain family member 255SN3 snoRNAornithine aminotransferase-like 1 | |
Modification date | 20180519 | 20180523 | |
UniProtAcc | Q9NZV1 | Q3MII6 | |
Ensembl transtripts involved in fusion gene | ENST00000280527, ENST00000473403, | ENST00000376771, ENST00000537536, ENST00000476141, | |
Fusion gene scores | * DoF score | 10 X 8 X 6=480 | 1 X 1 X 1=1 |
# samples | 10 | 1 | |
** MAII score | log2(10/480*10)=-2.26303440583379 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(1/1*10)=3.32192809488736 | |
Context | PubMed: CRIM1 [Title/Abstract] AND TBC1D25 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Partner | Gene | GO ID | GO term | PubMed ID |
Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | LUAD | TCGA-L9-A743-01A | CRIM1 | chr2 | 36583766 | + | TBC1D25 | chrX | 48417285 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
In-frame | ENST00000280527 | ENST00000376771 | CRIM1 | chr2 | 36583766 | + | TBC1D25 | chrX | 48417285 | + |
5CDS-intron | ENST00000280527 | ENST00000537536 | CRIM1 | chr2 | 36583766 | + | TBC1D25 | chrX | 48417285 | + |
5CDS-3UTR | ENST00000280527 | ENST00000476141 | CRIM1 | chr2 | 36583766 | + | TBC1D25 | chrX | 48417285 | + |
intron-3CDS | ENST00000473403 | ENST00000376771 | CRIM1 | chr2 | 36583766 | + | TBC1D25 | chrX | 48417285 | + |
intron-intron | ENST00000473403 | ENST00000537536 | CRIM1 | chr2 | 36583766 | + | TBC1D25 | chrX | 48417285 | + |
intron-3UTR | ENST00000473403 | ENST00000476141 | CRIM1 | chr2 | 36583766 | + | TBC1D25 | chrX | 48417285 | + |
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FusionProtFeatures for CRIM1_TBC1D25 |
Main function of each fusion partner protein. (from UniProt) |
Hgene | Tgene |
CRIM1 | TBC1D25 |
May play a role in CNS development by interacting withgrowth factors implicated in motor neuron differentiation andsurvival. May play a role in capillary formation and maintenanceduring angiogenesis. Modulates BMP activity by affecting itsprocessing and delivery to the cell surface.{ECO:0000269|PubMed:12464430, ECO:0000269|PubMed:12805376}. | Acts as a GTPase-activating protein specific for RAB33B.Involved in the regulation of autophagosome maturation, theprocess in which autophagosomes fuse with endosomes and lysosomes.{ECO:0000269|PubMed:21383079}. |
Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | CRIM1 | chr2:36583766 | chrX:48417285 | ENST00000280527 | + | 1 | 17 | 35_112 | 110 | 1037 | Domain | IGFBP N-terminal |
Tgene | >TBC1D25 | chr2:36583766 | chrX:48417285 | ENST00000376771 | + | 2 | 6 | 494_499 | 129 | 689 | Compositional bias | Note=Poly-Gly |
Tgene | >TBC1D25 | chr2:36583766 | chrX:48417285 | ENST00000376771 | + | 2 | 6 | 559_564 | 129 | 689 | Compositional bias | Note=Poly-Ser |
Tgene | >TBC1D25 | chr2:36583766 | chrX:48417285 | ENST00000376771 | + | 2 | 6 | 228_434 | 129 | 689 | Domain | Rab-GAP TBC |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | >CRIM1 | chr2:36583766 | chrX:48417285 | ENST00000280527 | + | 1 | 17 | 334_391 | 110 | 1037 | Domain | VWFC 1 |
Hgene | >CRIM1 | chr2:36583766 | chrX:48417285 | ENST00000280527 | + | 1 | 17 | 401_457 | 110 | 1037 | Domain | VWFC 2 |
Hgene | >CRIM1 | chr2:36583766 | chrX:48417285 | ENST00000280527 | + | 1 | 17 | 469_498 | 110 | 1037 | Domain | Antistasin-like 1 |
Hgene | >CRIM1 | chr2:36583766 | chrX:48417285 | ENST00000280527 | + | 1 | 17 | 505_532 | 110 | 1037 | Domain | Antistasin-like 2 |
Hgene | >CRIM1 | chr2:36583766 | chrX:48417285 | ENST00000280527 | + | 1 | 17 | 539_564 | 110 | 1037 | Domain | Antistasin-like 3 |
Hgene | >CRIM1 | chr2:36583766 | chrX:48417285 | ENST00000280527 | + | 1 | 17 | 567_592 | 110 | 1037 | Domain | Antistasin-like 4 |
Hgene | >CRIM1 | chr2:36583766 | chrX:48417285 | ENST00000280527 | + | 1 | 17 | 606_663 | 110 | 1037 | Domain | VWFC 3 |
Hgene | >CRIM1 | chr2:36583766 | chrX:48417285 | ENST00000280527 | + | 1 | 17 | 677_735 | 110 | 1037 | Domain | VWFC 4 |
Hgene | >CRIM1 | chr2:36583766 | chrX:48417285 | ENST00000280527 | + | 1 | 17 | 751_809 | 110 | 1037 | Domain | VWFC 5 |
Hgene | >CRIM1 | chr2:36583766 | chrX:48417285 | ENST00000280527 | + | 1 | 17 | 817_874 | 110 | 1037 | Domain | VWFC 6 |
Hgene | >CRIM1 | chr2:36583766 | chrX:48417285 | ENST00000280527 | + | 1 | 17 | 314_316 | 110 | 1037 | Motif | Cell attachment site |
Hgene | >CRIM1 | chr2:36583766 | chrX:48417285 | ENST00000280527 | + | 1 | 17 | 35_939 | 110 | 1037 | Topological domain | Extracellular |
