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Fusion gene ID: 8456 |
FusionGeneSummary for CRELD2_P2RX4 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: CRELD2_P2RX4 | Fusion gene ID: 8456 | Hgene | Tgene | Gene symbol | CRELD2 | P2RX4 | Gene ID | 79174 | 5025 |
| Gene name | cysteine rich with EGF like domains 2 | purinergic receptor P2X 4 | |
| Synonyms | - | P2X4|P2X4R | |
| Cytomap | 22q13.33 | 12q24.31 | |
| Type of gene | protein-coding | protein-coding | |
| Description | cysteine-rich with EGF-like domain protein 2 | P2X purinoceptor 4ATP receptorATP-gated cation channel proteinP2X receptor, subunit 4purinergic receptor P2X, ligand gated ion channel, 4purinergic receptor P2X4purinoceptor P2X4 | |
| Modification date | 20180519 | 20180523 | |
| UniProtAcc | Q6UXH1 | Q99571 | |
| Ensembl transtripts involved in fusion gene | ENST00000404488, ENST00000328268, ENST00000403427, ENST00000407217, ENST00000444954, | ENST00000337233, ENST00000359949, ENST00000540930, ENST00000541532, ENST00000543171, | |
| Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 2 X 2 X 2=8 |
| # samples | 1 | 2 | |
| ** MAII score | log2(1/1*10)=3.32192809488736 | log2(2/8*10)=1.32192809488736 | |
| Context | PubMed: CRELD2 [Title/Abstract] AND P2RX4 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | P2RX4 | GO:0007165 | signal transduction | 9016352 |
| Tgene | P2RX4 | GO:0010524 | positive regulation of calcium ion transport into cytosol | 10969036 |
| Tgene | P2RX4 | GO:0033198 | response to ATP | 9016352 |
| Tgene | P2RX4 | GO:0034220 | ion transmembrane transport | 10515189 |
| Tgene | P2RX4 | GO:0034405 | response to fluid shear stress | 10969036 |
| Tgene | P2RX4 | GO:0050850 | positive regulation of calcium-mediated signaling | 10969036 |
| Tgene | P2RX4 | GO:0051899 | membrane depolarization | 9016352 |
| Tgene | P2RX4 | GO:0070588 | calcium ion transmembrane transport | 9016352 |
| Tgene | P2RX4 | GO:0071318 | cellular response to ATP | 10515189 |
| Tgene | P2RX4 | GO:0097190 | apoptotic signaling pathway | 17264311 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | BF509192 | CRELD2 | chr22 | 50320941 | - | P2RX4 | chr12 | 121670259 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000404488 | ENST00000337233 | CRELD2 | chr22 | 50320941 | - | P2RX4 | chr12 | 121670259 | - |
| In-frame | ENST00000404488 | ENST00000359949 | CRELD2 | chr22 | 50320941 | - | P2RX4 | chr12 | 121670259 | - |
| 5CDS-intron | ENST00000404488 | ENST00000540930 | CRELD2 | chr22 | 50320941 | - | P2RX4 | chr12 | 121670259 | - |
| 5CDS-3UTR | ENST00000404488 | ENST00000541532 | CRELD2 | chr22 | 50320941 | - | P2RX4 | chr12 | 121670259 | - |
| 5CDS-3UTR | ENST00000404488 | ENST00000543171 | CRELD2 | chr22 | 50320941 | - | P2RX4 | chr12 | 121670259 | - |
| In-frame | ENST00000328268 | ENST00000337233 | CRELD2 | chr22 | 50320941 | - | P2RX4 | chr12 | 121670259 | - |
| In-frame | ENST00000328268 | ENST00000359949 | CRELD2 | chr22 | 50320941 | - | P2RX4 | chr12 | 121670259 | - |
| 5CDS-intron | ENST00000328268 | ENST00000540930 | CRELD2 | chr22 | 50320941 | - | P2RX4 | chr12 | 121670259 | - |
| 5CDS-3UTR | ENST00000328268 | ENST00000541532 | CRELD2 | chr22 | 50320941 | - | P2RX4 | chr12 | 121670259 | - |
| 5CDS-3UTR | ENST00000328268 | ENST00000543171 | CRELD2 | chr22 | 50320941 | - | P2RX4 | chr12 | 121670259 | - |
| In-frame | ENST00000403427 | ENST00000337233 | CRELD2 | chr22 | 50320941 | - | P2RX4 | chr12 | 121670259 | - |
| In-frame | ENST00000403427 | ENST00000359949 | CRELD2 | chr22 | 50320941 | - | P2RX4 | chr12 | 121670259 | - |
| 5CDS-intron | ENST00000403427 | ENST00000540930 | CRELD2 | chr22 | 50320941 | - | P2RX4 | chr12 | 121670259 | - |
| 5CDS-3UTR | ENST00000403427 | ENST00000541532 | CRELD2 | chr22 | 50320941 | - | P2RX4 | chr12 | 121670259 | - |
| 5CDS-3UTR | ENST00000403427 | ENST00000543171 | CRELD2 | chr22 | 50320941 | - | P2RX4 | chr12 | 121670259 | - |
| In-frame | ENST00000407217 | ENST00000337233 | CRELD2 | chr22 | 50320941 | - | P2RX4 | chr12 | 121670259 | - |
| In-frame | ENST00000407217 | ENST00000359949 | CRELD2 | chr22 | 50320941 | - | P2RX4 | chr12 | 121670259 | - |
