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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 8459

FusionGeneSummary for CRHR1_SPOP

check button Fusion gene summary
Fusion gene informationFusion gene name: CRHR1_SPOP
Fusion gene ID: 8459
HgeneTgene
Gene symbol

CRHR1

SPOP

Gene ID

1394

8405

Gene namecorticotropin releasing hormone receptor 1speckle type BTB/POZ protein
SynonymsCRF-R|CRF-R-1|CRF-R1|CRF1|CRFR-1|CRFR1|CRH-R-1|CRH-R1|CRHR|CRHR1LBTBD32|TEF2
Cytomap

17q21.31

17q21.33

Type of geneprotein-codingprotein-coding
Descriptioncorticotropin-releasing factor receptor 1CRH receptor 1corticotropin-releasing factor type 1 receptorseven transmembrane helix receptorspeckle-type POZ proteinHIB homolog 1roadkill homolog 1
Modification date2018052320180523
UniProtAcc

P34998

O43791

Ensembl transtripts involved in fusion geneENST00000293493, ENST00000339069, 
ENST00000314537, ENST00000352855, 
ENST00000577353, ENST00000398285, 
ENST00000548791, ENST00000551817, 
ENST00000550606, ENST00000552724, 
ENST00000547258, ENST00000551221, 
ENST00000393328, ENST00000393331, 
ENST00000347630, ENST00000504102, 
ENST00000503676, ENST00000513080, 
Fusion gene scores* DoF score3 X 3 X 3=279 X 4 X 5=180
# samples 38
** MAII scorelog2(3/27*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(8/180*10)=-1.16992500144231
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CRHR1 [Title/Abstract] AND SPOP [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneCRHR1

GO:0007189

adenylate cyclase-activating G-protein coupled receptor signaling pathway

18292205

HgeneCRHR1

GO:0071376

cellular response to corticotropin-releasing hormone stimulus

18292205

HgeneCRHR1

GO:1901386

negative regulation of voltage-gated calcium channel activity

18292205


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVUCSTCGA-N8-A56S-01ACRHR1chr17

43699407

+SPOPchr17

47700238

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-5UTRENST00000293493ENST00000393328CRHR1chr17