Hgene | >CRIM1 | chr2:36583766 | chrX:48417285 | ENST00000280527 | + | 1 | 17 | 961_1036 | 110 | 1037 | Topological domain | Cytoplasmic |
Hgene | >CRIM1 | chr2:36583766 | chrX:48417285 | ENST00000280527 | + | 1 | 17 | 940_960 | 110 | 1037 | Transmembrane | Helical |
Tgene | TBC1D25 | chr2:36583766 | chrX:48417285 | ENST00000376771 | + | 2 | 6 | 22_28 | 129 | 689 | Compositional bias | Note=Poly-Ala |
Tgene | TBC1D25 | chr2:36583766 | chrX:48417285 | ENST00000376771 | + | 2 | 6 | 29_34 | 129 | 689 | Compositional bias | Note=Poly-Glu |
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FusionGeneSequence for CRIM1_TBC1D25 |
For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
>In-frame_CRIM1_ENST00000280527_chr2_36583766_+_TBC1D25_ENST00000376771_chrX_48417285_+_670aa MYLVAGDRGLAGCGHLLVSLLGLLLLLARSGTRALVCLPCDESKCEEPRNCPGSIVQGVCGCCYTCASQRNESCGGTFGIYGTCDRGLRC VIRPPLNGDSLTEYEAGVCEGPLLEDWDIISPKDVIGSDVLLAEKRSSLTTAALPFTQSILTQVGRTLSKVQQVLSWSYGEDVKPFKPPL SDAEFHTYLNHEGQLSRPEELRLRIYHGGVEPSLRKVVWRYLLNVYPDGLTGRERMDYMKRKSREYEQLKSEWAQRANPEDLEFIRSTVL KDVLRTDRAHPYYAGPEDGPHLRALHDLLTTYAVTHPQVSYCQGMSDLASPILAVMDHEGHAFVCFCGIMKRLAANFHPDGRAMATKFAH LKLLLRHADPDFYQYLQEAGADDLFFCYRWLLLELKREFAFDDALRMLEVTWSSLPPDPPEHEVELVGPPSQVADAGFGGHRGWPVRQRH MLRPAGGGGSTFEDAVDHLATASQGPGGGGRLLRQASLDGLQQLRDNMGSRRDPLVQLPHPAALISSKSLSEPLLNSPDPLLSSFSHPDS PSSSSPPSTQEASPTGDMAVGSPLMQEVGSPKDPGKSLPPVPPMGLPPPQEFGRGNPFMLFLCLAILLEHRDHIMRNGLDYNELAMHFDR |
* Fusion transcript sequences (only coding sequence (CDS) region). |
>In-frame_CRIM1_ENST00000280527_chr2_36583766_+_TBC1D25_ENST00000376771_chrX_48417285_+_2010nt ATGTACTTGGTGGCGGGGGACAGGGGGTTGGCCGGCTGCGGGCACCTCCTGGTCTCGCTGCTGGGGCTGCTGCTGCTGCTGGCGCGCTCC GGCACCCGGGCGCTGGTCTGCCTGCCCTGTGACGAGTCCAAGTGCGAGGAGCCCAGGAACTGCCCGGGGAGCATCGTGCAGGGCGTCTGC GGCTGCTGCTACACGTGCGCCAGCCAGAGGAACGAGAGCTGCGGCGGCACCTTCGGGATTTACGGAACCTGCGACCGGGGGCTGCGTTGT GTCATCCGCCCCCCGCTCAATGGCGACTCCCTCACCGAGTACGAAGCGGGCGTTTGCGAAGGCCCATTGCTAGAAGACTGGGACATAATC AGCCCCAAAGATGTCATTGGCTCCGACGTGTTGCTGGCTGAGAAACGGTCATCACTGACGACTGCCGCCCTGCCCTTTACACAGTCCATC CTCACTCAGGTGGGCCGTACCTTGTCTAAGGTCCAACAAGTGCTGAGCTGGTCGTATGGGGAAGATGTCAAGCCCTTCAAGCCACCCCTG