FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 8450

FusionGeneSummary for CREBRF_CSNK1A1

check button Fusion gene summary
Fusion gene informationFusion gene name: CREBRF_CSNK1A1
Fusion gene ID: 8450
HgeneTgene
Gene symbol

CREBRF

CSNK1A1

Gene ID

153222

1452

Gene nameCREB3 regulatory factorcasein kinase 1 alpha 1
SynonymsC5orf41|LRFCK1|CK1a|CKIa|HEL-S-77p|HLCDGP1|PRO2975
Cytomap

5q35.1

5q32

Type of geneprotein-codingprotein-coding
DescriptionCREB3 regulatory factorUPF0474 protein C5orf41adult retina proteinluman recruitment factorluman-recruiting factorluman/CREB3 recruitment factorcasein kinase I isoform alphaCKI-alphaclock regulator kinasedown-regulated in lung cancerepididymis secretory sperm binding protein Li 77p
Modification date2018051920180523
UniProtAcc

Q8IUR6

P48729

Ensembl transtripts involved in fusion geneENST00000522692, ENST00000296953, 
ENST00000540014, ENST00000520420, 
ENST00000517882, 		ENST00000261798, 
ENST00000377843, ENST00000515435, 
ENST00000504676, ENST00000515768, 
ENST00000606719, ENST00000606299, 
ENST00000515748, 
Fusion gene scores* DoF score2 X 2 X 2=87 X 5 X 6=210
# samples 27
** MAII scorelog2(2/8*10)=1.32192809488736log2(7/210*10)=-1.58496250072116
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CREBRF [Title/Abstract] AND CSNK1A1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneCREBRF

GO:0045944

positive regulation of transcription by RNA polymerase II

16940180

TgeneCSNK1A1

GO:0006468

protein phosphorylation

18305108

TgeneCSNK1A1

GO:0018105

peptidyl-serine phosphorylation

25500533


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDLGGTCGA-HT-7860-01ACREBRFchr5

172483482

+CSNK1A1chr5

148899951

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3CDSENST00000522692ENST00000261798CREBRFchr5