43699407

+SPOPchr17

47700238

-
5UTR-5UTRENST00000293493ENST00000393331CRHR1chr17

43699407

+SPOPchr17

47700238

-
5UTR-5UTRENST00000293493ENST00000347630CRHR1chr17

43699407

+SPOPchr17

47700238

-
5UTR-5UTRENST00000293493ENST00000504102CRHR1chr17

43699407

+SPOPchr17

47700238

-
5UTR-5UTRENST00000293493ENST00000503676CRHR1chr17

43699407

+SPOPchr17

47700238

-
5UTR-5UTRENST00000293493ENST00000513080CRHR1chr17

43699407

+SPOPchr17

47700238

-
5UTR-5UTRENST00000339069ENST00000393328CRHR1chr17

43699407

+SPOPchr17

47700238

-
5UTR-5UTRENST00000339069ENST00000393331CRHR1chr17

43699407

+SPOPchr17

47700238

-
5UTR-5UTRENST00000339069ENST00000347630CRHR1chr17

43699407

+SPOPchr17

47700238

-
5UTR-5UTRENST00000339069ENST00000504102CRHR1chr17

43699407

+SPOPchr17

47700238

-
5UTR-5UTRENST00000339069ENST00000503676CRHR1chr17

43699407

+SPOPchr17

47700238

-
5UTR-5UTRENST00000339069ENST00000513080CRHR1chr17

43699407

+SPOPchr17

47700238

-
intron-5UTRENST00000314537ENST00000393328CRHR1chr17

43699407

+SPOPchr17

47700238

-
intron-5UTRENST00000314537ENST00000393331CRHR1chr17

43699407

+SPOPchr17

47700238

-
intron-5UTRENST00000314537ENST00000347630CRHR1chr17

43699407

+SPOPchr17

47700238

-
intron-5UTRENST00000314537ENST00000504102CRHR1chr17

43699407

+SPOPchr17

47700238

-
intron-5UTRENST00000314537ENST00000503676CRHR1chr17

43699407

+SPOPchr17

47700238

-
intron-5UTRENST00000314537ENST00000513080CRHR1chr17

43699407

+SPOPchr17

47700238

-
intron-5UTRENST00000352855ENST00000393328CRHR1chr17

43699407

+SPOPchr17

47700238

-
intron-5UTRENST00000352855ENST00000393331CRHR1chr17

43699407

+SPOPchr17

47700238

-
intron-5UTRENST00000352855ENST00000347630CRHR1chr17

43699407

+SPOPchr17

47700238

-
intron-5UTRENST00000352855ENST00000504102CRHR1chr17

43699407

+SPOPchr17

47700238

-
intron-5UTRENST00000352855ENST00000503676CRHR1chr17

43699407

+SPOPchr17

47700238

-
intron-5UTRENST00000352855ENST00000513080CRHR1chr17

43699407

+SPOPchr17

47700238

-
intron-5UTRENST00000577353ENST00000393328CRHR1chr17

43699407

+SPOPchr17

47700238

-
intron-5UTRENST00000577353ENST00000393331CRHR1chr17

43699407

+SPOPchr17

47700238

-
intron-5UTRENST00000577353ENST00000347630CRHR1chr17

43699407

+SPOPchr17

47700238

-
intron-5UTRENST00000577353ENST00000504102CRHR1chr17

43699407

+SPOPchr17

47700238

-
intron-5UTRENST00000577353ENST00000503676CRHR1chr17

43699407

+SPOPchr17

47700238

-
intron-5UTRENST00000577353ENST00000513080CRHR1chr17

43699407

+SPOPchr17

47700238

-
intron-5UTRENST00000398285ENST00000393328CRHR1chr17

43699407

+SPOPchr17

47700238

-
intron-5UTRENST00000398285ENST00000393331CRHR1chr17

43699407

+SPOPchr17

47700238

-
intron-5UTRENST00000398285ENST00000347630CRHR1chr17

43699407

+SPOPchr17

47700238

-
intron-5UTRENST00000398285ENST00000504102CRHR1chr17

43699407

+SPOPchr17

47700238

-
intron-5UTRENST00000398285ENST00000503676CRHR1chr17

43699407

+SPOPchr17

47700238

-
intron-5UTRENST00000398285ENST00000513080CRHR1chr17

43699407

+SPOPchr17

47700238

-
intron-5UTRENST00000548791ENST00000393328CRHR1chr17

43699407

+SPOPchr17

47700238

-
intron-5UTRENST00000548791ENST00000393331CRHR1chr17

43699407

+SPOPchr17

47700238

-
intron-5UTRENST00000548791ENST00000347630CRHR1chr17

43699407

+SPOPchr17

47700238

-
intron-5UTRENST00000548791ENST00000504102CRHR1chr17

43699407

+SPOPchr17

47700238

-
intron-5UTRENST00000548791ENST00000503676CRHR1chr17

43699407

+SPOPchr17

47700238

-
intron-5UTRENST00000548791ENST00000513080CRHR1chr17

43699407

+SPOPchr17

47700238

-
intron-5UTRENST00000551817ENST00000393328CRHR1chr17

43699407

+SPOPchr17

47700238

-
intron-5UTRENST00000551817ENST00000393331CRHR1chr17

43699407

+SPOPchr17

47700238

-
intron-5UTRENST00000551817ENST00000347630CRHR1chr17

43699407

+SPOPchr17

47700238

-
intron-5UTRENST00000551817ENST00000504102CRHR1chr17

43699407

+SPOPchr17

47700238

-
intron-5UTRENST00000551817ENST00000503676CRHR1chr17

43699407

+SPOPchr17

47700238

-
intron-5UTRENST00000551817ENST00000513080CRHR1chr17

43699407

+SPOPchr17

47700238

-
intron-5UTRENST00000550606ENST00000393328CRHR1chr17

43699407

+SPOPchr17

47700238

-
intron-5UTRENST00000550606ENST00000393331CRHR1chr17

43699407

+SPOPchr17

47700238

-
intron-5UTRENST00000550606ENST00000347630CRHR1chr17

43699407

+SPOPchr17

47700238

-
intron-5UTRENST00000550606ENST00000504102CRHR1chr17

43699407

+SPOPchr17

47700238

-
intron-5UTRENST00000550606ENST00000503676CRHR1chr17

43699407

+SPOPchr17

47700238

-
intron-5UTRENST00000550606ENST00000513080CRHR1chr17

43699407

+SPOPchr17

47700238

-
intron-5UTRENST00000552724ENST00000393328CRHR1chr17

43699407

+SPOPchr17

47700238

-
intron-5UTRENST00000552724ENST00000393331CRHR1chr17

43699407

+SPOPchr17

