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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 8409

FusionGeneSummary for CREB3L2_PPARG

check button Fusion gene summary
Fusion gene informationFusion gene name: CREB3L2_PPARG
Fusion gene ID: 8409
HgeneTgene
Gene symbol

CREB3L2

PPARG

Gene ID

64764

5468

Gene namecAMP responsive element binding protein 3 like 2peroxisome proliferator activated receptor gamma
SynonymsBBF2H7CIMT1|GLM1|NR1C3|PPARG1|PPARG2|PPARgamma
Cytomap

7q33

3p25.2

Type of geneprotein-codingprotein-coding
Descriptioncyclic AMP-responsive element-binding protein 3-like protein 2B-ZIB transcription factorBBF2 human homolog on chromosome 7FUS/BBF2H7 proteinTCAG_1951439basic transcription factor 2cAMP-responsive element-binding protein 3-like protein 2peroxisome proliferator-activated receptor gammaPPAR-gammanuclear receptor subfamily 1 group C member 3peroxisome proliferator-activated nuclear receptor gamma variant 1
Modification date2018052320180523
UniProtAcc

Q70SY1

P37231

Ensembl transtripts involved in fusion geneENST00000330387, ENST00000456390, 
ENST00000452463, ENST00000458726, 
ENST00000468127, 
ENST00000397010, 
ENST00000309576, ENST00000397015, 
ENST00000397012, ENST00000397026, 
ENST00000397000, ENST00000539812, 
ENST00000287820, 
Fusion gene scores* DoF score11 X 10 X 3=3308 X 5 X 4=160
# samples 1313
** MAII scorelog2(13/330*10)=-1.34395440121736
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(13/160*10)=-0.299560281858908
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CREB3L2 [Title/Abstract] AND PPARG [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneCREB3L2

GO:0045893

positive regulation of transcription, DNA-templated

17178827

TgenePPARG

GO:0000122

negative regulation of transcription by RNA polymerase II

12700342

TgenePPARG

GO:0006919

activation of cysteine-type endopeptidase activity involved in apoptotic process

18293083

TgenePPARG

GO:0007165

signal transduction

9568716

TgenePPARG

GO:0010742

macrophage derived foam cell differentiation

26504087

TgenePPARG

GO:0010745

negative regulation of macrophage derived foam cell differentiation

19114110

TgenePPARG

GO:0010871

negative regulation of receptor biosynthetic process

12700342

TgenePPARG

GO:0010887

negative regulation of cholesterol storage

19114110

TgenePPARG

GO:0010891

negative regulation of sequestering of triglyceride

12700342

TgenePPARG

GO:0016525

negative regulation of angiogenesis

28566713

TgenePPARG

GO:0030224

monocyte differentiation

9568716

TgenePPARG

GO:0032526

response to retinoic acid

16239304

TgenePPARG

GO:0042953

lipoprotein transport

9568716

TgenePPARG

GO:0043537

negative regulation of blood vessel endothelial cell migration

28566713

TgenePPARG

GO:0045713

low-density lipoprotein particle receptor biosynthetic process

9568716

TgenePPARG

GO:0045944

positive regulation of transcription by RNA polymerase II

9568715|12700342|16239304|17611579

TgenePPARG

GO:0048469

cell maturation

9568716

TgenePPARG

GO:0048662

negative regulation of smooth muscle cell proliferation

20622039

TgenePPARG

GO:0051091

positive regulation of DNA binding transcription factor activity

18293083

TgenePPARG

GO:0061614

pri-miRNA transcription by RNA polymerase II

28566713

TgenePPARG

GO:0071404

cellular response to low-density lipoprotein particle stimulus

9568716

TgenePPARG

GO:1904706

negative regulation of vascular smooth muscle cell proliferation

28522568


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AY222643CREB3L2chr7

137612896

-PPARGchr3

12421202

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000330387ENST00000397010CREB3L2chr7

