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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 8457

FusionGeneSummary for CREM_SEC61G

check button Fusion gene summary
Fusion gene informationFusion gene name: CREM_SEC61G
Fusion gene ID: 8457
HgeneTgene
Gene symbol

CREM

SEC61G

Gene ID

1390

23480

Gene namecAMP responsive element modulatorSec61 translocon gamma subunit
SynonymsCREM-2|ICER|hCREM-2SSS1
Cytomap

10p11.21

7p11.2

Type of geneprotein-codingprotein-coding
DescriptioncAMP-responsive element modulatorCREM 2alpha-b proteinCREM 2beta-a proteincAMP response element modulatorinducible cAMP early repressor ICERprotein transport protein Sec61 subunit gammaSec61 gamma subunitprotein transport protein SEC61 gamma subunit
Modification date2018052320180522
UniProtAcc

Q03060

P60059

Ensembl transtripts involved in fusion geneENST00000474362, ENST00000374721, 
ENST00000489388, ENST00000374726, 
ENST00000429130, ENST00000469949, 
ENST00000460270, ENST00000354759, 
ENST00000489321, ENST00000395895, 
ENST00000374728, ENST00000345491, 
ENST00000333809, ENST00000439705, 
ENST00000337656, ENST00000374734, 
ENST00000479070, ENST00000348787, 
ENST00000361599, ENST00000484283, 
ENST00000395887, ENST00000463314, 
ENST00000342105, ENST00000463960, 
ENST00000487763, ENST00000473940, 
ENST00000488328, ENST00000356917, 
ENST00000488741, ENST00000474931, 
ENST00000468236, ENST00000344351, 
ENST00000490511, 
ENST00000395535, 
ENST00000352861, ENST00000415949, 
ENST00000450622, 
Fusion gene scores* DoF score1 X 1 X 1=12 X 2 X 2=8
# samples 12
** MAII scorelog2(1/1*10)=3.32192809488736log2(2/8*10)=1.32192809488736
Context

PubMed: CREM [Title/Abstract] AND SEC61G [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneCREM

GO:0006355

regulation of transcription, DNA-templated

8206879


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BP384146CREMchr10

35500659

-SEC61Gchr7

54826908

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000474362ENST00000395535CREMchr10

