FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 8461

FusionGeneSummary for CRIM1_AFF3

check button Fusion gene summary
Fusion gene informationFusion gene name: CRIM1_AFF3
Fusion gene ID: 8461
HgeneTgene
Gene symbol

CRIM1

AFF3

Gene ID

51232

3899

Gene namecysteine rich transmembrane BMP regulator 1AF4/FMR2 family member 3
SynonymsCRIM-1|S52LAF4|MLLT2-like
Cytomap

2p22.2

2q11.2

Type of geneprotein-codingprotein-coding
Descriptioncysteine-rich motor neuron 1 proteincysteine rich transmembrane BMP regulator 1 (chordin-like)cysteine-rich repeat-containing protein S52AF4/FMR2 family member 3MLLT2-related proteinlymphoid nuclear protein 4lymphoid nuclear protein related to AF4protein LAF-4
Modification date2018051920180523
UniProtAcc

Q9NZV1

P51826

Ensembl transtripts involved in fusion geneENST00000280527, ENST00000473403, 
ENST00000409236, ENST00000356421, 
ENST00000317233, ENST00000409579, 
ENST00000483600, 
Fusion gene scores* DoF score10 X 8 X 6=4807 X 7 X 4=196
# samples 107
** MAII scorelog2(10/480*10)=-2.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(7/196*10)=-1.48542682717024
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CRIM1 [Title/Abstract] AND AFF3 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVMESOTCGA-LK-A4O0-01ACRIM1chr2

36669878

+AFF3chr2

100368763

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shitENST00000280527ENST00000409236CRIM1chr2

36669878

+AFF3chr2

100368763

-
Frame-shitENST00000280527ENST00000356421CRIM1chr2

36669878

+AFF3chr2

100368763

-
Frame-shitENST00000280527ENST00000317233CRIM1chr2

36669878

+AFF3chr2

100368763

-
Frame-shitENST00000280527ENST00000409579CRIM1chr2

36669878

+AFF3chr2

100368763

-
5CDS-intronENST00000280527ENST00000483600CRIM1chr2

36669878

+AFF3chr2

100368763

-
intron-3CDSENST00000473403ENST00000409236CRIM1chr2

36669878

+AFF3chr2

100368763

-
intron-3CDSENST00000473403ENST00000356421CRIM1chr2

36669878

+AFF3chr2

100368763

-
intron-3CDSENST00000473403ENST00000317233CRIM1chr2

36669878

+AFF3chr2

100368763

-
intron-3CDSENST00000473403ENST00000409579CRIM1chr2

36669878

+AFF3chr2

100368763

-
intron-intronENST00000473403ENST00000483600CRIM1chr2

36669878

+AFF3chr2

100368763

-

Top

FusionProtFeatures for CRIM1_AFF3


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CRIM1

Q9NZV1

AFF3

P51826

May play a role in CNS development by interacting withgrowth factors implicated in motor neuron differentiation andsurvival. May play a role in capillary formation and maintenanceduring angiogenesis. Modulates BMP activity by affecting itsprocessing and delivery to the cell surface.{ECO:0000269|PubMed:12464430, ECO:0000269|PubMed:12805376}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for CRIM1_AFF3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for CRIM1_AFF3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
CRIM1ATXN7, CACNA1A, TRIM25AFF3MLLT3, CDK9, PIP4K2A


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for CRIM1_AFF3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for CRIM1_AFF3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneAFF3C0003873Rheumatoid Arthritis2CTD_human
TgeneAFF3C0236969Substance-Related Disorders1CTD_human