137612896

-PPARGchr3

12421202

+
5CDS-5UTRENST00000330387ENST00000309576CREB3L2chr7

137612896

-PPARGchr3

12421202

+
5CDS-5UTRENST00000330387ENST00000397015CREB3L2chr7

137612896

-PPARGchr3

12421202

+
5CDS-5UTRENST00000330387ENST00000397012CREB3L2chr7

137612896

-PPARGchr3

12421202

+
5CDS-5UTRENST00000330387ENST00000397026CREB3L2chr7

137612896

-PPARGchr3

12421202

+
5CDS-5UTRENST00000330387ENST00000397000CREB3L2chr7

137612896

-PPARGchr3

12421202

+
5CDS-5UTRENST00000330387ENST00000539812CREB3L2chr7

137612896

-PPARGchr3

12421202

+
5CDS-5UTRENST00000330387ENST00000287820CREB3L2chr7

137612896

-PPARGchr3

12421202

+
5CDS-5UTRENST00000456390ENST00000397010CREB3L2chr7

137612896

-PPARGchr3

12421202

+
5CDS-5UTRENST00000456390ENST00000309576CREB3L2chr7

137612896

-PPARGchr3

12421202

+
5CDS-5UTRENST00000456390ENST00000397015CREB3L2chr7

137612896

-PPARGchr3

12421202

+
5CDS-5UTRENST00000456390ENST00000397012CREB3L2chr7

137612896

-PPARGchr3

12421202

+
5CDS-5UTRENST00000456390ENST00000397026CREB3L2chr7

137612896

-PPARGchr3

12421202

+
5CDS-5UTRENST00000456390ENST00000397000CREB3L2chr7

137612896

-PPARGchr3

12421202

+
5CDS-5UTRENST00000456390ENST00000539812CREB3L2chr7

137612896

-PPARGchr3

12421202

+
5CDS-5UTRENST00000456390ENST00000287820CREB3L2chr7

137612896

-PPARGchr3

12421202

+
5CDS-5UTRENST00000452463ENST00000397010CREB3L2chr7

137612896

-PPARGchr3

12421202

+
5CDS-5UTRENST00000452463ENST00000309576CREB3L2chr7

137612896

-PPARGchr3

12421202

+
5CDS-5UTRENST00000452463ENST00000397015CREB3L2chr7

137612896

-PPARGchr3

12421202

+
5CDS-5UTRENST00000452463ENST00000397012CREB3L2chr7

137612896

-PPARGchr3

12421202

+
5CDS-5UTRENST00000452463ENST00000397026CREB3L2chr7

137612896

-PPARGchr3

12421202

+
5CDS-5UTRENST00000452463ENST00000397000CREB3L2chr7

137612896

-PPARGchr3

12421202

+
5CDS-5UTRENST00000452463ENST00000539812CREB3L2chr7

137612896

-PPARGchr3

12421202

+
5CDS-5UTRENST00000452463ENST00000287820CREB3L2chr7

137612896

-PPARGchr3

12421202

+
5CDS-5UTRENST00000458726ENST00000397010CREB3L2chr7

137612896

-PPARGchr3

12421202

+
5CDS-5UTRENST00000458726ENST00000309576CREB3L2chr7

137612896

-PPARGchr3

12421202

+
5CDS-5UTRENST00000458726ENST00000397015CREB3L2chr7

137612896

-PPARGchr3

12421202

+
5CDS-5UTRENST00000458726ENST00000397012CREB3L2chr7

137612896

-PPARGchr3

12421202

+
5CDS-5UTRENST00000458726ENST00000397026CREB3L2chr7

137612896

-PPARGchr3

12421202

+
5CDS-5UTRENST00000458726ENST00000397000CREB3L2chr7

137612896

-PPARGchr3

12421202

+
5CDS-5UTRENST00000458726ENST00000539812CREB3L2chr7

137612896

-PPARGchr3

12421202

+
5CDS-5UTRENST00000458726ENST00000287820CREB3L2chr7

137612896

-PPARGchr3

12421202

+
intron-5UTRENST00000468127ENST00000397010CREB3L2chr7

137612896

-PPARGchr3

12421202

+
intron-5UTRENST00000468127ENST00000309576CREB3L2chr7

137612896

-PPARGchr3

12421202

+
intron-5UTRENST00000468127ENST00000397015CREB3L2chr7

137612896

-PPARGchr3

12421202

+
intron-5UTRENST00000468127ENST00000397012CREB3L2chr7

137612896

-PPARGchr3

12421202

+
intron-5UTRENST00000468127ENST00000397026CREB3L2chr7

137612896

-PPARGchr3

12421202

+
intron-5UTRENST00000468127ENST00000397000CREB3L2chr7

137612896

-PPARGchr3

12421202

+
intron-5UTRENST00000468127ENST00000539812CREB3L2chr7

137612896

-PPARGchr3

12421202

+
intron-5UTRENST00000468127ENST00000287820CREB3L2chr7

137612896

-PPARGchr3

12421202

+

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FusionProtFeatures for CREB3L2_PPARG


