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Fusion gene ID: 8433 |
FusionGeneSummary for CREBBP_KAT6B |
Fusion gene summary |
Fusion gene information | Fusion gene name: CREBBP_KAT6B | Fusion gene ID: 8433 | Hgene | Tgene | Gene symbol | CREBBP | KAT6B | Gene ID | 1387 | 23522 |
Gene name | CREB binding protein | lysine acetyltransferase 6B | |
Synonyms | CBP|KAT3A|RSTS|RSTS1 | GTPTS|MORF|MOZ2|MYST4|ZC2HC6B|qkf|querkopf | |
Cytomap | 16p13.3 | 10q22.2 | |
Type of gene | protein-coding | protein-coding | |
Description | CREB-binding protein | histone acetyltransferase KAT6BK(lysine) acetyltransferase 6BMOZ, YBF2/SAS3, SAS2 and TIP60 protein 4MOZ-related factorMYST histone acetyltransferase (monocytic leukemia) 4MYST-4histone acetyltransferase MORFhistone acetyltransferase MOZ2histone a | |
Modification date | 20180522 | 20180523 | |
UniProtAcc | Q92793 | Q8WYB5 | |
Ensembl transtripts involved in fusion gene | ENST00000262367, ENST00000382070, | ENST00000372725, ENST00000372724, ENST00000287239, ENST00000372714, ENST00000372711, ENST00000490365, | |
Fusion gene scores | * DoF score | 25 X 18 X 14=6300 | 4 X 5 X 2=40 |
# samples | 34 | 5 | |
** MAII score | log2(34/6300*10)=-4.21174517713694 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(5/40*10)=0.321928094887362 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: CREBBP [Title/Abstract] AND KAT6B [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation | Oncogene involved fusion gene, in-frame and retained their domain. Tumor suppressor gene involved fusion gene, in-frame but not retained their domain. Tumor suppressor gene involved fusion gene, retained protein feature but frameshift. DDR (DNA damage repair) gene involved fusion gene, in-frame but not retained their domain. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | CREBBP | GO:0000122 | negative regulation of transcription by RNA polymerase II | 21539536 |
Hgene | CREBBP | GO:0006355 | regulation of transcription, DNA-templated | 12169688 |
Hgene | CREBBP | GO:0006473 | protein acetylation | 15273251|24939902 |
Hgene | CREBBP | GO:0016573 | histone acetylation | 11742995 |
Hgene | CREBBP | GO:0018076 | N-terminal peptidyl-lysine acetylation | 12435739 |