AGCGATGCTGAGTTTCACACGTACCTGAACCACGAGGGCCAGCTCTCCCGACCCGAGGAGTTGCGCCTGCGGATCTATCATGGCGGTGTG GAGCCCTCGCTGCGAAAGGTGGTGTGGCGGTACCTGCTGAACGTGTATCCAGATGGACTGACAGGCCGAGAGCGGATGGACTACATGAAA CGCAAGAGCCGCGAGTATGAGCAGCTCAAGAGCGAGTGGGCCCAGCGAGCGAACCCTGAGGACCTGGAATTCATCCGCAGCACGGTCCTC AAGGATGTACTGCGCACTGACCGGGCCCACCCCTACTATGCGGGGCCTGAGGATGGCCCACATCTACGGGCGCTGCACGACCTGCTCACC ACCTATGCCGTTACCCACCCACAGGTGTCCTACTGCCAGGGCATGAGTGACCTTGCCTCACCCATCCTCGCTGTCATGGACCATGAGGGC CATGCCTTTGTTTGCTTTTGTGGCATCATGAAACGCCTGGCCGCCAACTTCCACCCTGACGGCCGCGCCATGGCCACCAAGTTTGCACAC TTGAAGCTGTTGCTGCGACACGCTGACCCTGACTTTTATCAATACCTGCAAGAGGCAGGCGCTGATGACCTCTTCTTCTGTTACCGCTGG CTGCTGCTGGAACTCAAGCGTGAGTTCGCCTTCGACGATGCCCTCCGCATGCTTGAGGTCACTTGGAGTTCGCTGCCCCCTGATCCTCCT GAACATGAGGTAGAGCTGGTTGGACCCCCCAGCCAAGTGGCAGACGCTGGTTTTGGTGGCCACAGGGGGTGGCCCGTGCGACAGAGGCAC ATGCTGAGGCCTGCTGGTGGAGGAGGTAGTACCTTTGAAGATGCTGTTGACCACCTGGCCACAGCCAGTCAGGGGCCTGGTGGTGGGGGG CGTCTCCTGAGACAGGCCAGCTTGGATGGCCTCCAGCAACTCAGGGATAACATGGGCTCCAGGAGGGACCCTCTGGTCCAGCTGCCCCAC CCAGCTGCCCTTATCAGCTCCAAGTCCCTCTCTGAGCCTTTATTGAACTCCCCAGACCCACTGCTCTCCTCCTTTTCCCACCCTGATTCC CCATCTTCCTCATCTCCACCATCCACCCAGGAGGCCTCTCCCACTGGTGATATGGCTGTAGGATCCCCCTTGATGCAAGAGGTAGGCTCC CCGAAAGACCCTGGAAAGTCCCTGCCACCTGTACCACCAATGGGCCTGCCCCCACCCCAGGAGTTTGGCCGGGGGAACCCATTCATGCTG TTCCTCTGCCTGGCCATCCTGCTGGAGCACCGCGACCACATCATGCGCAATGGGCTGGATTATAATGAGCTGGCCATGCACTTTGACCGC CTTGTGCGAAAACACCACCTGGGGCGCGTCCTGCGCCGGGCTAGGGCTCTCTTTGCTGATTACCTGCAGTCAGAGGTGTGGGACTCAGAG |
* Fusion transcript sequences (Full-length transcript). |
>In-frame_CRIM1_ENST00000280527_chr2_36583766_+_TBC1D25_ENST00000376771_chrX_48417285_+_4011nt GCCGCCGGCCCGGGCTGGAGCCGAGCGCAGCAGCCACCGCCGCCGCCGCGCCAGAAGTTTGGGTTGAACCGGAGCTGCCGGGAGGAAACT TTTTTCTTTTTTCCCCCTCCCTCCCGGGAGGAGGAGGAGGAGGAGGAGGGGAAGCTGCCGCCGGCGCCAAGGCTCGTGGGCTCGGGGTCG GCGCGGCCCGCAGAAGGGGCGGGGGCCTCGCCCCGCGAGGGGAGGCGCGCCCCGGGGGCCCCGAGAGGGGCGGTGAGGACCGCGGGCTGC TGGTGCGGCGGCGGCGGCGCGTGTGCCCCGCGCAGGGGAGGGCGCCCGCCCCGCTCCCGGCCCGGCTGCGAGGAGGAGGCGGCGGCGGCG CAGGAGGATGTACTTGGTGGCGGGGGACAGGGGGTTGGCCGGCTGCGGGCACCTCCTGGTCTCGCTGCTGGGGCTGCTGCTGCTGCTGGC GCGCTCCGGCACCCGGGCGCTGGTCTGCCTGCCCTGTGACGAGTCCAAGTGCGAGGAGCCCAGGAACTGCCCGGGGAGCATCGTGCAGGG CGTCTGCGGCTGCTGCTACACGTGCGCCAGCCAGAGGAACGAGAGCTGCGGCGGCACCTTCGGGATTTACGGAACCTGCGACCGGGGGCT