35500659

-SEC61Gchr7

54826908

-
5CDS-5UTRENST00000474362ENST00000352861CREMchr10

35500659

-SEC61Gchr7

54826908

-
5CDS-5UTRENST00000474362ENST00000415949CREMchr10

35500659

-SEC61Gchr7

54826908

-
5CDS-intronENST00000474362ENST00000450622CREMchr10

35500659

-SEC61Gchr7

54826908

-
3UTR-5UTRENST00000374721ENST00000395535CREMchr10

35500659

-SEC61Gchr7

54826908

-
3UTR-5UTRENST00000374721ENST00000352861CREMchr10

35500659

-SEC61Gchr7

54826908

-
3UTR-5UTRENST00000374721ENST00000415949CREMchr10

35500659

-SEC61Gchr7

54826908

-
3UTR-intronENST00000374721ENST00000450622CREMchr10

35500659

-SEC61Gchr7

54826908

-
intron-5UTRENST00000489388ENST00000395535CREMchr10

35500659

-SEC61Gchr7

54826908

-
intron-5UTRENST00000489388ENST00000352861CREMchr10

35500659

-SEC61Gchr7

54826908

-
intron-5UTRENST00000489388ENST00000415949CREMchr10

35500659

-SEC61Gchr7

54826908

-
intron-intronENST00000489388ENST00000450622CREMchr10

35500659

-SEC61Gchr7

54826908

-
intron-5UTRENST00000374726ENST00000395535CREMchr10

35500659

-SEC61Gchr7

54826908

-
intron-5UTRENST00000374726ENST00000352861CREMchr10

35500659

-SEC61Gchr7

54826908

-
intron-5UTRENST00000374726ENST00000415949CREMchr10

35500659

-SEC61Gchr7

54826908

-
intron-intronENST00000374726ENST00000450622CREMchr10

35500659

-SEC61Gchr7

54826908

-
5CDS-5UTRENST00000429130ENST00000395535CREMchr10

35500659

-SEC61Gchr7

54826908

-
5CDS-5UTRENST00000429130ENST00000352861CREMchr10

35500659

-SEC61Gchr7

54826908

-
5CDS-5UTRENST00000429130ENST00000415949CREMchr10

35500659

-SEC61Gchr7

54826908

-
5CDS-intronENST00000429130ENST00000450622CREMchr10

35500659

-SEC61Gchr7

54826908

-
intron-5UTRENST00000469949ENST00000395535CREMchr10

35500659

-SEC61Gchr7

54826908

-
intron-5UTRENST00000469949ENST00000352861CREMchr10

35500659

-SEC61Gchr7

54826908

-
intron-5UTRENST00000469949ENST00000415949CREMchr10

35500659

-SEC61Gchr7

54826908

-
intron-intronENST00000469949ENST00000450622CREMchr10

35500659

-SEC61Gchr7

54826908

-
3UTR-5UTRENST00000460270ENST00000395535CREMchr10

35500659

-SEC61Gchr7

54826908

-
3UTR-5UTRENST00000460270ENST00000352861CREMchr10

35500659

-SEC61Gchr7

54826908

-
3UTR-5UTRENST00000460270ENST00000415949CREMchr10

35500659

-SEC61Gchr7

54826908

-
3UTR-intronENST00000460270ENST00000450622CREMchr10

35500659

-SEC61Gchr7

54826908

-
3UTR-5UTRENST00000354759ENST00000395535CREMchr10

35500659

-SEC61Gchr7

54826908

-
3UTR-5UTRENST00000354759ENST00000352861CREMchr10

35500659

-SEC61Gchr7

54826908

-
3UTR-5UTRENST00000354759ENST00000415949CREMchr10

35500659

-SEC61Gchr7

54826908

-
3UTR-intronENST00000354759ENST00000450622CREMchr10

35500659

-SEC61Gchr7

54826908

-
intron-5UTRENST00000489321ENST00000395535CREMchr10

35500659

-SEC61Gchr7

54826908

-
intron-5UTRENST00000489321ENST00000352861CREMchr10

35500659

-SEC61Gchr7

54826908

-
intron-5UTRENST00000489321ENST00000415949CREMchr10

35500659

-SEC61Gchr7

54826908

-
intron-intronENST00000489321ENST00000450622CREMchr10

35500659

-SEC61Gchr7

54826908

-