Hgene | CREBBP | GO:0034644 | cellular response to UV | 24939902 |
Hgene | CREBBP | GO:0045893 | positive regulation of transcription, DNA-templated | 11742995 |
Tgene | KAT6B | GO:0016573 | histone acetylation | 11965546 |
Tgene | KAT6B | GO:0043966 | histone H3 acetylation | 16387653 |
Tgene | KAT6B | GO:0045892 | negative regulation of transcription, DNA-templated | 10497217 |
Tgene | KAT6B | GO:0045893 | positive regulation of transcription, DNA-templated | 10497217|11965546 |
Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | AJ299262 | CREBBP | chr16 | 3929833 | - | KAT6B | chr10 | 76788245 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
Frame-shift | ENST00000262367 | ENST00000372725 | CREBBP | chr16 | 3929833 | - | KAT6B | chr10 | 76788245 | + |
Frame-shift | ENST00000262367 | ENST00000372724 | CREBBP | chr16 | 3929833 | - | KAT6B | chr10 | 76788245 | + |
Frame-shift | ENST00000262367 | ENST00000287239 | CREBBP | chr16 | 3929833 | - | KAT6B | chr10 | 76788245 | + |
In-frame | ENST00000262367 | ENST00000372714 | CREBBP | chr16 | 3929833 | - | KAT6B | chr10 | 76788245 | + |
Frame-shift | ENST00000262367 | ENST00000372711 | CREBBP | chr16 | 3929833 | - | KAT6B | chr10 | 76788245 | + |
5CDS-intron | ENST00000262367 | ENST00000490365 | CREBBP | chr16 | 3929833 | - | KAT6B | chr10 | 76788245 | + |
Frame-shift | ENST00000382070 | ENST00000372725 | CREBBP | chr16 | 3929833 | - | KAT6B | chr10 | 76788245 | + |
Frame-shift | ENST00000382070 | ENST00000372724 | CREBBP | chr16 | 3929833 | - | KAT6B | chr10 | 76788245 | + |
Frame-shift | ENST00000382070 | ENST00000287239 | CREBBP | chr16 | 3929833 | - | KAT6B | chr10 | 76788245 | + |
In-frame | ENST00000382070 | ENST00000372714 | CREBBP | chr16 | 3929833 | - | KAT6B | chr10 | 76788245 | + |
Frame-shift | ENST00000382070 | ENST00000372711 | CREBBP | chr16 | 3929833 | - | KAT6B | chr10 | 76788245 | + |
5CDS-intron | ENST00000382070 | ENST00000490365 | CREBBP | chr16 | 3929833 | - | KAT6B | chr10 | 76788245 | + |
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FusionProtFeatures for CREBBP_KAT6B |
Main function of each fusion partner protein. (from UniProt) |
Hgene | Tgene |
CREBBP | KAT6B |