GCGTTGTGTCATCCGCCCCCCGCTCAATGGCGACTCCCTCACCGAGTACGAAGCGGGCGTTTGCGAAGGCCCATTGCTAGAAGACTGGGA CATAATCAGCCCCAAAGATGTCATTGGCTCCGACGTGTTGCTGGCTGAGAAACGGTCATCACTGACGACTGCCGCCCTGCCCTTTACACA GTCCATCCTCACTCAGGTGGGCCGTACCTTGTCTAAGGTCCAACAAGTGCTGAGCTGGTCGTATGGGGAAGATGTCAAGCCCTTCAAGCC ACCCCTGAGCGATGCTGAGTTTCACACGTACCTGAACCACGAGGGCCAGCTCTCCCGACCCGAGGAGTTGCGCCTGCGGATCTATCATGG CGGTGTGGAGCCCTCGCTGCGAAAGGTGGTGTGGCGGTACCTGCTGAACGTGTATCCAGATGGACTGACAGGCCGAGAGCGGATGGACTA CATGAAACGCAAGAGCCGCGAGTATGAGCAGCTCAAGAGCGAGTGGGCCCAGCGAGCGAACCCTGAGGACCTGGAATTCATCCGCAGCAC GGTCCTCAAGGATGTACTGCGCACTGACCGGGCCCACCCCTACTATGCGGGGCCTGAGGATGGCCCACATCTACGGGCGCTGCACGACCT GCTCACCACCTATGCCGTTACCCACCCACAGGTGTCCTACTGCCAGGGCATGAGTGACCTTGCCTCACCCATCCTCGCTGTCATGGACCA TGAGGGCCATGCCTTTGTTTGCTTTTGTGGCATCATGAAACGCCTGGCCGCCAACTTCCACCCTGACGGCCGCGCCATGGCCACCAAGTT TGCACACTTGAAGCTGTTGCTGCGACACGCTGACCCTGACTTTTATCAATACCTGCAAGAGGCAGGCGCTGATGACCTCTTCTTCTGTTA CCGCTGGCTGCTGCTGGAACTCAAGCGTGAGTTCGCCTTCGACGATGCCCTCCGCATGCTTGAGGTCACTTGGAGTTCGCTGCCCCCTGA TCCTCCTGAACATGAGGTAGAGCTGGTTGGACCCCCCAGCCAAGTGGCAGACGCTGGTTTTGGTGGCCACAGGGGGTGGCCCGTGCGACA GAGGCACATGCTGAGGCCTGCTGGTGGAGGAGGTAGTACCTTTGAAGATGCTGTTGACCACCTGGCCACAGCCAGTCAGGGGCCTGGTGG TGGGGGGCGTCTCCTGAGACAGGCCAGCTTGGATGGCCTCCAGCAACTCAGGGATAACATGGGCTCCAGGAGGGACCCTCTGGTCCAGCT GCCCCACCCAGCTGCCCTTATCAGCTCCAAGTCCCTCTCTGAGCCTTTATTGAACTCCCCAGACCCACTGCTCTCCTCCTTTTCCCACCC TGATTCCCCATCTTCCTCATCTCCACCATCCACCCAGGAGGCCTCTCCCACTGGTGATATGGCTGTAGGATCCCCCTTGATGCAAGAGGT AGGCTCCCCGAAAGACCCTGGAAAGTCCCTGCCACCTGTACCACCAATGGGCCTGCCCCCACCCCAGGAGTTTGGCCGGGGGAACCCATT CATGCTGTTCCTCTGCCTGGCCATCCTGCTGGAGCACCGCGACCACATCATGCGCAATGGGCTGGATTATAATGAGCTGGCCATGCACTT TGACCGCCTTGTGCGAAAACACCACCTGGGGCGCGTCCTGCGCCGGGCTAGGGCTCTCTTTGCTGATTACCTGCAGTCAGAGGTGTGGGA CTCAGAGGAGGGGGCTGAGGCCACAGCCGCATCTTGATCAGGCTTTCTCAAGCCCTCCATCGGCCCCACCAGATCTCCATTCTTTGCCAT GAGGGCCAACACATGAGACCCCACCTCCCTCCCTGCCTGCCAGCCCTAGACTTGTTGGAGCATAGAGCCCTTCCTCCCCAGGCCTAAGTA TGTGGAGCTCTGCTTTGGCACTGCCCCGCAGAGGCCACGCCTATTTATTCTGTTTCTGTTGTTTTGTTTTTAACAACTATACTTTGCACA CATGAAGGTCACTGTGGTTTGTGTGTTTCTCTGCCTCCTCCCTGGGTTTTGCTGTAGATGGAGTCCTCAGGGGCCCTTTACCTGATGGAG GGGAAATACTTCACTTGGTGGAGAGAGGCTCCAGCTTCCCCCTTGTGATGGGGAGAGTGGATGCTGACAATCAGTTCCCAAAGGTGAGCC