47700238

-
intron-5UTRENST00000552724ENST00000347630CRHR1chr17

43699407

+SPOPchr17

47700238

-
intron-5UTRENST00000552724ENST00000504102CRHR1chr17

43699407

+SPOPchr17

47700238

-
intron-5UTRENST00000552724ENST00000503676CRHR1chr17

43699407

+SPOPchr17

47700238

-
intron-5UTRENST00000552724ENST00000513080CRHR1chr17

43699407

+SPOPchr17

47700238

-
intron-5UTRENST00000547258ENST00000393328CRHR1chr17

43699407

+SPOPchr17

47700238

-
intron-5UTRENST00000547258ENST00000393331CRHR1chr17

43699407

+SPOPchr17

47700238

-
intron-5UTRENST00000547258ENST00000347630CRHR1chr17

43699407

+SPOPchr17

47700238

-
intron-5UTRENST00000547258ENST00000504102CRHR1chr17

43699407

+SPOPchr17

47700238

-
intron-5UTRENST00000547258ENST00000503676CRHR1chr17

43699407

+SPOPchr17

47700238

-
intron-5UTRENST00000547258ENST00000513080CRHR1chr17

43699407

+SPOPchr17

47700238

-
intron-5UTRENST00000551221ENST00000393328CRHR1chr17

43699407

+SPOPchr17

47700238

-
intron-5UTRENST00000551221ENST00000393331CRHR1chr17

43699407

+SPOPchr17

47700238

-
intron-5UTRENST00000551221ENST00000347630CRHR1chr17

43699407

+SPOPchr17

47700238

-
intron-5UTRENST00000551221ENST00000504102CRHR1chr17

43699407

+SPOPchr17

47700238

-
intron-5UTRENST00000551221ENST00000503676CRHR1chr17

43699407

+SPOPchr17

47700238

-
intron-5UTRENST00000551221ENST00000513080CRHR1chr17

43699407

+SPOPchr17

47700238

-

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FusionProtFeatures for CRHR1_SPOP


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CRHR1

P34998

SPOP

O43791

G-protein coupled receptor for CRH (corticotropin-releasing factor) and UCN (urocortin). Has high affinity for CRHand UCN. Ligand binding causes a conformation change that triggerssignaling via guanine nucleotide-binding proteins (G proteins) anddown-stream effectors, such as adenylate cyclase. Promotes theactivation of adenylate cyclase, leading to increasedintracellular cAMP levels. Inhibits the activity of the calciumchannel CACNA1H. Required for normal embryonic development of theadrenal gland and for normal hormonal responses to stress. Plays arole in the response to anxiogenic stimuli.{ECO:0000269|PubMed:18292205, ECO:0000269|PubMed:18801728,ECO:0000269|PubMed:23576434, ECO:0000269|PubMed:23863939}. Component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3ubiquitin-protein ligase complex that mediates the ubiquitinationof target proteins, leading most often to their proteasomaldegradation. In complex with CUL3, involved in ubiquitination andproteasomal degradation of BRMS1, DAXX, PDX1/IPF1, GLI2 and GLI3.In complex with CUL3, involved in ubiquitination of H2AFY andBMI1; this does not lead to their proteasomal degradation.Inhibits transcriptional activation of PDX1/IPF1 targets, such asinsulin, by promoting PDX1/IPF1 degradation. The cullin-RING-basedBCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex containinghomodimeric SPOP has higher ubiquitin ligase activity than thecomplex that contains the heterodimer formed by SPOP and SPOPL.{ECO:0000269|PubMed:14528312, ECO:0000269|PubMed:15897469,ECO:0000269|PubMed:16524876, ECO:0000269|PubMed:19818708,ECO:0000269|PubMed:22085717, ECO:0000269|PubMed:22632832}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for CRHR1_SPOP


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for CRHR1_SPOP


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
CRHR1UCN, CRH, GNAQ, GNAS, GNAO1, GNAI1, SRPK1SPOPZBTB16, DPPA2, RXRB, DDIT3, RTN3, MYD88, SIRT2, DOK2, KPNA6, GDI1, PIP5K1B, TRAF1, TRAF6, AR, BMI1, NCOA3, CUL3, ESR1, DAXX, SPOP, PIP4K2B, UBE2E3, FADD, PIAS1, GIT2, SRRM1, ATM, GLI2, DEK, BRMS1, NUP50, RTN4, GCC1, ERG, ERF, PGR, GLI3, UBE2D1, UBE2D2, NANOG, PTEN, DUSP7, EGLN2, RFWD2, SOST, ARIH1, MSRB3, BRD4, BRD3, BRD2


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for CRHR1_SPOP


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for CRHR1_SPOP


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneCRHR1C0001973Alcoholic Intoxication, Chronic5PSYGENET
HgeneCRHR1C0011570Mental Depression5PSYGENET
HgeneCRHR1C0011581Depressive disorder5PSYGENET
HgeneCRHR1C0041696Unipolar Depression5PSYGENET
HgeneCRHR1C0525045Mood Disorders5PSYGENET
HgeneCRHR1C1269683Major Depressive Disorder5CTD_human;PSYGENET
HgeneCRHR1C0005586Bipolar Disorder4PSYGENET
HgeneCRHR1C0003469Anxiety Disorders2CTD_human
HgeneCRHR1C0003123Anorexia1CTD_human
HgeneCRHR1C0011616Contact Dermatitis1CTD_human
HgeneCRHR1C0033975Psychotic Disorders1PSYGENET
HgeneCRHR1C0178417Anhedonia1PSYGENET
HgeneCRHR1C0236736Cocaine-Related Disorders1CTD_human
HgeneCRHR1C0349204Nonorganic psychosis1PSYGENET
HgeneCRHR1C0424295Hyperactive behavior1CTD_human
TgeneSPOPC0014170Endometrial Neoplasms1CTD_human
TgeneSPOPC0033578Prostatic Neoplasms1CTD_human