Acetylates histones, giving a specific tag fortranscriptional activation. Also acetylates non-histone proteins,like NCOA3 and FOXO1. Binds specifically to phosphorylated CREBand enhances its transcriptional activity toward cAMP-responsivegenes. Acts as a coactivator of ALX1. Acts as a circadiantranscriptional coactivator which enhances the activity of thecircadian transcriptional activators: NPAS2-ARNTL/BMAL1 and CLOCK-ARNTL/BMAL1 heterodimers. Acetylates PCNA; acetylation promotesremoval of chromatin-bound PCNA and its degradation duringnucleotide excision repair (NER) (PubMed:24939902).{ECO:0000269|PubMed:11154691, ECO:0000269|PubMed:12738767,ECO:0000269|PubMed:12929931, ECO:0000269|PubMed:14645221,ECO:0000269|PubMed:24939902, ECO:0000269|PubMed:9707565}. | Histone acetyltransferase which may be involved in bothpositive and negative regulation of transcription. Required forRUNX2-dependent transcriptional activation. May be involved incerebral cortex development. Component of the MOZ/MORF complexwhich has a histone H3 acetyltransferase activity.{ECO:0000269|PubMed:10497217, ECO:0000269|PubMed:11965546,ECO:0000269|PubMed:16387653}. |
Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for CREBBP_KAT6B |
For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
>In-frame_CREBBP_ENST00000262367_chr16_3929833_-_KAT6B_ENST00000372714_chr10_76788245_+_176aa MAENLLDGPPNPKRAKLSSPGFSANDSTGTRTAGPDPWPASTSHSRAAFLGHDFGFXQPQARAAGHXGGGQARRSNVPCRGGTCPECSPS >In-frame_CREBBP_ENST00000382070_chr16_3929833_-_KAT6B_ENST00000372714_chr10_76788245_+_176aa MAENLLDGPPNPKRAKLSSPGFSANDSTGTRTAGPDPWPASTSHSRAAFLGHDFGFXQPQARAAGHXGGGQARRSNVPCRGGTCPECSPS |
* Fusion transcript sequences (only coding sequence (CDS) region). |
>In-frame_CREBBP_ENST00000262367_chr16_3929833_-_KAT6B_ENST00000372714_chr10_76788245_+_529nt ATGGCTGAGAACTTGCTGGACGGACCGCCCAACCCCAAAAGAGCCAAACTCAGCTCGCCCGGTTTCTCGGCGAATGACAGCACAGGAACT AGAACTGCAGGCCCAGATCCATGGCCTGCCAGTACCTCCCACTCCAGGGCTGCTTTCCTTGGCCACGACTTCGGCTTCTGACAGCCTCAA GCCAGAGCAGCTGGACATTGAGGAGGAGGGCAGGCCAGGCGCAGCAACGTTCCATGTAGGGGGGGGACCTGCCCAGAATGCTCCCCATCA GCAGCCCCCTGCACCGCCCTCAGATGCCCTTCTGGACCTGCACTTTCCCAGCGACCACCTGGGGGACCTGGGAGACCCCTTCCACCTGGG GCTGGAGGACATTCTGATGGAGGAGGAGGAGGGGGTGGTGGGAGGACTGTCGGGGGGTGCCCTGTCCCCACTGCGGGCTGCCTCCGATCC >In-frame_CREBBP_ENST00000382070_chr16_3929833_-_KAT6B_ENST00000372714_chr10_76788245_+_529nt