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CREB3L2

Q70SY1

PPARG

P37231

Transcription factor involved in unfolded proteinresponse (UPR). In the absence of endoplasmic reticulum (ER)stress, inserted into ER membranes, with N-terminal DNA-bindingand transcription activation domains oriented toward the cytosolicface of the membrane. In response to ER stress, transported to theGolgi, where it is cleaved in a site-specific manner by residentproteases S1P/MBTPS1 and S2P/MBTPS2. The released N-terminalcytosolic domain is translocated to the nucleus to effecttranscription of specific target genes. Plays a critical role inchondrogenesis by activating the transcription of SEC23A, whichpromotes the transport and secretion of cartilage matrix proteins,and possibly that of ER biogenesis-related genes (By similarity).In a neuroblastoma cell line, protects cells from ER stress-induced death (PubMed:17178827). In vitro activates transcriptionof target genes via direct binding to the CRE site(PubMed:17178827). {ECO:0000250|UniProtKB:Q8BH52,ECO:0000269|PubMed:17178827}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for CREB3L2_PPARG


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for CREB3L2_PPARG


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
CREB3L2ELAVL1, PTP4A1, RND1, ZNF212, CEP19, PXN, RGS16, GCFC2, GAS7, GULP1, CREB3, FBXW7, CREB3L1, TRIM25PPARGNCOA4, GADD45G, DNTTIP2, PPARGC1A, HDAC3, HDAC4, RB1, EP300, EDF1, FABP1, NR0B2, SVIL, NRIP1, POU1F1, CREBBP, RXRA, MED24, MSX2, PML, ZBTB5, NR2E3, MAFF, ZBTB20, ZBTB3, ZNF496, ZBTB9, ZSCAN1, PIAS1, NCOR1, NCOR2, HMGA1, SP1, TFAP2A, CEBPB, MED1, ZNHIT3, TRIP4, JMJD1C, NFKBIB, SERPINH1, NCOA1, TRIM24, NCOA2, NCOA3, GRIP1, KAT5, LRIF1, HDAC1, MECP2, EZH2, NCOA6, NR0B1, COPS5, FHOD1, KIF1A, RXRB, ROBO4, KLF4, KDM4C, TNP1, KCTD13, RAD54L2, ANP32A, APP, RELA, UBC, CDC34, JAZF1, MED14, BCAS2, NEDD4, SMARCD3, SMARCA4, CDK5, MIF4GD, USP7, ALOX15B, SMAD2, ZFYVE9, NR3C1, MUC1, NSD1, PAXIP1, ASH2L, RBBP5, PRKAA1, PRKAA2, CTNNB1, SFPQ, NR4A1, NR4A2, JUN, NFE2L3, PHB2, STAT5A, VDR, RXRG, MAP2K1, CAV1, SMAD3, PDIA2, PPM1B, XRCC6, XRCC5, MAPK1, RANBP3, XPO1, JUND, LMO4, RFX5, CIITA, TCF4, NFKB1, PPARG, PRKCA, PIN1, STAT6, IKBKB, KAT2A, KIF11, CEP350, UBE2I, KLF5, IGFBP3, EGFR, MDM2, YWHAB, YWHAG, PPARGC1B, STAT1, STUB1, FLYWCH2


