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Fusion gene ID: 8396 |
FusionGeneSummary for CREB1_SUCNR1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: CREB1_SUCNR1 | Fusion gene ID: 8396 | Hgene | Tgene | Gene symbol | CREB1 | SUCNR1 | Gene ID | 1385 | 56670 |
| Gene name | cAMP responsive element binding protein 1 | succinate receptor 1 | |
| Synonyms | CREB|CREB-1 | GPR91 | |
| Cytomap | 2q33.3 | 3q25.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | cyclic AMP-responsive element-binding protein 1active transcription factor CREBcAMP-response element-binding protein-1cyclic adenosine 3',5'-monophosphate response element binding proteincyclic adenosine 3',5'-monophosphate response element-binding pr | succinate receptor 1G-protein coupled receptor 91P2Y purinoceptor 1 | |
| Modification date | 20180523 | 20180522 | |
| UniProtAcc | P16220 | Q9BXA5 | |
| Ensembl transtripts involved in fusion gene | ENST00000430624, ENST00000432329, ENST00000353267, ENST00000536726, ENST00000374397, ENST00000539789, ENST00000451164, | ENST00000362032, | |
| Fusion gene scores | * DoF score | 3 X 4 X 3=36 | 3 X 1 X 3=9 |
| # samples | 4 | 3 | |
| ** MAII score | log2(4/36*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(3/9*10)=1.73696559416621 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: CREB1 [Title/Abstract] AND SUCNR1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | CREB1 | GO:0006468 | protein phosphorylation | 8798441 |
| Hgene | CREB1 | GO:0010033 | response to organic substance | 8798441 |
| Hgene | CREB1 | GO:0010944 | negative regulation of transcription by competitive promoter binding | 19861239 |
| Hgene | CREB1 | GO:0045944 | positive regulation of transcription by RNA polymerase II | 1655749|8798441|19861239 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | PRAD | TCGA-M7-A720-01A | CREB1 | chr2 | 208425884 | + | SUCNR1 | chr3 | 151597640 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-5UTR | ENST00000430624 | ENST00000362032 | CREB1 | chr2 | 208425884 | + | SUCNR1 | chr3 | 151597640 | + |
| 5CDS-5UTR | ENST00000432329 | ENST00000362032 | CREB1 | chr2 | 208425884 | + | SUCNR1 | chr3 | 151597640 | + |
| intron-5UTR | ENST00000353267 | ENST00000362032 | CREB1 | chr2 | 208425884 | + | SUCNR1 | chr3 | 151597640 | + |
| intron-5UTR | ENST00000536726 | ENST00000362032 | CREB1 | chr2 | 208425884 | + | SUCNR1 | chr3 | 151597640 | + |
| 5CDS-5UTR | ENST00000374397 | ENST00000362032 | CREB1 | chr2 | 208425884 | + | SUCNR1 | chr3 | 151597640 | + |
| 5CDS-5UTR | ENST00000539789 | ENST00000362032 | CREB1 | chr2 | 208425884 | + | SUCNR1 | chr3 | 151597640 | + |
| intron-5UTR | ENST00000451164 | ENST00000362032 | CREB1 | chr2 | 208425884 | + | SUCNR1 | chr3 | 151597640 | + |
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FusionProtFeatures for CREB1_SUCNR1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| CREB1 | SUCNR1 |
| Phosphorylation-dependent transcription factor thatstimulates transcription upon binding to the DNA cAMP responseelement (CRE), a sequence present in many viral and cellularpromoters. Transcription activation is enhanced by the TORCcoactivators which act independently of Ser-133 phosphorylation.Involved in different cellular processes including thesynchronization of circadian rhythmicity and the differentiationof adipose cells. | Receptor for succinate. {ECO:0000269|PubMed:15141213}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for CREB1_SUCNR1 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for CREB1_SUCNR1 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| CREB1 | CREBBP, BRCA1, ABL1, CEBPB, KAT5, EP300, CAMK2A, TP53, RBBP4, RPS6KA5, RPS6KA4, RAB1A, C14orf1, RECQL5, VIM, CHD3, GLI2, FHL5, FHL2, FHL3, PRKACA, HNF1B, NR3C1, KCNIP3, HIST1H3B, HDAC8, GTF2A1, SREBF2, UBE2I, ZMYM2, PIAS1, TOX4, HIPK3, ZHX1, ATF6, POGZ, CRTC1, ZNF451, RNF111, ATF7IP, CHD8, KIAA2026, RFX3, ZNF35, TRIM22, MTF2, SUZ12, ZNF436, ZNF92, DACH1, SMARCA4, SMARCA5, CARM1, MYOD1, HDAC1, HDAC2, POU2F1, TAF4, CCDC6, PPP1CA, JUN, RGS13, YY1, DNMT3B, ATXN3, GSK3B, GSK3A, ATF7, DR1, SRA1, SIRT1, ATR, AKT1, MEIS1, DAXX, YAP1, MAPK14, PRKG1, CREB1, DEAF1, TSSK4, NR5A2, RPS6KA1, CREM, NCOR1, HTT, ATM, CTNNB1, ORC6, ARV1, LAX1, GPS2, TRPV5, TUFT1, ATF2, ATF1, ZBTB21, HIST1H2BA, HIST3H3, HMGA1, ZNF131, MECP2, NFIX, RECQL, HMGA2, TTF2, C5orf24, ARNT, HIST1H2BJ, NFATC2, NFIA, HOXD13, JUND, NFIC, NFIL3, NFYA, NIT2, PBX2, POLR2A, XRCC1, ANKRD17, FAM192A, NFATC1, FOXA1, FOXC1, FOXC2, FOXE1, TRAF3, DNMT3L, HIST1H3A, STAT3, CTAGE5, ARIH1, ARHGAP22, TRIM5, C16orf71, FEZ1, PRR20E, TRIM11, PFDN4, CSGALNACT2, IFT74, SYCP1 | SUCNR1 | MTCH2 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for CREB1_SUCNR1 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| Hgene | CREB1 | P16220 | DB01183 | Naloxone | Cyclic AMP-responsive element-binding protein 1 | small molecule | approved|vet_approved |
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RelatedDiseases for CREB1_SUCNR1 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | CREB1 | C0011570 | Mental Depression | 5 | PSYGENET |
| Hgene | CREB1 | C0011581 | Depressive disorder | 5 | PSYGENET |
| Hgene | CREB1 | C0041696 | Unipolar Depression | 5 | PSYGENET |
| Hgene | CREB1 | C0525045 | Mood Disorders | 5 | PSYGENET |
| Hgene | CREB1 | C1269683 | Major Depressive Disorder | 5 | PSYGENET |
| Hgene | CREB1 | C0001973 | Alcoholic Intoxication, Chronic | 3 | PSYGENET |
| Hgene | CREB1 | C0005586 | Bipolar Disorder | 3 | PSYGENET |
| Hgene | CREB1 | C0036341 | Schizophrenia | 3 | PSYGENET |
| Hgene | CREB1 | C0236736 | Cocaine-Related Disorders | 3 | CTD_human |
| Hgene | CREB1 | C0026552 | Morphine Dependence | 1 | CTD_human |
| Hgene | CREB1 | C0027051 | Myocardial Infarction | 1 | CTD_human |
| Hgene | CREB1 | C0038587 | Substance Withdrawal Syndrome | 1 | CTD_human |
| Hgene | CREB1 | C0600427 | Cocaine Dependence | 1 | PSYGENET |
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