ATGGCTGAGAACTTGCTGGACGGACCGCCCAACCCCAAAAGAGCCAAACTCAGCTCGCCCGGTTTCTCGGCGAATGACAGCACAGGAACT AGAACTGCAGGCCCAGATCCATGGCCTGCCAGTACCTCCCACTCCAGGGCTGCTTTCCTTGGCCACGACTTCGGCTTCTGACAGCCTCAA GCCAGAGCAGCTGGACATTGAGGAGGAGGGCAGGCCAGGCGCAGCAACGTTCCATGTAGGGGGGGGACCTGCCCAGAATGCTCCCCATCA GCAGCCCCCTGCACCGCCCTCAGATGCCCTTCTGGACCTGCACTTTCCCAGCGACCACCTGGGGGACCTGGGAGACCCCTTCCACCTGGG GCTGGAGGACATTCTGATGGAGGAGGAGGAGGGGGTGGTGGGAGGACTGTCGGGGGGTGCCCTGTCCCCACTGCGGGCTGCCTCCGATCC |
* Fusion transcript sequences (Full-length transcript). |
>In-frame_CREBBP_ENST00000262367_chr16_3929833_-_KAT6B_ENST00000372714_chr10_76788245_+_3597nt TTCTTTTTTTTTTAATTGAGGAATCAACAGCCGCCATCTTGTCGCGGACCCGACCGGGGCTTCGAGCGCGATCTACTCGGCCCCGCCGGT CCCGGGCCCCACAACCGCCCGCGCACCCCGCTCCGCCCGGCCGGCCCGCTCCGCCCGGCCCTCGGCGCCCGCCCCGGCGGCCCCGCTCGC CTCTCGGCTCGGCCTCCCGGAGCCCGGCGGCGGCGGCGGCGGCAGCGGCGGCGGCGGCGGCGGAACGGGGGGTGGGGGGGCCGCGGCGGC GGCGGCGACCCCGCTCGGCGCATTGTTTTTCCTCACGGCGGCGGCGGCGGCGGGCCGCGGGCCGGGAGCGGAGCCCGGAGCCCCCTCGTC GTCGGGCCGCGAGCGAATTCATTAAGTGGGGCGCGGGGGGGGAGCGAGGCGGCGGCGGCGGCGGCACCATGTTCTCGGGGACTGCCTGAG CCGCCCGGCCGGGCGCCGTCGCTGCCAGCCGGGCCCGGGGGGGCGGCCGGGCCGCCGGGGCGCCCCCACCGCGGAGTGTCGCGCTCGGGA GGCGGGCAGGGGATGAGGGGGCCGCGGCCGGCGGCGGCGGCGGCGGCCGGGGGCGGGCGGTGAGCGCTGCGGGGCGCTGTTGCTGTGGCT GAGATTTGGCCGCCGCCTCCCCCACCCGGCCTGCGCCCTCCCTCTCCCTCGGCGCCCGCCCGCCCGCTCGCGGCCCGCGCTCGCTCCTCT CCCTCGCAGCCGGCAGGGCCCCCGACCCCCGTCCGGGCCCTCGCCGGCCCGGCCGCCCGTGCCCGGGGCTGTTTTCGCGAGCAGGTGAAA ATGGCTGAGAACTTGCTGGACGGACCGCCCAACCCCAAAAGAGCCAAACTCAGCTCGCCCGGTTTCTCGGCGAATGACAGCACAGACAAT ATGAATGATGATTCAAGTAACTTGAAAGAAGGCAGTAAAGACAATCCCGAACCTCTAAAGTGCAAACAAGTGTGGCCAAAAGGAACAAAG CGCGGTCTATCTAAGTGGAGGCAAAACAAAGAGAGGAAGACCGGATTTAAACTGAATTTGTACACCCCGCCAGAAACACCCATGGAGCCT GACGAGCAGGTAACAGTGGAAGAACAGAAGGAGACTTCAGAAGGAAAAACCAGCCCCAGTCCCATCAGGATTGAGGAGGAGGTCAAGGAA ACTGGGGAAGCCCTGTTGCCTCAAGAGGAAAACAGAAGGGAAGAAACATGTGCCCCTGTAAGTCCAAACACATCACCAGGTGAAAAACCA GAAGATGATCTCATCAAACCTGAGGAAGAGGAAGAGGAGGAGGAGGAGGAAGAGGAAGAAGAGGAAGAAGAGGAAGGGGAAGAAGAAGAA GGAGGAGGAAATGTAGAAAAAGATCCAGATGGTGCTAAAAGCCAAGAAAAAGAGGAACCAGAAATCTCCACGGAAAAAGAAGACTCTGCA CGTTTGGATGATCACGAAGAGGAGGAGGAAGAGGATGAAGAGCCATCCCACAACGAGGACCATGATGCCGATGACGAGGATGACAGCCAC ATGGAGTCTGCCGAAGTGGAGAAGGAAGAGCTGCCCAGAGAAAGCTTCAAAGAAGTACTGGAAAACCAGGAGACTTTTTTAGACCTTAAT