5CDS-5UTRENST00000395895ENST00000395535CREMchr10

35500659

-SEC61Gchr7

54826908

-
5CDS-5UTRENST00000395895ENST00000352861CREMchr10

35500659

-SEC61Gchr7

54826908

-
5CDS-5UTRENST00000395895ENST00000415949CREMchr10

35500659

-SEC61Gchr7

54826908

-
5CDS-intronENST00000395895ENST00000450622CREMchr10

35500659

-SEC61Gchr7

54826908

-
5CDS-5UTRENST00000374728ENST00000395535CREMchr10

35500659

-SEC61Gchr7

54826908

-
5CDS-5UTRENST00000374728ENST00000352861CREMchr10

35500659

-SEC61Gchr7

54826908

-
5CDS-5UTRENST00000374728ENST00000415949CREMchr10

35500659

-SEC61Gchr7

54826908

-
5CDS-intronENST00000374728ENST00000450622CREMchr10

35500659

-SEC61Gchr7

54826908

-
5CDS-5UTRENST00000345491ENST00000395535CREMchr10

35500659

-SEC61Gchr7

54826908

-
5CDS-5UTRENST00000345491ENST00000352861CREMchr10

35500659

-SEC61Gchr7

54826908

-
5CDS-5UTRENST00000345491ENST00000415949CREMchr10

35500659

-SEC61Gchr7

54826908

-
5CDS-intronENST00000345491ENST00000450622CREMchr10

35500659

-SEC61Gchr7

54826908

-
3UTR-5UTRENST00000333809ENST00000395535CREMchr10

35500659

-SEC61Gchr7

54826908

-
3UTR-5UTRENST00000333809ENST00000352861CREMchr10

35500659

-SEC61Gchr7

54826908

-
3UTR-5UTRENST00000333809ENST00000415949CREMchr10

35500659

-SEC61Gchr7

54826908

-
3UTR-intronENST00000333809ENST00000450622CREMchr10

35500659

-SEC61Gchr7

54826908

-
3UTR-5UTRENST00000439705ENST00000395535CREMchr10

35500659

-SEC61Gchr7

54826908

-
3UTR-5UTRENST00000439705ENST00000352861CREMchr10

35500659

-SEC61Gchr7

54826908

-
3UTR-5UTRENST00000439705ENST00000415949CREMchr10

35500659

-SEC61Gchr7

54826908

-
3UTR-intronENST00000439705ENST00000450622CREMchr10

35500659

-SEC61Gchr7

54826908

-
intron-5UTRENST00000337656ENST00000395535CREMchr10

35500659

-SEC61Gchr7

54826908

-
intron-5UTRENST00000337656ENST00000352861CREMchr10

35500659

-SEC61Gchr7

54826908

-
intron-5UTRENST00000337656ENST00000415949CREMchr10

35500659

-SEC61Gchr7

54826908

-
intron-intronENST00000337656ENST00000450622CREMchr10

35500659

-SEC61Gchr7

54826908

-
intron-5UTRENST00000374734ENST00000395535CREMchr10

35500659

-SEC61Gchr7

54826908

-
intron-5UTRENST00000374734ENST00000352861CREMchr10

35500659

-SEC61Gchr7

54826908

-
intron-5UTRENST00000374734ENST00000415949CREMchr10

35500659

-SEC61Gchr7

54826908

-
intron-intronENST00000374734ENST00000450622CREMchr10

35500659

-SEC61Gchr7

54826908

-
5CDS-5UTRENST00000479070ENST00000395535CREMchr10

35500659

-SEC61Gchr7

54826908

-
5CDS-5UTRENST00000479070ENST00000352861CREMchr10

35500659

-SEC61Gchr7

54826908

-
5CDS-5UTRENST00000479070ENST00000415949CREMchr10

35500659

-SEC61Gchr7

54826908

-
5CDS-intronENST00000479070ENST00000450622CREMchr10

35500659

-SEC61Gchr7

54826908

-
5CDS-5UTRENST00000348787ENST00000395535CREMchr10

35500659

-SEC61Gchr7

54826908

-
5CDS-5UTRENST00000348787ENST00000352861CREMchr10

35500659

-SEC61Gchr7

54826908

-
5CDS-5UTRENST00000348787ENST00000415949CREMchr10

35500659

-SEC61Gchr7

54826908

-
5CDS-intronENST00000348787ENST00000450622CREMchr10

35500659

-SEC61Gchr7