CAGGTGGAGCACTGCTTGAGGAAGGCCTGAGTCTGTTTTTTTGGTACATCCATCGGCCTGTAAGGGTCTGTATTATGGCTGTGAATATAT GTTTTCAGGACAGCCCCCTGGATGAGAGATAAGAGAGTTCCTGGCTCAAAAAAGGACAAGATTCTTTACTGAGATTGGGAAGTATGGGCT ACTTAGAAACGTTGGAGCAGCCACCCCTGGCATTCCACATGTCACCATTTCTAGGATCTTGGCCTCTCTGTGAGGTTTATGCACCAATGC TGGCAGCCCTGGGCAGGGGCCTCGGCCTCCTTTTTGTTTTCCACTTCAGACAGGTACCGTGCAGATGTTAACAAGGTTTGAGCGAGGTGC ATCTCACACAAGTGTGAAAGCCCAATCATCACATTGTTGAATTACAAAAGGATCTAGGGCTCCTATTCTTGTCACTTGCTTTGGAGCCAG TTTGAAAGACTGGCCTAGCCCATGCCTAGCGGCCCTAAACTGGGATTCCAGCTCACAGCACCTGTCTTAACCATTTCAGCAGTAGAAACC ACTTATTTACCTTCTCCATCTCACTAATATGGACAAACAACAAGCACTGATAAAACGCAGGCCCTAATAGAATTCACTTCGTTATTTGGA GGATAATGATCAAAAAAAGGTCCTTTTTCCCACTGACATGCTCAGAGGGTGGGATTCTCTCACAGGCCAGGTGCTGTCATCCACAAAGGA TGGGTGAAATAACTGGGGTCCTCAGGTCACGGTCTAGCCACACCAGCTTCTCCCAAGTACTAACCAGGCTTGACCCTGCTTAGCTTCAGA GGTCAGACAAGATCTGGCATGTTCAGGATGGTATGGCTGTAGACCAGGCTGGGTTCTGGCCAGAGCTGTTGCACTAGGCAATGCTGCCAG AGATGAGGAGGCATCAGGGCAGTCATCCCTTCTGCTGTTTGCCCCAAGAATGCCATACAAACCTGGGGATGACCCTTAAAAGTCTCCCGT CACCCCCAGTATTGGGGGGAAGCTGACTATTCCTCAGATGATAGCCCAGTCACTTGAAGAACAGGACAAGACTATTCTGTGTCTAGGGGG CTCAAGCACTGTGTGTGGGTCTAACGAATGCATTTTGTGGAAATGGGCTCAGACTCCCCAAAGGGCCATCCAACCTATGGGAGTGTCTGG |
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FusionGenePPI for CRIM1_TBC1D25 |
Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
CRIM1 | ATXN7, CACNA1A, TRIM25 | TBC1D25 | FEZ1, FEZ2, GABARAP, GABARAPL2, MAP1LC3B, MAP1LC3A, GABARAPL1, RAB2A, ATF4, OMA1, RAB3IP, FAM110A, FAM53C, ANKRD34A, USP21, FAM110B, CDK16, CDC25B, AGAP1, SYDE1, SRSF12, ZNF638, DCLK1, TESK2, MAGI1, LIMA1, SIPA1L1, EIF4E2, SRGAP2, SH3PXD2A, DENND1A, LRFN1, GIGYF1, MAPKAP1, KSR1, SH3BP4, ZBTB21, MLLT4, KIF13B, GAB2, PPM1H, CBY1 |
- Retained PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
- Lost PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
- Retained PPIs, but lost function due to frame-shift fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for CRIM1_TBC1D25 |
Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for CRIM1_TBC1D25 |
Diseases associated with fusion partners. (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | TBC1D25 | C0525045 | Mood Disorders | 1 | PSYGENET |