GTGCAGCCTGGTCACTCGAACCCAGAGGTCTTAATGGACTGTGGCGTCGACCTGACAGCTTCTTGTAACAGTGAGCCCAAGGAGCTTGCT GGGGACCCTGAAGCTGTACCCGAATCTGACGAGGAGCCACCCCCAGGAGAACAGGCACAGAAGCAGGACCAAAAGAACAGCAAGGAAGTC GATACAGAGTTCAAAGAGGGAAACCCAGCAACCATGGAAATCGACTCTGAGACTGTCCAGGCCGTTCAGTCTTTGACCCAGGAGAGCAGC GAACAGGACGACACCTTTCAGGATTGTGCCGAGACTCAAGAGGCCTGTAGAAGCCTACAGAACTACACCCGTGCAGACCAAAGTCCACAG ATTGCCACCACGCTCGACGATTGCCAACAGTCGGACCACAGTAGCCCAGTTTCATCCGTCCACTCCCATCCTGGCCAGTCCGTACGTTCT GTCAACAGCCCAAGTGTCCCTGCTCTGGAAAACAGCTACGCCCAAATCAGCCCAGATCAAAGTGCCATCTCAGTGCCATCTCTGCAGAAC ATGGAAACCAGTCCCATGATGGATGTCCCATCAGTTTCAGATCATTCACAGCAAGTCGTAGACAGTGGATTTAGTGACCTGGGCAGTATC GAGAGCACAACTGAGAACTACGAAAACCCAAGCAGCTACGATTCTACTATGGGAGGCAGCATCTGTGGAAACGGCTCTTCACAGAACAGC TGCTCCTATAGCAACCTCACCTCCAGCAGTCTGACACAGAGCAGCTGTGCTGTCACCCAGCAGATGTCCAACATCAGCGGGAGCTGCAGC ATGCTGCAGCAAACCAGCATCAGCTCCCCTCCGACCTGCAGCGTCAAGTCTCCTCAAGGCTGTGTGGTGGAGAGGCCTCCGAGCAGCAGC CAGCAGCTGGCTCAGTGCAGCATGGCTGCTAACTTCACCCCACCCATGCAGCTGGCTGAAATCCCCGAGACGAGCAACGCCAACATTGGC TTATACGAGCGAATGGGTCAGAGTGATTTTGGGGCTGGGCATTACCCGCAGCCGTCAGCCACCTTCAGCCTTGCCAAACTGCAGCAGTTA ACTAATACACTTATTGATCATTCATTGCCTTACAGCCATTCCGCTGCTGTGACTTCCTATGCAAACAGTGCCTCTTTGTCCACACCATTA AGTAACACAGGGCTTGTTCAACTTTCTCAGTCTCCACACTCCGTCCCTGGGGGACCCCAAGCACAAGCTACCATGACCCCACCCCCCAAC CTGACTCCTCCTCCAATGAATCTGCCGCCGCCTCTTTTGCAACGGAACATGGCTGCATCAAATATTGGCATCTCTCACAGCCAAAGACTG CAAACCCAGATTGCCAGCAAGGGCCACATCTCCATGAGAACCAAGTCAGCGTCTCTGTCACCAGCCGCTGCCACCCATCAGTCACAAATC TATGGGCGCTCCCAGACTGTAGCCATGCAGGGTCCTGCACGGACTTTAACGATGCAAAGAGGCATGAACATGAGTGTGAACCTGATGCCA GCGCCAGCCTACAATGTCAACTCTGTGAACATGAACATGAACACTCTCAACGCCATGAATGGGTACAGCATGTCCCAGCCAATGATGAAC AGTGGCTACCACAGCAATCATGGCTATATGAATCAAACGCCCCAATACCCTATGCAGATGCAGATGGGCATGATGGGCACCCAGCCATAT GCCCAGCAGCCAATGCAGACCCCACCCCACGGTAACATGATGTACACGGCCCCCGGACATCACGGCTACATGAACACAGGCATGTCCAAA CAGTCTCTCAATGGCTCCTACATGAGAAGGTAGACAACGTGGGCAGTCCACAAAACCTACGGGGCATCACTATTGGATTGATCTGCACAA >In-frame_CREBBP_ENST00000382070_chr16_3929833_-_KAT6B_ENST00000372714_chr10_76788245_+_2991nt CTGCGGGGCGCTGTTGCTGTGGCTGAGATTTGGCCGCCGCCTCCCCCACCCGGCCTGCGCCCTCCCTCTCCCTCGGCGCCCGCCCGCCCG CTCGCGGCCCGCGCTCGCTCCTCTCCCTCGCAGCCGGCAGGGCCCCCGACCCCCGTCCGGGCCCTCGCCGGCCCGGCCGCCCGTGCCCGG GGCTGTTTTCGCGAGCAGGTGAAAATGGCTGAGAACTTGCTGGACGGACCGCCCAACCCCAAAAGAGCCAAACTCAGCTCGCCCGGTTTC