54826908

-
5CDS-5UTRENST00000361599ENST00000395535CREMchr10

35500659

-SEC61Gchr7

54826908

-
5CDS-5UTRENST00000361599ENST00000352861CREMchr10

35500659

-SEC61Gchr7

54826908

-
5CDS-5UTRENST00000361599ENST00000415949CREMchr10

35500659

-SEC61Gchr7

54826908

-
5CDS-intronENST00000361599ENST00000450622CREMchr10

35500659

-SEC61Gchr7

54826908

-
5CDS-5UTRENST00000484283ENST00000395535CREMchr10

35500659

-SEC61Gchr7

54826908

-
5CDS-5UTRENST00000484283ENST00000352861CREMchr10

35500659

-SEC61Gchr7

54826908

-
5CDS-5UTRENST00000484283ENST00000415949CREMchr10

35500659

-SEC61Gchr7

54826908

-
5CDS-intronENST00000484283ENST00000450622CREMchr10

35500659

-SEC61Gchr7

54826908

-
5CDS-5UTRENST00000395887ENST00000395535CREMchr10

35500659

-SEC61Gchr7

54826908

-
5CDS-5UTRENST00000395887ENST00000352861CREMchr10

35500659

-SEC61Gchr7

54826908

-
5CDS-5UTRENST00000395887ENST00000415949CREMchr10

35500659

-SEC61Gchr7

54826908

-
5CDS-intronENST00000395887ENST00000450622CREMchr10

35500659

-SEC61Gchr7

54826908

-
5CDS-5UTRENST00000463314ENST00000395535CREMchr10

35500659

-SEC61Gchr7

54826908

-
5CDS-5UTRENST00000463314ENST00000352861CREMchr10

35500659

-SEC61Gchr7

54826908

-
5CDS-5UTRENST00000463314ENST00000415949CREMchr10

35500659

-SEC61Gchr7

54826908

-
5CDS-intronENST00000463314ENST00000450622CREMchr10

35500659

-SEC61Gchr7

54826908

-
5CDS-5UTRENST00000342105ENST00000395535CREMchr10

35500659

-SEC61Gchr7

54826908

-
5CDS-5UTRENST00000342105ENST00000352861CREMchr10

35500659

-SEC61Gchr7

54826908

-
5CDS-5UTRENST00000342105ENST00000415949CREMchr10

35500659

-SEC61Gchr7

54826908

-
5CDS-intronENST00000342105ENST00000450622CREMchr10

35500659

-SEC61Gchr7

54826908

-
5CDS-5UTRENST00000463960ENST00000395535CREMchr10

35500659

-SEC61Gchr7

54826908

-
5CDS-5UTRENST00000463960ENST00000352861CREMchr10

35500659

-SEC61Gchr7

54826908

-
5CDS-5UTRENST00000463960ENST00000415949CREMchr10

35500659

-SEC61Gchr7

54826908

-
5CDS-intronENST00000463960ENST00000450622CREMchr10

35500659

-SEC61Gchr7

54826908

-
5CDS-5UTRENST00000487763ENST00000395535CREMchr10

35500659

-SEC61Gchr7

54826908

-
5CDS-5UTRENST00000487763ENST00000352861CREMchr10

35500659

-SEC61Gchr7

54826908

-
5CDS-5UTRENST00000487763ENST00000415949CREMchr10

35500659

-SEC61Gchr7

54826908

-
5CDS-intronENST00000487763ENST00000450622CREMchr10

35500659

-SEC61Gchr7

54826908

-
3UTR-5UTRENST00000473940ENST00000395535CREMchr10

35500659

-SEC61Gchr7

54826908

-
3UTR-5UTRENST00000473940ENST00000352861CREMchr10

35500659

-SEC61Gchr7

54826908

-
3UTR-5UTRENST00000473940ENST00000415949CREMchr10

35500659

-SEC61Gchr7

54826908

-
3UTR-intronENST00000473940ENST00000450622CREMchr10

35500659

-SEC61Gchr7

54826908

-
5CDS-5UTRENST00000488328ENST00000395535CREMchr10

35500659

-SEC61Gchr7

54826908

-
5CDS-5UTRENST00000488328ENST00000352861CREMchr10

35500659

-SEC61Gchr7

54826908

-
5CDS-5UTRENST00000488328ENST00000415949CREMchr10

35500659

-SEC61Gchr7

54826908

-
5CDS-intronENST00000488328ENST00000450622CREMchr10

35500659