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for CREB3L2_PPARG


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgenePPARGP37231DB00244MesalazinePeroxisome proliferator-activated receptor gammasmall moleculeapproved
TgenePPARGP37231DB00573FenoprofenPeroxisome proliferator-activated receptor gammasmall moleculeapproved
TgenePPARGP37231DB00795SulfasalazinePeroxisome proliferator-activated receptor gammasmall moleculeapproved
TgenePPARGP37231DB01039FenofibratePeroxisome proliferator-activated receptor gammasmall moleculeapproved
TgenePPARGP37231DB01050IbuprofenPeroxisome proliferator-activated receptor gammasmall moleculeapproved
TgenePPARGP37231DB13873Fenofibric acidPeroxisome proliferator-activated receptor gammasmall moleculeapproved
TgenePPARGP37231DB00313Valproic AcidPeroxisome proliferator-activated receptor gammasmall moleculeapproved|investigational
TgenePPARGP37231DB00328IndomethacinPeroxisome proliferator-activated receptor gammasmall moleculeapproved|investigational
TgenePPARGP37231DB00412RosiglitazonePeroxisome proliferator-activated receptor gammasmall moleculeapproved|investigational
TgenePPARGP37231DB00731NateglinidePeroxisome proliferator-activated receptor gammasmall moleculeapproved|investigational
TgenePPARGP37231DB00912RepaglinidePeroxisome proliferator-activated receptor gammasmall moleculeapproved|investigational
TgenePPARGP37231DB00966TelmisartanPeroxisome proliferator-activated receptor gammasmall moleculeapproved|investigational
TgenePPARGP37231DB01014BalsalazidePeroxisome proliferator-activated receptor gammasmall moleculeapproved|investigational
TgenePPARGP37231DB01067GlipizidePeroxisome proliferator-activated receptor gammasmall moleculeapproved|investigational
TgenePPARGP37231DB01118AmiodaronePeroxisome proliferator-activated receptor gammasmall moleculeapproved|investigational
TgenePPARGP37231DB01132PioglitazonePeroxisome proliferator-activated receptor gammasmall moleculeapproved|investigational
TgenePPARGP37231DB01252MitiglinidePeroxisome proliferator-activated receptor gammasmall moleculeapproved|investigational
TgenePPARGP37231DB01393BezafibratePeroxisome proliferator-activated receptor gammasmall moleculeapproved|investigational
TgenePPARGP37231DB08604TriclosanPeroxisome proliferator-activated receptor gammasmall moleculeapproved|investigational
TgenePPARGP37231DB09213DexibuprofenPeroxisome proliferator-activated receptor gammasmall moleculeapproved|investigational

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RelatedDiseases for CREB3L2_PPARG


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgenePPARGC0011860Diabetes Mellitus, Non-Insulin-Dependent5CTD_human
TgenePPARGC0011853Diabetes Mellitus, Experimental3CTD_human
TgenePPARGC0020538Hypertensive disease3CTD_human;HPO
TgenePPARGC0021655Insulin Resistance3CTD_human;HPO
TgenePPARGC0035126Reperfusion Injury3CTD_human
TgenePPARGC2609414Acute kidney injury3CTD_human
TgenePPARGC0002395Alzheimer's Disease2CTD_human
TgenePPARGC0021368Inflammation2CTD_human
TgenePPARGC0022116Ischemia2CTD_human
TgenePPARGC0028754Obesity2CTD_human;HPO;UNIPROT
TgenePPARGC0030297Pancreatic Neoplasm2CTD_human
TgenePPARGC0038356Stomach Neoplasms2CTD_human
TgenePPARGC1720861Familial Partial Lipodystrophy, Type 32ORPHANET;UNIPROT
TgenePPARGC0001418Adenocarcinoma1CTD_human
TgenePPARGC0004153Atherosclerosis1CTD_human
TgenePPARGC0004763Barrett Esophagus1CTD_human
TgenePPARGC0009375Colonic Neoplasms1CTD_human
TgenePPARGC0009404Colorectal Neoplasms1CTD_human
TgenePPARGC0010346Crohn Disease1CTD_human
TgenePPARGC0011849Diabetes Mellitus1CTD_human;HPO
TgenePPARGC0017658Glomerulonephritis1CTD_human
TgenePPARGC0018801Heart failure1CTD_human
TgenePPARGC0023794Lipoidosis1CTD_human
TgenePPARGC0023903Liver neoplasms1CTD_human
TgenePPARGC0025202melanoma1CTD_human
TgenePPARGC0025517Metabolic Diseases1CTD_human
TgenePPARGC0027746Nerve Degeneration1CTD_human
TgenePPARGC0029408Degenerative polyarthritis1CTD_human
TgenePPARGC0033860Psoriasis1CTD_human
TgenePPARGC0036341Schizophrenia1PSYGENET
TgenePPARGC0040136Thyroid Neoplasm1CTD_human
TgenePPARGC0079772T-Cell Lymphoma1CTD_human
TgenePPARGC0085413Polycystic Kidney, Autosomal Dominant1CTD_human
TgenePPARGC0221406Pituitary-dependent Cushing's disease1CTD_human
TgenePPARGC0236811Chronobiology Disorders1CTD_human
TgenePPARGC0242339Dyslipidemias1CTD_human
TgenePPARGC0242488Acute Lung Injury1CTD_human
TgenePPARGC0271694Familial partial lipodystrophy1CTD_human
TgenePPARGC0282548Leukostasis1CTD_human
TgenePPARGC0525045Mood Disorders1PSYGENET
TgenePPARGC2239176Liver carcinoma1CTD_human
TgenePPARGC2931367Thyroid cancer, follicular1CTD_human