TCGGCGAATGACAGCACAGACAATATGAATGATGATTCAAGTAACTTGAAAGAAGGCAGTAAAGACAATCCCGAACCTCTAAAGTGCAAA CAAGTGTGGCCAAAAGGAACAAAGCGCGGTCTATCTAAGTGGAGGCAAAACAAAGAGAGGAAGACCGGATTTAAACTGAATTTGTACACC CCGCCAGAAACACCCATGGAGCCTGACGAGCAGGTAACAGTGGAAGAACAGAAGGAGACTTCAGAAGGAAAAACCAGCCCCAGTCCCATC AGGATTGAGGAGGAGGTCAAGGAAACTGGGGAAGCCCTGTTGCCTCAAGAGGAAAACAGAAGGGAAGAAACATGTGCCCCTGTAAGTCCA AACACATCACCAGGTGAAAAACCAGAAGATGATCTCATCAAACCTGAGGAAGAGGAAGAGGAGGAGGAGGAGGAAGAGGAAGAAGAGGAA GAAGAGGAAGGGGAAGAAGAAGAAGGAGGAGGAAATGTAGAAAAAGATCCAGATGGTGCTAAAAGCCAAGAAAAAGAGGAACCAGAAATC TCCACGGAAAAAGAAGACTCTGCACGTTTGGATGATCACGAAGAGGAGGAGGAAGAGGATGAAGAGCCATCCCACAACGAGGACCATGAT GCCGATGACGAGGATGACAGCCACATGGAGTCTGCCGAAGTGGAGAAGGAAGAGCTGCCCAGAGAAAGCTTCAAAGAAGTACTGGAAAAC CAGGAGACTTTTTTAGACCTTAATGTGCAGCCTGGTCACTCGAACCCAGAGGTCTTAATGGACTGTGGCGTCGACCTGACAGCTTCTTGT AACAGTGAGCCCAAGGAGCTTGCTGGGGACCCTGAAGCTGTACCCGAATCTGACGAGGAGCCACCCCCAGGAGAACAGGCACAGAAGCAG GACCAAAAGAACAGCAAGGAAGTCGATACAGAGTTCAAAGAGGGAAACCCAGCAACCATGGAAATCGACTCTGAGACTGTCCAGGCCGTT CAGTCTTTGACCCAGGAGAGCAGCGAACAGGACGACACCTTTCAGGATTGTGCCGAGACTCAAGAGGCCTGTAGAAGCCTACAGAACTAC ACCCGTGCAGACCAAAGTCCACAGATTGCCACCACGCTCGACGATTGCCAACAGTCGGACCACAGTAGCCCAGTTTCATCCGTCCACTCC CATCCTGGCCAGTCCGTACGTTCTGTCAACAGCCCAAGTGTCCCTGCTCTGGAAAACAGCTACGCCCAAATCAGCCCAGATCAAAGTGCC ATCTCAGTGCCATCTCTGCAGAACATGGAAACCAGTCCCATGATGGATGTCCCATCAGTTTCAGATCATTCACAGCAAGTCGTAGACAGT GGATTTAGTGACCTGGGCAGTATCGAGAGCACAACTGAGAACTACGAAAACCCAAGCAGCTACGATTCTACTATGGGAGGCAGCATCTGT GGAAACGGCTCTTCACAGAACAGCTGCTCCTATAGCAACCTCACCTCCAGCAGTCTGACACAGAGCAGCTGTGCTGTCACCCAGCAGATG TCCAACATCAGCGGGAGCTGCAGCATGCTGCAGCAAACCAGCATCAGCTCCCCTCCGACCTGCAGCGTCAAGTCTCCTCAAGGCTGTGTG GTGGAGAGGCCTCCGAGCAGCAGCCAGCAGCTGGCTCAGTGCAGCATGGCTGCTAACTTCACCCCACCCATGCAGCTGGCTGAAATCCCC GAGACGAGCAACGCCAACATTGGCTTATACGAGCGAATGGGTCAGAGTGATTTTGGGGCTGGGCATTACCCGCAGCCGTCAGCCACCTTC AGCCTTGCCAAACTGCAGCAGTTAACTAATACACTTATTGATCATTCATTGCCTTACAGCCATTCCGCTGCTGTGACTTCCTATGCAAAC AGTGCCTCTTTGTCCACACCATTAAGTAACACAGGGCTTGTTCAACTTTCTCAGTCTCCACACTCCGTCCCTGGGGGACCCCAAGCACAA GCTACCATGACCCCACCCCCCAACCTGACTCCTCCTCCAATGAATCTGCCGCCGCCTCTTTTGCAACGGAACATGGCTGCATCAAATATT GGCATCTCTCACAGCCAAAGACTGCAAACCCAGATTGCCAGCAAGGGCCACATCTCCATGAGAACCAAGTCAGCGTCTCTGTCACCAGCC