| 5CDS-intron | ENST00000407217 | ENST00000540930 | CRELD2 | chr22 | 50320941 | - | P2RX4 | chr12 | 121670259 | - |
| 5CDS-3UTR | ENST00000407217 | ENST00000541532 | CRELD2 | chr22 | 50320941 | - | P2RX4 | chr12 | 121670259 | - |
| 5CDS-3UTR | ENST00000407217 | ENST00000543171 | CRELD2 | chr22 | 50320941 | - | P2RX4 | chr12 | 121670259 | - |
| intron-3CDS | ENST00000444954 | ENST00000337233 | CRELD2 | chr22 | 50320941 | - | P2RX4 | chr12 | 121670259 | - |
| intron-3CDS | ENST00000444954 | ENST00000359949 | CRELD2 | chr22 | 50320941 | - | P2RX4 | chr12 | 121670259 | - |
| intron-intron | ENST00000444954 | ENST00000540930 | CRELD2 | chr22 | 50320941 | - | P2RX4 | chr12 | 121670259 | - |
| intron-3UTR | ENST00000444954 | ENST00000541532 | CRELD2 | chr22 | 50320941 | - | P2RX4 | chr12 | 121670259 | - |
| intron-3UTR | ENST00000444954 | ENST00000543171 | CRELD2 | chr22 | 50320941 | - | P2RX4 | chr12 | 121670259 | - |
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FusionProtFeatures for CRELD2_P2RX4 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| CRELD2 | P2RX4 |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for CRELD2_P2RX4 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_CRELD2_ENST00000404488_chr22_50320941_-_P2RX4_ENST00000337233_chr12_121670259_-_0aa >In-frame_CRELD2_ENST00000404488_chr22_50320941_-_P2RX4_ENST00000359949_chr12_121670259_-_0aa >In-frame_CRELD2_ENST00000328268_chr22_50320941_-_P2RX4_ENST00000337233_chr12_121670259_-_0aa >In-frame_CRELD2_ENST00000328268_chr22_50320941_-_P2RX4_ENST00000359949_chr12_121670259_-_0aa >In-frame_CRELD2_ENST00000403427_chr22_50320941_-_P2RX4_ENST00000337233_chr12_121670259_-_0aa >In-frame_CRELD2_ENST00000403427_chr22_50320941_-_P2RX4_ENST00000359949_chr12_121670259_-_0aa >In-frame_CRELD2_ENST00000407217_chr22_50320941_-_P2RX4_ENST00000337233_chr12_121670259_-_0aa >In-frame_CRELD2_ENST00000407217_chr22_50320941_-_P2RX4_ENST00000359949_chr12_121670259_-_0aa |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_CRELD2_ENST00000404488_chr22_50320941_-_P2RX4_ENST00000337233_chr12_121670259_-_0nt >In-frame_CRELD2_ENST00000404488_chr22_50320941_-_P2RX4_ENST00000359949_chr12_121670259_-_0nt >In-frame_CRELD2_ENST00000328268_chr22_50320941_-_P2RX4_ENST00000337233_chr12_121670259_-_0nt >In-frame_CRELD2_ENST00000328268_chr22_50320941_-_P2RX4_ENST00000359949_chr12_121670259_-_0nt >In-frame_CRELD2_ENST00000403427_chr22_50320941_-_P2RX4_ENST00000337233_chr12_121670259_-_0nt >In-frame_CRELD2_ENST00000403427_chr22_50320941_-_P2RX4_ENST00000359949_chr12_121670259_-_0nt >In-frame_CRELD2_ENST00000407217_chr22_50320941_-_P2RX4_ENST00000337233_chr12_121670259_-_0nt >In-frame_CRELD2_ENST00000407217_chr22_50320941_-_P2RX4_ENST00000359949_chr12_121670259_-_0nt |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_CRELD2_ENST00000404488_chr22_50320941_-_P2RX4_ENST00000337233_chr12_121670259_-_0nt >In-frame_CRELD2_ENST00000404488_chr22_50320941_-_P2RX4_ENST00000359949_chr12_121670259_-_0nt >In-frame_CRELD2_ENST00000328268_chr22_50320941_-_P2RX4_ENST00000337233_chr12_121670259_-_0nt >In-frame_CRELD2_ENST00000328268_chr22_50320941_-_P2RX4_ENST00000359949_chr12_121670259_-_0nt >In-frame_CRELD2_ENST00000403427_chr22_50320941_-_P2RX4_ENST00000337233_chr12_121670259_-_0nt >In-frame_CRELD2_ENST00000403427_chr22_50320941_-_P2RX4_ENST00000359949_chr12_121670259_-_0nt >In-frame_CRELD2_ENST00000407217_chr22_50320941_-_P2RX4_ENST00000337233_chr12_121670259_-_0nt >In-frame_CRELD2_ENST00000407217_chr22_50320941_-_P2RX4_ENST00000359949_chr12_121670259_-_0nt |
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FusionGenePPI for CRELD2_P2RX4 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for CRELD2_P2RX4 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| Tgene | P2RX4 | Q99571 | DB09119 | Eslicarbazepine acetate | P2X purinoceptor 4 | small molecule | approved |
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RelatedDiseases for CRELD2_P2RX4 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Tgene | P2RX4 | C0014544 | Epilepsy | 1 | CTD_human |
| Tgene | P2RX4 | C0014556 | Epilepsy, Temporal Lobe | 1 | CTD_human |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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