-SEC61Gchr7

54826908

-
3UTR-5UTRENST00000356917ENST00000395535CREMchr10

35500659

-SEC61Gchr7

54826908

-
3UTR-5UTRENST00000356917ENST00000352861CREMchr10

35500659

-SEC61Gchr7

54826908

-
3UTR-5UTRENST00000356917ENST00000415949CREMchr10

35500659

-SEC61Gchr7

54826908

-
3UTR-intronENST00000356917ENST00000450622CREMchr10

35500659

-SEC61Gchr7

54826908

-
intron-5UTRENST00000488741ENST00000395535CREMchr10

35500659

-SEC61Gchr7

54826908

-
intron-5UTRENST00000488741ENST00000352861CREMchr10

35500659

-SEC61Gchr7

54826908

-
intron-5UTRENST00000488741ENST00000415949CREMchr10

35500659

-SEC61Gchr7

54826908

-
intron-intronENST00000488741ENST00000450622CREMchr10

35500659

-SEC61Gchr7

54826908

-
intron-5UTRENST00000474931ENST00000395535CREMchr10

35500659

-SEC61Gchr7

54826908

-
intron-5UTRENST00000474931ENST00000352861CREMchr10

35500659

-SEC61Gchr7

54826908

-
intron-5UTRENST00000474931ENST00000415949CREMchr10

35500659

-SEC61Gchr7

54826908

-
intron-intronENST00000474931ENST00000450622CREMchr10

35500659

-SEC61Gchr7

54826908

-
5CDS-5UTRENST00000468236ENST00000395535CREMchr10

35500659

-SEC61Gchr7

54826908

-
5CDS-5UTRENST00000468236ENST00000352861CREMchr10

35500659

-SEC61Gchr7

54826908

-
5CDS-5UTRENST00000468236ENST00000415949CREMchr10

35500659

-SEC61Gchr7

54826908

-
5CDS-intronENST00000468236ENST00000450622CREMchr10

35500659

-SEC61Gchr7

54826908

-
3UTR-5UTRENST00000344351ENST00000395535CREMchr10

35500659

-SEC61Gchr7

54826908

-
3UTR-5UTRENST00000344351ENST00000352861CREMchr10

35500659

-SEC61Gchr7

54826908

-
3UTR-5UTRENST00000344351ENST00000415949CREMchr10

35500659

-SEC61Gchr7

54826908

-
3UTR-intronENST00000344351ENST00000450622CREMchr10

35500659

-SEC61Gchr7

54826908

-
5CDS-5UTRENST00000490511ENST00000395535CREMchr10

35500659

-SEC61Gchr7

54826908

-
5CDS-5UTRENST00000490511ENST00000352861CREMchr10

35500659

-SEC61Gchr7

54826908

-
5CDS-5UTRENST00000490511ENST00000415949CREMchr10

35500659

-SEC61Gchr7

54826908

-
5CDS-intronENST00000490511ENST00000450622CREMchr10

35500659

-SEC61Gchr7

54826908

-

Top

FusionProtFeatures for CREM_SEC61G


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CREM

Q03060

SEC61G

P60059

Necessary for protein translocation in the endoplasmicreticulum. {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for CREM_SEC61G


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for CREM_SEC61G


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for CREM_SEC61G


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for CREM_SEC61G


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneCREMC0005586Bipolar Disorder1PSYGENET
HgeneCREMC0011875Diabetic Angiopathies1CTD_human
HgeneCREMC0020564Hypertrophy1CTD_human
HgeneCREMC0027051Myocardial Infarction1CTD_human
HgeneCREMC0036341Schizophrenia1PSYGENET
HgeneCREMC0041696Unipolar Depression1PSYGENET
HgeneCREMC0162820Dermatitis, Allergic Contact1CTD_human
HgeneCREMC0263454Chloracne1CTD_human
HgeneCREMC1269683Major Depressive Disorder1PSYGENET
HgeneCREMC3495559Juvenile arthritis1CTD_human