GCTGCCACCCATCAGTCACAAATCTATGGGCGCTCCCAGACTGTAGCCATGCAGGGTCCTGCACGGACTTTAACGATGCAAAGAGGCATG AACATGAGTGTGAACCTGATGCCAGCGCCAGCCTACAATGTCAACTCTGTGAACATGAACATGAACACTCTCAACGCCATGAATGGGTAC AGCATGTCCCAGCCAATGATGAACAGTGGCTACCACAGCAATCATGGCTATATGAATCAAACGCCCCAATACCCTATGCAGATGCAGATG GGCATGATGGGCACCCAGCCATATGCCCAGCAGCCAATGCAGACCCCACCCCACGGTAACATGATGTACACGGCCCCCGGACATCACGGC TACATGAACACAGGCATGTCCAAACAGTCTCTCAATGGCTCCTACATGAGAAGGTAGACAACGTGGGCAGTCCACAAAACCTACGGGGCA TCACTATTGGATTGATCTGCACAAATACCTTTGAAGAGTACGATTTCAAAACCAGCAATTGGTGTGAATGCAAAAACATTTGTTGGCACC |
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FusionGenePPI for CREBBP_KAT6B |
Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
CREBBP | EGR1, HNF4A, NFE2L2, TDG, AIRE, NCOA6, BRCA1, CREB1, AR, N4BP2, CTNNB1, RELA, SS18L1, PIAS3, NPAS2, EBF1, E2F1, E2F3, KLF5, PML, SRF, TP53, KLF1, ING1, SMAD1, CSNK2A1, CUX1, ATF1, EWSR1, NR3C1, HNF1A, HOXB7, MSX1, HTT, TCF3, MGMT, KMT2A, MYOD1, ATF2, JUN, MECOM, GLI3, DDX5, PTMA, MYB, FOXO1, FOXO4, RPS6KA3, CITED1, STAT1, STAT6, MAF, PELP1, RPS6KA2, RBBP4, RBBP7, ONECUT1, SERTAD1, SREBF1, SREBF2, NFATC2, TRIP4, HIF1A, NFE2, STAT2, SMARCA4, NCOA1, ESR1, MAML1, MYBL2, KAT2B, GTF2B, CITED2, IRF3, NUP98, TRERF1, TGS1, KLF4, STAT3, NEUROG1, HIPK2, KHDRBS1, GATA1, PHOX2A, SNIP1, NFATC4, KLF13, XRCC6, FOS, POLR2A, SMARCB1, CCNC, CDK8, MED21, NKX2-1, NCOA3, PPARG, ATF4, RPA2, PPARGC1A, HIST3H3, HIST4H4, EP300, ANAPC7, ANAPC5, CDC16, ANAPC2, CDH1, CDC20, REL, DDX17, GCM1, MAP3K5, MAPK10, MKNK1, APC, PAPOLA, CPSF6, TBX21, NCOR1, NCOR2, CARM1, ESR2, YY1, MYC, PLAGL1, MIER1, HDAC1, SP1, SP3, HDAC3, VDR, DAXX, CEBPB, CEBPD, PARP1, PTMS, ATXN3, CTBP1, HIST1H3A, MTF1, SETD1A, MYBL1, NLK, SMAD3, DEK, FGFR1, RPS6KA1, CDKN1A, SND1, NCOA2, KAT6A, SRCAP, TAF6L, ETS1, ETS2, RUNX2, MAFK, TCF12, HDAC2, HOXB6, KPNA2, KPNA6, NR5A1, HMGA1, FOXO3, HIST1H4A, HES6, RUVBL1, FOSL1, FOSB, JUNB, FOXM1, HMGB1, HMGB2, POU1F1, IRF1, SMAD2, RARA, SH3GL1, BCL6, GRIP1, KLF8, NFYB, TRIM28, POT1, WDR5, IRF5, AKT1, CDC27, ATF3, ATG3, MDM2, HOXB2, HOXB3, HOXB9, HOXD12, HOXD13, HOXD10, HOXD4, HOXB4, HOXA10, HOXA9, PBX1, SMARCA2, MYH9, MSH6, MSH2, ZBTB2, ZNF639, ACTA2, CSNK2A2, TP73, PRLR, MED25, PTOV1, IFNAR2, IRF9, TBP, RPS6KA5, IRF7, KAT5, PYGO2, HBP1, TACC2, NPAT, CCNE1, ELAVL1, KDM3B, PSMC5, MDC1