172483482

+CSNK1A1chr5

148899951

-
5UTR-3CDSENST00000522692ENST00000377843CREBRFchr5

172483482

+CSNK1A1chr5

148899951

-
5UTR-3CDSENST00000522692ENST00000515435CREBRFchr5

172483482

+CSNK1A1chr5

148899951

-
5UTR-3CDSENST00000522692ENST00000504676CREBRFchr5

172483482

+CSNK1A1chr5

148899951

-
5UTR-3CDSENST00000522692ENST00000515768CREBRFchr5

172483482

+CSNK1A1chr5

148899951

-
5UTR-intronENST00000522692ENST00000606719CREBRFchr5

172483482

+CSNK1A1chr5

148899951

-
5UTR-intronENST00000522692ENST00000606299CREBRFchr5

172483482

+CSNK1A1chr5

148899951

-
5UTR-intronENST00000522692ENST00000515748CREBRFchr5

172483482

+CSNK1A1chr5

148899951

-
5UTR-3CDSENST00000296953ENST00000261798CREBRFchr5

172483482

+CSNK1A1chr5

148899951

-
5UTR-3CDSENST00000296953ENST00000377843CREBRFchr5

172483482

+CSNK1A1chr5

148899951

-
5UTR-3CDSENST00000296953ENST00000515435CREBRFchr5

172483482

+CSNK1A1chr5

148899951

-
5UTR-3CDSENST00000296953ENST00000504676CREBRFchr5

172483482

+CSNK1A1chr5

148899951

-
5UTR-3CDSENST00000296953ENST00000515768CREBRFchr5

172483482

+CSNK1A1chr5

148899951

-
5UTR-intronENST00000296953ENST00000606719CREBRFchr5

172483482

+CSNK1A1chr5

148899951

-
5UTR-intronENST00000296953ENST00000606299CREBRFchr5

172483482

+CSNK1A1chr5

148899951

-
5UTR-intronENST00000296953ENST00000515748CREBRFchr5

172483482

+CSNK1A1chr5

148899951

-
5UTR-3CDSENST00000540014ENST00000261798CREBRFchr5

172483482

+CSNK1A1chr5

148899951

-
5UTR-3CDSENST00000540014ENST00000377843CREBRFchr5

172483482

+CSNK1A1chr5

148899951

-
5UTR-3CDSENST00000540014ENST00000515435CREBRFchr5

172483482

+CSNK1A1chr5

148899951

-
5UTR-3CDSENST00000540014ENST00000504676CREBRFchr5

172483482

+CSNK1A1chr5

148899951

-
5UTR-3CDSENST00000540014ENST00000515768CREBRFchr5

172483482

+CSNK1A1chr5

148899951

-
5UTR-intronENST00000540014ENST00000606719CREBRFchr5

172483482

+CSNK1A1chr5

148899951

-
5UTR-intronENST00000540014ENST00000606299CREBRFchr5

172483482

+CSNK1A1chr5

148899951

-
5UTR-intronENST00000540014ENST00000515748CREBRFchr5

172483482

+CSNK1A1chr5

148899951

-
5UTR-3CDSENST00000520420ENST00000261798CREBRFchr5

172483482

+CSNK1A1chr5

148899951

-
5UTR-3CDSENST00000520420ENST00000377843CREBRFchr5

172483482

+CSNK1A1chr5

148899951

-
5UTR-3CDSENST00000520420ENST00000515435CREBRFchr5

172483482

+CSNK1A1chr5

148899951

-
5UTR-3CDSENST00000520420ENST00000504676CREBRFchr5

172483482

+CSNK1A1chr5

148899951

-
5UTR-3CDSENST00000520420ENST00000515768CREBRFchr5

172483482

+CSNK1A1chr5

148899951

-
5UTR-intronENST00000520420ENST00000606719CREBRFchr5

172483482

+CSNK1A1chr5

148899951

-
5UTR-intronENST00000520420ENST00000606299CREBRFchr5

172483482

+CSNK1A1chr5

148899951

-
5UTR-intronENST00000520420ENST00000515748CREBRFchr5

172483482

+CSNK1A1chr5

148899951

-
intron-3CDSENST00000517882ENST00000261798CREBRFchr5

172483482

+CSNK1A1chr5

148899951

-
intron-3CDSENST00000517882ENST00000377843CREBRFchr5

172483482

+CSNK1A1chr5

148899951

-
intron-3CDSENST00000517882ENST00000515435CREBRFchr5

172483482

+CSNK1A1chr5

148899951

-
intron-3CDSENST00000517882ENST00000504676CREBRFchr5

172483482

+CSNK1A1chr5

148899951

-
intron-3CDSENST00000517882ENST00000515768CREBRFchr5

172483482

+CSNK1A1chr5

148899951

-
intron-intronENST00000517882ENST00000606719CREBRFchr5

172483482

+CSNK1A1chr5

148899951

-
intron-intronENST00000517882ENST00000606299CREBRFchr5

172483482

+CSNK1A1chr5

148899951

-
intron-intronENST00000517882ENST00000515748CREBRFchr5

172483482

+CSNK1A1chr5

148899951

-

Top

FusionProtFeatures for CREBRF_CSNK1A1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CREBRF

Q8IUR6

CSNK1A1

P48729


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for CREBRF_CSNK1A1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for CREBRF_CSNK1A1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
CREBRFCD2BP2, BTRC, ATF1CSNK1A1HMGB1, HMGB2, RCC1, PPP1R14A, SYT9, ERF, ADAP1, KPNA2, PPP2CA, ACTA1, AXIN1, TNFRSF1B, CHRM3, APC, PHLPP1, MDM4, MALT1, BCL10, NFKBIA, MDM2, TP53, E2F1, COPS5, ELAVL1, SH3KBP1, CDC25A, PDE4D, HSPA4, HSP90AA1, GLI3, MAPT, SNCA, PIP5K1A, CPSF6, PPP1CC, VCAM1, YWHAE, ITGA4, HNRNPC, GNB2, RPA3, RPA2, RPA1, FAM83G, BACH1, SEC16A, HMMR, CSNK1D, CSNK1E, SEC13, DYNLL1, ACACA, SEC23B, FAM83B, ZNF618, MZT2B, MZT2A, FAM83H, USP34, EPM2AIP1, DYNLL2, SNX22, UNC45A, FAM83D, RASAL2, DBR1, SNX24, EGFR, TIAM1, OCLN, SIK2, BTRC, C1orf111, NFATC3, TEX264, FAM170A, NTRK1, PCM1, CEP170, CEP128, CEP135, NIN, XPO1, CLTC, XRCC6, GTSE1, MYO18A, CARD11, NFATC1, SQSTM1, ATOH1, CRBN, CDH1, ZDBF2, SSMEM1, GAPVD1, POTEC, LRP5, HERC1, POTEB3, ARHGAP22, LRP6, TTC9C, NCKIPSD, WEE1, KCTD3, KIF13B, BCR, CGN, ZBTB21, DENND4C, KSR1, GIGYF1, CBY1, WDR92, FOXA1, TRIM25


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for CREBRF_CSNK1A1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for CREBRF_CSNK1A1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneCSNK1A1C0023493Adult T-Cell Lymphoma/Leukemia1CTD_human
TgeneCSNK1A1C0376634Craniofacial Abnormalities1CTD_human