, LYN, HCK, SRC, ZCCHC12, RAD23A, RUNX1, CHUK, IKBKB, IKBKG, HIST2H2BE, LIG4, TLR2, EPAS1, MTDH, MEIS1, LDLR, DYRK1B, DYRK1A, CDK2, EID1, COPS2, PSME3, WRN, KLF2, UBE2D1, CREBBP, UBE2I, MAPK3, FHL1, HIST1H2BB, EID3, POU2F3, ELK1, MAPK1, TFDP1, CREM, ZEB1, CRTC1, MAML2, CENPJ, HSF1, FHL2, CDH2, PHOX2B, DDIT3, XAF1, BMI1, CCND3, TXNDC11, CCNA2, C3orf62, PPP1R13L, BRMS1, PCNA, UBE2S, TLE3, MUS81, PTTG1, MED23, SNAI1, TFAP2B, SMAD4, NR3C2, ARNTL, CLOCK, SUMO1, NFATC1, CPSF4, RFPL3, CTGF, NFYA, KIAA0430, HELZ, NISCH, SOWAHA, PCGF3, EIF4ENIF1, PAN2, JUP, HSPA8, LAMP2, TRIM25 | KAT6B | RUNX2, RUNX1, ING5, ATN1, HIST3H3, UBE2I, SGOL1, MEAF6 |
- Retained PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
- Lost PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
- Retained PPIs, but lost function due to frame-shift fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for CREBBP_KAT6B |
Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for CREBBP_KAT6B |
Diseases associated with fusion partners. (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | CREBBP | C0035934 | Rubinstein-Taybi Syndrome | 3 | CTD_human;ORPHANET;UNIPROT |
Hgene | CREBBP | C0033578 | Prostatic Neoplasms | 2 | CTD_human |
Hgene | CREBBP | C0005586 | Bipolar Disorder | 1 | PSYGENET |
Hgene | CREBBP | C0005695 | Bladder Neoplasm | 1 | CTD_human |
Hgene | CREBBP | C0007137 | Squamous cell carcinoma | 1 | CTD_human |
Hgene | CREBBP | C0007138 | Carcinoma, Transitional Cell | 1 | CTD_human |
Hgene | CREBBP | C0010606 | Adenoid Cystic Carcinoma | 1 | CTD_human |
Hgene | CREBBP | C0011573 | Endogenous depression | 1 | PSYGENET |
Hgene | CREBBP | C0024301 | Lymphoma, Follicular | 1 | CTD_human |
Hgene | CREBBP | C0036341 | Schizophrenia | 1 | PSYGENET |
Hgene | CREBBP | C0036920 | Sezary Syndrome | 1 | CTD_human |
Hgene | CREBBP | C0149925 | Small cell carcinoma of lung | 1 | CTD_human |
Hgene | CREBBP | C0152013 | Adenocarcinoma of lung (disorder) | 1 | CTD_human |
Hgene | CREBBP | C0279626 | Squamous cell carcinoma of esophagus | 1 | CTD_human |
Hgene | CREBBP | C1862939 | AMYOTROPHIC LATERAL SCLEROSIS 1 | 1 | CTD_human |
Tgene | KAT6B | C0853193 | Bipolar I disorder | 1 | PSYGENET |
Tgene | KAT6B | C3495559 | Juvenile arthritis | 1 | CTD_human |